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1.发明申请DETECTING PROLONGED MYOCARDIAL REPOLARIZATION INDICATIVE OF CARDIAC CONDITION 审中-公开检测心脏病条件下的多发性心肌梗死公开(公告)号：US20100010359A1
公开(公告)日：2010-01-14
申请号：US12400556
申请日：2009-03-09
IPC分类号： A61B5/0452
CPC分类号： A61B5/0468 , A61B5/04525
摘要： The present invention comprises methods and apparatus for detecting prolonged myocardial repolarization as an indicator of cardiac conditions, including without limitation, transmural ischemia. In some embodiments, without limitation, the present invention comprises methods and apparatus to detect prolonged repolarization using electrocardiographic and electrophysiological tools and measurements.
摘要翻译： 本发明包括用于检测延长的心肌复极化作为心脏病症指标的方法和装置，包括但不限于透壁性缺血。 在一些实施方案中，但不限于，本发明包括使用心电图和电生理学工具和测量来检测延长的复极化的方法和装置。
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2.发明申请公开(公告)号：US20080161708A1
公开(公告)日：2008-07-03
申请号：US10588585
申请日：2005-02-11
IPC分类号： A61B5/0468
CPC分类号： A61B5/0468 , A61B5/04525
摘要： The present invention comprises methods and apparatus for detecting prolonged myocardial repolarization as an indicator of cardiac conditions, including without limitation, transmural ischemia. In some embodiments, without limitation, the present invention comprises methods and apparatus to detect prolonged repolarization using electrocardiographic and electrophysiological tools and measurements.
摘要翻译： 本发明包括用于检测延长的心肌复极化作为心脏病症指标的方法和装置，包括但不限于透壁性缺血。 在一些实施方案中，但不限于，本发明包括使用心电图和电生理学工具和测量来检测延长的复极化的方法和装置。
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3.发明授权Methods and systems for gated or pulsed application of ablative energy in the treatment of cardiac disorders 有权门控或脉冲应用消融能量治疗心脏疾病的方法和系统公开(公告)号：US07871408B2
公开(公告)日：2011-01-18
申请号：US11259881
申请日：2005-10-27
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2017/00703 , A61B2018/00839
摘要： The present invention comprises methods and systems for treating a cardiac arrhythmia in a mammal by administering gated or pulsed radiofrequency current or other ablative energy to the mammal during one or more time periods of increased coronary blood flow. Preferred embodiments of the invention comprise, without limitation, the gated or pulsed administration of radiofrequency current in association with the formation of the dicrotic notch in the arterial blood pressure curve of the mammal. In accordance with the invention, the thermal effects of ablative energy application on the coronary artery are avoided or mitigated due to rapid coronary blood flow resulting in heat loss and minimization of damage to blood vessels.
摘要翻译： 本发明包括通过在增加的冠状动脉血流的一个或多个时间期间向哺乳动物施用门控或脉冲射频电流或其他消融能量来治疗哺乳动物心律失常的方法和系统。 本发明的优选实施方案包括但不限于与哺乳动物的动脉血压曲线中形成重瘤切口相关的射频电流的门控或脉冲施用。 根据本发明，由于快速的冠状动脉血流导致热损失和对血管损伤的最小化，避免或减轻了消融能量对冠状动脉的热效应。
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4.发明申请Methods and systems for gated or pulsed application of ablative energy in the treatment of cardiac disorders 有权门控或脉冲应用消融能量治疗心脏疾病的方法和系统公开(公告)号：US20060200118A1
公开(公告)日：2006-09-07
申请号：US11259881
申请日：2005-10-27
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2017/00703 , A61B2018/00839
摘要： The present invention comprises methods and systems for treating a cardiac arrhythmia in a mammal by administering gated or pulsed radiofrequency current or other ablative energy to the mammal during one or more time periods of increased coronary blood flow. Preferred embodiments of the invention comprise, without limitation, the gated or pulsed administration of radiofrequency current in association with the formation of the dicrotic notch in the arterial blood pressure curve of the mammal. In accordance with the invention, the thermal effects of ablative energy application on the coronary artery are avoided or mitigated due to rapid coronary blood flow resulting in heat loss and minimization of damage to blood vessels.
摘要翻译： 本发明包括通过在增加的冠状动脉血流的一个或多个时间期间向哺乳动物施用门控或脉冲射频电流或其他消融能量来治疗哺乳动物心律失常的方法和系统。 本发明的优选实施方案包括但不限于与哺乳动物的动脉血压曲线中形成重瘤切口相关的射频电流的门控或脉冲施用。 根据本发明，由于快速的冠状动脉血流导致热损失和对血管损伤的最小化，避免或减轻了消融能量对冠状动脉的热效应。
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公开(公告)号：US20060277143A1
公开(公告)日：2006-12-07
申请号：US11465033
申请日：2006-08-16
申请人： Eddy Almonte , Steven Aponte , Gennaro Bruni , Luiz Couto , Gabriela Crespo , Nageswararao Dasari , Nina Eckstein , Joseph Fernandez , Bill Gilbert , Gordon Joost , George Kreiner , Subramaniam Krishnan , Ramaswamy Madhavan , Arthur McGrath , Colleen Wolfe
发明人： Eddy Almonte , Steven Aponte , Gennaro Bruni , Luiz Couto , Gabriela Crespo , Nageswararao Dasari , Nina Eckstein , Joseph Fernandez , Bill Gilbert , Gordon Joost , George Kreiner , Subramaniam Krishnan , Ramaswamy Madhavan , Arthur McGrath , Colleen Wolfe
IPC分类号： G06Q40/00
CPC分类号： G06Q20/02 , G06Q20/04 , G06Q20/10 , G06Q20/102 , G06Q40/00
摘要： A system for facilitating electronic transfer of funds includes a transfer administrator in communication with a transferor institution, one or more intermediary institution, and a transferee institution, the transferor institution having an account at the one or more intermediary institution. The transfer administrator may be configured to receive an incoming payment request designating said transferor institution, a quantity of funds to be transferred, and the transferee institution. The transfer administrator generates and issues a translated payment order based at least in part on the incoming payment request and configured to accomplish a transfer among the transferor institution, the one or more intermediary institution, and the transferee institution. Finally, the transfer administrator may facilitate processing of a balancing payment among the transferor institution, the one or more intermediary institution, and the transferee institution.
摘要翻译： 促进电子资金转移的系统包括与转让机构，一个或多个中介机构和受让机构进行通信的转让管理员，转让机构在一个或多个中介机构具有账户。 转移管理员可以被配置为接收指定所述转移机构的接收到的支付请求，要转移的资金数量和受让机构。 转移管理员至少部分地根据收到的付款请求生成并发布翻译的支付订单，并配置为在转让机构，一个或多个中介机构和受让机构之间完成转移。 最后，转让管理员可以方便处理转让机构，一个或多个中介机构和受让机构之间的平衡支付。
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6.发明申请Method and apparatus for locating the fossa ovalis and performing transseptal puncture 有权用于定位卵圆窝的方法和装置，并进行经血穿刺公开(公告)号：US20080103400A1
公开(公告)日：2008-05-01
申请号：US11901755
申请日：2007-09-19
申请人： Subramaniam Krishnan
发明人： Subramaniam Krishnan
CPC分类号： A61B5/0422 , A61B5/042 , A61B5/0432 , A61B5/05 , A61B5/068 , A61B5/1076 , A61B5/4836 , A61B17/3478 , A61B2017/00044 , A61B2017/00243 , A61B2017/00247 , A61B2562/0209 , A61M25/0662 , A61M2025/0166
摘要： A method of identifying the fossa ovalis in a patient by positioning one or more electrodes against the tissue of the interatrial septum of the patient and acquiring unipolar and/or bipolar electrograms of the tissue of the interatrial septum while moving the electrodes to a plurality of positions against the tissue of the interatrial septum. The fossa ovalis is identified on the basis of unipolar voltage reduction, signal fractionation, broadened signal, reduced signal slew rate, reduced local myocardial impedance, increased phase angle and/or increased pacing threshold. An apparatus for identify the fossa ovalis is also provided.
摘要翻译： 一种通过将一个或多个电极定位在患者的房间隔膜的组织上并识别房间隔的组织的单极和/或双极电描记图，同时将电极移动到多个位置来识别患者中的卵圆窝的方法 针对房间隔的组织。 基于单极电压降低，信号分级，扩大信号，降低的信号转换速率，降低的局部心肌阻抗，增加的相位角和/或增加的起搏阈值来鉴定卵圆窝。 还提供了一种用于鉴定卵圆窝的装置。
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7.发明申请Method and apparatus for locating the fossa ovalis, creating a virtual fossa ovalis and performing transseptal puncture 有权用于定位卵圆窝的方法和装置，产生一个虚拟的卵窝，并进行经血穿刺公开(公告)号：US20060276710A1
公开(公告)日：2006-12-07
申请号：US11367941
申请日：2006-03-03
申请人： Subramaniam Krishnan
发明人： Subramaniam Krishnan
IPC分类号： A61B5/05
CPC分类号： A61B5/042 , A61B5/06 , A61B5/063 , A61B5/1076 , A61B34/10 , A61B34/20 , A61B2017/00044 , A61B2017/00053 , A61B2017/00243 , A61B2034/105 , A61B2034/2051 , A61M25/0041
摘要： A method of locating the fossa ovalis in a patient by locating the His bundle, plane of the interatrial septum, and coronary sinus ostium in a patient, and thereafter locating the fossa ovalis on the basis of one or more predetermined distances between the fossa ovalis and the His bundle and the coronary sinus ostium. An apparatus for locating the fossa ovalis and performing a transseptal puncture is also provided.
摘要翻译： 通过将患者的His束，房间隔间隔和冠状窦口放置在患者体内，然后基于卵圆窝和卵圆窝之间的一个或多个预定距离来定位卵巢卵窝，定位卵巢窝的方法 他的束和冠状窦口。 还提供了一种用于定位卵圆窝并进行经内穿刺的装置。
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公开(公告)号：US20110008329A1
公开(公告)日：2011-01-13
申请号：US12600292
申请日：2008-06-25
申请人： Subramaniam Krishnan , JoAnn Suzich , Peter Kiener , Genevieve Losonsky , Herren Wu , William Dall'Acqua , Bettina Richter
发明人： Subramaniam Krishnan , JoAnn Suzich , Peter Kiener , Genevieve Losonsky , Herren Wu , William Dall'Acqua , Bettina Richter
IPC分类号： A61K39/395 , C07K16/10 , A61P31/14 , A61P37/04
CPC分类号： C07K16/1027 , A61K2039/505 , A61K2039/545 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/77
摘要： The present invention provides methods for managing, treating and/or ameliorating a respiratory syncytial virus (RSV) infection (e.g., acute RSV disease, or a RSV upper respiratory tract infection (URI) and/or lower respiratory tract infection (LRI)), and/or a symptom or a long-term respiratory condition relating thereto (e.g., asthma, wheezing, reactive airway disease (RAD), or chronic obstructive pulmonary disease (COPD)) in a subject, comprising administering to said human an effective amount of one or more antibodies that immunospecifically bind to one or more RSV antigens with a high affinity and/or high avidity and further comprise a modified IgG constant domain, or FcRn-binding fragment thereof, to not only decrease RSV infection, but also decrease the pro-inflammatory epithelial cell immune responses in order to mitigate the later development of asthma and/or wheezing and/or COPD in said patient.
摘要翻译： 本发明提供了用于管理，治疗和/或改善呼吸道合胞病毒（RSV）感染（例如急性RSV疾病或RSV上呼吸道感染（URI）和/或下呼吸道感染（LRI））的方法， 和/或与受试者相关的症状或长期呼吸道状况（例如，哮喘，喘鸣，反应性气道疾病（RAD）或慢性阻塞性肺疾病（COPD））），包括向所述人施用有效量的 一种或多种以高亲和性和/或高亲合力免疫特异性结合一种或多种RSV抗原的抗体，并且还包含经修饰的IgG恒定结构域或其FcRn结合片段，以不仅降低RSV感染，而且减少pro - 炎症性上皮细胞免疫应答，以减轻所述患者中哮喘和/或喘息和/或COPD的后期发展。
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公开(公告)号：US07110980B2
公开(公告)日：2006-09-19
申请号：US10358801
申请日：2003-02-05
申请人： Eddy Almonte , Steven Aponte , Gennaro Bruni , Luiz C. Couto , Gabriela Crespo , Nageswararao Dasari , Nina Eckstein , Joseph Fernandez , Bill Gilbert , Gordon Joost , George Kreiner , Subramaniam Krishnan , Ramaswamy Madhavan , Arthur McGrath , Colleen Wolfe
发明人： Eddy Almonte , Steven Aponte , Gennaro Bruni , Luiz C. Couto , Gabriela Crespo , Nageswararao Dasari , Nina Eckstein , Joseph Fernandez , Bill Gilbert , Gordon Joost , George Kreiner , Subramaniam Krishnan , Ramaswamy Madhavan , Arthur McGrath , Colleen Wolfe
IPC分类号： G06F17/60
CPC分类号： G06Q20/02 , G06Q20/04 , G06Q20/10 , G06Q20/102 , G06Q40/00
摘要： A system for facilitating electronic transfer of funds includes a transfer administrator in communication with a transferor institution, one or more intermediary institution, and a transferee institution, the transferor institution having an account at the one or more intermediary institution. The transfer administrator may be configured to receive an incoming payment request designating said transferor institution, a quantity of funds to be transferred, and the transferee institution. The transfer administrator generates and issues a translated payment order based at least in part on the incoming payment request and configured to accomplish a transfer among the transferor institution, the one or more intermediary institution, and the transferee institution. Finally, the transfer administrator may facilitate processing of a balancing payment among the transferor institution, the one or more intermediary institution, and the transferee institution.
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