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公开(公告)号：US20090130774A1
公开(公告)日：2009-05-21
申请号：US11795163
申请日：2006-01-13
申请人： David Peretz , Melissa Michelitsch , Celine Hu , Xuemei Wang , Man Gao , Michael Connolly , Thomas Horn , Ronald Zuckermann , David Chien
发明人： David Peretz , Melissa Michelitsch , Celine Hu , Xuemei Wang , Man Gao , Michael Connolly , Thomas Horn , Ronald Zuckermann , David Chien
IPC分类号： G01N33/566
CPC分类号： B82Y30/00 , G01N33/6896 , G01N2800/2828
摘要： Peptide reagents that interact preferentially with the PrPsc form of the prion protein are described for use in detecting PrPsc in biological samples. In particular, ELISA assays are described.
摘要翻译： 描述了与PrPsc形式的朊病毒蛋白优先相互作用的肽试剂用于检测生物样品中的PrPsc。 特别地，描述了ELISA测定。
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公开(公告)号：US20060035242A1
公开(公告)日：2006-02-16
申请号：US11056950
申请日：2005-02-11
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/47 , G01N2800/2828
摘要： Peptide reagents that interact preferentially with the PrPsc form of the prion protein are described. Methods of using the reagents or antibodies to the reagents for detection, diagnosis, purification, therapy and prophylaxis for prions and prion-associated diseases are also described.
摘要翻译： 描述了与Prion蛋白质的PrPßsc形式优先相互作用的肽试剂。 还描述了将试剂或抗体用于检测，诊断，纯化，治疗和预防朊病毒和朊病毒相关疾病的方法。
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公开(公告)号：US20070087972A1
公开(公告)日：2007-04-19
申请号：US11518091
申请日：2006-09-08
申请人： David Peretz , Michael Connolly , Ronald Zuckermann , Man Gao , Gulliver Timoteo , Robert Shimizu
发明人： David Peretz , Michael Connolly , Ronald Zuckermann , Man Gao , Gulliver Timoteo , Robert Shimizu
CPC分类号： C07K14/001 , A61K38/00 , C07K14/47 , Y02P20/55
摘要： The invention relates to peptoid reagents that interact preferentially with a pathogenic form of a conformational disease protein as compared to a nonpathogenic form of the conformational disease protein where the peptoid reagent comprises an amino-terminal region, a carboxy-terminal region, and at least one peptoid region between the amino-terminal region and the carboxy-terminal region where the peptoid region comprises 3 to about 30 N-substituted glycines, and optionally one or more amino acids. The invention also relates to methods of using the peptoids in detecting and isolating prions, and in the treatment and prevention of prion-related diseases.
摘要翻译： 本发明涉及与构象疾病蛋白质的非致病形式相比优先与构象疾病蛋白质的致病形式相互作用的拟肽试剂，其中拟肽试剂包含氨基末端区域，羧基末端区域和至少一个 氨基末端区域和羧基末端区域之间的拟肽区域，其中拟肽区域包含3至约30个N-取代的甘氨酸，以及任选的一个或多个氨基酸。 本发明还涉及使用拟肽来检测和分离朊病毒以及治疗和预防朊病毒相关疾病的方法。
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公开(公告)号：US20120027677A1
公开(公告)日：2012-02-02
申请号：US12924872
申请日：2010-10-07
申请人： David Peretz , Michael D. Connolly , Ronald Zuckermann , Man Gao , Gulliver Timoteo , Robert M. Shimizu
发明人： David Peretz , Michael D. Connolly , Ronald Zuckermann , Man Gao , Gulliver Timoteo , Robert M. Shimizu
IPC分类号： A61K38/03 , C07K5/083 , C07K5/103 , C07K7/06 , C07K7/08 , C07K14/00 , C07K17/00 , G01N33/53 , A61K49/00 , A61P25/28 , C07K19/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/16 , C07K1/14 , A61P37/02 , G01N33/02 , B01D15/00 , C07K4/00
CPC分类号： C07K14/001 , A61K38/00 , C07K14/47 , Y02P20/55
摘要： The invention relates to peptoid reagents that interact preferentially with a pathogenic form of a conformational disease protein as compared to a nonpathogenic form of the conformational disease protein where the peptoid reagent comprises an amino-terminal region, a carboxy-terminal region, and at least one peptoid region between the amino-terminal region and the carboxy-terminal region where the peptoid region comprises 3 to about 30 N-substituted glycines, and optionally one or more amino acids. The invention also relates to methods of using the peptoids in detecting and isolating prions, and in the treatment and prevention of prion-related diseases.
摘要翻译： 本发明涉及与构象疾病蛋白质的非致病形式相比优先与构象疾病蛋白质的致病形式相互作用的拟肽试剂，其中拟肽试剂包含氨基末端区域，羧基末端区域和至少一个 氨基末端区域和羧基末端区域之间的拟肽区域，其中拟肽区域包含3至约30个N-取代的甘氨酸，以及任选的一个或多个氨基酸。 本发明还涉及使用拟肽来检测和分离朊病毒以及治疗和预防朊病毒相关疾病的方法。
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公开(公告)号：US07834144B2
公开(公告)日：2010-11-16
申请号：US11518091
申请日：2006-09-08
申请人： David Peretz , Michael D. Connolly , Ronald Zuckermann , Man Gao , Gulliver Timoteo , Robert M. Shimizu
发明人： David Peretz , Michael D. Connolly , Ronald Zuckermann , Man Gao , Gulliver Timoteo , Robert M. Shimizu
IPC分类号： C07K7/00
CPC分类号： C07K14/001 , A61K38/00 , C07K14/47 , Y02P20/55
摘要： The invention relates to peptoid reagents that interact preferentially with a pathogenic form of a conformational disease protein as compared to a nonpathogenic form of the conformational disease protein where the peptoid reagent comprises an amino-terminal region, a carboxy-terminal region, and at least one peptoid region between the amino-terminal region and the carboxy-terminal region where the peptoid region comprises 3 to about 30 N-substituted glycines, and optionally one or more amino acids. The invention also relates to methods of using the peptoids in detecting and isolating prions, and in the treatment and prevention of prion-related diseases.
摘要翻译： 本发明涉及与构象疾病蛋白质的非致病形式相比优先与构象疾病蛋白质的致病形式相互作用的拟肽试剂，其中拟肽试剂包含氨基末端区域，羧基末端区域和至少一个 氨基末端区域和羧基末端区域之间的拟肽区域，其中拟肽区域包含3至约30个N-取代的甘氨酸，以及任选的一个或多个氨基酸。 本发明还涉及使用拟肽来检测和分离朊病毒以及治疗和预防朊病毒相关疾病的方法。
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公开(公告)号：US20060188916A1
公开(公告)日：2006-08-24
申请号：US11398576
申请日：2006-04-04
申请人： Thomas Horn , Ronald Zuckermann
发明人： Thomas Horn , Ronald Zuckermann
摘要： Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecules of the invention are made entirely by solid phase synthesis. In other instances, the spacer groups are hydrophilic and compositions containing them, and to solid phase synthesis of varied structure peptoids using chemoselective ligation moieties.
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公开(公告)号：US20080089938A9
公开(公告)日：2008-04-17
申请号：US10278751
申请日：2002-10-22
申请人： Ronald Zuckermann , Nathalie Dubois-Stringfellow , Varavani Dwarki , Michael Innis , John Murphy , Fred Cohen , Tetsuo Uno
发明人： Ronald Zuckermann , Nathalie Dubois-Stringfellow , Varavani Dwarki , Michael Innis , John Murphy , Fred Cohen , Tetsuo Uno
CPC分类号： A61K38/2264 , A61K38/1816 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0041 , C07K7/08 , C07K14/001 , C12N15/87 , C12N2810/858
摘要： This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.
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公开(公告)号：US20060128033A1
公开(公告)日：2006-06-15
申请号：US11343886
申请日：2006-01-30
申请人： Daniel Suich , Ronald Zuckermann
发明人： Daniel Suich , Ronald Zuckermann
IPC分类号： C40B40/02 , C40B40/10 , C07D311/82
CPC分类号： C07D493/10 , C09B11/24 , C09B49/126 , Y10T436/173845 , Y10T436/182
摘要： Fluorogenic or chromogenic dyes are useful as reporter molecules for detecting cell entry by a specific molecule.
摘要翻译： 荧光或显色染料可用作用于检测特定分子进入细胞的报道分子。
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公开(公告)号：US20090061462A1
公开(公告)日：2009-03-05
申请号：US12079573
申请日：2008-03-27
IPC分类号： G01N33/567 , G01N33/68 , G01N33/536
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/47 , G01N2800/2828
摘要： Peptide reagents that interact preferentially with the PrPsc form of the prion protein are described. Methods of using the reagents or antibodies to the reagents for detection, diagnosis, purification, therapy and prophylaxis for prions and prion-associated diseases are also described.
摘要翻译： 描述了与PrPsc形式的朊病毒蛋白优先相互作用的肽试剂。 还描述了将试剂或抗体用于检测，诊断，纯化，治疗和预防朊病毒和朊病毒相关疾病的方法。
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公开(公告)号：US20050209152A1
公开(公告)日：2005-09-22
申请号：US11120071
申请日：2005-05-02
申请人： Annelise Barron , Ronald Zuckermann , Cindy Wu
发明人： Annelise Barron , Ronald Zuckermann , Cindy Wu
IPC分类号： A61K38/00 , A61K31/685 , A61K38/17 , A61P11/00 , C07K14/785
CPC分类号： C07K14/785 , A61K38/1709 , Y10S930/32 , A61K31/74 , A61K31/685 , A61K31/66 , A61K31/20 , A61K31/195 , A61K2300/00
摘要： The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.
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