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1.发明申请Highly Pure Crystalline Benzphetamine Hydrochloride and Processes for Preparing 审中-公开高纯度结晶苯并苯丙胺盐酸盐及其制备方法公开(公告)号：US20100113831A1
公开(公告)日：2010-05-06
申请号：US12444597
申请日：2006-10-17
IPC分类号： C07C211/27
CPC分类号： C07C211/27
摘要： A highly pure crystalline form of benzphetamine hydrochloride and methods for the purification and crystallization of benzphetamine hydrochloride in high yield are disclosed.
摘要翻译： 公开了一种高纯度的苯并菲胺盐酸盐结晶形式以及以高产率纯化和结晶盐酸苯丙胺的方法。
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公开(公告)号：US07750187B2
公开(公告)日：2010-07-06
申请号：US11719001
申请日：2005-11-02
申请人： Dennis J. Kalota , Keith G. Tomazi
发明人： Dennis J. Kalota , Keith G. Tomazi
IPC分类号： C07C211/00
CPC分类号： C07C209/84 , C07C211/27
摘要： There is disclosed a method for the crystallization of benzphetamine hydrochloride from an organic medium by the steps of removing water from the system to a very low level and then reducing the temperature of the organic medium to provide crystallization of the acid salt. In the event that crystallization does not occur upon lowering the temperature of the medium, it has been discovered that gentle heating of the organic medium results in crystallization of the acid salt. It has also been discovered that higher temperature crystallization has been provided by removal of methamphetamine from the composition. The crystalline benzphetamine hydrochloride can then be isolated by typical liquid/solid separation means such as filtration or centrifugation.
摘要翻译： 公开了通过以下步骤从有机介质中结晶苯并特苯胺盐酸盐的方法：将水从体系中除去至非常低的水平，然后降低有机介质的温度以提供酸盐的结晶。 在降低介质温度时不发生结晶的情况下，发现有机介质的温和加热导致酸盐的结晶。 还已经发现，通过从组合物中除去甲基苯丙胺已经提供了较高温度的结晶。 然后可以通过典型的液体/固体分离方法如过滤或离心分离结晶苯并特苯胺盐酸盐。
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公开(公告)号：US20080262268A1
公开(公告)日：2008-10-23
申请号：US11719001
申请日：2005-11-02
申请人： Dennis J. Kalota , Keith G. Tomazi
发明人： Dennis J. Kalota , Keith G. Tomazi
IPC分类号： C07C211/27
CPC分类号： C07C209/84 , C07C211/27
摘要： There is disclosed a method for the crystallization of benzphetamine hydrochloride from an organic medium by the steps of removing water from the system to a very low level and then reducing the temperature of the organic medium to provide crystallization of the acid salt. In the event that crystallization does not occur upon lowering the temperature of the medium, it has been discovered that gentle heating of the organic medium results in crystallization of the acid salt. It has also been discovered that higher temperature crystallization has been provided by removal of methamphetamine from the composition. The crystalline benzphetamine hydrochloride can then be isolated by typical liquid/solid separation means such as filtration or centrifugation.
摘要翻译： 公开了通过以下步骤从有机介质中结晶苯并特苯胺盐酸盐的方法：将水从体系中除去至非常低的水平，然后降低有机介质的温度以提供酸盐的结晶。 在降低介质温度时不发生结晶的情况下，发现有机介质的温和加热导致酸盐的结晶。 还已经发现，通过从组合物中除去甲基苯丙胺已经提供了较高温度的结晶。 然后可以通过典型的液体/固体分离方法如过滤或离心分离结晶苯并特苯胺盐酸盐。
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4.发明授权公开(公告)号：US08232397B2
公开(公告)日：2012-07-31
申请号：US12586855
申请日：2009-09-29
申请人： Brenda E. Allen , Esa T. Jarvi , Dennis J. Kalota , James R. Meyer , Keith G. Tomazi , Anthony Mannino , Brian Orr
发明人： Brenda E. Allen , Esa T. Jarvi , Dennis J. Kalota , James R. Meyer , Keith G. Tomazi , Anthony Mannino , Brian Orr
IPC分类号： C07D489/12 , C07D489/02
CPC分类号： C07D489/12
摘要： The present invention provides process for the production of opiate alkaloids. In particular, the present invention provides processes for the production of buprenorphine or a derivative of buprenorphine that minimizes the formation of impurities.
摘要翻译： 本发明提供了生产阿片碱生物碱的方法。 特别地，本发明提供生产丁丙诺啡或丁丙诺啡衍生物的方法，其使杂质的形成最小化。
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5.发明申请公开(公告)号：US20100087647A1
公开(公告)日：2010-04-08
申请号：US12586855
申请日：2009-09-29
申请人： Brenda E. Allen , Esa T. Jarvi , Dennis J. Kalota , James R. Meyer , Keith G. Tomazi , Anthony Mannino , Brian Orr
发明人： Brenda E. Allen , Esa T. Jarvi , Dennis J. Kalota , James R. Meyer , Keith G. Tomazi , Anthony Mannino , Brian Orr
IPC分类号： C07D491/08
CPC分类号： C07D489/12
摘要： The present invention provides process for the production of opiate alkaloids. In particular, the present invention provides processes for the production of buprenorphine or a derivative of buprenorphine that minimizes the formation of impurities.
摘要翻译： 本发明提供了生产阿片碱生物碱的方法。 特别地，本发明提供生产丁丙诺啡或丁丙诺啡衍生物的方法，其使杂质的形成最小化。
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公开(公告)号：US5525703A
公开(公告)日：1996-06-11
申请号：US364634
申请日：1994-12-27
申请人： Dennis J. Kalota
发明人： Dennis J. Kalota
CPC分类号： C08G73/0672 , C08G73/1092
摘要： There is disclosed novel cross linked polyanhydroaspartic acid which is the product of the reaction of a polysuccinidmide with triaminononoane (TAN). Depending upon the amount a cross linking agent employed compositions of varying degrees of cross linking are produced. Mole ratio of polysuccinimide to TAN such as from 3 to 1 provides a water insoluble material while a mole ratio of 102 to 1 provides a water soluble material at 28% by weight. Such compounds find utility as thickeners, deflocculants, flocculants and water absorbers.
摘要翻译： 公开了聚琥珀酰亚胺与三氨基壬烷（TAN）的反应产物的新型交联聚水天冬氨酸。 取决于交联剂使用的交联程度不同程度的组合物的量。 聚琥珀酰亚胺与TAN的摩尔比例如3比1提供了水不溶性材料，而摩尔比为102比1则提供了28重量％的水溶性物质。 这些化合物可用作增稠剂，抗絮凝剂，絮凝剂和吸水剂。
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公开(公告)号：US20080188685A1
公开(公告)日：2008-08-07
申请号：US11722767
申请日：2005-11-02
申请人： Dennis J. Kalota
发明人： Dennis J. Kalota
IPC分类号： C07C209/08
CPC分类号： C07C209/08 , C07C2601/14 , Y02P20/582 , C07C211/27
摘要： This present invention relates to a process for preparing benzylated amines by the reaction of an amine selected from methamphetamine and propylhexedrine with benzyl halide. Numerous improvements are obtained by employing the amine in molar excess with respect to benzyl halide, preferably in a molar ratio of 2 to 1. The excess amine is employed to selectively neutralize by-product acid as the amine salt. The amine salt is then separated from the reaction mixture and basified to reclaim starting amine for recycle to the process.
摘要翻译： 本发明涉及通过选自甲基苯丙胺和丙基己烯胺与苄基卤的反应制备苄化胺的方法。 通过使用相对于苄基卤的摩尔过量的胺，优选以2:1的摩尔比来获得许多改进。过量的胺用于选择性中和作为胺盐的副产物酸。 然后将胺盐与反应混合物分离并碱化以回收起始胺以再循环至该方法。
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8.发明授权
公开(公告)号：US6020520A
公开(公告)日：2000-02-01
申请号：US101605
申请日：1998-09-24
CPC分类号： C25B3/105
摘要： Electrolytic hydrodimeric coupling of dialkyl maleates in alkanol solutions containing an alkanol-soluble alkali metal acetate/quatemary ammonium tetrafluoroborate mixed supporting electrolyte yields tetraalkyl 1,2,3,4-butanetetracarboxylates.
摘要翻译： PCT No.PCT / US97 / 00658 Sec。 371日期：1998年9月24日 102（e）1998年9月24日PCT 1997年1月16日PCT PCT。 公开号WO97 / 26389 PCT 日期1997年7月24日马来酸二烷基酯在含有链烷醇可溶性碱金属乙酸盐/季铵四氟硼酸盐混合支持电解质的链烷醇溶液中的电解加氢偶联偶联得到四烷基1,2,3,4-丁烷四羧酸盐。
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公开(公告)号：US5401428A
公开(公告)日：1995-03-28
申请号：US133720
申请日：1993-10-08
IPC分类号： C10M107/44 , B23Q11/10 , B24B55/02 , C10M125/24 , C10M129/50 , C10M149/18 , C10M173/02 , C10N10/02 , C10N30/12 , C10N40/20 , C10M149/04
CPC分类号： C10M173/02 , C10M2201/02 , C10M2201/085 , C10M2209/12 , C10M2217/044 , C10M2217/045 , C10M2225/00 , C10M2225/02 , C10N2240/40 , C10N2240/401 , C10N2250/02
摘要： There are disclosed novel water soluble metal working fluids comprising polyaspartic acid and salts thereof useful as a lubricant in process to cut, bend, grind and shape both ferrous and non-ferrous metal. The polyaspartic acid and salts thereof are particularly advantageous in that the fluids can be easily disposed of after use with special treatment because polyaspartic acid and salts thereof are readily biodegradable.
摘要翻译： 已经公开了包含聚天冬氨酸及其盐的新型水溶性金属工作流体在用于切割，弯曲，研磨和成形黑色金属和有色金属的过程中用作润滑剂。 聚天冬氨酸及其盐特别有利的是，由于聚天冬氨酸及其盐易于生物降解，流体可以在使用后特别处理而容易地处理。
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10.发明授权公开(公告)号：US08232398B2
公开(公告)日：2012-07-31
申请号：US12586856
申请日：2009-09-29
申请人： Dennis J. Kalota
发明人： Dennis J. Kalota
IPC分类号： C07D489/12 , C07D489/10
CPC分类号： C07D489/12 , Y02P20/582
摘要： The present invention provides processes for the production of opiate alkaloids. In particular, the present invention provides processes for increasing the yield of opiate alkaloids by introducing at least one recycling step.
摘要翻译： 本发明提供了生产阿片碱生物碱的方法。 特别地，本发明提供通过引入至少一个回收步骤来提高阿片碱生物碱的产量的方法。
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