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公开(公告)号：US07132284B2
公开(公告)日：2006-11-07
申请号：US11240406
申请日：2005-10-03
申请人： Yuanhao Li , Deborah Farson , Luqun Tao , DeChao Yu
发明人： Yuanhao Li , Deborah Farson , Luqun Tao , DeChao Yu
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/10343 , C12N2710/10352 , C12N2830/00 , C12N2830/15 , C12N2830/48 , C12N2830/60 , C12N2830/90 , C12N2840/44
摘要： Adenovirus packaging cell lines for growth of an E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA) are provided. Methods for producing adenovirus substantially free of RCA are also provided, wherein the adenovirus is grown in a cell line containing coding sequences for adenovirus E1A and E1B, which are operably linked to promoters that lack polynucleotide sequences sharing substantial sequence identity with the native adenovirus E1A and E1B promoters.
摘要翻译： 提供了基本上不含复制型腺病毒（RCA）的E1A / E1B缺陷型腺病毒生长的腺病毒包装细胞系。 还提供了用于产生基本上不含RCA的腺病毒的方法，其中腺病毒在含有腺病毒E1A和E1B编码序列的细胞系中生长，所述编码序列与腺病毒E1A和E1B的编码序列可操作地连接，所述编码序列与缺乏与天然腺病毒E1A具有实质序列同一性的多核苷酸序列的启动子连接， E1B启动子。
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公开(公告)号：US07473418B2
公开(公告)日：2009-01-06
申请号：US11074694
申请日：2005-03-09
申请人： DeChao Yu , Yuanhao Li
发明人： DeChao Yu , Yuanhao Li
CPC分类号： C12N15/86 , A61K48/005 , C12N7/00 , C12N2710/10321 , C12N2710/10332 , C12N2710/10343 , C12N2830/00 , C12N2830/001 , C12N2830/85 , C12N2840/203
摘要： Replication-competent adenoviral vectors which selectively replicate in cancer cells are provided. The replication-competent viral vectors comprise an E2F responsive promoter and/or a telomerase promoter operatively linked to an adenoviral coding region. The replication-competent adenoviral vectors effectively replicate in a variety of types of cancer cells and find broad utility in the treatment of cancer.
摘要翻译： 提供了在癌细胞中选择性复制的复制能力的腺病毒载体。 复制能力的病毒载体包含可操作地连接到腺病毒编码区的E2F应答启动子和/或端粒酶启动子。 复制能力的腺病毒载体在多种类型的癌细胞中有效地复制，并且在治疗癌症中发现广泛的用途。
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公开(公告)号：US20060024829A1
公开(公告)日：2006-02-02
申请号：US11240406
申请日：2005-10-03
申请人： Yuanhao Li , Deborah Farson , Luqun Tao , DeChao Yu
发明人： Yuanhao Li , Deborah Farson , Luqun Tao , DeChao Yu
IPC分类号： C12N15/861 , C12N5/06
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/10343 , C12N2710/10352 , C12N2830/00 , C12N2830/15 , C12N2830/48 , C12N2830/60 , C12N2830/90 , C12N2840/44
摘要： Adenovirus packaging cell lines for growth of an E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA) are provided. Methods for producing adenovirus substantially free of RCA are also provided, wherein the adenovirus is grown in a cell line containing coding sequences for adenovirus E1A and E1B, which are operably linked to promoters that lack polynucleotide sequences sharing substantial sequence identity with the native adenovirus E1A and E1B promoters.
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公开(公告)号：US20070141706A1
公开(公告)日：2007-06-21
申请号：US11545917
申请日：2006-10-11
申请人： Yuanhao Li , Deborah Farson , Luqun Tao , DeChao Yu
发明人： Yuanhao Li , Deborah Farson , Luqun Tao , DeChao Yu
IPC分类号： C12N15/861 , C12N5/10
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/10343 , C12N2710/10352 , C12N2830/00 , C12N2830/15 , C12N2830/48 , C12N2830/60 , C12N2830/90 , C12N2840/44
摘要： Adenovirus packaging cell lines for growth of an E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA) are provided. Methods for producing adenovirus substantially free of RCA are also provided, wherein the adenovirus is grown in a cell line containing coding sequences for adenovirus E1A and E1B, which are operably linked to promoters that lack polynucleotide sequences sharing substantial sequence identity with the native adenovirus E1A and E1B promoters.
摘要翻译： 提供了基本上不含复制性腺病毒（RCA）的E1A / E1B缺陷型腺病毒生长的腺病毒包装细胞系。 还提供了用于产生基本上不含RCA的腺病毒的方法，其中腺病毒在含有腺病毒E1A和E1B编码序列的细胞系中生长，所述编码序列与腺病毒E1A和E1B的编码序列可操作地连接，所述编码序列与缺乏与天然腺病毒E1A具有实质序列同一性的多核苷酸序列的启动子连接， E1B启动子。
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公开(公告)号：US07026164B2
公开(公告)日：2006-04-11
申请号：US10613106
申请日：2003-07-03
申请人： Yuanhao Li , Deborah Farson , Luqun Tao , DeChao Yu
发明人： Yuanhao Li , Deborah Farson , Luqun Tao , DeChao Yu
IPC分类号： C12N15/867 , C12N5/10 , C12N15/63
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/10343 , C12N2710/10352 , C12N2830/00 , C12N2830/15 , C12N2830/48 , C12N2830/60 , C12N2830/90 , C12N2840/44
摘要： Adenovirus packaging cell lines for growth of an E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA) are provided. Methods for producing adenovirus substantially free of RCA are also provided, wherein the adenovirus is grown in a cell line containing coding sequences for adenovirus E1A and E1B, which are operably linked to promoters that lack polynucleotide sequences sharing substantial sequence identity with the native adenovirus E1A and E1B promoters.
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公开(公告)号：US20050214923A1
公开(公告)日：2005-09-29
申请号：US11074694
申请日：2005-03-09
申请人： DeChao Yu , Yuanhao Li
发明人： DeChao Yu , Yuanhao Li
IPC分类号： A61K48/00 , C12N7/00 , C12N15/861
CPC分类号： C12N15/86 , A61K48/005 , C12N7/00 , C12N2710/10321 , C12N2710/10332 , C12N2710/10343 , C12N2830/00 , C12N2830/001 , C12N2830/85 , C12N2840/203
摘要： Replication-competent adenoviral vectors which selectively replicate in cancer cells are provided. The replication-competent viral vectors comprise an E2F responsive promoter and/or a telomerase promoter operatively linked to an adenoviral coding region. The replication-competent adenoviral vectors effectively replicate in a variety of types of cancer cells and find broad utility in the treatment of cancer.
摘要翻译： 提供了在癌细胞中选择性复制的复制能力的腺病毒载体。 复制能力的病毒载体包含可操作地连接到腺病毒编码区的E2F应答启动子和/或端粒酶启动子。 复制能力的腺病毒载体在多种类型的癌细胞中有效地复制，并且在治疗癌症中发现广泛的用途。
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公开(公告)号：US20050003545A1
公开(公告)日：2005-01-06
申请号：US10613106
申请日：2003-07-03
申请人： Yuanhao Li , Deborah Farson , Luqun Tao , DeChao Yu
发明人： Yuanhao Li , Deborah Farson , Luqun Tao , DeChao Yu
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/10343 , C12N2710/10352 , C12N2830/00 , C12N2830/15 , C12N2830/48 , C12N2830/60 , C12N2830/90 , C12N2840/44
摘要： Adenovirus packaging cell lines for growth of an E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA) are provided. Methods for producing adenovirus substantially free of RCA are also provided, wherein the adenovirus is grown in a cell line containing coding sequences for adenovirus E1A and E1B, which are operably linked to promoters that lack polynucleotide sequences sharing substantial sequence identity with the native adenovirus E1A and E1B promoters.
摘要翻译： 提供了基本上不含复制性腺病毒（RCA）的E1A / E1B缺陷型腺病毒生长的腺病毒包装细胞系。 还提供了用于产生基本上不含RCA的腺病毒的方法，其中腺病毒在含有腺病毒E1A和E1B编码序列的细胞系中生长，所述编码序列与腺病毒E1A和E1B的编码序列可操作地连接，所述编码序列与缺乏与天然腺病毒E1A具有实质序列同一性的多核苷酸序列的启动子连接， E1B启动子。
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8.发明申请公开(公告)号：US20090099125A1
公开(公告)日：2009-04-16
申请号：US12327936
申请日：2008-12-04
申请人： DeChao Yu , Yuanhao Li
发明人： DeChao Yu , Yuanhao Li
IPC分类号： A61K31/7088 , C12N15/63 , C12N5/02
CPC分类号： C12N15/86 , A61K48/005 , C12N7/00 , C12N2710/10321 , C12N2710/10332 , C12N2710/10343 , C12N2830/00 , C12N2830/001 , C12N2830/85 , C12N2840/203
摘要： Replication-competent adenoviral vectors which selectively replicate in cancer cells are provided. The replication-competent viral vectors comprise an E2F responsive promoter and/or a telomerase promoter operatively linked to an adenoviral coding region. The replication-competent adenoviral vectors effectively replicate in a variety of types of cancer cells and find broad utility in the treatment of cancer.
摘要翻译： 提供了在癌细胞中选择性复制的复制能力的腺病毒载体。 复制能力的病毒载体包含可操作地连接到腺病毒编码区的E2F应答启动子和/或端粒酶启动子。 复制能力的腺病毒载体在多种类型的癌细胞中有效地复制，并且在治疗癌症中发现广泛的用途。
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公开(公告)号：US07858083B2
公开(公告)日：2010-12-28
申请号：US12327936
申请日：2008-12-04
申请人： DeChao Yu , Yuanhao Li
发明人： DeChao Yu , Yuanhao Li
CPC分类号： C12N15/86 , A61K48/005 , C12N7/00 , C12N2710/10321 , C12N2710/10332 , C12N2710/10343 , C12N2830/00 , C12N2830/001 , C12N2830/85 , C12N2840/203
摘要： Replication-competent adenoviral vectors which selectively replicate in cancer cells are provided. The replication-competent viral vectors comprise an E2F responsive promoter and/or a telomerase promoter operatively linked to an adenoviral coding region. The replication-competent adenoviral vectors effectively replicate in a variety of types of cancer cells and find broad utility in the treatment of cancer.
摘要翻译： 提供了在癌细胞中选择性复制的复制能力的腺病毒载体。 复制能力的病毒载体包含可操作地连接到腺病毒编码区的E2F应答启动子和/或端粒酶启动子。 复制能力的腺病毒载体在多种类型的癌细胞中有效地复制，并且在治疗癌症中发现广泛的用途。
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公开(公告)号：US20050003506A1
公开(公告)日：2005-01-06
申请号：US10857137
申请日：2004-05-28
申请人： Yuanhao Li , Deborah Farson , Luqun Tao , DeChao Yu
发明人： Yuanhao Li , Deborah Farson , Luqun Tao , DeChao Yu
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/10343 , C12N2710/10352 , C12N2830/00 , C12N2830/15 , C12N2830/48 , C12N2830/60 , C12N2830/90 , C12N2840/44
摘要： Adenovirus packaging cell lines for growth of E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA), are provided. Methods for producing adenovirus substantially free of RCA are also provided, wherein the adenovirus is grown in a cell line containing coding sequences for adenovirus E1A and E1B, are operably linked to promoters that lack polynucleotide sequences sharing substantial sequence identity with the native adenovirus E1A and E1B promoters.
摘要翻译： 提供了基本上不含复制性腺病毒（RCA）的E1A / E1B缺陷型腺病毒生长的腺病毒包装细胞系。 还提供了用于产生基本上不含RCA的腺病毒的方法，其中腺病毒在含有腺病毒E1A和E1B编码序列的细胞系中生长，可操作地连接于缺乏与天然腺病毒E1A和E1B具有大体序列同一性的多核苷酸序列的启动子 发起人。
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