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公开(公告)号：US07034045B1
公开(公告)日：2006-04-25
申请号：US09958262
申请日：2000-04-17
申请人： David Michael Bender , Buddy Eugene Cantrell , Andrew Hendley Fray , Winton Dennis Jones , William David Miller , David Mitchell , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： David Michael Bender , Buddy Eugene Cantrell , Andrew Hendley Fray , Winton Dennis Jones , William David Miller , David Mitchell , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： A61K31/44 , A61K31/40 , A61K31/38 , A61K31/275 , A61K31/195
CPC分类号： C07D213/81 , C07C307/06 , C07C311/03 , C07C311/04 , C07C311/05 , C07C311/06 , C07C311/08 , C07C311/39 , C07D209/34 , C07D213/38 , C07D213/61 , C07D213/82 , C07D261/18 , C07D295/192 , C07D333/20 , C07D333/38
摘要： The present invention provides certain monofluoroalkyl derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.
摘要翻译： 本发明提供某些用于增强哺乳动物谷氨酸受体功能的单氟代烷基衍生物，因此可用于治疗各种各样的病症如精神病和神经障碍。
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公开(公告)号：US06358981B1
公开(公告)日：2002-03-19
申请号：US09744414
申请日：2001-01-23
申请人： Macklin Brian Arnold , David Michael Bender , Andrew Hendley Fray , Winton Dennis Jones , Paul Leslie Ornstein , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： Macklin Brian Arnold , David Michael Bender , Andrew Hendley Fray , Winton Dennis Jones , Paul Leslie Ornstein , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： C07D23504
CPC分类号： C07D213/42 , C07C311/03 , C07C311/04 , C07D213/26 , C07D213/81 , C07D333/16 , C07D333/20
摘要： The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及使用某些磺酰胺衍生物增强谷氨酸受体功能。 它还涉及新型磺酰胺衍生物，其制备方法和含有它们的药物组合物。
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公开(公告)号：US06713516B2
公开(公告)日：2004-03-30
申请号：US10318483
申请日：2002-12-12
申请人： Macklin Brian Arnold , David Michael Bender , Andrew Hendley Fray , Winton Dennis Jones , Paul Leslie Ornstein , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： Macklin Brian Arnold , David Michael Bender , Andrew Hendley Fray , Winton Dennis Jones , Paul Leslie Ornstein , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： A61K3118
CPC分类号： C07D213/42 , C07C311/03 , C07C311/04 , C07D213/26 , C07D213/81 , C07D333/16 , C07D333/20
摘要： The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
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公开(公告)号：US06693137B1
公开(公告)日：2004-02-17
申请号：US09744418
申请日：2001-01-23
申请人： Macklin Brian Arnold , David Michael Bender , Buddy Eugene Cantrell , Winton Dennis Jones , Paul Leslie Ornstein , Richard Lee Simon , Edward C. R. Smith , Eric George Tromiczak , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： Macklin Brian Arnold , David Michael Bender , Buddy Eugene Cantrell , Winton Dennis Jones , Paul Leslie Ornstein , Richard Lee Simon , Edward C. R. Smith , Eric George Tromiczak , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： A61K3118
CPC分类号： C07D213/64 , C07C311/04 , C07C311/05 , C07C323/12 , C07C323/60 , C07C2601/14 , C07D211/58 , C07D213/65 , C07D239/34 , C07D295/088 , C07D295/15
摘要： The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及使用某些磺酰胺衍生物增强谷氨酸受体功能。 它还涉及新型磺酰胺衍生物，其制备方法和含有它们的药物组合物。
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公开(公告)号：US06900353B2
公开(公告)日：2005-05-31
申请号：US10380485
申请日：2001-09-28
申请人： Buddy Eugene Cantrell , Winton Dennis Jones, Jr. , Timothy Alan Shepherd , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： Buddy Eugene Cantrell , Winton Dennis Jones, Jr. , Timothy Alan Shepherd , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： A61P9/10 , A61K31/145 , A61K31/18 , A61K31/275 , A61K31/277 , A61P25/00 , A61P25/14 , A61P25/18 , A61P25/24 , A61P25/28 , A61P43/00 , C07C307/08 , C07C311/07 , C07C311/08 , C07C311/09 , C07C311/16 , C07C311/37 , A61K31/16 , A61K31/17 , A61K31/38 , A61K31/44
CPC分类号： C07C307/08 , C07C311/07 , C07C311/08 , C07C311/37 , C07C2601/08 , C07C2601/14
摘要： The present invention provides compounds of formula (I): useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.
摘要翻译： 本发明提供式（I）化合物：可用于增强哺乳动物的谷氨酸受体功能，因此可用于治疗各种各样的病症如精神病和神经障碍。
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公开(公告)号：US06358982B1
公开(公告)日：2002-03-19
申请号：US09744460
申请日：2001-01-23
申请人： Buddy Eugene Cantrell , Paul Leslie Ornstein , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： Buddy Eugene Cantrell , Paul Leslie Ornstein , Richard Lee Simon , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： A61K31445
CPC分类号： C07D211/26 , C07D211/22 , C07D211/28 , C07D211/76
摘要： The present invention relates to the potentiation of glutamate receptor function using certain heterocyclyl sulphonamide derivatives. It also relates to novel heterocyclyl sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及使用某些杂环基磺酰胺衍生物增强谷氨酸受体功能。 它还涉及新的杂环基磺酰胺衍生物，其制备方法和含有它们的药物组合物。
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公开(公告)号：US06617351B1
公开(公告)日：2003-09-09
申请号：US09744412
申请日：2001-01-23
申请人： Macklin Brian Arnold , David Michael Bender , Thomas John Bleisch , Winton Dennis Jones , Paul Leslie Ornstein , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： Macklin Brian Arnold , David Michael Bender , Thomas John Bleisch , Winton Dennis Jones , Paul Leslie Ornstein , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： A01N3734
CPC分类号： C07C275/24 , C07C233/13 , C07C233/18 , C07C255/58 , C07C255/60 , C07C271/14 , C07C271/20 , C07C275/28 , C07C311/05 , C07D333/20 , C07D333/24
摘要： The present invention provides certain amide, carbamate and urea derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.
摘要翻译： 本发明提供了某些用于增强哺乳动物谷氨酸受体功能的酰胺，氨基甲酸酯和尿素衍生物，因此可用于治疗各种各样的病症如精神病和神经障碍。
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公开(公告)号：US06255494B1
公开(公告)日：2001-07-03
申请号：US08775538
申请日：1997-01-09
申请人： Thomas Charles Britton , Robert Frederick Bruns, Jr. , Buddy Eugene Cantrell , Philip Arthur Hipskind , Karen Lynn Lobb , James Arthur Nixon , Paul Leslie Ornstein , Edward C. R. Smith , Hamideh Zarrinmayeh , Dennis Michael Zimmerman , Anne Marie Nunes , James Jeffry Howbert
发明人： Thomas Charles Britton , Robert Frederick Bruns, Jr. , Buddy Eugene Cantrell , Philip Arthur Hipskind , Karen Lynn Lobb , James Arthur Nixon , Paul Leslie Ornstein , Edward C. R. Smith , Hamideh Zarrinmayeh , Dennis Michael Zimmerman , Anne Marie Nunes , James Jeffry Howbert
IPC分类号： C07D23512
CPC分类号： A61K31/454 , C07D235/12 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/14
摘要： This invention provides a series of substituted benzimidazoles which are useful in treating or preventing a condition associated with an excess of neuropeptide Y. This invention also provides methods employing these substituted benzimidazoles as well as pharmaceutical formulations with comprise as an active ingredient one or more of these compounds.
摘要翻译： 本发明提供了一系列取代的苯并咪唑，其可用于治疗或预防与过量神经肽Y相关的病症。本发明还提供了使用这些取代的苯并咪唑的方法以及包含作为活性成分的一种或多种这些 化合物。
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公开(公告)号：US06355655B1
公开(公告)日：2002-03-12
申请号：US09744457
申请日：2001-01-23
申请人： Ana Maria Escribano , Winton Dennis Jones , Paul Leslie Ornstein , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： Ana Maria Escribano , Winton Dennis Jones , Paul Leslie Ornstein , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： A61K31445
CPC分类号： C07D207/09 , C07D211/28
摘要： The present invention relates to the potentiation of glutamate receptor function using certain heterocyclic sulphonamide derivatives. It also relates to novel heterocyclic sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及使用某些杂环磺酰胺衍生物增强谷氨酸受体功能。 它还涉及新型杂环磺酰胺衍生物，其制备方法和含有它们的药物组合物。
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公开(公告)号：US06911476B2
公开(公告)日：2005-06-28
申请号：US10204339
申请日：2001-02-26
IPC分类号： A61K31/18 , A61K31/192 , A61K31/216 , A61K31/27 , A61K31/275 , A61K31/36 , A61K31/381 , A61P15/10 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/32 , A61P25/36 , A61P43/00 , C07C311/04 , C07C311/08 , C07C311/09 , C07D317/54 , C07D333/16
CPC分类号： C07D317/54 , C07C311/04 , C07C311/08 , C07C311/09 , C07D333/16
摘要： The present invention provides certain sulfonamide derivatives useful for potentiating glutamate receptor function in a patient and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.
摘要翻译： 本发明提供某些可用于增强患者谷氨酸受体功能的磺酰胺衍生物，因此可用于治疗各种各样的病症，例如精神病和神经障碍。
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