Method of preventing abuse of opioid dosage forms
    10.
    发明申请
    Method of preventing abuse of opioid dosage forms 审中-公开
    防止阿片类药物剂型滥用的方法

    公开(公告)号:US20050192309A1

    公开(公告)日:2005-09-01

    申请号:US10665735

    申请日:2003-09-18

    摘要: The invention relates in part to a method of reducing the abuse potential of an oral dosage form of an opioid analgesic, wherein an analgesically effective amount of an orally active opioid agonist is combined with an opioid antagonist into an oral dosage form which would require at least a two-step extraction process to be separated from the opioid agonist, the amount of opioid antagonist including being sufficient to counteract opioid effects if extracted together with the opioid agonist and administered parenterally.

    摘要翻译: 本发明部分地涉及减少口服剂型阿片类止痛剂的滥用潜力的方法,其中止痛有效量的口服活性阿片样物质激动剂与阿片样物质拮抗剂组合成口服剂型,其至少需要 与阿片样物质激动剂分离的两步提取过程,阿片样物质拮抗剂的量如果与阿片样物质激动剂一起提取并肠胃外给药,则其量足以抵消阿片样物质的影响。