公开(公告)号：US07102803B2

公开(公告)日：2006-09-05

申请号：US10716322

申请日：2003-11-18

申请人： Demetri Psaltis ,  George Panotopoulos ,  Hung-Te Hsieh

发明人： Demetri Psaltis ,  George Panotopoulos ,  Hung-Te Hsieh

IPC分类号： G02B5/32

CPC分类号： G02B6/0218

摘要： A temperature compensated apparatus for filtering light is comprised of a holographically recorded grating defined in a photosensitive layer for providing optical filtration for light incident on the grating with a predetermined angle of incidence, and an angulation means responsive to temperature for tilting the grating relative to the angle of incidence of the light as a function of temperature of the grating so that changes in the filtration by the grating compensate for changes in temperature of the grating to maintain effective filtration of the light approximately constant.

摘要翻译： 用于过滤光的温度补偿装置由定义在感光层中的全息记录光栅组成，用于以预定的入射角为入射光栅提供光学过滤，以及响应温度的角度装置，用于使光栅相对于 光的入射角作为光栅的温度的函数，使得光栅的过滤变化补偿光栅的温度变化，以保持光的有效过滤大致恒定。

公开(公告)号：US20110210002A1

公开(公告)日：2011-09-01

申请号：US12782682

申请日：2010-05-18

申请人： Hung-Te Hsieh ,  Steven P. Trainoff

发明人： Hung-Te Hsieh ,  Steven P. Trainoff

IPC分类号： G01N27/447

CPC分类号： C08K5/20 ,  C08J3/203 ,  C08K5/098 ,  C08K5/523 ,  C08L23/12 ,  G01N27/44721 ,  G01N2021/4769 ,  G01N2021/479 ,  G01N2021/513

摘要： A method and apparatus is disclosed for measurement of the electrophoretic mobility of particles and molecules in solution. A sample of particles is placed in a cell containing two electrodes that apply an alternating electric field. A monochromatic light beam passes through the sample. Light scattered by the particles, along with the unscattered beam, is collected and collimated as it exits the cell. This beam is combined in free space with a phase modulated reference beam. The interference forms a frequency modulated speckle pattern, which is detected by a photodetector array. Each array element collects a narrow range of well-defined scattering angles. The signal from each is demodulated to extract the optical phase information providing a first-principle measurement of the electrophoretic mobility of the scattering particles. Each detector element provides a simultaneous independent measurement. This inherent parallelism drastically increases the amount of information available in a given time. The resulting increased sensitivity extends the mobility measurement to particles below one nanometer, reduces the required concentration and electric field compared to previous methods. This minimizes damage to fragile samples, increases the electrode useful life, and reduces joule heating. Electrophoretic mobility is a critically important parameter for predicting the stability of nanoparticle suspensions and pharmaceutical formulations such as protein therapeutics. This invention enables reliable free-solution phase measurement of these samples.

摘要翻译： 公开了用于测量溶液中颗粒和分子的电泳迁移率的方法和装置。 将颗粒样品放置在包含施加交变电场的两个电极的电池中。 单色光束通过样品。 颗粒散射的光以及未散射的光束在离开细胞时被收集和准直。 该光束在自由空间中与相位调制参考光束组合。 干扰形成调频散斑图案，其由光电检测器阵列检测。 每个阵列元素收集一系列精确定义的散射角。 来自每个的信号被解调以提取光学相位信息，提供散射粒子的电泳迁移率的第一原理测量。 每个检测器元件提供同时独立的测量。 这种固有的并行性大大增加了在给定时间内可用的信息量。 所产生的增加的灵敏度将迁移率测量扩展到低于1纳米的颗粒，与以前的方法相比，减少了所需的浓度和电场。 这最大限度地减少对脆性样品的损伤，增加电极的使用寿命，并减少焦耳加热。 电泳迁移率是预测纳米颗粒悬浮液和药物制剂如蛋白质治疗剂的稳定性的关键参数。 本发明能够对这些样品进行可靠的自溶相测定。

公开(公告)号：US08441638B2

公开(公告)日：2013-05-14

申请号：US12782682

申请日：2010-05-18

申请人： Hung-Te Hsieh ,  Steven P. Trainoff

发明人： Hung-Te Hsieh ,  Steven P. Trainoff

IPC分类号： G01N21/00

CPC分类号： C08K5/20 ,  C08J3/203 ,  C08K5/098 ,  C08K5/523 ,  C08L23/12 ,  G01N27/44721 ,  G01N2021/4769 ,  G01N2021/479 ,  G01N2021/513

摘要： A method and apparatus are disclosed for measurement of the electrophoretic mobility of particles in solution. A sample is placed in a cell containing two electrodes that apply an alternating electric field. A monochromatic light beam passes through the sample. Light scattered by the particles, along with the unscattered beam, is collected and collimated as it exits the cell. This beam is combined in free space with a phase modulated reference beam. The interference forms a frequency modulated speckle pattern, which is detected by a photodetector array. Each array element collects a narrow range of well-defined scattering angles. The signal from each is demodulated to provide a measurement of the electrophoretic mobility of the scattering particles. Each detector element provides a simultaneous independent measurement, increasing the amount of information which results in increased sensitivity, extending mobility measurements to particles below one nanometer while reducing the required concentration and electric field.

摘要翻译： 公开了用于测量溶液中颗粒的电泳迁移率的方法和装置。 将样品放置在包含施加交变电场的两个电极的电池中。 单色光束通过样品。 颗粒散射的光以及未散射的光束在离开细胞时被收集和准直。 该光束在自由空间中与相位调制参考光束组合。 干扰形成调频散斑图案，其由光电检测器阵列检测。 每个阵列元素收集一系列精确定义的散射角。 解调每个信号以提供散射粒子的电泳迁移率的测量。 每个检测器元件提供同时独立的测量，增加导致灵敏度增加的信息量，将移动性测量扩展到低于1纳米的粒子，同时减少所需的浓度和电场。