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    LIPOPROTEINS, LIPOPEPTIDES AND ANALOGS, AND METHODS FOR MAKING AND USING THEM
    8.
    发明申请
    LIPOPROTEINS, LIPOPEPTIDES AND ANALOGS, AND METHODS FOR MAKING AND USING THEM 有权
    脂蛋白，脂蛋白和类似物，以及制备和使用它们的方法

    公开(公告)号：US20100266675A1

    公开(公告)日：2010-10-21

    申请号：US12600930

    申请日：2008-05-21

    申请人： William Gerwick ,  Wolfgang Wrasidlo ,  Dennis Carson ,  Dwayne Stupack ,  Takashi Suyama

    发明人： William Gerwick ,  Wolfgang Wrasidlo ,  Dennis Carson ,  Dwayne Stupack ,  Takashi Suyama

    IPC分类号： A61K9/127 ,  C07K2/00 ,  A61K38/00 ,  A61P35/00

    CPC分类号： C07C323/60 ,  C07C233/47

    摘要： The invention provides novel compositions—lipopeptides and analogs, including somocystinamide A, and somocystinamide A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these lipopeptides and analogs are used to induce apoptosis in a cell, which can be a normal cell, a dysfunctional cell and/or a cancer (tumor) cell. In alternative embodiments, the compositions of the invention, including the lipopeptides and analogs of the invention, and the pharmaceutical compositions comprising them, are used to treat or ameliorate (including slowing the progression of) normal, dysfunctional (e.g., abnormally proliferating) and/or tumor associated blood vessels, including endothelial and/or capillary cell growth; including neovasculature related to (within, providing a blood supply to) a tumor.

    摘要翻译： 本发明提供了新颖的组合物 - 脂肽和类似物，包括胞质酰胺A和胞囊酰胺A变体和类似物，以及包含它们的药物组合物，脂质体和纳米颗粒，以及制备和使用它们的方法。 在一个实施方案中，这些脂肽和类似物用于诱导细胞凋亡，细胞可以是正常细胞，功能障碍细胞和/或癌症（肿瘤）细胞。 在替代实施方案中，本发明的组合物，包括本发明的脂肽和类似物以及包含它们的药物组合物用于治疗或改善（包括减缓正常，功能障碍（例如异常增殖）和/ 或肿瘤相关血管，包括内皮细胞和/或毛细胞生长; 包括与肿瘤相关的新血管生成（内部，提供血液供应）。