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1.发明申请METHODS AND COMPOSITIONS FOR ATTENUATING ANTI-VIRAL TRANSFER VECTOR IMMUNE RESPONSES 审中-公开抗病毒转染载体免疫反应的方法和组合物公开(公告)号：US20160067228A1
公开(公告)日：2016-03-10
申请号：US14846949
申请日：2015-09-07
IPC分类号： A61K31/436 , A61K31/7088
CPC分类号： A61K31/7088 , A61K9/1271 , A61K9/5115 , A61K9/5153 , A61K31/00 , A61K31/436 , A61K31/439 , A61K39/001 , A61K45/06 , A61K47/593 , A61K47/6923 , A61K47/6929 , A61K47/6935 , A61K47/6937 , A61K48/00 , A61K48/005 , A61K2039/545 , A61K2039/577 , C12N7/00 , C12N15/86 , C12N2710/00041 , C12N2710/10032 , C12N2710/10043 , C12N2740/10041 , C12N2740/15032 , C12N2740/15043 , C12N2740/16043 , C12N2750/14132 , C12N2750/14141 , C12N2750/14143 , G06Q99/00 , A61K2300/00
摘要： Provided herein are methods and related compositions for administering viral transfer vectors and antigen-presenting cell targeted immunosuppressants.
摘要翻译： 本文提供了用于施用病毒转移载体和抗原呈递细胞靶向免疫抑制剂的方法和相关组合物。
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2.发明授权Second generation virus-like particles (VLP) from Epstein-Barr viruses for vaccination purposes 有权来自爱泼斯坦 - 巴尔病毒的第二代病毒样颗粒（VLP）用于疫苗接种目的公开(公告)号：US09517261B2
公开(公告)日：2016-12-13
申请号：US14366645
申请日：2012-12-28
IPC分类号： A61K39/245 , C12N15/86 , C12N7/00 , A61K39/00 , A61K39/12 , C07K14/005 , C07K16/08
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/525 , A61K2039/5258 , C07K14/005 , C07K14/05 , C07K16/081 , C12N7/00 , C12N15/86 , C12N2700/00 , C12N2710/00041 , C12N2710/10021 , C12N2710/16134 , C12N2710/16171 , C12N2710/16223 , C12N2710/16234 , C12N2710/16242 , C12N2710/16243 , C12N2710/16262 , C12N2710/16634 , C12N2710/16734 , C12N2710/20034 , C12N2800/204
摘要： The present invention relates to an Epstein-Barr virus-like particle (EB-VLP) substantially free of Epstein-Barr Virus (EBV) DNA. The present invention also relates to a polynucleotide comprising an EBV genome a) lacking at least one expressible gene selected from the group consisting of the BFLF1 gene, the BBRF gene, the BGRF1 gene, the BDRF1 gene, the BALF3 gene, the BFRF1A gene, and the BFRF1 gene, and b) producing the EB-VLP of the invention in a suitable host cell. The present invention further relates to a vector and a host cell comprising the polynucleotide of the invention as well to a method of manufacturing the EB-VLPs, a method of manufacturing a vaccine thereof, a vaccine and a composition comprising the EB-VLPs.
摘要翻译： 本发明涉及基本上不含爱泼斯坦 - 巴尔病毒（EBV）DNA的爱泼斯坦 - 巴尔病毒样颗粒（EB-VLP）。 本发明还涉及包含EBV基因组的多核苷酸a）缺少选自BFLF1基因，BBRF基因，BGRF1基因，BDRF1基因，BALF3基因，BFRF1A基因中的至少一种可表达基因， 和BFRF1基因，以及b）在合适的宿主细胞中产生本发明的EB-VLP。 本发明还涉及包含本发明的多核苷酸的载体和宿主细胞以及制备EB-VLP的方法，其疫苗的制备方法，疫苗和包含EB-VLP的组合物。
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公开(公告)号：US10071114B2
公开(公告)日：2018-09-11
申请号：US14846964
申请日：2015-09-07
IPC分类号： A61K35/00 , A61K31/7088 , A61K31/439 , A61K31/00
CPC分类号： A61K31/7088 , A61K9/1271 , A61K9/5115 , A61K9/5153 , A61K31/00 , A61K31/436 , A61K31/439 , A61K39/001 , A61K45/06 , A61K47/593 , A61K47/6923 , A61K47/6929 , A61K47/6935 , A61K47/6937 , A61K48/00 , A61K48/005 , A61K2039/545 , A61K2039/577 , C12N7/00 , C12N15/86 , C12N2710/00041 , C12N2710/10032 , C12N2710/10043 , C12N2740/10041 , C12N2740/15032 , C12N2740/15043 , C12N2740/16043 , C12N2750/14132 , C12N2750/14141 , C12N2750/14143 , G06Q99/00 , A61K2300/00
摘要： Provided herein are methods and related compositions for administering viral transfer vectors and antigen-presenting cell targeted immunosuppressants.
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4.发明申请METHODS AND COMPOSITIONS FOR ATTENUATING EXON SKIPPING ANTI-VIRAL TRANSFER VECTOR IMMUNE RESPONSES 审中-公开用于减轻外部逃跑的方法和组合抗病毒转运载体免疫应答公开(公告)号：US20160074372A1
公开(公告)日：2016-03-17
申请号：US14846967
申请日：2015-09-07
IPC分类号： A61K31/436 , A61K48/00 , C12N7/00
CPC分类号： A61K48/00 , A61K9/1271 , A61K9/5115 , A61K9/5153 , A61K31/436 , A61K31/7088 , A61K39/001 , A61K45/06 , A61K47/593 , A61K47/6923 , A61K47/6929 , A61K47/6935 , A61K47/6937 , A61K48/005 , A61K2039/545 , A61K2039/577 , C12N7/00 , C12N15/86 , C12N2710/00041 , C12N2710/10032 , C12N2710/10043 , C12N2740/10041 , C12N2740/15032 , C12N2740/15043 , C12N2740/16043 , C12N2750/14132 , C12N2750/14141 , C12N2750/14143 , G06Q99/00 , A61K2300/00
摘要： Provided herein are methods and related compositions for administering viral transfer vectors and antigen-presenting cell targeted immunosuppressants.
摘要翻译： 本文提供了用于施用病毒转移载体和抗原呈递细胞靶向免疫抑制剂的方法和相关组合物。
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5.发明申请METHODS AND COMPOSITIONS FOR ATTENUATING GENE EDITING ANTI-VIRAL TRANSFER VECTOR IMMUNE RESPONSES 审中-公开抗原转染载体免疫反应的基因编码方法和组合公开(公告)号：US20160074532A1
公开(公告)日：2016-03-17
申请号：US14846958
申请日：2015-09-07
IPC分类号： A61K48/00 , G06Q99/00 , A61K38/48 , C12N15/86 , A61K31/436
CPC分类号： A61K31/7088 , A61K9/1271 , A61K9/5115 , A61K9/5153 , A61K31/00 , A61K31/436 , A61K31/439 , A61K39/001 , A61K45/06 , A61K47/593 , A61K47/6923 , A61K47/6929 , A61K47/6935 , A61K47/6937 , A61K48/00 , A61K48/005 , A61K2039/545 , A61K2039/577 , C12N7/00 , C12N15/86 , C12N2710/00041 , C12N2710/10032 , C12N2710/10043 , C12N2740/10041 , C12N2740/15032 , C12N2740/15043 , C12N2740/16043 , C12N2750/14132 , C12N2750/14141 , C12N2750/14143 , G06Q99/00 , A61K2300/00
摘要： Provided herein are methods and related compositions for administering viral transfer vectors and antigen-presenting cell targeted immunosuppressants.
摘要翻译： 本文提供了用于施用病毒转移载体和抗原呈递细胞靶向免疫抑制剂的方法和相关组合物。
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6.发明申请公开(公告)号：US20160074531A1
公开(公告)日：2016-03-17
申请号：US14846952
申请日：2015-09-07
IPC分类号： A61K48/00 , G06Q99/00 , A61K38/48 , C12N15/86 , A61K31/436
CPC分类号： A61K31/7088 , A61K9/1271 , A61K9/5115 , A61K9/5153 , A61K31/00 , A61K31/436 , A61K31/439 , A61K39/001 , A61K45/06 , A61K47/593 , A61K47/6923 , A61K47/6929 , A61K47/6935 , A61K47/6937 , A61K48/00 , A61K48/005 , A61K2039/545 , A61K2039/577 , C12N7/00 , C12N15/86 , C12N2710/00041 , C12N2710/10032 , C12N2710/10043 , C12N2740/10041 , C12N2740/15032 , C12N2740/15043 , C12N2740/16043 , C12N2750/14132 , C12N2750/14141 , C12N2750/14143 , G06Q99/00 , A61K2300/00
摘要： Provided herein are methods and related compositions for administering viral transfer vectors and antigen-presenting cell targeted immunosuppressants.
摘要翻译： 本文提供了用于施用病毒转移载体和抗原呈递细胞靶向免疫抑制剂的方法和相关组合物。
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7.发明申请SECOND GENERATION VIRUS-LIKE PARTICLES (VLP) FROM EPSTEIN-BARR VIRUSES FOR VACCINATION PURPOSES 有权来自用于疫苗用途的EPSTEIN-BARR病毒的第二代病毒样颗粒（VLP）公开(公告)号：US20140322255A1
公开(公告)日：2014-10-30
申请号：US14366645
申请日：2012-12-28
IPC分类号： A61K39/245
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/525 , A61K2039/5258 , C07K14/005 , C07K14/05 , C07K16/081 , C12N7/00 , C12N15/86 , C12N2700/00 , C12N2710/00041 , C12N2710/10021 , C12N2710/16134 , C12N2710/16171 , C12N2710/16223 , C12N2710/16234 , C12N2710/16242 , C12N2710/16243 , C12N2710/16262 , C12N2710/16634 , C12N2710/16734 , C12N2710/20034 , C12N2800/204
摘要： The present invention relates to an Epstein-Barr virus-like particle (EB-VLP) substantially free of Epstein-Barr Virus (EBV) DNA. The present invention also relates to a polynucleotide comprising an EBV genome a) lacking at least one expressible gene selected from the group consisting of the BFLF1 gene, the BBRF gene, the BGRF1 gene, the BDRF1 gene, the BALF3 gene, the BFRF1A gene, and the BFRF1 gene, and b) producing the EB-VLP of the invention in a suitable host cell. The present invention further relates to a vector and a host cell comprising the polynucleotide of the invention as well to a method of manufacturing said EB-VLPs, a method of manufacturing a vaccine thereof, a vaccine and a composition comprising said EB-VLPs.
摘要翻译： 本发明涉及基本上不含爱泼斯坦 - 巴尔病毒（EBV）DNA的爱泼斯坦 - 巴尔病毒样颗粒（EB-VLP）。 本发明还涉及包含EBV基因组的多核苷酸a）缺少选自BFLF1基因，BBRF基因，BGRF1基因，BDRF1基因，BALF3基因，BFRF1A基因中的至少一种可表达基因， 和BFRF1基因，以及b）在合适的宿主细胞中产生本发明的EB-VLP。 本发明还涉及包含本发明的多核苷酸的载体和宿主细胞以及制备所述EB-VLP的方法，其疫苗的制备方法，疫苗和包含所述EB-VLP的组合物。
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