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1.发明申请公开(公告)号：US20170065644A1
公开(公告)日：2017-03-09
申请号：US15357449
申请日：2016-11-21
CPC分类号： A61K35/51 , A61K9/0019 , A61K38/1841 , A61K38/1858 , C12N5/0605
摘要： Methods for treating a patient having a disease or condition related to IVD degeneration are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. In some embodiments, administering the cells promotes repair and regeneration of degenerated IVD tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.
摘要翻译： 提供了治疗患有与IVD变性相关的疾病或病症的患者的方法。 所述方法包括施用从人脐带组织获得的细胞，或施用包含此类细胞的药物组合物或由此类细胞制备。 在一些实施方案中，施用细胞促进患者中退化的IVD组织的修复和再生。 还提供了用于本发明方法的药物组合物，以及用于实施该方法的试剂盒。
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2.发明申请公开(公告)号：US20180344900A9
公开(公告)日：2018-12-06
申请号：US15357539
申请日：2016-11-21
CPC分类号： A61L27/3878 , A61K35/12 , A61K35/50 , A61K35/51 , A61K38/1774 , A61K38/1841 , A61K38/1858 , A61L27/225 , A61L27/227 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L2300/414 , A61L2400/06 , A61L2430/38 , C12N5/0605
摘要： Methods for treating a patient having a disease or condition related to IVD degeneration are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells and optionally a hydrogel. In some embodiments, administering the cells promotes repair and regeneration of degenerated IVD tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.
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3.发明申请公开(公告)号：US20170065745A1
公开(公告)日：2017-03-09
申请号：US15357539
申请日：2016-11-21
CPC分类号： A61L27/3878 , A61K35/12 , A61K35/50 , A61K35/51 , A61K38/1774 , A61K38/1841 , A61K38/1858 , A61L27/225 , A61L27/227 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L2300/414 , A61L2400/06 , A61L2430/38 , C12N5/0605
摘要： Methods for treating a patient having a disease or condition related to IVD degeneration are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells and optionally a hydrogel. In some embodiments, administering the cells promotes repair and regeneration of degenerated IVD tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.
摘要翻译： 提供了治疗患有与IVD变性相关的疾病或病症的患者的方法。 所述方法包括施用从人脐带组织获得的细胞，或施用包含此类细胞的药物组合物或由此类细胞制备，以及任选的水凝胶。 在一些实施方案中，施用细胞促进患者中退化的IVD组织的修复和再生。 还提供了用于本发明方法的药物组合物，以及用于实施该方法的试剂盒。
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4.发明申请公开(公告)号：US20190105352A9
公开(公告)日：2019-04-11
申请号：US15357449
申请日：2016-11-21
摘要： Methods for treating a patient having a disease or condition related to IVD degeneration are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. In some embodiments, administering the cells promotes repair and regeneration of degenerated IVD tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.
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公开(公告)号：US09579348B2
公开(公告)日：2017-02-28
申请号：US14252132
申请日：2014-04-14
CPC分类号： A61K35/22 , A61K9/0024 , A61K9/1652 , A61K9/48 , A61K35/12 , A61L27/34 , A61L27/3604 , A61L27/365 , A61L27/3683
摘要： Provided are therapeutic implants comprising renal tissue encapsulated within a polymer bead. Also disclosed are methods for treating a disease state in a subject comprising implanting within said subject a therapeutic implant comprising renal tissue encapsulated within a polymer bead. Also provided are methods for making a therapeutic implant comprising: providing renal tissue; mixing the renal tissue with a solution comprising a polymer, thereby forming a tissue-polymer suspension; extruding the tissue-polymer suspension into an bead-forming solution, thereby forming a therapeutic implant comprising beads of said polymer within which the renal tissue is encapsulated.
摘要翻译： 提供包含包封在聚合物珠内的肾组织的治疗性植入物。 还公开了用于治疗受试者的疾病状态的方法，包括在所述受试者内植入包含封装在聚合物珠内的肾组织的治疗性植入物。 还提供了用于制备治疗性植入物的方法，包括：提供肾组织; 将肾组织与包含聚合物的溶液混合，由此形成组织 - 聚合物悬浮液; 将组织 - 聚合物悬浮液挤出成珠形成溶液，由此形成治疗性植入物，其包含所述聚合物的珠粒，肾组织在其中被包封。
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