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公开(公告)号：US4614590A
公开(公告)日：1986-09-30
申请号：US655731
申请日：1984-09-28
申请人： Dieter Rath , Peter Seeck
发明人： Dieter Rath , Peter Seeck
摘要： A dialysis apparatus utilizes an expansion chamber in parallel with a pump from which the chamber receives blood via a valve. During the return flow phase the pump rotates in the same direction; but, the valve is closed and a valve at the chamber outlet is opened. The pump draws blood from the chamber and transports it to a dialyzer. A control device regulates the pump and valves depending on the time integral of the pump delivery. In each phase, blood is transported until the chamber has received or discharged a predetermined volume. The pump speed is variable during operation.
摘要翻译： 透析装置利用与泵平行的膨胀室，通过该阀从腔室接收血液。 在回流阶段期间，泵以相同的方向旋转; 但阀关闭，并且室出口处的阀打开。 泵从腔室抽出血液并将其运送到透析器。 控制装置根据泵输送的时间积分来调节泵和阀。 在每个阶段，血液被输送直到腔室接收或排出了预定的体积。 泵的运行速度是可变的。
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2.发明授权
公开(公告)号：US5080845A
公开(公告)日：1992-01-14
申请号：US439883
申请日：1989-11-21
申请人： Heinz Herrmann , Dieter Rath
发明人： Heinz Herrmann , Dieter Rath
CPC分类号： C08F6/005 , B29C47/40 , B29C47/50 , B29C47/6037 , B29C47/762 , B29C47/0009 , B29K2105/0002 , Y02P20/544
摘要： The removal of impurities, for example monomeric low-molecular substances, solvents or the like, from polymeric synthetic plastics materials takes place by the admixture of extraction gas in a first extruder in a supercritical state. The mixture is transferred to a second extruder where, in a first separating zone, and by a counter-current method, it is cleansed of the major part of the extraction gas containing the impurities, this being passed through a discharge orifice. Separation of any residue takes place in a vacuum zone on the downstream side. The high pressure in the first extruder is maintained by a counter-pressure valve in the connecting pipe between the first and second extruders. By the separation of contaminated extraction gas from molten synthetic plastics material in a closed space, namely the second extruder, it is possible to achieve an ordered dissipation of extraction gas on the one hand and molten synthetic plastics material on the other hand.
摘要翻译： 从聚合合成塑料材料中去除杂质，例如单体低分子物质，溶剂等，是通过在超临界状态下将第一挤出机中的萃取气体混合而进行的。 将混合物转移到第二挤出机中，其中在第一分离区域中，并且通过逆流方法，将含有杂质的提取气体的主要部分清洗，其通过排出孔。 任何残留物的分离在下游侧的真空区域中进行。 第一挤出机中的高压由第一和第二挤出机之间的连接管中的反压阀保持。 通过在封闭空间（即第二挤出机）中将熔融的合成塑料材料中的污染的提取气体分离出来，另一方面可以实现萃取气体和熔融的合成塑料材料的排序。
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3.发明授权
公开(公告)号：US5306132A
公开(公告)日：1994-04-26
申请号：US661560
申请日：1991-02-26
申请人： Andre Grundmann , Dieter Rath
发明人： Andre Grundmann , Dieter Rath
CPC分类号： B29C47/767 , B29C47/0009 , B29C47/40
摘要： A process and a degassing unit for the degassing of plastic melt in a screw extruder in which a surface of the degassing unit facing the screws of the extruder are heated to prevent deposition of entrained plastic particles, particularly at the corners or edges of the degassing unit. Prior to the commencement of the treatment process, the degassing unit is heated to a temperature which is at least as high as the melting point of the plastic to be treated. Heating can be effected by conveying a heating medium through a channel in the degassing unit located in proximity to the surface facing the extrusion screws and especially the corner or edge regions.
摘要翻译： 一种用于在螺杆挤出机中对塑料熔体进行脱气的工艺和脱气单元，其中脱气单元的面对挤出机的螺杆的表面被加热以防止夹带的塑料颗粒的沉积，特别是在脱气单元的拐角或边缘处 。 在处理过程开始之前，将脱气单元加热到至少等于待处理塑料的熔点的温度。 可以通过将加热介质通过位于靠近挤压螺钉，特别是拐角或边缘区域的表面的脱气单元中的通道传送加热介质来实现加热。
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4.发明授权Process for the selective extracorporeal precipitation of low-density lipoproteins from whole serum or plasma 失效来自全血清或血浆的低密度脂蛋白选择性体外沉淀的方法
公开(公告)号：US4923439A
公开(公告)日：1990-05-08
申请号：US172953
申请日：1988-03-23
CPC分类号： A61M1/3472 , A61M1/3479 , A61M1/3482 , G01N33/92 , A61M1/3675 , A61M2202/046 , A61M2205/7554 , G01N2800/044 , Y10T436/104165
摘要： Processes are described for the selective extracorporeal precipitation of low density lipoproteins or beta-lipoproteins from whole serum or plasma, wherein a treating agent comprising heparin or a polyanion, such as dextran sulfate or sodium-phosphorus tungstate, in a buffer is added to the whole serum or plasma and the beta-llipoprotein-complex which thereupon forms with the treating agent is precipitated at the isoelectric point at a pH value in the range of from about 5.05 to about 5.25, and is then separated. Optionally, the precipitate or respecively the filtrate is further analyzed for diagnostic purposes. When heparin is employed, the process may be employed therapeutically.Apparatus is described for the continuous therapeutic practice of such a process, employing heparin, including means for flushing to reduce clogging of the filter employed to separate the precipitated lipoprotein-complex.
摘要翻译： 对来自全血清或血浆的低密度脂蛋白或β-脂蛋白的选择性体外沉淀的方法进行了描述，其中在缓冲液中将包含肝素或聚阴离子如硫酸葡聚糖或磷酸钠磷酸钠的处理剂全部加入 血浆或血浆和随后与处理剂形成的β-IIipoprotein-复合物在等电点处沉淀，pH值在约5.05至约5.25范围内，然后分离。 任选地，沉淀物或分开的滤液进一步分析用于诊断目的。 当使用肝素时，该方法可以在治疗上使用。 描述了用于这种方法的连续治疗实践的装置，其使用肝素，包括用于冲洗以减少用于分离沉淀的脂蛋白复合物的过滤器堵塞的装置。
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公开(公告)号：US4758336A
公开(公告)日：1988-07-19
申请号：US940927
申请日：1986-12-12
申请人： Gerhard Bock , Michael Panse , Dieter Rath , Heinrich Eckel , Rolf Heitmeier
发明人： Gerhard Bock , Michael Panse , Dieter Rath , Heinrich Eckel , Rolf Heitmeier
摘要： A dialytic apparatus for single-needle dialysis comprises a first pump in the artery conduit, which first pump in the first phase conveys blood from the patient into the expansion chamber while the vein conduit is shut off. At the same time, the second pump transports blood from the expansion chamber to the dialyzer. This regulation is performed in dependence from the pressure in the vein conduit so that the pressure decrease caused by ultrafiltration is counterbalanced. In the second phase, the first pump stands still and closes the artery conduit while the second pump conveys blood out of the expansion chamber to the dialyzer at a constant rate.
摘要翻译： 用于单针透析的透析装置包括动脉导管中的第一泵，第一阶段中的第一泵将血液从患者输送到膨胀室中，同时静脉导管被切断。 同时，第二个泵将血液从膨胀室输送到透析器。 该调节依赖于静脉导管中的压力进行，使得由超滤引起的压力降低是平衡的。 在第二阶段，第一个泵静止并且关闭动脉导管，而第二个泵以恒定速率将血液从膨胀室输送到透析器。
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公开(公告)号：US4735727A
公开(公告)日：1988-04-05
申请号：US844238
申请日：1986-03-25
申请人： Rolf Heitmeier , Dieter Rath
发明人： Rolf Heitmeier , Dieter Rath
CPC分类号： B01D61/22 , A61M1/16 , Y10S210/929
摘要： The dialysis equipment has a dialysate path connectable to a dialysate source 1, and contains a feed pump 6, a dialyzer 10, and a controlled suction pump 13. During the operative phase, this dialysate path is traversed by the dialysate with a constant negative pressure being maintained in the dialysate chamber 101 of the dialyzer 10 relative to the blood chamber 102. In a subsequent measuring phase, the dialysate path is cut off from the dialysate source 1 and from a drain 15 via a valve device 2, 14. The same negative pressure is maintained in the dialysate chamber 101 as in the operative phase. The ultrafiltrate passing from the blood chamber 102 into the dialysate chamber 101 during the measuring phase causes the filling of a volume measuring device 5.
摘要翻译： 透析设备具有可连接到透析液源1的透析液路径，并且包含进料泵6，透析器10和受控抽吸泵13.在操作阶段期间，该透析液路径由透析液以恒定的负压 保持在透析器10相对于血液室102的透析液室101.在随后的测量阶段，透析液路径被从透析液源1和排出口15经由阀装置2,14被切断。相同 如在操作阶段那样在透析液室101中保持负压。 在测量阶段，从血液室102进入透析液室101的超滤液使体积测量装置5的填充。
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公开(公告)号：US06423022B1
公开(公告)日：2002-07-23
申请号：US09310994
申请日：1999-05-13
IPC分类号： A61M3700
CPC分类号： G05B13/0275 , A61M1/16 , A61M2230/30 , Y10S706/924 , A61M2230/005
摘要： The ultrafiltration rate of a blood purification apparatus is controlled by a fuzzy control device in dependence on the patient's (16) blood pressure measured by a blood pressure monitor (24). For this purpose the blood pressure (P), a short-term blood pressure trend value (TRK) and a long-term blood pressure trend value (TRL) are fed as input variables for the fuzzy controller to the control device (23). The ultrafiltration rate (UFR) is determined by the volumetric ultrafiltration pump (36). According to the patient's (16) blood pressure situation a prestored profile of the ultrafiltration rate is modified. This avoids the necessity of an additional infusion to prevent too strong a blood pressure decrease.
摘要翻译： 血液净化装置的超滤速度由模糊控制装置根据由血压计（24）测得的患者血压（16）来控制。 为此，将血压（P），短期血压趋势值（TRK）和长期血压趋势值（TRL）作为模糊控制器作为控制装置（23）的输入变量进行输入。 超滤速率（UFR）由体积超滤泵（36）确定。 根据患者的（16）血压情况，预先设定的超滤速率曲线被修改。 这避免了需要额外的输液以防止血压过低降低。
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公开(公告)号：US5088522A
公开(公告)日：1992-02-18
申请号：US496792
申请日：1990-03-21
CPC分类号： F04B43/0072
摘要： A pump hose for a peristaltic pump consists of two arcuate portions that merge along kink lines so that the undeformed hose lumen has the cross-sectional shape of a convex lens. The joinings of the arcuate portions are joined by outwardly extending ribs. When the hose is pressed, only minor squeezing occurs at the joinings. The hose has a considerably improved squeezing and restoring behavior. The ribs prevent an excessive squeezing.
摘要翻译： 用于蠕动泵的泵软管由沿着扭结线合并的两个弓形部分组成，使得未变形的软管内腔具有凸透镜的横截面形状。 弓形部分的接合通过向外延伸的肋连接。 当软管被按压时，在连接处仅发生轻微的挤压。 软管具有显着提高的挤压和恢复行为。 肋骨防止过度挤压。
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公开(公告)号：US5018388A
公开(公告)日：1991-05-28
申请号：US532023
申请日：1990-06-01
申请人： Wolfgang Mosebach , Rolf Heitmeier , Hans Gerlach , Dieter Rath
发明人： Wolfgang Mosebach , Rolf Heitmeier , Hans Gerlach , Dieter Rath
CPC分类号： G01L9/0004
摘要： A pressure sensor for determining the pressure of a medium in an elastic hose section. A pressure member acts on a unilaterally fixed bar carrying an influencing member at its free end. This influencing member is a core of a coil arrangement, the position of the core changing the frequencies of the oscillator coils. Numerous pressure values are received at regular intervals and, subsequently, a representative pressure value is obtained by averaging.
摘要翻译： 一种用于确定弹性软管部分中的介质的压力的压力传感器。 压力构件作用于在其自由端承载影响构件的单方向固定杆。 该影响部件是线圈装置的核心，芯的位置改变振荡线圈的频率。 以规则的间隔接收许多压力值，随后通过平均获得代表性的压力值。
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公开(公告)号：US4708802A
公开(公告)日：1987-11-24
申请号：US897704
申请日：1986-08-18
申请人： Dieter Rath , Rolf Heitmeier
发明人： Dieter Rath , Rolf Heitmeier
CPC分类号： B01D61/22 , A61M1/16 , A61M1/3437 , A61M1/3465 , A61M1/3413
摘要： An apparatus for hemodiafiltration that maintains the blood concentration of the patient relatively constant. A pump is connected to a branch off the external flow path of the dialysator which pumps fluid to the circulation system of the patient to compensate for the patient's fluid loss through the hemodiafilter membrane. A suction pump which affects the transmembrane pressure across the hemodiafilter membrane is controlled to achieve the desired filtrate flow necessary to balance the return flow to the patient.
摘要翻译： 一种维持患者血液浓度相对恒定的血液透析滤过装置。 泵连接到离开透析器的外部流动路径的分支，其将流体泵送到患者的循环系统，以补偿患者通过血液透析膜的流体损失。 控制影响血液透析膜的跨膜压力的抽吸泵被控制以达到平衡向患者返回流量所需的所需滤液流量。
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