Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72
    1.
    发明授权
    Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72 失效
    编码神经肽受体HFGAN72配体的多核苷酸

    公开(公告)号:US06309854B1

    公开(公告)日:2001-10-30

    申请号:US08939093

    申请日:1997-09-26

    IPC分类号: C07H2104

    摘要: Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment by administering the identified agonists or antagonists to patients in need thereof are further disclosed.

    摘要翻译: 提供HFGAN72受体配体的多肽和编码多肽的多核苷酸。 还提供了使用这些多肽诊断与HFGAN72受体配体的低表达或过度表达有关的疾病的方法。 另外,提供了识别HFGAN72受体配体与HFGAN72受体相互作用的激动剂或拮抗剂的方法。 还公开了通过将所鉴定的激动剂或拮抗剂给予需要的患者的治疗方法。

    Screening methods using ligands of the neutropeptide receptor HFGAN72
    2.
    发明授权
    Screening methods using ligands of the neutropeptide receptor HFGAN72 有权
    使用中性肽受体HFGAN72配体的筛选方法

    公开(公告)号:US06750026B2

    公开(公告)日:2004-06-15

    申请号:US09737379

    申请日:2000-12-15

    IPC分类号: G01N3353

    摘要: Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment by administering the identified agonists or antagonists to patients in need thereof are further disclosed.

    摘要翻译: 提供HFGAN72受体配体的多肽和编码多肽的多核苷酸。 还提供了使用这些多肽诊断与HFGAN72受体配体的低表达或过度表达有关的疾病的方法。 另外,提供了识别HFGAN72受体配体与HFGAN72受体相互作用的激动剂或拮抗剂的方法。 还公开了通过将所鉴定的激动剂或拮抗剂给予需要的患者的治疗方法。

    Drilling control apparatus of rock drill
    5.
    发明授权
    Drilling control apparatus of rock drill 失效
    凿岩钻机控制装置

    公开(公告)号:US5844133A

    公开(公告)日:1998-12-01

    申请号:US915223

    申请日:1997-08-20

    CPC分类号: E21B44/00

    摘要: A drilling control apparatus for automatically controlling the drilling operation of a rock drill includes a control unit for storing known criteria drilling patterns for various rock properties. A specific drilling pattern is selected based upon a collaring procedure for operation of the rock drill. A detector continually monitors variables such as rotational pressure, feed pressure and flushing pressure during the drilling process to determine a change in condition of the rock for determination of automatic selection of another more appropriate drilling pattern.

    摘要翻译: 用于自动控制凿岩机钻孔操作的钻孔控制装置包括用于存储用于各种岩石特性的已知标准钻孔图案的控制单元。 基于钻凿操作的碰撞过程来选择特定钻孔图案。 检测器在钻井过程中连续监测诸如旋转压力,进料压力和冲洗压力之类的变量,以确定岩石状态的变化,以确定另一种更合适的钻孔模式的自动选择。

    Small-molecule agonists for type-2 orexin receptor
    6.
    发明授权
    Small-molecule agonists for type-2 orexin receptor 有权
    2型食欲素受体的小分子激动剂

    公开(公告)号:US08258163B2

    公开(公告)日:2012-09-04

    申请号:US12478753

    申请日:2009-06-04

    IPC分类号: A61K31/4168

    摘要: Methods and compositions for agonizing a type-2 orexin receptor (OX2R) in a cell determined to be in need thereof, including the general method of (a) administering to a subject a cyclic guanidinyl OX2R agonist and (b) detecting a resultant enhanced wakefulness or increased resistance to diet-induced accumulation of body fat, or abbreviated recovery from general anesthesia or jet lag.

    摘要翻译: 包括通常的方法(a)向受试者施用环状胍基OX2R激动剂和(b)检测所得到的增强的觉醒性的方法和组合物,所述方法和组合物用于激活确定为需要的细胞中的2型食欲蛋白受体(OX2R) 或增加对饮食诱导的身体脂肪积累的抵抗力,或缩小从全身麻醉或射精滞后的恢复。

    Abrasive tool and the method of producing the same
    7.
    发明授权
    Abrasive tool and the method of producing the same 有权
    研磨工具及其制造方法

    公开(公告)号:US06200360B1

    公开(公告)日:2001-03-13

    申请号:US09289954

    申请日:1999-04-13

    IPC分类号: B24D300

    摘要: An abrasive tool includes an electroformed layer having superabrasive grains electroplated on an outer surface of the electroformed layer, and a plurality of dimples arranged on the outer surface of the electroformed layer using a mold with projections made of gel adhesive. The concentration of the abrasive gains is regulated by changing the number of the dimples (i.e., changing a dimple-area-rate). The gel adhesive preferably has a viscosity of 500,000 cP or smaller. The dimple-area-rate is preferably from 7 to 70%.

    摘要翻译: 研磨工具包括电铸层,其电镀在电铸层的外表面上,并且使用具有由凝胶粘合剂制成的凸起的模具布置在电铸层的外表面上的多个凹坑。 通过改变凹坑的数量(即,改变凹坑面积率)来调节磨料增益的浓度。 凝胶粘合剂优选具有500,000cP以下的粘度。 凹坑面积率优选为7至70%。

    Recombinant endothelin converting enzyme-2 and its use in ECE inhibitor
screening
    8.
    发明授权
    Recombinant endothelin converting enzyme-2 and its use in ECE inhibitor screening 失效
    重组内皮素转化酶-2及其在ECE抑制剂筛选中的应用

    公开(公告)号:US5736376A

    公开(公告)日:1998-04-07

    申请号:US574763

    申请日:1995-12-19

    摘要: Disclosed is a nucleic acid segment encoding endothelin converting enzyme-2 (ECE-2), that produces mature ET-1 from big ET-1 both in vitro and in transfected cells. Also disclosed is a polypeptide composition comprising partially purified ECE-2 and methods of using ECE-2 to screen candidate substances as inhibitors of ECE-2. Methods of producing recombinant ECE-2 are also disclosed.

    摘要翻译: 公开了一种编码内皮素转化酶-2(ECE-2)的核酸片段,其在体外和转染的细胞中都能从大的ET-1产生成熟的ET-1。 还公开了包含部分纯化的ECE-2的多肽组合物和使用ECE-2筛选候选物质作为ECE-2抑制剂的方法。 还公开了重组ECE-2的制备方法。

    Small-molecule agonists for type-2 orexin receptor
    10.
    发明申请
    Small-molecule agonists for type-2 orexin receptor 有权
    2型食欲素受体的小分子激动剂

    公开(公告)号:US20100150840A1

    公开(公告)日:2010-06-17

    申请号:US12478753

    申请日:2009-06-04

    摘要: Methods and compositions for agonizing a type-2 orexin receptor (OX2R) in a cell determined to be in need thereof, including the general method of (a) administering to a subject a cyclic guanidinyl OX2R agonist and (b) detecting a resultant enhanced wakefulness or increased resistance to diet-induced accumulation of body fat, or abbreviated recovery from general anesthesia or jet lag.

    摘要翻译: 包括通常的方法(a)向受试者施用环状胍基OX2R激动剂和(b)检测所得到的增强的觉醒性的方法和组合物,所述方法和组合物用于激活确定为需要的细胞中的2型食欲蛋白受体(OX2R) 或增加对饮食诱导的身体脂肪积累的抵抗力,或缩小从全身麻醉或射精滞后的恢复。