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公开(公告)号：US20090136495A1
公开(公告)日：2009-05-28
申请号：US12260125
申请日：2008-10-29
申请人： Dennis Patrick Gately , Donmienne Doen Mun Leung , Barbara Anne Swanson , Ying Tang , YuPing Anthony Cai , LuHong He , Peng Luan , Derrick Ryan Witcher
发明人： Dennis Patrick Gately , Donmienne Doen Mun Leung , Barbara Anne Swanson , Ying Tang , YuPing Anthony Cai , LuHong He , Peng Luan , Derrick Ryan Witcher
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
摘要翻译： 提供选择性结合人hepcidin-25的单克隆抗体，其特征在于具有对人hepcidin-25的高亲和力和强的人成熟铁调素中和特性。 本发明的抗体治疗性地用于增加人的血清铁水平，网织红细胞计数，红细胞计数，血红蛋白和/或血细胞比容，以及用于治疗和诊断人中成熟的铁调素促进的疾病如贫血 学科。
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公开(公告)号：US07820163B2
公开(公告)日：2010-10-26
申请号：US12260125
申请日：2008-10-29
IPC分类号： C07K16/00
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
摘要翻译： 提供选择性结合人hepcidin-25的单克隆抗体，其特征在于具有对人hepcidin-25的高亲和力和强的人成熟铁调素中和特性。 本发明的抗体治疗性地用于增加人的血清铁水平，网织红细胞计数，红细胞计数，血红蛋白和/或血细胞比容，以及用于治疗和诊断人中成熟的铁调素促进的疾病如贫血 学科。
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公开(公告)号：US20110027261A1
公开(公告)日：2011-02-03
申请号：US12872172
申请日：2010-08-31
IPC分类号： A61K39/395 , C07K16/00 , A61P7/06 , G01N33/53
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
摘要翻译： 提供选择性结合人hepcidin-25的单克隆抗体，其特征在于具有对人hepcidin-25的高亲和力和强的人成熟铁调素中和特性。 本发明的抗体治疗性地用于增加人的血清铁水平，网织红细胞计数，红细胞计数，血红蛋白和/或血细胞比容，以及用于治疗和诊断人中成熟的铁调素促进的疾病如贫血 学科。
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公开(公告)号：US08329174B2
公开(公告)日：2012-12-11
申请号：US12872172
申请日：2010-08-31
IPC分类号： C07K16/00
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
摘要翻译： 提供选择性结合人hepcidin-25的单克隆抗体，其特征在于具有对人hepcidin-25的高亲和力和强的人成熟铁调素中和特性。 本发明的抗体治疗性地用于增加人的血清铁水平，网织红细胞计数，红细胞计数，血红蛋白和/或血细胞比容，以及用于治疗和诊断人中成熟的铁调素促进的疾病如贫血 学科。
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公开(公告)号：US20100260754A1
公开(公告)日：2010-10-14
申请号：US12754637
申请日：2010-04-06
IPC分类号： A61K39/395 , C07K16/00 , A61P35/04
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention provides human engineered antibodies, antigen-binding fragments thereof, that bind to, and inhibit the activity of, human DKK-1, and which are effective in treating diseases in which pathogenesis is mediated by DKK-1.
摘要翻译： 本发明提供人类工程化抗体，其抗原结合片段，其结合并抑制人DKK-1的活性，并且其有效治疗由DKK-1介导的发病机制的疾病。
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公开(公告)号：US20090060924A1
公开(公告)日：2009-03-05
申请号：US12160472
申请日：2008-03-11
IPC分类号： A61K39/395 , C07K16/18 , A61P19/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： Humanized and chimeric antibodies are provided that specifically bind human sclerostin and are characterized as having high affinity and strong neutralizing properties. The antibodies of the invention are useful for increasing bone mass, bone mineral density and bone strength and for the treatment of various disorders, e.g., osteoporosis, in human subject.
摘要翻译： 提供特异性结合人类硬化蛋白的人源化和嵌合抗体，其特征在于具有高亲和力和强中和性质。 本发明的抗体可用于增加骨量，骨矿物质密度和骨强度以及用于治疗人受试者中的各种疾病，例如骨质疏松症。
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公开(公告)号：US08148498B2
公开(公告)日：2012-04-03
申请号：US12754637
申请日：2010-04-06
IPC分类号： C12P21/08
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention provides human engineered antibodies, antigen-binding fragments thereof, that bind to, and inhibit the activity of, human DKK-1, and which are effective in treating diseases in which pathogenesis is mediated by DKK-1.
摘要翻译： 本发明提供人类工程化抗体，其抗原结合片段，其结合并抑制人DKK-1的活性，并且其有效治疗由DKK-1介导的发病机制的疾病。
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8.发明授权公开(公告)号：US07988970B2
公开(公告)日：2011-08-02
申请号：US12779438
申请日：2010-05-13
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： Humanized and chimeric antibodies are provided that specifically bind human sclerostin and are characterized as having high affinity and strong neutralizing properties. The antibodies of the invention are useful for increasing bone mass, bone mineral density and bone strength and for the treatment of various disorders, e.g., osteoporosis, in human subject.
摘要翻译： 提供特异性结合人类硬化蛋白的人源化和嵌合抗体，其特征在于具有高亲和力和强中和性质。 本发明的抗体可用于增加骨量，骨矿物质密度和骨强度以及用于治疗人受试者中的各种疾病，例如骨质疏松症。
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公开(公告)号：US20100221263A1
公开(公告)日：2010-09-02
申请号：US12779438
申请日：2010-05-13
IPC分类号： A61K39/395 , A61P19/00 , A61P19/10 , A61P19/08
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： Humanized and chimeric antibodies are provided that specifically bind human sclerostin and are characterized as having high affinity and strong neutralizing properties. The antibodies of the invention are useful for increasing bone mass, bone mineral density and bone strength and for the treatment of various disorders, e.g., osteoporosis, in human subject.
摘要翻译： 提供特异性结合人类硬化蛋白的人源化和嵌合抗体，其特征在于具有高亲和力和强中和性质。 本发明的抗体可用于增加骨量，骨矿物质密度和骨强度以及用于治疗人受试者中的各种疾病，例如骨质疏松症。
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公开(公告)号：US08257704B2
公开(公告)日：2012-09-04
申请号：US13165126
申请日：2011-06-21
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： Humanized and chimeric antibodies are provided that specifically bind human sclerostin and are characterized as having high affinity and strong neutralizing properties. The antibodies of the invention are useful for increasing bone mass, bone mineral density and bone strength and for the treatment of various disorders, e.g., osteoporosis, in human subject.
摘要翻译： 提供特异性结合人类硬化蛋白的人源化和嵌合抗体，其特征在于具有高亲和力和强中和性质。 本发明的抗体可用于增加骨量，骨矿物质密度和骨强度以及用于治疗人受试者中的各种疾病，例如骨质疏松症。
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