公开(公告)号：US20070015287A1

公开(公告)日：2007-01-18

申请号：US11457408

申请日：2006-07-13

申请人： David Robbins ,  Charles Hwang ,  Rebecca Eaton

发明人： David Robbins ,  Charles Hwang ,  Rebecca Eaton

IPC分类号： G01N31/22

CPC分类号： A61B10/0051 ,  A61B10/0064 ,  G01N33/523 ,  G01N33/84 ,  G01N2333/924

摘要： Methods and devices for measuring analyte concentration in a nonblood body fluid sample enable rapid-results, low-cost diagnosis of various medical conditions in an outpatient setting. In one embodiment, measured patient sodium concentration is used by the patient or the patient's healthcare provider to guide medical decision-making. In another embodiment, measured patient sodium concentration is processed to mechanically adjust the concentration of sodium in an aqueous solution to be delivered to the patient for oral administration. In yet another embodiment, a closed loop system measures saliva sodium concentration and uses any of a number of different types of feedback control systems to monitor and control the fluid and/or electrolyte state of the patient.

摘要翻译： 用于测量非血液体液样品中分析物浓度的方法和设备能够在门诊设置中快速，低成本诊断各种医疗状况。 在一个实施方案中，患者或患者的医疗保健提供者使用测量的患者钠浓度来指导医学决策。 在另一个实施方案中，处理测量的患者钠浓度以机械调节待递送至患者口服给药的水溶液中的钠浓度。 在另一个实施方案中，闭环系统测量唾液钠浓度并且使用多种不同类型的反馈控制系统中的任何一种来监测和控制患者的流体和/或电解质状态。

公开(公告)号：US20060121548A1

公开(公告)日：2006-06-08

申请号：US11270194

申请日：2005-11-08

申请人： David Robbins ,  Charles Hwang

发明人： David Robbins ,  Charles Hwang

IPC分类号： C12Q1/34 ,  A61M35/00 ,  C12M1/34

CPC分类号： G01N33/84 ,  C12Q1/34 ,  G01N33/523 ,  G01N2333/924 ,  G01N2800/04

摘要： Systems and methods for measuring saliva sodium concentration using a chromatographic reaction enable rapid-results, low-cost diagnosis of various medical conditions in an outpatient setting. In one embodiment, measured patient saliva sodium concentration is used by the patient or the patient's healthcare provider to guide medical decision making. In another embodiment, measured patient saliva sodium concentration is processed to mechanically adjust the concentration of sodium in an aqueous solution to be delivered to the patient for oral administration. In yet another embodiment, a closed loop system measures saliva sodium concentration and uses any of a number of different types of feedback control systems to monitor and control the fluid and/or electrolyte state of the patient.

摘要翻译： 使用色谱反应测量唾液钠浓度的系统和方法可以在门诊设置中快速，低成本诊断各种医疗条件。 在一个实施例中，测量的患者唾液钠浓度由患者或患者的医疗保健提供者用于指导医学决策。 在另一个实施方案中，处理测量的患者唾液钠浓度以机械调节待递送至患者口服的水溶液中的钠浓度。 在另一个实施方案中，闭环系统测量唾液钠浓度并且使用多种不同类型的反馈控制系统中的任何一种来监测和控制患者的流体和/或电解质状态。

公开(公告)号：US20070094387A1

公开(公告)日：2007-04-26

申请号：US11564370

申请日：2006-11-29

申请人： Mark Hahn ,  Kevin Brophy ,  Anita Chow ,  Luis Letjer ,  David Robbins

发明人： Mark Hahn ,  Kevin Brophy ,  Anita Chow ,  Luis Letjer ,  David Robbins

IPC分类号： G06F15/16

CPC分类号： G06Q10/107

摘要： A personal messaging agent (220) performs enhanced messaging services. The personal messaging agent (220) includes a user profile (310), a message filter (320), and at least one external helper (330). The user profile (310) stores user preferences for processing messages. The message filter (320) receives messages, performs in-band processing on the messages based on the user preferences, and generates at least one event for triggering out-of-band processing of the messages. The external helpers (330) perform the out-of-band processing of the messages in response to the event(s).

摘要翻译： 个人消息代理（220）执行增强的消息服务。 个人消息传递代理（220）包括用户简档（310），消息过滤器（320）和至少一个外部帮助器（330）。 用户简档（310）存储用于处理消息的用户偏好。 消息过滤器（320）接收消息，基于用户偏好对消息执行带内处理，并且生成用于触发消息的带外处理的至少一个事件。 外部助手（330）响应于事件执行消息的带外处理。

公开(公告)号：US20060196082A1

公开(公告)日：2006-09-07

申请号：US11364567

申请日：2006-02-28

申请人： David Robbins

发明人： David Robbins

IPC分类号： A43C13/00 ,  A43B13/28 ,  A43B21/36

CPC分类号： A43B3/246 ,  A43B3/24 ,  A43B21/42

摘要： The present invention relates to a removable modular heel assembly that is attached to a high heel shoe, which shoe may be adapted to accept the assembly, and which assembly is designed to increase the surface area of the heel or shoe to enhance stability, comfort, and/or balance for the wearer.

摘要翻译： 本发明涉及一种可移动的模块化跟部组件，其附接到高跟鞋，该鞋可以适于接受该组件，并且该组件被设计成增加鞋跟或鞋的表面面积以增强其稳定性，舒适性， 和/或佩戴者的平衡。

公开(公告)号：US3982289A

公开(公告)日：1976-09-28

申请号：US567039

申请日：1975-04-10

申请人： David Robbins

发明人： David Robbins

IPC分类号： E03C1/264 ,  E03C1/26

CPC分类号： E03C1/264

摘要： A disposable sink strainer comprising a cylindrical portion having a plurality of openings therein and a bottom portion substantially constituting a disc and integrally connected to and depending from a lowermost portion of the cylindrical portion, the bottom portion being formed with a plurality of holes therein. The cylindrical walls are adapted to fit complementarily in a conventional sink strainer, and have a rim extending horizontally and radially outwardly and integrally therefrom at an uppermost portion thereof.

摘要翻译： 一种一次性水槽过滤器，包括其中具有多个开口的圆柱形部分和基本上构成盘的底部，并且一体地连接到圆柱形部分的最下部分并且从圆柱形部分的最下部排出，底部在其中形成有多个孔。 圆柱形壁适于在传统的下沉过滤器中互补配合，并且具有在其最上部分水平和径向向外并与其一体地延伸的边缘。

公开(公告)号：US20070130260A1

公开(公告)日：2007-06-07

申请号：US11612245

申请日：2006-12-18

申请人： Michael Weintraub ,  David Robbins

发明人： Michael Weintraub ,  David Robbins

IPC分类号： G06F15/16

CPC分类号： H04L29/06027 ,  H04L12/1818 ,  H04L51/043 ,  H04L51/10 ,  H04L65/1069 ,  H04L67/24 ,  H04M3/42365

摘要： A device is provided including a processor and a display configured to list more than one presence enabled contact. A user agent is configured to indicate an availability status of the device to a presence server. The user agent is at least partially executed by the processor. Moreover, at least one input is configured to enable a device user to request a communications session with at least one of the plurality of presence enabled contacts. The request is initiated by the user agent when the requested presence enabled contact is available.

摘要翻译： 提供了一种设备，包括处理器和配置为列出多于一个存在使能联系人的显示器。 用户代理被配置为向存在服务器指示设备的可用性状态。 用户代理至少部分地由处理器执行。 此外，至少一个输入被配置为使设备用户能够请求与多个存在启用的联系人中的至少一个的通信会话。 当请求的存在启用联系人可用时，请求由用户代理启动。

公开(公告)号：US07022472B2

公开(公告)日：2006-04-04

申请号：US09426548

申请日：1999-10-22

申请人： David Robbins ,  Juili Lillian Lin-Goerke ,  Jessica C. Ling

发明人： David Robbins ,  Juili Lillian Lin-Goerke ,  Jessica C. Ling

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/156

摘要： Variant human MLH1 and MSH2 genes are provided. Methods of using these variant genes to diagnose hereditary non-polyposis colorectal cancer (HNPCC) and/or determine a patient's susceptibility to developing HNPCC are also provided. Methods and compositions for identifying new variant MLH1 of MSH2 genes are also provided. In addition, experimental models for hereditary non-polyposis colorectal cancer comprising these variant genes are provided.

摘要翻译： 提供变体人MLH1和MSH2基因。 还提供了使用这些变体基因来诊断遗传性非息肉病结直肠癌（HNPCC）和/或确定患者对发展中的HNPCC的易感性的方法。 还提供了用于鉴定MSH2基因的新变体MLH1的方法和组合物。 此外，提供了包含这些变体基因的遗传性非息肉病结肠直肠癌的实验模型。

公开(公告)号：US20050258340A1

公开(公告)日：2005-11-24

申请号：US10520850

申请日：2003-07-03

申请人： John Glasper ,  David Robbins ,  Weng Leong

发明人： John Glasper ,  David Robbins ,  Weng Leong

IPC分类号： H01L27/14 ,  H01L27/144 ,  H01L27/146 ,  H01L31/00 ,  H01L31/107 ,  H01L31/18

CPC分类号： H01L27/1443 ,  H01L27/14603 ,  H01L27/14687 ,  H01L31/107

摘要： A photodetector circuit incorporates an avalanche photodiode structure having a contact layer (14) forming an ohmic contact over an annular region (18) with the annular guard ring (8). In the fabrication process, the starting substrate can either be the handle wafer of a p− silicon-on-insulator wafer, or a p-Si substrate with an insulating SiO2 layer (4). A window (6) is produced in the insulating layer (4) by conventional photolithographic and etching. A n+ guard ring (8) is created by diffusing donor impurities into the substrate, and a thinner insulating SiO2 layer (22) is thermally grown so as to cover the exposed surface of the substrate within the window (6). P-type dopant is then implanted through the thin oxide layer to increase the doping level near the surface of the substrate. Subsequently a second window (24) is made in the insulating layer (22), and the layer (12) is then epitaxially grown selectively on the area of the substrate exposed by the window (24) in the insulating layer (22). The use of the thin oxide layer (22) reduces the area of the interface between the silicon of the layer (12) and the SiO2 of the layer (22) during the selective epitaxial deposition, thus leading to a reduction in the detrimental effect of the thermal expansion coefficient mismatch and producing less epitaxial defects at the window edge. After the epitaxial layer (12) has been grown the remaining part of the insulating layer (22) is removed by wet oxide etch which exposes an annular portion (26) of the underlying guard ring (8). Subsequently a n+ silicon epi-poly layer (14) is deposited on the surface of the device, and forms an ohmic contact with the guard ring (8), and simultaneously forms the top contact of the photodiode. Such a fabrication process does not significantly increase the fabrication complexity. Although an additional mask is required as compared with the conventional fabrication process, the fact that the layer (14) is in ohmic contact with the guard ring (8) means that it is no longer necessary to provide a separate contact to the guard ring, and as a result the overall number of masks or process steps used may be similar in both processes.

公开(公告)号：US20090183070A1

公开(公告)日：2009-07-16

申请号：US12300165

申请日：2007-05-11

申请人： David Robbins

发明人： David Robbins

IPC分类号： G06F3/00 ,  G06F3/01 ,  G06F15/18

CPC分类号： H04B1/202

摘要： Systems and methods are provided that enable multimodal communication command and control of various systems, such as the Internet, cable or satellite television, and other systems, with utilization of a device configured to accept user command and control inputs and an interface to the system or systems being controlled.

摘要翻译： 提供的系统和方法使得能够使用被配置为接受用户命令和控制输入的设备以及到系统的接口的各种系统（诸如因特网，有线电视或卫星电视）和其他系统的多模式通信命令和控制，或者 受到控制的系统

公开(公告)号：US20080008768A1

公开(公告)日：2008-01-10

申请号：US11718752

申请日：2005-11-09

申请人： David Robbins ,  Ziqiang Yuan ,  John Goetz ,  William Scott ,  Sheila Bell ,  Claire Schreiner

发明人： David Robbins ,  Ziqiang Yuan ,  John Goetz ,  William Scott ,  Sheila Bell ,  Claire Schreiner

IPC分类号： A61K33/24 ,  A61P35/00 ,  G01N33/53

CPC分类号： A61K33/24 ,  G01N33/502

摘要： The present invention relates to the use of sonic hedgehog antagonists in the prevention and treatment of cancer and other hyperproliferative diseases or disorders. Methods for identifying such antagonists are also provided.

摘要翻译： 本发明涉及声波刺猬蛋白拮抗剂在预防和治疗癌症及其它过度增生性疾病或病症中的应用。 还提供了鉴定这种拮抗剂的方法。