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    Composition and methods for cryopreservation of hUTC
    1.
    发明授权
    Composition and methods for cryopreservation of hUTC 有权

    公开(公告)号：US10791730B2

    公开(公告)日：2020-10-06

    申请号：US15400022

    申请日：2017-01-06

    申请人： DePuy Synthes Products, Inc.

    发明人： Anna Gosiewska ,  Anthony J. Kihm

    IPC分类号： A01N1/02

    摘要： This invention provides for compositions for cryopreservation of human umbilical cord tissue-derived cells. The cryopreservation compositions may comprise: (a) amino acids; (b) vitamins; (c) inorganic salts; and (d) DMSO, sucrose, mannitol, and lactobionic acid. The invention also provides for kits comprising the composition and human umbilical cord tissue-derived cells and methods of cryopreserving the cells, which utilize the compositions.

    COMPOSITION AND METHODS FOR CRYOPRESERVATION OF HUTC
    2.
    发明申请
    COMPOSITION AND METHODS FOR CRYOPRESERVATION OF HUTC 审中-公开

    公开(公告)号：US20170202212A1

    公开(公告)日：2017-07-20

    申请号：US15400022

    申请日：2017-01-06

    申请人： DePuy Synthes Products, Inc.

    发明人： Anna Gosiewska ,  Anthony J. Kihm

    IPC分类号： A01N1/02

    摘要： This invention provides for compositions for cryopreservation of human umbilical cord tissue-derived cells. The cryopreservation compositions may comprise: (a) amino acids; (b) vitamins; (c) inorganic salts; and (d) DMSO, sucrose, mannitol, and lactobionic acid. The invention also provides for kits comprising the composition and human umbilical cord tissue-derived cells and methods of cryopreserving the cells, which utilize the compositions.

    TREATMENT OF INTERVERTEBRAL DISC DEGENERATION USING HUMAN UMBILICAL CORD TISSUE-DERIVED CELLS
    3.
    发明申请
    TREATMENT OF INTERVERTEBRAL DISC DEGENERATION USING HUMAN UMBILICAL CORD TISSUE-DERIVED CELLS 审中-公开
    使用人脐带组织细胞治疗椎间盘脱位

    公开(公告)号：US20170065644A1

    公开(公告)日：2017-03-09

    申请号：US15357449

    申请日：2016-11-21

    申请人： DePuy Synthes Products, Inc.

    发明人： Laura J. Brown ,  Anna Gosiewska ,  Anthony J. Kihm ,  Brian C. Kramer

    IPC分类号： A61K35/51 ,  A61K38/18 ,  A61K9/00

    CPC分类号： A61K35/51 ,  A61K9/0019 ,  A61K38/1841 ,  A61K38/1858 ,  C12N5/0605

    摘要： Methods for treating a patient having a disease or condition related to IVD degeneration are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. In some embodiments, administering the cells promotes repair and regeneration of degenerated IVD tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.

    摘要翻译： 提供了治疗患有与IVD变性相关的疾病或病症的患者的方法。 所述方法包括施用从人脐带组织获得的细胞，或施用包含此类细胞的药物组合物或由此类细胞制备。 在一些实施方案中，施用细胞促进患者中退化的IVD组织的修复和再生。 还提供了用于本发明方法的药物组合物，以及用于实施该方法的试剂盒。

    hUTC MODULATION OF PRO-INFLAMMATORY MEDIATORS OF LUNG AND PULMONARY DISEASES AND DISORDERS
    7.
    发明申请
    hUTC MODULATION OF PRO-INFLAMMATORY MEDIATORS OF LUNG AND PULMONARY DISEASES AND DISORDERS 审中-公开

    公开(公告)号：US20190054125A1

    公开(公告)日：2019-02-21

    申请号：US16178240

    申请日：2018-11-01

    申请人： Depuy Synthes Products, Inc.

    发明人： Anthony J. Kihm

    IPC分类号： A61K35/51 ,  A61P11/16 ,  A61K35/34 ,  A61K35/44

    摘要： This invention encompasses methods, pharmaceutical compositions, and kits for modulating (e.g. reducing) the production of pro-inflammatory mediators involved in the pathology of a lung disease, disorder, and/or injury in a patient having the lung disease, disorder, and/or injury. The invention also encompasses methods, pharmaceutical compositions, and kits for inhibiting the production of pro-inflammatory mediators involved in the pathology of a lung disease, disorder, and/or injury in a patient having the lung disease, disorder, and/or injury. In one embodiment, the umbilical cord tissue-derived cells are isolated from human umbilical cord tissue substantially free of blood, are capable of self-renewal and expansion in culture, lack the production of CD117 or CD45, and do not express hTERT or telomerase.

    DETECTION OF HUMAN UMBILICAL CORD TISSUE-DERIVED CELLS
    9.
    发明申请
    DETECTION OF HUMAN UMBILICAL CORD TISSUE-DERIVED CELLS 审中-公开

    公开(公告)号：US20170335409A1

    公开(公告)日：2017-11-23

    申请号：US15476460

    申请日：2017-03-31

    申请人： DEPUY SYNTHES PRODUCTS, INC.

    发明人： Haimanti Dorai ,  Reyna L. Favis ,  Xiang Yao ,  Yu Sun ,  Anthony J. Kihm ,  Stefanie Rassnick

    IPC分类号： C12Q1/68 ,  G01N33/569 ,  G01N33/68

    摘要： The invention relates to methods for detecting allogeneic therapeutic cells (such as human umbilical cord tissue-derived cells (hUTC)) in blood. The methods includes the steps of identifying one or more one or more markers positive for allogeneic therapeutic cells (e.g. hUTC) and one or more markers positive for human peripheral blood mononuclear cells (PBMC); providing a blood sample from a patient that has been treated with allogeneic therapeutic cells (e.g. hUTC), analyzing the sample using an assay method to detect one or more markers positive for PBMC and one or more markers positive for allogeneic therapeutic cells (e.g. hUTC); and distinguishing between the PBMC and one or more markers positive for allogeneic therapeutic cells (e.g. hUTC). In one embodiment, the cells are hUTC and the markers positive of hUTC include CD10 and/or CD13 and the one or more markers positive for PBMC includes CD45.