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    Method for measuring β-glucan, and β-glucan-binding protein for use in the method
    5.
    发明授权
    Method for measuring β-glucan, and β-glucan-binding protein for use in the method 有权
    用于测量葡萄糖和葡萄糖结合蛋白的方法

    公开(公告)号：US08822163B2

    公开(公告)日：2014-09-02

    申请号：US13257080

    申请日：2010-03-17

    申请人： Akito Yoneda

    发明人： Akito Yoneda

    IPC分类号： G01N33/53 ,  C07K14/435 ,  G01N33/569

    CPC分类号： G01N33/579 ,  C07K14/43509 ,  C12N9/6408 ,  G01N33/5308 ,  G01N33/56961 ,  G01N2333/38 ,  G01N2333/40 ,  G01N2333/43504 ,  G01N2400/24 ,  G01N2469/10 ,  Y10S435/935

    摘要： Disclosed are a method for measuring βG comprising the steps of bringing a sample into contact with a βG-binding protein 1 and a βG-binding protein 2, each comprising an amino acid sequence which is identical or substantially identical to an amino acid sequence shown in any one of SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:10, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, or SEQ ID NO:20, and having the β-glucan binding activity, to form a complex of the βG-binding protein 1, βG in the sample and the βG-binding protein 2, measuring quantity of the complex, and determining βG concentration in the sample based on the quantity of the complex; a reagent and a kit for use in said method; a novel βG-binding protein; a nucleic acid molecule encoding the βG-binding protein; and a method for producing the aforementioned βG-binding protein.

    摘要翻译： 本发明公开了一种测定G蛋白的方法，其包括使样品与G结合蛋白1和结合蛋白2接触的步骤，每个G结合蛋白2均包含与 SEQ ID NO：4，SEQ ID NO：6，SEQ ID NO：8，SEQ ID NO：10，SEQ ID NO：14，SEQ ID NO：16，SEQ ID NO：18中任一项所示的氨基酸序列 或SEQ ID NO：20，并且具有葡聚糖结合活性，以形成样品中的G结合蛋白1和b结合蛋白与G结合蛋白2的复合物，测量量 的复合物，并根据复合物的数量确定样品中的G浓度; 用于所述方法的试剂和试剂盒; 一种新型的G结合蛋白; 编码G结合蛋白的核酸分子; 以及制备上述结合蛋白的方法。

    Method for detecting candida on skin
    6.
    发明授权
    Method for detecting candida on skin 有权
    检测皮肤上念珠菌的方法

    公开(公告)号：US07763442B2

    公开(公告)日：2010-07-27

    申请号：US11513500

    申请日：2006-08-31

    申请人： Stephanie M. Martin ,  Andrew M. Long ,  J. Gavin MacDonald ,  Jason Lye

    发明人： Stephanie M. Martin ,  Andrew M. Long ,  J. Gavin MacDonald ,  Jason Lye

    IPC分类号： C12Q1/04 ,  C12P1/00

    CPC分类号： A61L15/56 ,  G01N2333/245 ,  G01N2333/31 ,  G01N2333/40

    摘要： A method and system for rapidly detecting Candida on the skin of a host, such as an infant with diaper rash, is provided. The method includes contacting a dermal sample with a colorant that exhibits a certain spectral response (e.g., color change) in the presence of Candida. For example, the colorant may change from a first color to a second color, from colorless to a color, or from a color to colorless. The colorant is typically capable of differentiating between Candida (e.g., Candida albicans) and other microorganisms commonly associated with diaper rash, such as S. aureus and E. coli. Thus, when a dermal sample is placed into contact with the colorant, the color change may simply be observed to determine whether the infection is caused by Candida. If the color change occurs to a certain extent (e.g., from yellow to bright red), it may be determined that the test sample contains Candida. Likewise, if a color change occurs to a lesser extent (e.g., from yellow to faint orange) or not at all, it may be determined that the dermal sample contains other microorganisms (e.g., S. aureus or E. coli), no infection is present, or that the infection is simply due to other causes. Regardless, it will become readily apparent whether or not treatment for Candida is needed.

    摘要翻译： 提供了用于快速检测宿主皮肤上的假丝酵母的方法和系统，例如具有尿布疹的婴儿。 该方法包括使真皮样品与在假丝酵母存在下显示特定光谱响应（例如颜色变化）的着色剂接触。 例如，着色剂可以从第一颜色变为第二颜色，从无色到颜色，或从颜色变为无色。 着色剂通常能够区分假丝酵母（例如白色念珠菌）和通常与尿布疹相关的其它微生物，例如金黄色葡萄球菌和大肠杆菌。 因此，当真皮样品与着色剂接触时，可以简单地观察颜色变化以确定感染是否由念珠菌引起。 如果颜色变化发生一定程度（例如，从黄色到鲜红色），则可以确定测试样品含有念珠菌。 同样地，如果在较小程度上发生颜色变化（例如，从黄色到微弱橙色），或根本不发生变色，则可以确定真皮样品含有其他微生物（例如金黄色葡萄球菌或大肠杆菌），无感染 存在，或感染仅仅是由于其他原因。 无论是否需要对念珠菌的治疗，将变得显而易见。

    CYTOPLASMIC ANTIGENS FOR DETECTION OF CANDIDA
    7.
    发明申请
    CYTOPLASMIC ANTIGENS FOR DETECTION OF CANDIDA 审中-公开
    用于检测坎迪达的CYTOPLASMIC抗原

    公开(公告)号：US20090030054A1

    公开(公告)日：2009-01-29

    申请号：US12242663

    申请日：2008-09-30

    申请人： John Warmington ,  Denis Ballantyne

    发明人： John Warmington ,  Denis Ballantyne

    IPC分类号： A61K31/4196 ,  C12M1/34 ,  A61P31/10 ,  G01N33/53

    CPC分类号： G01N33/56961 ,  C07K14/40 ,  G01N33/571 ,  G01N2333/40

    摘要： The present invention relates to a method and a means of diagnosing Candida infection. In particular the present invention relates to a method of diagnosing Candida infection by measuring the levels of antibody to Candida cytoplasmic antigen present in a biological sample taken from a subject at risk of, or suspected to be suffering from a Candida infection.

    摘要翻译： 本发明涉及诊断念珠菌感染的方法和手段。 特别地，本发明涉及一种通过测量存在于患有或怀疑患有念珠菌感染的受试者的生物样品中的念珠菌细胞质抗原的抗体水平来诊断念珠菌感染的方法。

    Cytoplasmic antigens for detection of Candida
    8.
    发明申请
    Cytoplasmic antigens for detection of Candida 审中-公开
    用于检测念珠菌的细胞质抗原

    公开(公告)号：US20060105406A1

    公开(公告)日：2006-05-18

    申请号：US11316739

    申请日：2005-12-27

    申请人： John Warmington ,  Denis Ballantyne

    发明人： John Warmington ,  Denis Ballantyne

    IPC分类号： G01N33/569 ,  G01N33/53

    CPC分类号： G01N33/56961 ,  C07K14/40 ,  G01N33/571 ,  G01N2333/40

    摘要： The present invention relates to a method and a means of diagnosing Candida infection. In particular the present invention relates to a method of diagnosing Candida infection by measuring the levels of antibody to Candida cytoplasmic antigen present in a biological sample taken from a subject at risk of, or suspected to be suffering from a Candida infection.

    摘要翻译： 本发明涉及诊断念珠菌感染的方法和手段。 特别地，本发明涉及一种通过测量存在于患有或怀疑患有念珠菌感染的受试者的生物样品中的念珠菌细胞质抗原的抗体水平来诊断念珠菌感染的方法。

    Detecting yeast infections using a lateral flow assay
    9.
    发明申请
    Detecting yeast infections using a lateral flow assay 审中-公开
    使用侧流测定法检测酵母菌感染

    公开(公告)号：US20060068500A1

    公开(公告)日：2006-03-30

    申请号：US10951367

    申请日：2004-09-28

    申请人： Ning Wei ,  Shu-Ping Yang ,  Rosann Kaylor

    发明人： Ning Wei ,  Shu-Ping Yang ,  Rosann Kaylor

    IPC分类号： G01N33/558

    CPC分类号： G01N33/558 ,  G01N2333/40

    摘要： There is provided a lateral flow assay device for detecting the presence or quantity of an analyte residing in a test sample where the lateral flow assay device has a porous membrane in liquid communication with a conjugate pad and a wicking pad. The conjugate pad has a gold colloid-containing detection probe. The porous membrane has a detection zone where an immobilized first capture reagent configured to bind to at least a portion of the analyte and analyte-conjugate complexes to generate a detection signal. The control zone is located downstream from the detection zone on the porous membrane and has a second capture reagent immobilized within the control zone. The conjugate pad is located upstream from the detection zone, and has detection probes with specific binding members for the analyte. A sample containing an analyte is deposited on the conjugate pad, interacts with the detection probes, and moves toward the control zone for detection.

    摘要翻译： 提供了一种侧流测定装置，用于检测驻留在测试样品中的分析物的存在或数量，其中侧流测定装置具有与结合垫和芯吸垫液体连通的多孔膜。 共轭垫具有含金胶体的检测探针。 多孔膜具有检测区，其中固定的第一捕获试剂被配置为结合至少一部分分析物和分析物 - 共轭复合物以产生检测信号。 控制区位于多孔膜上的检测区的下游，并且具有固定在控制区内的第二捕获试剂。 缀合垫位于检测区的上游，并具有用于分析物的具有特异性结合构件的检测探针。 将含有分析物的样品沉积在共轭垫上，与检测探针相互作用，并朝向控制区移动进行检测。

    Detection of Candida
    10.
    发明授权
    Detection of Candida 失效
    检测念珠菌

    公开(公告)号：US06916626B1

    公开(公告)日：2005-07-12

    申请号：US09841188

    申请日：2001-04-25

    申请人： John Warmington ,  Denis Ballantyne

    发明人： John Warmington ,  Denis Ballantyne

    IPC分类号： G01N33/53 ,  C07K14/40 ,  G01N33/48 ,  G01N33/531 ,  G01N33/543 ,  G01N33/569 ,  G01N33/571 ,  G01N33/573 ,  C12P19/34 ,  C12Q1/32 ,  C12Q1/68

    CPC分类号： G01N33/56961 ,  C07K14/40 ,  G01N33/571 ,  G01N2333/40

    摘要： The present invention relates to a method and a means of diagnosing Candida infection. In particular, the present invention relates to a method of diagnosing Candida infection comprising the steps of obtaining a biological sample from a subject at risk of, or suspected to be suffering from, Candida infection, contacting the sample with a mannose depleted antigen composition comprising a soluble cytoplasmic antigen preparation comprising antigens of molecular weight 55 kDa, 30 kDa and 20 kDa and detecting the antigen/antibody reaction.

    摘要翻译： 本发明涉及诊断念珠菌感染的方法和手段。 特别地，本发明涉及一种诊断念珠菌感染的方法，其包括以下步骤：从患有或怀疑患有念珠菌感染风险的受试者获得生物样品，使样品与含有甘露糖的抗原组合物接触，所述组合物包含 包含分子量为55kDa，30kDa和20kDa的抗原的可溶性细胞质抗原制剂，并检测抗原/抗体反应。