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16 条记录 (耗时 0.022 秒)

    Polyazamacrocycles for magnetic resonance imaging
    6.
    发明授权
    Polyazamacrocycles for magnetic resonance imaging 失效
    用于磁共振成像的多氮唑烷

    公开(公告)号：US5314680A

    公开(公告)日：1994-05-24

    申请号：US12185

    申请日：1993-05-04

    申请人： Raghavan Rajagopalan ,  Rebecca A. Wallace ,  Muthunadar P. Periasamy

    发明人： Raghavan Rajagopalan ,  Rebecca A. Wallace ,  Muthunadar P. Periasamy

    IPC分类号： A61K49/06 ,  G01R33/28 ,  A61B5/055 ,  C07D255/02

    CPC分类号： G01R33/5601 ,  A61K49/06 ,  Y10S514/836 ,  Y10T436/24

    摘要： Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions.A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.

    摘要翻译： 新型磁共振成像剂包括顺磁离子与聚氨基羧酸螯合剂的酰肼衍生物的复合物。 这些新型成像剂的特征在于优异的NMR图像对比性质和生理溶液中的高溶解度。 执行NMR诊断程序的新方法包括向温血动物施用有效量的如上所述的复合物，然后将温血动物暴露于NMR成像过程，从而使至少一部分身体成像 温血动物。

    Complexes and compositions for magnetic resonance imaging and usage methods
    7.
    发明授权
    Complexes and compositions for magnetic resonance imaging and usage methods 失效
    用于磁共振成像和使用方法的复合物和组合物

    公开(公告)号：US5141740A

    公开(公告)日：1992-08-25

    申请号：US616450

    申请日：1990-11-21

    申请人： Raghavan Rajagopalan ,  Rebecca A. Wallace ,  Muthunadar P. Periasamy

    发明人： Raghavan Rajagopalan ,  Rebecca A. Wallace ,  Muthunadar P. Periasamy

    IPC分类号： A61K49/06 ,  G01R33/28

    CPC分类号： G01R33/5601 ,  A61K49/06 ,  Y10S436/806 ,  Y10S514/836 ,  Y10T436/24

    摘要： Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.

    摘要翻译： 新型磁共振成像剂包括顺磁离子与聚氨基羧酸螯合剂的酰肼衍生物的复合物。 这些新型成像剂的特征在于优异的NMR图像对比性质和生理溶液中的高溶解度。 执行NMR诊断程序的新方法包括向温血动物施用有效量的如上所述的复合物，然后将温血动物暴露于NMR成像过程，从而使至少一部分身体成像 温血动物。

    X-ray contrast agents, compositions and methods
    8.
    发明授权
    X-ray contrast agents, compositions and methods 失效
    X射线造影剂，组合物和方法

    公开(公告)号：US5356613A

    公开(公告)日：1994-10-18

    申请号：US829026

    申请日：1992-05-08

    申请人： Youlin Lin ,  Rebecca A. Wallace ,  David H. White

    发明人： Youlin Lin ,  Rebecca A. Wallace ,  David H. White

    IPC分类号： A61K49/04 ,  C07C237/46 ,  C07C233/05

    CPC分类号： A61K49/0433 ,  C07C237/46

    摘要： The compound N-(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl)-glycolamido]-N'-methyl-2,4,6-triiodoisophthalamide and similar such compounds may be used as x-ray contrast agents which are water-soluble, safe and in an aqueous solution are non-viscous. Methods of preparing N-(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl)-glycolamido]-N'-methyl-2,4,6-triiodoisophthalamide and the analogous compounds are provided.

    摘要翻译： PCT No.PCT / US91 / 01827 Sec。 371日期：1992年5月8日 化合物N-（2,3-二羟基丙基）-5- [N-（2-羟乙基） - 乙酰氨基] -N'-甲基-2（1H， 4,6-三碘间苯二酰胺和类似的这样的化合物可以用作水溶性，安全的并且在水溶液中是非粘性的x射线造影剂。 提供制备N-（2,3-二羟基丙基）-5- [N-（2-羟乙基） - 乙酰氨基] -N'-甲基-2,4,6-三碘间苯二酰胺及其类似化合物的方法。

    Functionalized aza-crytand ligands for diagnostic imaging applications
    10.
    发明授权
    Functionalized aza-crytand ligands for diagnostic imaging applications 失效
    用于诊断成像应用的官能化氮杂 - crytand配体

    公开(公告)号：US5417959A

    公开(公告)日：1995-05-23

    申请号：US130618

    申请日：1993-10-04

    申请人： Rebecca A. Wallace

    发明人： Rebecca A. Wallace

    IPC分类号： A61K49/00 ,  A61K49/06 ,  C07D487/08 ,  C07K14/00 ,  A61B5/055 ,  C07D225/00 ,  C07D245/00

    CPC分类号： C07D487/08 ,  A61K49/0002 ,  A61K49/06 ,  C07K14/001 ,  Y10T436/24

    摘要： The present invention provides new and structurally diverse compositions comprising compounds of the general formula: ##STR1## Wherein V is CR.sub.1 or N; W is CR.sub.2 or N; R.sub.1 and R.sub.2 may be the same or different and are hydrogen, C.sub.1 -C.sub.8 alkyl, or C.sub.6 -C.sub.10 aryl, optionally R.sub.1 and R.sub.2 may be substituted by one or more hydroxy, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 hydroxyalkyl, C.sub.1 -C.sub.8 alkoxy, C.sub.6 -C.sub.10 aryl, C.sub.6 -C.sub.10 hydroxyaryl, C.sub.6 -C.sub.10 aryloxy, --CO.sub.2 R.sub.3, CONR.sub.4 R.sub.5, or --NR.sub.4 R.sub.5 ; X and Y may be the same or different and the O, NR.sub.6, S, or CR.sub.7 R.sub.8 ; R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 may be the same or different and are hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 hydroxyalkyl, or C.sub.1 -C.sub.8 alkoxyalkyl; R.sub.4 and R.sub.5 may form a 5 or 6 membered carbocyclic ring optionally containing singularly or in combination nitrogen, oxygen or sulfur; a, b, c, d and e may be same or different and are zero to about 10; and Z is --CO.sub.2 H, --PO.sub.3 H.sub.2, --SO.sub.3 H, or --CONHOH.Methods for imaging using compositions of the invention as diagnostic imaging agents are also provided.

    摘要翻译： 本发明提供新的和结构不同的组合物，其包含以下通式的化合物：其中V是CR 1或N; W为CR2或N; R 1和R 2可以相同或不同，为氢，C 1 -C 8烷基或C 6 -C 10芳基，任选地R 1和R 2可以被一个或多个羟基，C 1 -C 8烷基，C 1 -C 8羟烷基，C 1 -C 8 烷氧基，C 6 -C 10芳基，C 6 -C 10羟基芳基，C 6 -C 10芳氧基，-CO 2 R 3，CONR 4 R 5或-NR 4 R 5; X和Y可以相同或不同，O，NR6，S或CR7R8; R 3，R 4，R 5，R 6，R 7和R 8可以相同或不同，为氢，C 1 -C 8烷基，C 1 -C 8羟烷基或C 1 -C 8烷氧基烷基; R4和R5可以形成任选地单独或组合地含有氮，氧或硫的5或6元碳环; a，b，c，d和e可以相同或不同，为零至约10; Z是-CO 2 H，-PO 3 H 2，-SO 3 H或-CONHOH。 还提供了使用本发明的组合物作为诊断成像剂成像的方法。