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公开(公告)号：US20140134220A1
公开(公告)日：2014-05-15
申请号：US14062229
申请日：2013-10-24
CPC分类号： A61K8/025 , A61K8/85 , A61K9/1647 , A61K2800/412 , A61L27/18 , A61L27/50 , A61L27/58 , Y10T428/2982 , C08L67/04
摘要： Absorbable microspheres comprising a copolymer formed from greater than 80 to about 99 mole percent D,L-lactide, L(−)-lactide, D(+)-lactide, or meso-lactide and combinations thereof, and about 1 to less than 20 mole percent of a different second monomer selected from the group consisting of p-dioxanone and trimethylene carbonate and combinations thereof, said microspheres having a particle size ranging from about 5 to 2000 microns. Also described herein are formulations comprising such absorbable microspheres.
摘要翻译： 可吸收的微球包含由大于80-约99摩尔％的D，L-丙交酯，L（ - ） - 丙交酯，D（+） - 丙交酯或内消旋丙交酯及其组合形成的共聚物和约1至小于20 摩尔百分比的选自对二恶烷酮和三亚甲基碳酸酯及其组合的不同的第二单体，所述微球具有约5至2000微米的粒度。 本文还描述了包含这种可吸收微球体的制剂。
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公开(公告)号：US08580307B2
公开(公告)日：2013-11-12
申请号：US11472830
申请日：2006-06-22
IPC分类号： A61K9/14
CPC分类号： A61K8/025 , A61K8/85 , A61K9/1647 , A61K2800/412 , A61L27/18 , A61L27/50 , A61L27/58 , Y10T428/2982 , C08L67/04
摘要： Absorbable microspheres comprising a copolymer formed from greater than 80 to about 99 mole percent D,L-lactide, L(−)-lactide, D(+)-lactide, or meso-lactide and combinations thereof, and about 1 to less than 20 mole percent of a different second monomer selected from the group consisting of p-dioxanone and trimethylene carbonate and combinations thereof, said microspheres having a particle size ranging from about 5 to 2000 microns. Also described herein are formulations comprising such absorbable microspheres.
摘要翻译： 可吸收的微球包含由大于80-约99摩尔％的D，L-丙交酯，L（ - ） - 丙交酯，D（+） - 丙交酯或内消旋丙交酯及其组合形成的共聚物和约1至小于20 摩尔百分比的选自对二恶烷酮和三亚甲基碳酸酯及其组合的不同的第二单体，所述微球具有约5至2000微米的粒度。 本文还描述了包含这种可吸收微球体的制剂。
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3.发明申请Copolymers of Epsilon-Caprolactone and Glycolide for Melt Blown Nonwoven Applications 有权用于熔喷无纺布应用的ε-己内酯和乙交酯的共聚物公开(公告)号：US20090264040A1
公开(公告)日：2009-10-22
申请号：US12107614
申请日：2008-04-22
CPC分类号： C08G63/08 , B29C47/0014 , B29C47/385 , B29C47/6087 , B29C47/889 , B29C2947/92514 , B29C2947/9259 , B29C2947/92704 , B29C2947/92885 , B29C2947/92895 , B29C2947/92904 , D04H1/56 , D04H3/02 , D04H3/16 , Y10T442/68
摘要： Copolymers exhibiting the following combinations of properties, including without limitation, ε-caprolactone in an amount ranging from about 12 to about 70 mole percent, glycolide in an amount ranging from about 30 to about 88 mole percent, crystallinity ranging from about 10 to about 50% as measured by WAXD or about 10 to about 50 J/g as measured by DSC, and an inherent viscosity ranging from about 0.5 to about 1.45 dL/g as measured in a 0.1 g/dl solution of HFIP at 25° C.; a method for melt blowing such copolymers and nonwoven constructs produced therefrom are described herein.
摘要翻译： 表现出以下组合性质的共聚物，包括但不限于ε-己内酯，其量为约12至约70摩尔％，乙交酯的量为约30至约88摩尔％，结晶度为约10至约50 ％，通过DSC测量为约10至约50J / g，并且在25℃下在0.1g / dl HFIP溶液中测量的特性粘度范围为约0.5至约1.45dL / g。 本文描述了熔融吹制由此产生的共聚物和非织造构造物的方法。
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4.发明申请Segmented, epsilon-Caprolactone-Rich, Poly(epsilon-Caprolactone-co-p-Dioxanone) Copolymers for Medical Applications and Devices Therefrom 审中-公开用于医疗应用和器件的分段，ε-己内酯丰富的聚（ε-己内酯 - 共对二恶烷酮）共聚物公开(公告)号：US20130005829A1
公开(公告)日：2013-01-03
申请号：US13249730
申请日：2011-10-14
CPC分类号： A61L27/18 , A61K31/09 , A61L17/005 , A61L17/105 , A61L17/12 , A61L27/3826 , A61L27/507 , A61L27/54 , A61L27/56 , A61L31/06 , A61L31/16 , A61L2300/202 , A61L2300/404 , C08G63/08 , C08G63/664 , C08L67/04
摘要： Novel semi-crystalline, epsilon-caprolactone-rich block copolymers of epsilon-caprolactone and p-dioxanone for long term absorbable medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, and other medical devices. Also disclosed are compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease.
摘要翻译： 公开了用于长期吸收医疗应用的ε-己内酯和对二恶烷酮的新型半结晶，ε-己内酯的嵌段共聚物。 新型聚合物组合物可用于长期可吸收外科缝合线和其它医疗器械。 还公开了使用组织工程化血管修复和再生血管疾病患者血管的组合物和方法。
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5.发明授权Copolymers of epsilon-caprolactone and glycolide for melt blown nonwoven applications 有权ε-己内酯和乙交酯的共聚物用于熔喷非织造应用公开(公告)号：US08278409B2
公开(公告)日：2012-10-02
申请号：US12107614
申请日：2008-04-22
IPC分类号： C08G63/08
CPC分类号： C08G63/08 , B29C47/0014 , B29C47/385 , B29C47/6087 , B29C47/889 , B29C2947/92514 , B29C2947/9259 , B29C2947/92704 , B29C2947/92885 , B29C2947/92895 , B29C2947/92904 , D04H1/56 , D04H3/02 , D04H3/16 , Y10T442/68
摘要： Copolymers exhibiting the following combinations of properties, including without limitation, ε-caprolactone in an amount ranging from about 12 to about 70 mole percent, glycolide in an amount ranging from about 30 to about 88 mole percent, crystallinity ranging from about 10 to about 50% as measured by WAXD or about 10 to about 50 J/g as measured by DSC, and an inherent viscosity ranging from about 0.5 to about 1.45 dL/g as measured in a 0.1 g/dl solution of HFIP at 25° C.; a method for melt blowing such copolymers and nonwoven constructs produced therefrom are described herein.
摘要翻译： 表现出以下组合性能的共聚物，包括但不限于约12至约70摩尔％的量的ε-己内酯，其量为约30至约88摩尔％，约10至约88摩尔％的结晶度 通过WAXD测量为50％，通过DSC测量为约10至约50J / g，并且在25℃下以0.1g / dl HFIP溶液测量的特性粘度为约0.5至约1.45dL / g。 ; 本文描述了熔融吹制由此产生的共聚物和非织造构造物的方法。
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公开(公告)号：US09149558B2
公开(公告)日：2015-10-06
申请号：US12688435
申请日：2010-01-15
申请人： Modesto Erneta , Robert DiLuccio
发明人： Modesto Erneta , Robert DiLuccio
IPC分类号： A61L17/00 , A01N59/16 , A61L17/10 , A61L24/00 , A61L24/04 , A61L27/18 , A61L27/54 , A61L29/06 , A61L29/16 , A61L31/06 , A61L31/16 , C08G63/68 , C08G63/91 , C08L67/04 , C08K5/00
CPC分类号： A61L17/005 , A01N59/16 , A61L17/105 , A61L24/0015 , A61L24/046 , A61L27/18 , A61L27/54 , A61L29/06 , A61L29/16 , A61L31/06 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/606 , A61L2300/80 , C08G63/681 , C08G63/91 , C08K5/0058 , C08K5/0091 , C08L67/04 , A01N25/10 , C08L2666/54 , A01N2300/00 , C08L67/00
摘要： An antimicrobial composition comprising an ionic complex of an anionic polyester with an antimicrobial metal, wherein the anionic polyester has an ion exchange capacity from about 0.19 meq/g to about 1.0 meq/g.
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公开(公告)号：US20100204411A1
公开(公告)日：2010-08-12
申请号：US12688435
申请日：2010-01-15
申请人： Modesto Erneta , Robert DiLuccio
发明人： Modesto Erneta , Robert DiLuccio
IPC分类号： C08G63/91
CPC分类号： A61L17/005 , A01N59/16 , A61L17/105 , A61L24/0015 , A61L24/046 , A61L27/18 , A61L27/54 , A61L29/06 , A61L29/16 , A61L31/06 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/606 , A61L2300/80 , C08G63/681 , C08G63/91 , C08K5/0058 , C08K5/0091 , C08L67/04 , A01N25/10 , C08L2666/54 , A01N2300/00 , C08L67/00
摘要： An antimicrobial composition comprising an ionic complex of an anionic polyester with an antimicrobial metal, wherein the anionic polyester has an ion exchange capacity from about 0.19 meq/g to about 1.0 meq/g.
摘要翻译： 一种抗微生物组合物，其包含阴离子聚酯与抗微生物金属的离子络合物，其中所述阴离子聚酯具有约0.19meq / g至约1.0meq / g的离子交换容量。
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公开(公告)号：US07964211B2
公开(公告)日：2011-06-21
申请号：US12793217
申请日：2010-06-03
申请人： Modesto Erneta , Zhangwen Wu
发明人： Modesto Erneta , Zhangwen Wu
摘要： The present invention is directed to absorbable microspheres comprising a copolymer formed from greater than 88 to about 99 mole percent ε-caprolactone or p-dioxanone, and about 1 to less than 12 mole percent of a different second monomer selected from the group consisting of glycolide, p-dioxanone, trimethylene carbonate and the lactides and combinations thereof, said microspheres having a particle size ranging from about 5 to 2,000 microns. Also described herein are a method for making such microspheres and formulations comprising such absorbable microspheres.
摘要翻译： 本发明涉及可吸收微球，其包含由大于88至约99摩尔％的ε-己内酯或对二恶烷酮形成的共聚物和约1至小于12摩尔％的选自下组的不同的第二单体： 乙交酯，对二恶烷酮，三亚甲基碳酸酯和丙交酯及其组合，所述微球具有约5至2,000微米的粒度。 本文还描述了制备这种微球体和包含这种可吸收微球体的制剂的方法。
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9.发明授权Absorbable copolyesters of poly(ethoxyethylene diglycolate) and glycolide 有权聚（乙氧基乙二醇二乙酸酯）和乙交酯的可吸收共聚酯公开(公告)号：US07868127B2
公开(公告)日：2011-01-11
申请号：US11693118
申请日：2007-03-29
申请人： Sasa Andjelic , Modesto Erneta , Michel Gensini
发明人： Sasa Andjelic , Modesto Erneta , Michel Gensini
CPC分类号： A61L17/12 , A61L31/06 , C08G63/664 , Y10T442/626 , C08L67/04
摘要： A semi-crystalline, absorbable copolyester composition comprising the reaction product of a polycondensation polyester and at least one lactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and diethylene glycol; and the copolyester comprises about 30 to 60% by weight of the polycondensation polyester based on the total weight of the copolyester. Also medical devices such as absorbable sutures comprising such copolyesters and absorbable microspheres comprising such copolyesters and methods of making of such absorbable microspheres.
摘要翻译： 包含缩聚聚酯和至少一种内酯的反应产物的半结晶可吸收的共聚酯组合物，其中所述缩聚聚酯包括二甘醇酸和/或其衍生物与二甘醇的反应产物; 共聚聚酯包含基于共聚酯总重量的约30至60重量％的缩聚聚酯。 还可以使用包括这种共聚酯和包含这种共聚酯的可吸收微球的可吸收缝合线的医疗装置和制造这种可吸收的微球的方法。
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10.发明授权Monomer addition techniques to control manufacturing of bioabsorbable copolymers 有权用于控制生物可吸收性共聚物制造的单体添加技术公开(公告)号：US07148315B2
公开(公告)日：2006-12-12
申请号：US10278494
申请日：2002-10-23
申请人： Modesto Erneta , Terry E. Lawler
发明人： Modesto Erneta , Terry E. Lawler
IPC分类号： C08G63/06
摘要： Monomer addition methodology is provided to adjust monomer addition rates to a polymerization reactor. Advantages of the invention include control of bioabsorbable copolymer structure, improvement of monomer conversion, control of reaction temperature, and reduced reaction time. The overall result is an improved process and enhanced product performance. The technology is particularly useful in the copolymerization of monomers with different reactivity ratios, such as glycolide/lactide copolymers and glycolide/caprolactone copolymers. Monomer reactivity ratios and reaction kinetics are utilized to adjust monomer addition rates.
摘要翻译： 提供单体添加方法以调节单体加入聚合反应器的速率。 本发明的优点包括生物可吸收共聚物结构的控制，单体转化率的提高，反应温度的控制以及反应时间的缩短。 总体结果是改进的过程和增强的产品性能。 该技术在具有不同反应性比例的单体如乙交酯/丙交酯共聚物和乙交酯/己内酯共聚物的共聚中是特别有用的。 单体反应活性比和反应动力学被用于调节单体添加速率。
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