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122 条记录 (耗时 0.042 秒)

    Novel 1,2,4-benzotriazine-1,4-dioxides
    8.
    发明申请
    Novel 1,2,4-benzotriazine-1,4-dioxides 有权
    新的1,2,4-苯并三嗪-1,4-二氧化物

    公开(公告)号：US20070197534A1

    公开(公告)日：2007-08-23

    申请号：US10590796

    申请日：2005-03-01

    申请人： William Denny ,  Michael Hay ,  Kevin Hicks ,  Frederik Pruijn ,  William Wilson ,  Karin Pchalek

    发明人： William Denny ,  Michael Hay ,  Kevin Hicks ,  Frederik Pruijn ,  William Wilson ,  Karin Pchalek

    IPC分类号： C07D253/08 ,  A61K31/28 ,  A61K31/53

    CPC分类号： C07D253/10 ,  C07D253/08 ,  C07D401/12

    摘要： The present invention provides a simplified set of characteristics that can be used to select 1,2,4 benzotriazine 1,4 dioxide compounds (TPZ analogues) with therapeutic activity against hypoxic cells in human tumour xenografts, and to further provide a novel class of 1,2,4-benzotriazine-1,4-dioxides (TPZ analogues) with predicted in vivo activity against tumours, to their preparation, and to their use as hypoxia-selective cytotoxic drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.

    摘要翻译： 本发明提供了可用于选择具有对人类肿瘤异种移植物中的缺氧细胞具有治疗活性的1,2,4苯并三嗪二氧化物化合物（TPZ类似物）的简化特征集，并进一步提供新的1类 ，具有预测的针对肿瘤的体内活性的2,4-苯并三嗪-1,4-二氧化物（TPZ类似物），其制备及其作为用于癌症治疗的缺氧选择性细胞毒性药物和放射增敏剂的用途，单独或与 辐射和/或其他抗癌药物。

    Arthropodicidal carboxanilides
    9.
    发明申请
    Arthropodicidal carboxanilides 失效
    节肢动物杀虫甲酰苯胺

    公开(公告)号：US20030139397A1

    公开(公告)日：2003-07-24

    申请号：US10220446

    申请日：2002-08-28

    发明人： David Walter Piotrowski

    IPC分类号： A61K031/549 ,  A61K031/541 ,  A61K031/5395 ,  A61K031/5377 ,  A61K031/506 ,  A61K031/444 ,  C07D417/02 ,  C07D43/02 ,  C07D413/02

    CPC分类号： C07D253/06 ,  A01N43/707 ,  A01N43/90 ,  A01N47/02 ,  A01N47/16 ,  C07D239/20 ,  C07D239/70 ,  C07D253/10 ,  C07D273/00 ,  C07D273/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

    摘要： Compounds of Formula (I), and their N-oxides and agriculturally suitable salts, are disclosed which are useful as arthropodicides wherein A is H; E is H or C1-C3 alkyl; or A and E can be taken together to form nullCH2null, nullCH2CH2null, nullOnull, nullSnull, nullS(O)null, nullS(O)2null, nullNR8null, nullOCH2null, nullSCH2null, nullN(R8)CH2null, substituted nullCH2null and substituted nullCH2CH2null, the substituents independently selected from 1-2 halogen and 1-2 methyl; W is N or CR4;X is CR5R6, O, S, NR7 or a direct bond, provided that when W is N, then X is other than a direct bond; Y is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C3 alkylsulfonyl, C3-C6 cycloalkyl, C3-C6 cycloalkylalkyl, NR9R10, NnullCR11R12, OR7, COR13, CO2R14 or C1-C6 alkyl substituted by at least one group selected from halogen, C1-C3 alkoxy, CN, NO2, S(O)1R15, COR13, CO2R14 and optionally substituted phenyl; Z is O or S; and R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, G, n and r are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (I) and a method for controlling arthropods which involves contacting the arthropods or their environment with an effective amount of a compound of Formula (I).

    摘要翻译： 公开了式（I）化合物及其N-氧化物和农业上合适的盐，其可用作其中A为H的杀虫剂; E是H或C 1 -C 3烷基; 或者A和E可以一起形成-CH 2 - ， - CH 2 CH 2 - ， - O - ， - S - ， - S（O） - ， - S（O）2 - ， - NR 8 - ， - OCH 2 - SCH 2 - ， - N（R 8）CH 2 - ，取代的-CH 2 - 和取代的-CH 2 CH 2 - ，独立地选自1-2个卤素和1-2个甲基的取代基; W是N或CR4; X是CR5R6，O，S，NR7或直接键，条件是当W是N时，X不是直接键; Y是H，C1-C6烷基，C2-C6烯基，C2-C6炔基，C1-C3烷基磺酰基，C3-C6环烷基，C3-C6环烷基烷基，NR9R10，N = CR11R12，OR7，COR13，CO2R14或C1-C6烷基 被选自卤素，C 1 -C 3烷氧基，CN，NO 2，S（O）1 R 15，COR 13，CO 2 R 14和任选取代的苯基中的至少一个基团取代; Z是O或S; 并且R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11，R 12，R 13，R 14，R 15，G，n和r如本公开中所定义。 也披露了