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    ACOUSTICALLY RESPONSIVE PARTICLES WITH DECREASED CAVITATION THRESHOLD
    3.
    发明申请
    ACOUSTICALLY RESPONSIVE PARTICLES WITH DECREASED CAVITATION THRESHOLD 审中-公开
    具有降低裂隙阈值的有声响应的颗粒

    公开(公告)号：US20140046181A1

    公开(公告)日：2014-02-13

    申请号：US13978140

    申请日：2012-01-05

    申请人： Michael Benchimol ,  Sadik C. Esener ,  Dmitri Simberg ,  Stuart Ibsen

    发明人： Michael Benchimol ,  Sadik C. Esener ,  Dmitri Simberg ,  Stuart Ibsen

    IPC分类号： A61K41/00 ,  A61M5/00 ,  A61M37/00

    CPC分类号： A61K41/0047 ,  A61K9/0009 ,  A61K9/1273 ,  A61K41/0028 ,  A61M5/007 ,  A61M37/0092

    摘要： Techniques, systems, devices and materials are disclosed for implementing and fabricating drug delivery and imaging vehicles, which are activated in the body at a tissue of interest by focused ultrasound. In one aspect, a drug delivery vehicle can include a carrier having an outer membrane that envelopes an acoustic sensitizer particle and a payload substance to be delivered to the target tissue. The outer membrane can protect the acoustic sensitizer particle and the payload substance from degradation and opsonization. The outer membrane can be functionalized with a tumor targeting ligand to cause the drug delivery vehicle to selectively accumulate in a tumor region over other tissues, as well as with an agent to increase circulation time by reducing uptake from undesired body tissues, organs, and systems.

    摘要翻译： 公开了用于实施和制造药物递送和成像载体的技术，系统，装置和材料，其通过聚焦超声在感兴趣的组织在体内被激活。 在一个方面，药物递送载体可以包括具有外膜的载体，其包围声敏剂颗粒和有效载体物质被输送到目标组织。 外膜可以保护声学敏化剂颗粒和有效载荷物质免于降解和调理。 外膜可以用肿瘤靶向配体进行功能化，以使药物递送媒介物在其他组织上选择性地积聚在肿瘤区域中，以及通过减少来自不期望的身体组织，器官和系统的摄取而增加循环时间的试剂 。

    Dual-scale topology optoelectronic matrix algebraic processing system
    5.
    发明授权
    Dual-scale topology optoelectronic matrix algebraic processing system 失效
    双尺度拓扑光电矩阵代数处理系统

    公开(公告)号：US5321639A

    公开(公告)日：1994-06-14

    申请号：US846277

    申请日：1992-03-02

    申请人： Ashok V. Krishnamoorthy ,  Gary C. Marsden ,  Joseph E. Ford ,  Sadik C. Esener

    发明人： Ashok V. Krishnamoorthy ,  Gary C. Marsden ,  Joseph E. Ford ,  Sadik C. Esener

    IPC分类号： G06E1/02 ,  G06N3/067 ,  G06E3/00

    CPC分类号： G06N3/0675 ,  G06E1/02

    摘要： A parallel architecture matrix algebraic processing system exhibits patterns of arrayed (i) light transmitters and (ii) light receivers that are identical, but at differing scales. Planar arrays of one or more optoelectronic processors--principally semiconductor chips or chip arrays--having both computational and light input/output capabilities optically communicate from one plane to the next through free-space space-invariant optical data distributions--principally lenses and computer-generated holograms--having both replication and distribution capabilities. Each optoelectronic processor, or OP, consists of a number of arrayed optoelectronic processing elements, or OPEs. The OPEs, in turn, typically consist of a number of optoelectronic sub-processing units are preferably electrically interconnected in a tree-based structure, preferably an H-tree. Leaf units include typically one light detector plus local memory, logic circuitry, and electrical input/output. Fanning units typically include local memory, logic circuitry, and electrical input/output. A root unit typically includes electrically-connected local memory, logic circuitry, electrical input/output, and a light transmitter. Vector results of algebraic computations and combinations are flexibly performable in the units of each OPE, and variously optically distributable to other OPEs in successive OPs. The versatile algebraic vector manipulations and vector distributions support primitive functions such as intrinsic and extrinsic vector outer products; operations such as vector-matrix multiplication; and complex systems such as neural networks, fuzzy logic and relational databases. A system of .gtoreq.10.sup.3 fully optically communicating OPEs achieves capacities of 10.sup.6 -10.sup.8 interconnects, and processing speeds of 10.sup.12 interconnects/second.

    摘要翻译： 并行架构矩阵代数处理系统呈现阵列（i）光发射器和（ii）相同但不同尺度的光接收器的图案。 具有计算和光输入/输出能力的一个或多个光电子处理器的平面阵列主要是具有计算和光输入/输出能力的光学通信通过自由空间空间不变的光学数据分布从一个平面到下一个光学通信，主要是透镜和计算机生成的 全息图 - 具有复制和分发功能。 每个光电处理器或OP由多个阵列的光电处理元件或OPE组成。 OPE通常由多个光电子处理单元组成，优选在基于树的结构中，优选地H-tree电互连。 叶单元通常包括一个光检测器加本地存储器，逻辑电路和电输入/输出。 扇形单元通常包括本地存储器，逻辑电路和电输入/输出。 根单元通常包括电连接的本地存储器，逻辑电路，电输入/输出和光发射器。 代数计算和组合的向量结果可以在每个OPE的单元中灵活地执行，并且可以在各个OP中以各种光学方式分配给其他OPE。 通用代数向量操纵和向量分布支持原始函数，如内在和外在矢量外积; 诸如矢量矩阵乘法的运算; 和复杂系统，如神经网络，模糊逻辑和关系数据库。 全面光通信OPE的系统实现106-108互连的容量，以及1012互连/秒的处理速度。

    Single photon IR detectors and their integration with silicon detectors
    6.
    发明授权
    Single photon IR detectors and their integration with silicon detectors 有权
    单光子红外探测器及其与硅探测器的集成

    公开(公告)号：US08637875B2

    公开(公告)日：2014-01-28

    申请号：US12502225

    申请日：2009-07-13

    申请人： Hod Finkelstein ,  Sadik C. Esener ,  Yu-Hwa Lo ,  Kai Zhao ,  James Cheng ,  Sifang You

    发明人： Hod Finkelstein ,  Sadik C. Esener ,  Yu-Hwa Lo ,  Kai Zhao ,  James Cheng ,  Sifang You

    IPC分类号： H01L31/12

    CPC分类号： H01L31/055 ,  H01L31/0336 ,  Y02E10/52

    摘要： Apparatuses and systems for photon detection can include a first optical sensing structure structured to absorb light at a first optical wavelength; and a second optical sensing structure engaged with the first optical sensing structure to allow optical communication between the first and the second optical sensing structures. The second optical sensing structure can be structured to absorb light at a second optical wavelength longer than the first optical wavelength and to emit light at the first optical wavelength which is absorbed by the first optical sensing structure. Apparatuses and systems can include a bandgap grading region.

    摘要翻译： 用于光子检测的装置和系统可以包括被构造为吸收第一光波长的光的第一光学感测结构; 以及与第一光学感测结构接合以允许第一和第二光学感测结构之间的光学通信的第二光学感测结构。 第二光学感测结构可被构造为吸收长于第一光学波长的第二光学波长的光并且发射由第一光学感测结构吸收的第一光学波长的光。 设备和系统可以包括带隙分级区域。

    Motionless parallel readout head for an optical disk recorded with arrayed one-dimensional holograms
    9.
    发明授权
    Motionless parallel readout head for an optical disk recorded with arrayed one-dimensional holograms 失效
    用于记录有阵列一维全息图的光盘的无运动并行读出头

    公开(公告)号：US5285438A

    公开(公告)日：1994-02-08

    申请号：US785742

    申请日：1991-10-31

    申请人： Philippe J. Marchand ,  Ashok V. Krishnamoorthy ,  Pierre Ambs ,  Kristopher Urquhart ,  Sadik C. Esener ,  H. Sing Lee

    发明人： Philippe J. Marchand ,  Ashok V. Krishnamoorthy ,  Pierre Ambs ,  Kristopher Urquhart ,  Sadik C. Esener ,  H. Sing Lee

    IPC分类号： G03H1/26 ,  G11B7/0065 ,  H04N1/41 ,  H04N7/30 ,  G11B7/00

    CPC分类号： H04N19/60 ,  G03H1/26 ,  G11B7/0065 ,  G03H2210/40 ,  G03H2270/22

    摘要： A motionless parallel head reads an optical disk having an active surface encoded with an arrayed multiplicity of one-dimensional holograms. Each 1-D hologram is a computer-encoded representation of, typically, one 128 pixel slice of an image. A group, typically 128, 1-D holograms are positionally distributed, and positionally shifted or staggered one to the next, radially along the disk's active surface so as to fit a complete radius. Typically 14,000 groups are circumferentially-displaced around a 51/4" Compact Disk (CD), forming a herringbone pattern. During readout the encoded CD is simultaneously illuminated along the entirety of one of its radius lines within which a group of holographic data blocks are fitted. The illuminated group of holographic data blocks are optically transformed in parallel by one or more lenses, and preferably by a Hybrid refractive/diffractive Optical Lens (HOL), so as to two-dimensionally spatially encode the wavefront of the light beam by which the group of holographic data blocks was illuminated. The 2-D spatially-encoded light beam is detectable by an array of light detectors. When the disk is rotated then sucessive groups of holographic data blocks that are fitted along successive radius lines are successively retrieved, group by group, at a typically 1.1 Gbyte/sec rate. Such an optical memory is useable as the secondary storage of a high performance optoelectronic associative memory system.

    摘要翻译： 静止平行头读取具有编码有排列的多维一维全息图的活性表面的光盘。 每个1-D全息图是通常是图像的一个128像素切片的计算机编码表示。 一组通常为128个1-D全息图的位置分布，并且沿着盘的有效表面径向地位移或交错一个到下一个，以便适合完整的半径。 通常，14,000组围绕51/4“压缩盘（CD）周向移位，形成人字形图案。在读出期间，编码的CD同时沿着其一个半径线的整个照明，其中一组全息数据块是 通过一个或多个透镜，优选地通过混合折射/衍射光学透镜（HOL）将全息数据块的照明组并行光学变换，以二维空间编码光束的波前，由此， 全息数据块被照亮，二维空间编码的光束可以通过光检测器阵列检测，当光盘旋转时，依次检索沿连续半径线拟合的全息数据块组， 按照一般的1.1Gbyte /秒的速率，这种光学存储器可用作高性能光电关联备忘录的二次存储 ry系统。

    Single Photon IR Detectors and Their Integration With Silicon Detectors
    10.
    发明申请
    Single Photon IR Detectors and Their Integration With Silicon Detectors 有权
    单光子红外探测器及其与硅探测器的集成

    公开(公告)号：US20130082286A1

    公开(公告)日：2013-04-04

    申请号：US12502225

    申请日：2009-07-13

    申请人： Hod Finkelstein ,  Sadik C. Esener ,  Yu-Hwa Lo ,  Kai Zhao ,  James Cheng ,  Sifang You

    发明人： Hod Finkelstein ,  Sadik C. Esener ,  Yu-Hwa Lo ,  Kai Zhao ,  James Cheng ,  Sifang You

    IPC分类号： H01L31/12

    CPC分类号： H01L31/055 ,  H01L31/0336 ,  Y02E10/52

    摘要： Apparatuses and systems for photon detection can include a first optical sensing structure structured to absorb light at a first optical wavelength; and a second optical sensing structure engaged with the first optical sensing structure to allow optical communication between the first and the second optical sensing structures. The second optical sensing structure can be structured to absorb light at a second optical wavelength longer than the first optical wavelength and to emit light at the first optical wavelength which is absorbed by the first optical sensing structure. Apparatuses and systems can include a bandgap grading region.

    摘要翻译： 用于光子检测的装置和系统可以包括被构造为吸收第一光波长的光的第一光学感测结构; 以及与第一光学感测结构接合以允许第一和第二光学感测结构之间的光学通信的第二光学感测结构。 第二光学感测结构可被构造为吸收长于第一光学波长的第二光学波长的光并且发射由第一光学感测结构吸收的第一光学波长的光。 设备和系统可以包括带隙分级区域。