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    POSITIVELY CHARGED SPECIES AS BINDING REAGENTS IN THE SEPARATION OF PROTEIN AGGREGATES FROM MONOMERS
    3.
    发明申请
    POSITIVELY CHARGED SPECIES AS BINDING REAGENTS IN THE SEPARATION OF PROTEIN AGGREGATES FROM MONOMERS 审中-公开
    作为联合试剂在单体分离蛋白质聚集体中的积极物种

    公开(公告)号：US20130109581A1

    公开(公告)日：2013-05-02

    申请号：US13508037

    申请日：2010-11-04

    申请人： David Peretz ,  Alice Yam ,  Xuemei Wang ,  Man Gao

    发明人： Cleo Salisbury ,  David Peretz ,  Alice Yam ,  Xuemei Wang ,  Man Gao

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6896 ,  A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  G01N33/531 ,  G01N2800/2821 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

    摘要： The invention provides methods for detecting the presence of an aggregate in a sample by contacting the sample suspected of containing an aggregate with an aggregate-specific binding reagent under conditions that allow the binding of the reagent to the aggregate, if present; and detecting the presence of the aggregate, if any, in the sample by its binding to the reagent; where the aggregate-specific binding reagent typically has a net charge of at least about positive one at the pH at which the sample is contacted with the ASB reagent, is attached to a solid support at a charge density of at least about 60 nmol net charge per square meter, and binds preferentially with aggregates over monomers when attached to the solid support. Methods for detecting the presence of oligomer are also provided. Compositions for use in the methods are provided.

    摘要翻译： 本发明提供了在允许试剂与聚集体结合的条件下（如果有的话），将怀疑含有骨料的样品与聚集体特异性结合试剂接触的方式来检测样品中骨料的存在; 并通过与样品的结合来检测样品中聚集体（如果有的话）的存在; 其中聚集体特异性结合试剂通常在样品与ASB试剂接触的pH下通常具有至少约为1的净电荷，以至少约60nmol净电荷的电荷密度附着于固体支持物 当连接到固体支持物上时，优先与聚集体相对于单体结合。 还提供了检测低聚物存在的方法。 提供了用于该方法的组合物。

    Prion-specific peptoid reagents
    5.
    发明授权
    Prion-specific peptoid reagents 有权
    朊病毒特异性拟肽试剂

    公开(公告)号：US07834144B2

    公开(公告)日：2010-11-16

    申请号：US11518091

    申请日：2006-09-08

    申请人： David Peretz ,  Michael D. Connolly ,  Ronald Zuckermann ,  Man Gao ,  Gulliver Timoteo ,  Robert M. Shimizu

    发明人： David Peretz ,  Michael D. Connolly ,  Ronald Zuckermann ,  Man Gao ,  Gulliver Timoteo ,  Robert M. Shimizu

    IPC分类号： C07K7/00

    CPC分类号： C07K14/001 ,  A61K38/00 ,  C07K14/47 ,  Y02P20/55

    摘要： The invention relates to peptoid reagents that interact preferentially with a pathogenic form of a conformational disease protein as compared to a nonpathogenic form of the conformational disease protein where the peptoid reagent comprises an amino-terminal region, a carboxy-terminal region, and at least one peptoid region between the amino-terminal region and the carboxy-terminal region where the peptoid region comprises 3 to about 30 N-substituted glycines, and optionally one or more amino acids. The invention also relates to methods of using the peptoids in detecting and isolating prions, and in the treatment and prevention of prion-related diseases.

    摘要翻译： 本发明涉及与构象疾病蛋白质的非致病形式相比优先与构象疾病蛋白质的致病形式相互作用的拟肽试剂，其中拟肽试剂包含氨基末端区域，羧基末端区域和至少一个 氨基末端区域和羧基末端区域之间的拟肽区域，其中拟肽区域包含3至约30个N-取代的甘氨酸，以及任选的一个或多个氨基酸。 本发明还涉及使用拟肽来检测和分离朊病毒以及治疗和预防朊病毒相关疾病的方法。

    Prion-specific peptoid reagents
    6.
    发明申请
    Prion-specific peptoid reagents 有权
    朊病毒特异性拟肽试剂

    公开(公告)号：US20070087972A1

    公开(公告)日：2007-04-19

    申请号：US11518091

    申请日：2006-09-08

    申请人： David Peretz ,  Michael Connolly ,  Ronald Zuckermann ,  Man Gao ,  Gulliver Timoteo ,  Robert Shimizu

    发明人： David Peretz ,  Michael Connolly ,  Ronald Zuckermann ,  Man Gao ,  Gulliver Timoteo ,  Robert Shimizu

    IPC分类号： A61K38/08 ,  C07K7/06

    CPC分类号： C07K14/001 ,  A61K38/00 ,  C07K14/47 ,  Y02P20/55

    摘要： The invention relates to peptoid reagents that interact preferentially with a pathogenic form of a conformational disease protein as compared to a nonpathogenic form of the conformational disease protein where the peptoid reagent comprises an amino-terminal region, a carboxy-terminal region, and at least one peptoid region between the amino-terminal region and the carboxy-terminal region where the peptoid region comprises 3 to about 30 N-substituted glycines, and optionally one or more amino acids. The invention also relates to methods of using the peptoids in detecting and isolating prions, and in the treatment and prevention of prion-related diseases.

    摘要翻译： 本发明涉及与构象疾病蛋白质的非致病形式相比优先与构象疾病蛋白质的致病形式相互作用的拟肽试剂，其中拟肽试剂包含氨基末端区域，羧基末端区域和至少一个 氨基末端区域和羧基末端区域之间的拟肽区域，其中拟肽区域包含3至约30个N-取代的甘氨酸，以及任选的一个或多个氨基酸。 本发明还涉及使用拟肽来检测和分离朊病毒以及治疗和预防朊病毒相关疾病的方法。