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公开(公告)号：US20110027261A1
公开(公告)日：2011-02-03
申请号：US12872172
申请日：2010-08-31
IPC分类号： A61K39/395 , C07K16/00 , A61P7/06 , G01N33/53
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
摘要翻译： 提供选择性结合人hepcidin-25的单克隆抗体，其特征在于具有对人hepcidin-25的高亲和力和强的人成熟铁调素中和特性。 本发明的抗体治疗性地用于增加人的血清铁水平，网织红细胞计数，红细胞计数，血红蛋白和/或血细胞比容，以及用于治疗和诊断人中成熟的铁调素促进的疾病如贫血 学科。
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公开(公告)号：US20090136495A1
公开(公告)日：2009-05-28
申请号：US12260125
申请日：2008-10-29
申请人： Dennis Patrick Gately , Donmienne Doen Mun Leung , Barbara Anne Swanson , Ying Tang , YuPing Anthony Cai , LuHong He , Peng Luan , Derrick Ryan Witcher
发明人： Dennis Patrick Gately , Donmienne Doen Mun Leung , Barbara Anne Swanson , Ying Tang , YuPing Anthony Cai , LuHong He , Peng Luan , Derrick Ryan Witcher
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
摘要翻译： 提供选择性结合人hepcidin-25的单克隆抗体，其特征在于具有对人hepcidin-25的高亲和力和强的人成熟铁调素中和特性。 本发明的抗体治疗性地用于增加人的血清铁水平，网织红细胞计数，红细胞计数，血红蛋白和/或血细胞比容，以及用于治疗和诊断人中成熟的铁调素促进的疾病如贫血 学科。
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公开(公告)号：US08329174B2
公开(公告)日：2012-12-11
申请号：US12872172
申请日：2010-08-31
IPC分类号： C07K16/00
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
摘要翻译： 提供选择性结合人hepcidin-25的单克隆抗体，其特征在于具有对人hepcidin-25的高亲和力和强的人成熟铁调素中和特性。 本发明的抗体治疗性地用于增加人的血清铁水平，网织红细胞计数，红细胞计数，血红蛋白和/或血细胞比容，以及用于治疗和诊断人中成熟的铁调素促进的疾病如贫血 学科。
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公开(公告)号：US07820163B2
公开(公告)日：2010-10-26
申请号：US12260125
申请日：2008-10-29
IPC分类号： C07K16/00
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
摘要翻译： 提供选择性结合人hepcidin-25的单克隆抗体，其特征在于具有对人hepcidin-25的高亲和力和强的人成熟铁调素中和特性。 本发明的抗体治疗性地用于增加人的血清铁水平，网织红细胞计数，红细胞计数，血红蛋白和/或血细胞比容，以及用于治疗和诊断人中成熟的铁调素促进的疾病如贫血 学科。
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公开(公告)号：US08609817B2
公开(公告)日：2013-12-17
申请号：US13055201
申请日：2009-07-29
CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/92 , G01N33/74
摘要： Monoclonal antibodies are provided that bind to the N-terminus of human hepcidin-25 and are characterized as having high affinity and selectivity for the polypeptide. The antibodies of the invention are useful for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment of various disorders, such as anemia, in a human subject. The antibodies of the invention are also useful as analytical tools, such as in sandwich ELISA.
摘要翻译： 提供结合人hepcidin-25的N末端的单克隆抗体，其特征在于对多肽具有高亲和力和选择性。 本发明的抗体可用于增加人类血清铁水平，网织红细胞计数，红细胞计数，血红蛋白和/或血细胞比容，以及用于治疗人类受试者中的各种疾病如贫血。 本发明的抗体也可用作分析工具，例如夹心ELISA。
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公开(公告)号：US20120100148A9
公开(公告)日：2012-04-26
申请号：US12628263
申请日：2009-12-01
申请人： Donmienne Doen Mun Leung , Peng Luan , Joseph Vincent Manetta , Ying Tang , Derrick Ryan Witcher
发明人： Donmienne Doen Mun Leung , Peng Luan , Joseph Vincent Manetta , Ying Tang , Derrick Ryan Witcher
IPC分类号： A61K39/395 , C07H21/00 , A61P35/00 , C12N5/07 , C12P21/08 , A61P7/00 , C07K16/00 , C12N15/63
CPC分类号： C07K16/2869 , A61K38/1816 , A61K39/3955 , C07K16/28 , C07K2317/34 , C07K2317/70 , C07K2317/76 , C07K2317/77 , C07K2317/90
摘要： Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.
摘要翻译： 提供了结合并抑制人FPN1的活性的单克隆抗体和其抗原结合片段，并且其有效维持或增加铁离开哺乳动物细胞的运输和/或维持或提高血清铁的水平， 网织红细胞计数，红细胞计数，血红蛋白和/或体内血细胞比容。
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公开(公告)号：US08679497B2
公开(公告)日：2014-03-25
申请号：US13465462
申请日：2012-05-07
申请人： Donmienne Doen Mun Leung , Peng Luan , Joseph Vincent Manetta , Ying Tang , Derrick Ryan Witcher
发明人： Donmienne Doen Mun Leung , Peng Luan , Joseph Vincent Manetta , Ying Tang , Derrick Ryan Witcher
IPC分类号： A61K39/395
CPC分类号： C07K16/2869 , A61K38/1816 , A61K39/3955 , C07K16/28 , C07K2317/34 , C07K2317/70 , C07K2317/76 , C07K2317/77 , C07K2317/90
摘要： Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.
摘要翻译： 提供了结合并抑制人FPN1的活性的单克隆抗体和其抗原结合片段，并且其有效维持或增加铁离开哺乳动物细胞的运输和/或维持或提高血清铁的水平， 网织红细胞计数，红细胞计数，血红蛋白和/或体内血细胞比容。
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公开(公告)号：US08183346B2
公开(公告)日：2012-05-22
申请号：US12628263
申请日：2009-12-01
申请人： Donmienne Doen Mun Leung , Peng Luan , Joseph Vincent Manetta , Ying Tang , Derrick Ryan Witcher
发明人： Donmienne Doen Mun Leung , Peng Luan , Joseph Vincent Manetta , Ying Tang , Derrick Ryan Witcher
CPC分类号： C07K16/2869 , A61K38/1816 , A61K39/3955 , C07K16/28 , C07K2317/34 , C07K2317/70 , C07K2317/76 , C07K2317/77 , C07K2317/90
摘要： Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.
摘要翻译： 提供了结合并抑制人FPN1的活性的单克隆抗体和其抗原结合片段，并且其有效维持或增加铁离开哺乳动物细胞的运输和/或维持或提高血清铁的水平， 网织红细胞计数，红细胞计数，血红蛋白和/或体内血细胞比容。
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公开(公告)号：US20110189190A1
公开(公告)日：2011-08-04
申请号：US13055201
申请日：2009-07-29
CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/92 , G01N33/74
摘要： Monoclonal antibodies are provided that bind to the N-terminus of human hepcidin-25 and are characterized as having high affinity and selectivity for the polypeptide. The antibodies of the invention are useful for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment of various disorders, such as anemia, in a human subject. The antibodies of the invention are also useful as analytical tools, such as in sandwich ELISA.
摘要翻译： 提供结合人hepcidin-25的N末端的单克隆抗体，其特征在于对多肽具有高亲和力和选择性。 本发明的抗体可用于增加人类血清铁水平，网织红细胞计数，红细胞计数，血红蛋白和/或血细胞比容，以及用于治疗人类受试者中的各种疾病如贫血。 本发明的抗体也可用作分析工具，例如夹心ELISA。
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公开(公告)号：US20110129480A1
公开(公告)日：2011-06-02
申请号：US12628263
申请日：2009-12-01
申请人： Donmienne Doen Mun Leung , Peng Luan , Joseph Vincent Manetta , Ying Tang , Derrick Ryan Witcher
发明人： Donmienne Doen Mun Leung , Peng Luan , Joseph Vincent Manetta , Ying Tang , Derrick Ryan Witcher
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , C12N15/63 , C12N5/07 , C12P21/08 , A61P7/00 , A61P35/00
CPC分类号： C07K16/2869 , A61K38/1816 , A61K39/3955 , C07K16/28 , C07K2317/34 , C07K2317/70 , C07K2317/76 , C07K2317/77 , C07K2317/90
摘要： Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.
摘要翻译： 提供了结合并抑制人FPN1的活性的单克隆抗体和其抗原结合片段，并且其有效维持或增加铁离开哺乳动物细胞的运输和/或维持或提高血清铁的水平， 网织红细胞计数，红细胞计数，血红蛋白和/或体内血细胞比容。
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