Pox virus vaccine
    2.
    发明授权
    Pox virus vaccine 失效
    痘病毒疫苗

    公开(公告)号:US5368855A

    公开(公告)日:1994-11-29

    申请号:US993073

    申请日:1992-12-18

    摘要: A gene sequence including a first promoter for the expression of a major early fowlpox virus (FPV) protein. In a preferred aspect, the gene sequence further includes a second promoter for the expression of a late fowlpox virus protein in opposite orientation to said first promoter. The promoter is useful in developing FPV based vectors for the delivery of vaccine antigens preferably to poultry, and as a tool to study the temporal regulation of poxvirus genes. The invention also offers methods useful in the construction of recombinant fowlpox viruses or related avian poxviruses, which methods are characterized by the introduction of foreign DNA into the fowlpox virus or into virus DNA sequences, which sequences are able to use native FPV promoter regions.

    摘要翻译: 包括用于表达主要早期禽痘病毒(FPV)蛋白的第一启动子的基因序列。 在优选的方面,基因序列还包括用于表达与所述第一启动子相反方向的晚期禽痘病毒蛋白质的第二启动子。 该启动子可用于开发用于将疫苗抗原优先递送至家禽的FPV基载体,并用作研究痘病毒基因的时间调控的工具。 本发明还提供了用于构建重组禽痘病毒或相关禽痘病毒的方法,该方法的特征在于将外源DNA引入禽痘病毒或病毒DNA序列,该序列能够使用天然FPV启动子区。