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8 条记录 (耗时 0.035 秒)

    Useful halophilic, thermostable and ionic liquids tolerant cellulases
    2.
    发明申请
    Useful halophilic, thermostable and ionic liquids tolerant cellulases 有权
    有用的嗜盐，耐热和离子液体耐受性纤维素酶

    公开(公告)号：US20130023015A1

    公开(公告)日：2013-01-24

    申请号：US13493938

    申请日：2012-06-11

    申请人： Tao Zhang ,  Supratim Datta ,  Blake A. Simmons ,  Edward M. Rubin

    发明人： Tao Zhang ,  Supratim Datta ,  Blake A. Simmons ,  Edward M. Rubin

    IPC分类号： C12P19/12 ,  C12N9/42

    CPC分类号： C12P19/14 ,  C12N9/2437 ,  C12P19/02 ,  C12P2201/00 ,  C12P2203/00 ,  C12Y302/01091 ,  Y02P20/52

    摘要： The present invention provides for an isolated or recombinant polypeptide comprising an amino acid sequence having at least 70% identity with the amino acid sequence of a Halorhabdus utahensis cellulase, such as Hu-CBH1, wherein said amino acid sequence has a halophilic thermostable and/or thermophilic cellobiohydrolase (CBH) activity. In some embodiments, the polypeptide has a CBH activity that is resistant to up to about 20% of ionic liquids. The present invention also provides for compositions comprising and methods using the isolated or recombinant polypeptide.

    摘要翻译： 本发明提供了一种分离的或重组的多肽，其包含与乌尔氏假单胞菌纤维素酶如Hu-CBH1的氨基酸序列具有至少70％同一性的氨基酸序列，其中所述氨基酸序列具有嗜盐热稳定剂和/或 嗜热纤维二糖水解酶（CBH）活性。 在一些实施方案中，多肽具有耐高达约20％离子液体的CBH活性。 本发明还提供包含使用分离或重组多肽的方法的组合物。

    Diagnostic test for prenatal identification of Down's syndrome and mental retardation and gene therapy therefor
    3.
    发明授权
    Diagnostic test for prenatal identification of Down's syndrome and mental retardation and gene therapy therefor 失效
    唐氏综合征和精神发育迟滞及基因治疗产前鉴定诊断试验

    公开(公告)号：US6100033A

    公开(公告)日：2000-08-08

    申请号：US71074

    申请日：1998-04-30

    申请人： Desmond J. Smith ,  Edward M. Rubin

    发明人： Desmond J. Smith ,  Edward M. Rubin

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12Q1/6883 ,  C12Q2600/158

    摘要： A a diagnostic test useful for prenatal identification of Down syndrome and mental retardation. A method for gene therapy for correction and treatment of Down syndrome. DYRK gene involved in the ability to learn. A method for diagnosing Down's syndrome and mental retardation and an assay therefor. A pharmaceutical composition for treatment of Down's syndrome mental retardation.

    摘要翻译： 一种诊断测试可用于产前鉴别唐氏综合症和智力低下症。 一种用于唐氏综合征矫正和治疗的基因治疗方法。 参与DYRK基因的学习能力。 一种诊断唐氏综合征和精神发育迟滞的方法及其分析方法。 用于治疗唐氏综合征精神发育迟滞的药物组合物。

    Compositions and methods for altering bone density and bone patterning
    5.
    发明申请
    Compositions and methods for altering bone density and bone patterning 审中-公开
    用于改变骨密度和骨图案的组合物和方法

    公开(公告)号：US20090017008A1

    公开(公告)日：2009-01-15

    申请号：US11953796

    申请日：2007-12-10

    申请人： Gabriela G. Loots ,  Edward M. Rubin

    发明人： Gabriela G. Loots ,  Edward M. Rubin

    IPC分类号： A61K39/395 ,  C12N5/06 ,  A01K67/027 ,  C12N15/00 ,  A61P43/00 ,  C12Q1/68 ,  C12N15/11 ,  A61K31/70

    CPC分类号： A01K67/0276 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306 ,  A61K38/00 ,  C07K14/51 ,  C12N15/8509 ,  C12N2800/204

    摘要： By exploiting cross-species sequence comparisons with in vitro and in vivo enhancer assays we were able to identify enhancer elements that drives human SOST expression in the adult mouse skeleton, and discovered a novel function for sclerostin during limb development. The enhancer elements and reagents described in the present invention facilitate the methods for development of products and methods to increase the mineral content of bone, which can consequently be utilized to treat a wide variety of bone related conditions, including, osteopenia, osteoporosis, fractures and other disorders in which low bone mineral density are the main cause of the disease as well as sclerosteosis, Van Buchem disease and other related disorders of the skeleton. Furthermore, the present invention provides enhancer elements and reagents useful for bone pattering and growth, limb development, and the formation of individual bones

    摘要翻译： 通过利用体外和体内增强剂测定的物种间序列比较，我们能够鉴定在成年小鼠骨架中驱动人类SOST表达的增强子元件，并且在肢体发育过程中发现了一种用于硬皮蛋白的新功能。 本发明中描述的增强元件和试剂有助于开发用于增加骨矿物质含量的产品和方法的方法，其可用于治疗多种骨相关病症，包括骨质减少，骨质疏松症，骨折和骨质疏松症 其他低骨矿物质密度是疾病的主要原因以及硬皮病，Van Buchem病和骨骼相关疾病的其他疾病。 此外，本发明提供增强剂元件和试剂，其可用于骨图案和生长，肢体发育和单个骨骼的形成