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    Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72
    1.
    发明授权
    Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72 失效
    编码神经肽受体HFGAN72配体的多核苷酸

    公开(公告)号：US06309854B1

    公开(公告)日：2001-10-30

    申请号：US08939093

    申请日：1997-09-26

    申请人： Derk J. Bergsma ,  David P. Brooks ,  Miklos Gellai ,  Shelagh Wilson ,  Masashi Yanagisawa

    发明人： Derk J. Bergsma ,  David P. Brooks ,  Miklos Gellai ,  Shelagh Wilson ,  Masashi Yanagisawa

    IPC分类号： C07H2104

    CPC分类号： C07K14/575 ,  A61K38/00 ,  C07K16/26

    摘要： Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment by administering the identified agonists or antagonists to patients in need thereof are further disclosed.

    摘要翻译： 提供HFGAN72受体配体的多肽和编码多肽的多核苷酸。 还提供了使用这些多肽诊断与HFGAN72受体配体的低表达或过度表达有关的疾病的方法。 另外，提供了识别HFGAN72受体配体与HFGAN72受体相互作用的激动剂或拮抗剂的方法。 还公开了通过将所鉴定的激动剂或拮抗剂给予需要的患者的治疗方法。

    Screening methods using ligands of the neutropeptide receptor HFGAN72
    2.
    发明授权
    Screening methods using ligands of the neutropeptide receptor HFGAN72 有权
    使用中性肽受体HFGAN72配体的筛选方法

    公开(公告)号：US06750026B2

    公开(公告)日：2004-06-15

    申请号：US09737379

    申请日：2000-12-15

    申请人： Derk J. Bergsma ,  David P. Brooks ,  Miklos Gellai ,  Shelagh Wilson ,  Masashi Yanagisawa

    发明人： Derk J. Bergsma ,  David P. Brooks ,  Miklos Gellai ,  Shelagh Wilson ,  Masashi Yanagisawa

    IPC分类号： G01N3353

    CPC分类号： C07K14/575 ,  A61K38/00 ,  C07K16/26

    摘要： Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment by administering the identified agonists or antagonists to patients in need thereof are further disclosed.

    摘要翻译： 提供HFGAN72受体配体的多肽和编码多肽的多核苷酸。 还提供了使用这些多肽诊断与HFGAN72受体配体的低表达或过度表达有关的疾病的方法。 另外，提供了识别HFGAN72受体配体与HFGAN72受体相互作用的激动剂或拮抗剂的方法。 还公开了通过将所鉴定的激动剂或拮抗剂给予需要的患者的治疗方法。

    Mouse CC-CKR5 receptor polypeptide
    4.
    发明授权
    Mouse CC-CKR5 receptor polypeptide 失效
    小鼠CC-CKR5受体多肽

    公开(公告)号：US06388055B1

    公开(公告)日：2002-05-14

    申请号：US08724984

    申请日：1996-10-03

    申请人： Derk J. Bergsma ,  Mary E. Brawner ,  Usman Shabon

    发明人： Derk J. Bergsma ,  Mary E. Brawner ,  Usman Shabon

    IPC分类号： C07K1400

    CPC分类号： C07K14/7158 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00

    摘要： Mouse CC-CKR5 polypeptides and DNA (RNA) encoding such mouse CC-CKR5 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such mouse CC-CKR5 in the development of gene knockout mice for use as a model for human immunodeficiency virus.

    摘要翻译： 公开了编码这种小鼠CC-CKR5的小鼠CC-CKR5多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了在基因敲除小鼠的开发中利用这种小鼠CC-CKR5用作人类免疫缺陷病毒模型的方法。

    G-protein coupled receptor HUVCT36
    6.
    发明授权
    G-protein coupled receptor HUVCT36 失效
    G蛋白偶联受体HUVCT36

    公开(公告)号：US5912335A

    公开(公告)日：1999-06-15

    申请号：US724974

    申请日：1996-10-03

    申请人： Derk J. Bergsma ,  Catherine E. Ellis

    发明人： Derk J. Bergsma ,  Catherine E. Ellis

    IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P9/00 ,  A61P9/02 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/26 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  C07K14/705 ,  C12N5/00 ,  C12N5/10 ,  C12N9/00 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/02 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： Human HUVCT36 polypeptides and DNA (RNA) encoding such HUVCT36 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HUVCT36 for the treatment of infections, such as bacterial, fungal, protozoan and viral infections, particularly infection caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HUVCT36 and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人HUVCT36多肽和编码这种HUVCT36的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种HUVCT36来治疗感染的方法，例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染; 疼痛; 癌症; 厌食症 贪食 哮喘; 帕金森病 急性心力衰竭 低血压 高血压; 尿潴留 骨质疏松症 心绞痛; 心肌梗死; 溃疡 过敏 良性前列腺肥大; 还公开了精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett's等。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码HUVCT36的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

    cDNA clone HNFDY20 that encodes a novel human 7-transmembrane receptor
    7.
    发明授权
    cDNA clone HNFDY20 that encodes a novel human 7-transmembrane receptor 有权

    公开(公告)号：US06207800B1

    公开(公告)日：2001-03-27

    申请号：US09248715

    申请日：1999-02-09

    申请人： Derk J. Bergsma ,  Ganesh M. Sathe ,  Wendy S. Fuetterer ,  Joyce Y. Mao

    发明人： Derk J. Bergsma ,  Ganesh M. Sathe ,  Wendy S. Fuetterer ,  Joyce Y. Mao

    IPC分类号： C07K14705

    摘要： HNFDY20 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNFDY20 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    Cloning of a novel G-Protein coupled 7TM receptor
    8.
    发明授权
    Cloning of a novel G-Protein coupled 7TM receptor 失效
    克隆一种新的G蛋白偶联的7TM受体

    公开(公告)号：US5871967A

    公开(公告)日：1999-02-16

    申请号：US788539

    申请日：1997-01-24

    申请人： Usman Shabon ,  Derk J. Bergsma ,  Ganesh M. Sathe

    发明人： Usman Shabon ,  Derk J. Bergsma ,  Ganesh M. Sathe

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  C07K14/705 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/00 ,  C12Q1/68 ,  C12R1/91

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： HNHCI32 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNHCI32 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    摘要翻译： 公开了HNHCI32多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗感染例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的方案中使用HNHCI32多肽和多核苷酸的方法; 疼痛; 癌症; 厌食症 贪食 哮喘; 帕金森病 急性心力衰竭 低血压 高血压; 尿潴留 骨质疏松症 心绞痛; 心肌梗死; 溃疡 哮喘; 过敏 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征以及这些病症的诊断测定。

    Human 7-transmembrane receptor and DNA
    9.
    发明授权
    Human 7-transmembrane receptor and DNA 失效
    人类7-跨膜受体和DNA

    公开(公告)号：US5824504A

    公开(公告)日：1998-10-20

    申请号：US742011

    申请日：1996-10-31

    申请人： Nabil A. Elshourbagy ,  Derk J. Bergsma ,  Catherine E. Ellis

    发明人： Nabil A. Elshourbagy ,  Derk J. Bergsma ,  Catherine E. Ellis

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/10 ,  A61P19/10 ,  A61P25/00 ,  A61P25/28 ,  A61P31/12 ,  A61P35/00 ,  A61P37/08 ,  C07K14/705 ,  C07K14/715 ,  C07K16/28 ,  C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  C12R1/91 ,  C12N15/63 ,  C12N15/85

    CPC分类号： C07K14/7158 ,  A61K38/00

    摘要： Human HBMBU14 polypeptides and DNA (RNA) encoding such HBMBU14 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HBMBU14 for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 and HIV-2, pain, cancers, anorexia, bulimia, asthma, Parkinson's disease, acute heart failure, atherosclerosis, hypotension, hypertension, urinary retention, osteoporosis, angina pectoris, myocardial infarction, ulcers, asthma, allergies, benign prostatic hypertrophy and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia or severe mental retardation, and dyskinesias, such as Huntington's disease or Gilles dela Tourette's syndrome, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HBMBU14 and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人HBMBU14多肽和编码这种HBMBU14的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种HBMBU14来治疗感染例如细菌，真菌，原生动物和病毒感染的方法，特别是HIV-1和HIV-2引起的感染，疼痛，癌症，厌食症，贪食症，哮喘，帕金森病，急性 心力衰竭，动脉粥样硬化，低血压，高血压，尿潴留，骨质疏松症，心绞痛，心肌梗塞，溃疡，哮喘，过敏，良性前列腺肥大和精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁，del妄，痴呆或严重智力迟钝 ，以及运动障碍，如亨廷顿病或吉列斯·杜拉图雷特综合征等。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码HBMBU14的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。