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公开(公告)号：US09012516B2
公开(公告)日：2015-04-21
申请号：US13997179
申请日：2011-12-21
申请人： Decheng Wu , Ye Liu , Jianwei Xu , Chaobin He
发明人： Decheng Wu , Ye Liu , Jianwei Xu , Chaobin He
IPC分类号： A61K8/81 , A61K47/32 , C08F290/14
CPC分类号： A61K8/8152 , A61K47/32 , A61K2800/10 , A61K2800/48 , A61Q19/00 , C08F290/148
摘要： A copolymer for modifying rheology is formed of monomer units consisting essentially of at least one first monomer unit comprising a polyhedral oligomeric silsesquioxane having an ethylenically unsaturated radical; at least one second monomer unit comprising an unsaturated oligo-poly(dimethyl siloxane)(meth)acrylate; and a sufficient amount of at least one unsaturated water-soluble monomer, such that the copolymer is soluble in water. A composition may comprise an electrolyte and the copolymer. The rheology of an environment comprising an electrolyte may be modified by adding the copolymer to the environment.
摘要翻译： 用于改性流变学的共聚物由基本上由至少一种第一单体单元组成的单体形成，所述第一单体单元包含具有烯属不饱和基团的多面体低聚倍半硅氧烷; 包含不饱和低聚 - 聚（二甲基硅氧烷）（甲基）丙烯酸酯的至少一个第二单体单元; 和足够量的至少一种不饱和水溶性单体，使得共聚物可溶于水。 组合物可以包含电解质和共聚物。 包含电解质的环境的流变学可以通过将共聚物加入到环境中进行改性。
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公开(公告)号：US20130296444A1
公开(公告)日：2013-11-07
申请号：US13997179
申请日：2011-12-21
申请人： Decheng Wu , Ye Liu , Jianwei Xu , Chaobin He
发明人： Decheng Wu , Ye Liu , Jianwei Xu , Chaobin He
CPC分类号： A61K8/8152 , A61K47/32 , A61K2800/10 , A61K2800/48 , A61Q19/00 , C08F290/148
摘要： A copolymer for modifying rheology is formed of monomer units consisting essentially of at least one first monomer unit comprising a polyhedral oligomeric silsesquioxane having an ethylenically unsaturated radical; at least one second monomer unit comprising an unsaturated oligo-poly(dimethyl siloxane)(meth)acrylate; and a sufficient amount of at least one unsaturated water-soluble monomer, such that the copolymer is soluble in water. A composition may comprise an electrolyte and the copolymer. The rheology of an environment comprising an electrolyte may be modified by adding the copolymer to the environment.
摘要翻译： 用于改性流变学的共聚物由基本上由至少一种第一单体单元组成的单体形成，所述第一单体单元包含具有烯属不饱和基团的多面体低聚倍半硅氧烷; 包含不饱和低聚 - 聚（二甲基硅氧烷）（甲基）丙烯酸酯的至少一个第二单体单元; 和足够量的至少一种不饱和水溶性单体，使得共聚物可溶于水。 组合物可以包含电解质和共聚物。 包含电解质的环境的流变学可以通过将共聚物加入到环境中进行改性。
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公开(公告)号：US08658209B2
公开(公告)日：2014-02-25
申请号：US11934638
申请日：2007-11-02
申请人： Ye Liu , Decheng Wu , Chaobin He
发明人： Ye Liu , Decheng Wu , Chaobin He
IPC分类号： A61K9/14
摘要： There is presently provided a stimulus-responsive polymer comprising a biodegradable polymer backbone and a stimulus-responsive pendant group attached to the biodegradable polymer backbone, wherein the biodegradable polymer backbone comprises a poly(amino ester) or a poly(amido amine), the poly(amido amine) optionally comprising a disulfide linkage in the backbone.
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公开(公告)号：US20100279095A1
公开(公告)日：2010-11-04
申请号：US12738602
申请日：2007-10-17
申请人： Xu Li , Chaobin He , Decheng Wu , Ye Liu
发明人： Xu Li , Chaobin He , Decheng Wu , Ye Liu
CPC分类号： C25D13/02 , B82Y30/00 , C08J5/005 , C08K3/041 , C08K9/04 , C09D5/4461 , C09D5/448 , C09D7/62 , C09D7/70 , C09D179/08 , C25D13/04 , C25D13/22 , Y10T428/249948
摘要： A process for forming a composite film on a substrate comprises providing a suspension comprising an ionised polymer and functionalised carbon nanotubes in a solvent, at least partially immersing the substrate and a counterelectrode in the suspension, and applying a voltage between the substrate and the counterelectrode so as to form the composite film on the substrate. Electrical charges on the polymer and on the nanotubes have the same sign and the voltage is applied such that the charge on the substrate has the opposite sign to the charge on the polymer and the nanotubes.
摘要翻译： 在基材上形成复合膜的方法包括在溶剂中提供包含电离聚合物和官能化碳纳米管的悬浮液，至少部分地将基材和反电极浸渍在悬浮液中，并在基板和反电极之间施加电压，因此 以在基板上形成复合膜。 聚合物和纳米管上的电荷具有相同的符号，施加电压使得基底上的电荷与聚合物和纳米管上的电荷具有相反的符号。
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公开(公告)号：US20090123544A1
公开(公告)日：2009-05-14
申请号：US11934638
申请日：2007-11-02
申请人： Ye Liu , Decheng Wu , Chaobin He
发明人： Ye Liu , Decheng Wu , Chaobin He
IPC分类号： A61K9/00 , C08F120/10 , C08F120/54 , A61K38/02 , A61K48/00 , A61K39/00
CPC分类号： A61K9/1075 , A61K9/06 , A61K47/34 , C08F120/10 , C08F120/54
摘要： There is presently provided a stimulus-responsive polymer comprising a biodegradable polymer backbone and a stimulus-responsive pendant group attached to the biodegradable polymer backbone, wherein the biodegradable polymer backbone comprises a poly(amino ester) or a poly(amido amine), the poly(amido amine) optionally comprising a disulfide linkage in the backbone.
摘要翻译： 目前提供了包含可生物降解的聚合物主链和连接到可生物降解的聚合物主链的刺激响应侧基的刺激响应性聚合物，其中生物可降解的聚合物主链包含聚（氨基酯）或聚（酰氨基胺），聚 （酰胺胺），其任选地在主链中包含二硫键。
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公开(公告)号：US08476386B2
公开(公告)日：2013-07-02
申请号：US13415801
申请日：2012-03-08
申请人： Ye Liu , Decheng Wu , Chaobin He
发明人： Ye Liu , Decheng Wu , Chaobin He
CPC分类号： C08G63/6854 , A61K9/0019 , A61K47/6949 , A61K48/0041 , A61K49/0017 , B82Y5/00 , C08G63/40 , C08G73/02 , C08G83/002 , C08G83/005 , C12N15/87
摘要： The present invention provides a branched, a dendritic, or a hyperbranched poly(amino ester) having a polymer backbone comprising a plurality of branches, wherein the polymer backbone has at least one secondary and at least one tertiary amine linkage. Branched poly(amino ester)s are prepared via a Michael addition reaction of a tris(acrylate ester)monomer with a diamine monomer. In one aspect, the diamine monomer has a primary amino group and a secondary amino group. The poly(amino ester) compounds can be end-capped by reacting with a suitable agent. The present invention also provides applications including, but are not limited to, the delivery of bioactive agents, such as drugs, DNA or RNA; or biocompatible imaging.
摘要翻译： 本发明提供了具有包含多个分支的聚合物主链的支链，树枝状或超支化聚（氨基酯），其中所述聚合物主链具有至少一个仲和至少一个叔胺键。 通过三（丙烯酸酯）单体与二胺单体的迈克尔加成反应制备分支的聚（氨基酯）。 一方面，二胺单体具有伯氨基和仲氨基。 聚（氨基酯）化合物可以通过与合适的试剂反应而封端。 本发明还提供包括但不限于生物活性剂如药物，DNA或RNA的递送的应用; 或生物相容性成像。
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公开(公告)号：US20120259084A1
公开(公告)日：2012-10-11
申请号：US13415801
申请日：2012-03-08
申请人： Ye Liu , Decheng Wu , Chaobin He
发明人： Ye Liu , Decheng Wu , Chaobin He
IPC分类号： C08F26/06
CPC分类号： C08G63/6854 , A61K9/0019 , A61K47/6949 , A61K48/0041 , A61K49/0017 , B82Y5/00 , C08G63/40 , C08G73/02 , C08G83/002 , C08G83/005 , C12N15/87
摘要： The present invention provides a branched, a dendritic, or a hyperbranched poly(amino ester) having a polymer backbone comprising a plurality of branches, wherein the polymer backbone has at least one secondary and at least one tertiary amine linkage. Branched poly(amino ester)s are prepared via a Michael addition reaction of a tris(acrylate ester)monomer with a diamine monomer. In one aspect, the diamine monomer has a primary amino group and a secondary amino group. The poly(amino ester) compounds can be end-capped by reacting with a suitable agent. The present invention also provides applications including, but are not limited to, the delivery of bioactive agents, such as drugs, DNA or RNA; or biocompatible imaging.
摘要翻译： 本发明提供了具有包含多个分支的聚合物主链的支链，树枝状或超支化聚（氨基酯），其中聚合物主链具有至少一个仲和至少一个叔胺键。 通过三（丙烯酸酯）单体与二胺单体的迈克尔加成反应制备分支的聚（氨基酯）。 一方面，二胺单体具有伯氨基和仲氨基。 聚（氨基酯）化合物可以通过与合适的试剂反应而封端。 本发明还提供包括但不限于生物活性剂如药物，DNA或RNA的递送的应用; 或生物相容性成像。
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公开(公告)号：US08703194B2
公开(公告)日：2014-04-22
申请号：US11934638
申请日：2007-11-02
申请人： Ye Liu , Decheng Wu , Chaobin He
发明人： Ye Liu , Decheng Wu , Chaobin He
IPC分类号： A61K9/14
CPC分类号： A61K9/1075 , A61K9/06 , A61K47/34 , C08F120/10 , C08F120/54
摘要： There is presently provided a stimulus-responsive polymer comprising a biodegradable polymer backbone and a stimulus-responsive pendant group attached to the biodegradable polymer backbone, wherein the biodegradable polymer backbone comprises a poly(amino ester) or a poly(amido amine), the poly(amido amine) optionally comprising a disulfide linkage in the backbone.
摘要翻译： 目前提供了包含可生物降解的聚合物主链和连接到可生物降解的聚合物主链的刺激响应侧基的刺激响应性聚合物，其中生物可降解的聚合物主链包含聚（氨基酯）或聚（酰氨基胺），聚 （酰胺胺），其任选地在主链中包含二硫键。
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公开(公告)号：US08496796B2
公开(公告)日：2013-07-30
申请号：US12738602
申请日：2007-10-17
申请人： Xu Li , Chaobin He , Decheng Wu , Ye Liu
发明人： Xu Li , Chaobin He , Decheng Wu , Ye Liu
IPC分类号： C25D13/02
CPC分类号： C25D13/02 , B82Y30/00 , C08J5/005 , C08K3/041 , C08K9/04 , C09D5/4461 , C09D5/448 , C09D7/62 , C09D7/70 , C09D179/08 , C25D13/04 , C25D13/22 , Y10T428/249948
摘要： A process for forming a composite film on a substrate comprises providing a suspension comprising an ionised polymer and functionalised carbon nanotubes in a solvent, at least partially immersing the substrate and a counterelectrode in the suspension, and applying a voltage between the substrate and the counterelectrode so as to form the composite film on the substrate. Electrical charges on the polymer and on the nanotubes have the same sign and the voltage is applied such that the charge on the substrate has the opposite sign to the charge on the polymer and the nanotubes.
摘要翻译： 在基材上形成复合膜的方法包括在溶剂中提供包含电离聚合物和官能化碳纳米管的悬浮液，至少部分地将基材和反电极浸渍在悬浮液中，并在基板和反电极之间施加电压，因此 以在基板上形成复合膜。 聚合物和纳米管上的电荷具有相同的符号，施加电压使得基底上的电荷与聚合物和纳米管上的电荷具有相反的符号。
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公开(公告)号：US20120045515A1
公开(公告)日：2012-02-23
申请号：US13148046
申请日：2010-01-25
申请人： Ye Liu , Decheng Wu
发明人： Ye Liu , Decheng Wu
CPC分类号： A61K9/5115 , A61K9/5146 , A61K47/34 , A61K47/6921 , A61K47/6923 , A61K47/6925 , B82Y30/00 , C01P2002/82 , C01P2002/86 , C01P2002/88 , C01P2004/04 , C01P2004/34 , C01P2004/61 , C01P2004/62 , C01P2004/64 , C09C1/3072 , C09C1/3081 , C09C1/309
摘要： The present invention provides a hollow silica micro- or nanoparticle with a polymer immobilized thereon. The polymer is covalently linked to the silica particle via urethane groups. Provided is also a method of covalently coupling a polymer to a silica surface. The method comprises contacting a silica surface that carries amino functional groups with a polymer with a carbonate group of the general Formula (2). R2 in Formula (2) is the polymer and R3 is one of an aliphatic, an alicyclic an aromatic and an arylaliphatic group or a silyl group with a main chain of about 1 to about 20 carbon atoms and 0 to about 6 heteroatoms selected from the group consisting of N, O, S, Se and Si. The method further comprises allowing the carbonate group of the polymer and an amino functional group on the silica surface to undergo a coupling reaction, thereby covalently coupling the polymer to the silica surface.
摘要翻译： 本发明提供了在其上固定有聚合物的中空二氧化硅微粒或纳米颗粒。 聚合物通过氨基甲酸酯基团与二氧化硅颗粒共价连接。 还提供了将聚合物共价偶联到二氧化硅表面上的方法。 该方法包括将携带氨基官能团的二氧化硅表面与聚合物与通式（2）的碳酸酯基团接触。 式（2）中的R 2是聚合物，R 3是脂族，脂环族，芳族和芳基脂族基团或具有约1至约20个碳原子的主链和选自以下的0至约6个杂原子的甲硅烷基 由N，O，S，Se和Si组成的组。 该方法还包括使聚合物的碳酸酯基团和二氧化硅表面上的氨基官能团进行偶联反应，从而将聚合物共价偶联到二氧化硅表面上。
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