公开(公告)号：US09895481B2

公开(公告)日：2018-02-20

申请号：US15357178

申请日：2016-11-21

申请人： Fresenius Medical Care Deutschland GmbH

发明人： Götz Günther ,  Michael Herrenbauer ,  Martin Lauer ,  Ralf Müller

IPC分类号： A61M37/00 ,  A61M1/30

CPC分类号： A61M1/306 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/307 ,  A61M1/308 ,  A61M2205/07 ,  A61M2205/3337 ,  A61M2205/3368

摘要： A device and a method are provided for blood treatment in a single-needle operating mode. The blood treatment device has an extracorporeal blood circuit comprising a blood supply line leading to the inlet of a blood treatment unit and a blood return line leading away from the outlet of the blood treatment unit. A blood collecting container is provided in the blood return line, and is connected to an air reservoir by a flow line. The flow connection comprises two line branches, one branch being used to transfer gas from the air reservoir into the blood collecting container and the other branch being used to transfer gas from the blood collecting container into the air reservoir. The connection branch for transferring gas from the air store into the blood collecting container can contain a compressor.

公开(公告)号：US20130331758A1

公开(公告)日：2013-12-12

申请号：US13994379

申请日：2011-12-14

申请人： Joern Meibaum ,  Gerhard Bock

发明人： Joern Meibaum ,  Gerhard Bock

IPC分类号： A61M1/30

CPC分类号： A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/306

摘要： The invention relates to an extracorporeal blood treatment apparatus with a control device (50) for controlling the opening and closing of an arterial line (2) with simultaneous closing and opening of a venous line (3) in a single-lumen-arrangement (10), with which untreated blood is removed through the single-lumen-arrangement (10) and the arterial line (2), led through a blood treatment device (5) and treated blood is fed back through the venous line (3) and the single-lumen-arrangement (10), an arterial line container (20) which is arranged in the arterial line (2) in front of the blood treatment device (5), a venous line container (30) which is arranged in the venous line (3) following the blood treatment device (5), a sensor device (31) for detecting an amount of treated blood being above a limit value in the venous line container (30), a sensor device (21) for detecting an amount of untreated blood being below a limit value in the arterial line container (20), an arterial line closure device (22) for closing the arterial line (2) with simultaneous opening of the venous line (3) in response to a signal A which is transmitted by the sensor device (31) to the arterial line closure device (22), a venous line closure device (32) for closing the venous line (3) with simultaneous opening of the arterial line (2) in response to a signal B which is transmitted by the sensor device (21) to a venous line closure device (32) and at least one pump (40) and is characterized in that a control device (50) is provided, with which a phase volume Vact is adjustable automatically in dependence on the current pumping rate QBP of the at least one pump (40) during a phase to a predefined value Vnom (FIG. 1).

摘要翻译： 本发明涉及一种具有控制装置（50）的体外血液处理装置，该控制装置（50）用于控制动脉管线（2）的打开和关闭，同时以单腔排列（10）静脉打开静脉管线（3） ），通过单腔排列（10）和动脉管线（2）除去未处理的血液，通过血液处理装置（5）引导，并且处理的血液通过静脉管线（3）反馈，并且 单腔排列（10），布置在血液处理装置（5）前方的动脉管线（2）中的动脉管路容器（20），静脉管容器（30） 在血液处理装置（5）之后的管线（3），用于检测处于静脉管路容器（30）中的限制值以上的处理血液量的传感器装置（31） 未经处理的血液低于动脉管路容器（20）中的极限值，动脉线cl 用于响应于由传感器装置（31）传送到动脉线路闭合装置（22）的信号A同时打开静脉线（3）而关闭动脉管线（2）的开口装置（22）， 用于响应于由传感器装置（21）传送到静脉闭路装置（32）的信号B同时打开动脉线（2）而关闭静脉线（3）的静脉线闭合装置（32） 和至少一个泵（40），其特征在于提供一个控制装置（50），根据所述控制装置（50），相位体积Vact根据所述至少一个泵（40）的当前泵送速率QBP自动调节 阶段到预定义值Vnom（图1）。 1）。

公开(公告)号：US06527957B1

公开(公告)日：2003-03-04

申请号：US09287671

申请日：1999-04-07

申请人： Jose C. Deniega ,  Daniel H. Duff ,  Maria D. Gudino ,  Donald H. Buchholz

发明人： Jose C. Deniega ,  Daniel H. Duff ,  Maria D. Gudino ,  Donald H. Buchholz

IPC分类号： B01D6100

CPC分类号： A61M1/30 ,  A01N1/02 ,  A01N1/0226 ,  A01N1/0242 ,  A61M1/265 ,  A61M1/303 ,  A61M1/306 ,  A61M1/308 ,  A61M1/309 ,  A61M2205/3393 ,  A61M2209/082

摘要： Methods are disclosed for the collection of red blood cells whereby whole blood is combined with an anticoagulant, red cells are separated from the whole blood and the separated red cells are combined with a storage solution. The red cells may be stored for an extended period of time.

摘要翻译： 公开了用于收集红细胞的方法，其中全血与抗凝血剂结合，将红细胞与全血分离，将分离的红细胞与储存溶液组合。 红细胞可能被长时间储存​​。

公开(公告)号：US5762791A

公开(公告)日：1998-06-09

申请号：US512807

申请日：1995-08-09

申请人： Jose C. Deniega ,  Daniel H. Duff

发明人： Jose C. Deniega ,  Daniel H. Duff

IPC分类号： A61M1/34 ,  A61M1/26 ,  A61M1/30 ,  B01D21/28 ,  B01D21/30 ,  B01D61/14 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D61/00 ,  B01D61/22

CPC分类号： A61M1/30 ,  A61M1/265 ,  A61M1/303 ,  A61M1/306 ,  A61M1/308 ,  A61M1/309 ,  A61M2205/3393 ,  A61M2209/082

摘要： Blood separation systems and methods utilize a membrane separation device comprising a gap between a microporous membrane and a surface facing the microporous membrane, one of the microporous membrane and the surface being rotatable relative to the other to cause separation of whole blood in the gap into plasma and concentrated red blood cells. The systems and methods include an inlet pump element coupled to the membrane separation device to convey whole blood having a known beginning hematocrit value into the gap for separation. The systems and methods also include a drive element coupled to the membrane separation device to cause rotation of the rotatable one of the microporous membrane and the facing surface. The systems and methods command the inlet pump element and the drive element as a function of the known beginning hematocrit value. This command technique obtains concentrated red blood cells having a high end hematocrit value that remains substantially constant despite variances in the known beginning hematocrit value, and, in particular, when the known beginning hematocrit value is low.

摘要翻译： 血液分离系统和方法利用膜分离装置，其包括微孔膜与面向微多孔膜的表面之间的间隙，微孔膜和表面之一可相对于另一个旋转，以使间隙中的全血分离成等离子体 和浓红细胞。 该系统和方法包括连接到膜分离装置的入口泵元件，以将具有已知开始血细胞比容值的全血输送到用于分离的间隙中。 所述系统和方法还包括联接到膜分离装置的驱动元件，以引起微孔膜和面向表面中的可旋转的一个旋转。 系统和方法根据已知的开始血细胞比容值命令入口泵元件和驱动元件。 该命令技术获得具有高端血细胞比容值的浓缩红细胞，尽管在已知的开始血细胞比容值中有变化，特别是当已知的开始血细胞比容值低时，其保持基本恒定。

公开(公告)号：US5536237A

公开(公告)日：1996-07-16

申请号：US891527

申请日：1992-06-01

申请人： Paul R. Prince ,  Robin Huff

发明人： Paul R. Prince ,  Robin Huff

IPC分类号： A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  G05D7/06

CPC分类号： G05D7/0682 ,  A61M1/303 ,  A61M1/306 ,  A61M1/3639 ,  A61M1/3656 ,  A61M1/30 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  Y10S128/13

摘要： A method and system for calibrating and controlling the withdrawal of a fluid, such as blood, from a fluid source, such as a blood vessel, includes a fluid pump, a pressure sensor, a flow rate sensor, and a microprocessor based flow control subsystem. The flow control subsystem optimizes the flow rate by sensing zero flow rate pressure within the subject, making a plurality of periodic flow path pressure measurements and extrapolating a calibration flow rate curve. A control curve is generated by utilizing the zero-flow rate pressure point, the slope of the calibration curve, and an empirically predetermined pressure. The blood pump is then operated at a maximum speed that is limited by the flow control curve to maximize flow without occlusion or collapse of the blood vessel during blood withdrawal. The method and system of the invention is particularly applicable to automated apheresis systems.

摘要翻译： 用于校准和控制诸如血管等流体源的流体（例如血液）的取出的方法和系统包括流体泵，压力传感器，流量传感器和基于微处理器的流量控制子系统 。 流量控制子系统通过感测对象内的零流量压力来优​​化流量，进行多个周期性流动路径压力测量并外推校准流量曲线。 通过利用零流量压力点，校准曲线的斜率和经验上预定的压力来产生控制曲线。 然后以最大速度操作血泵，该最大速度受到流量控制曲线的限制，以最大程度地流动，而不会在抽血期间血管闭塞或塌陷。 本发明的方法和系统特别适用于自动取样系统。

公开(公告)号：US4596550A

公开(公告)日：1986-06-24

申请号：US574791

申请日：1984-01-27

申请人： Vernon H. Troutner

发明人： Vernon H. Troutner

IPC分类号： A61M1/30 ,  A61M1/03

CPC分类号： A61M1/30 ,  A61M1/303 ,  A61M1/306 ,  A61M1/308 ,  A61M2205/50 ,  Y10S128/13

摘要： A blood flow system for processing blood has two phases of operation, an arterial phase and a venous phase. During the arterial phase, the system is filled with blood through operation of an arterial blood pump. When a predetermined blood pressure level in the system has been attained, the arterial blood pump is inactivated and a venous blood pump removes blood from the system for a given number of pump turns. By accurately monitoring both arterial and venous pumps operating cycles, ultrafiltration volume and rate may be determined.

摘要翻译： 用于处理血液的血液流动系统具有两个操作阶段，动脉期和静脉期。 在动脉期，通过动脉血泵的操作，系统充满血液。 当达到系统中的预定血压水平时，动脉血泵失活，并且静脉血泵在给定数量的泵匝中从系统中移除血液。 通过精确监测动脉和静脉泵的运行周期，可以确定超滤体积和速率。

公开(公告)号：US4486189A

公开(公告)日：1984-12-04

申请号：US423376

申请日：1982-09-24

申请人： Vernon H. Troutner ,  Richard A. Morrow

发明人： Vernon H. Troutner ,  Richard A. Morrow

IPC分类号： A61M1/30 ,  A61M1/03

CPC分类号： A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/306 ,  A61M1/308 ,  Y10S128/03

摘要： A hemodialysis system capable of operation in either a single needle mode or a double needle mode includes an arterial blood pump which is the sole blood pump in the system during the double needle mode. For single needle mode operation a venous blood pump is employed to return blood to the patient. A pump speed control adjusts the speed of the arterial pump in the double needle mode, and the speeds of both blood pumps in the single needle mode. A controller continuously operates the arterial pump in the double needle mode, and alternately activates the two pumps in the single needle mode. A module for modifying a commercially available double needle system for operation in either of the two modes is also described.

摘要翻译： 能够以单针模式或双针模式操作的血液透析系统包括在双针模式期间系统中唯一的血液泵的动脉血泵。 对于单针模式操作，使用静脉血泵将血液返回给患者。 泵速度控制器以双针模式调节动脉泵的速度，并以单针模式调节两个血液泵的速度。 控制器以双针模式连续操作动脉泵，并以单针模式交替启动两个泵。 还描述了用于修改用于在两种模式中的任一种中操作的市售双针系统的模块。

公开(公告)号：US20230218807A1

公开(公告)日：2023-07-13

申请号：US18125094

申请日：2023-03-22

申请人： Fenwal, Inc.

发明人： Benjamin E. Kusters ,  Kyungyoon Min

IPC分类号： A61M1/16 ,  A61M1/36 ,  A61M1/02 ,  A61M1/30 ,  A61M5/168 ,  A61M1/34

CPC分类号： A61M1/1603 ,  A61M1/0272 ,  A61M1/306 ,  A61M1/367 ,  A61M1/3693 ,  A61M1/3696 ,  A61M5/16845 ,  A61M5/16854 ,  A61M1/3403 ,  A61M2205/14 ,  A61M2205/15 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3393

摘要： A computer-implemented method comprises providing a fluid circuit comprising fluid pathways configured to mount and associate with a durable processing device comprising a pressure sensor in communication with a controller and a fluid pathway. A container is connected to the pressure sensor and may receive a volume of fluid. A change in pressure values between a first and second time is measured from when the volume of fluid is not in communication with the pressure sensor to when the volume of fluid is in communication with the pressure sensor, the volume of fluid within the container or a presence or absence of a fluid connection to the fluid pathway based on the change in pressure values is determined, and a response action is executed if the volume of fluid within the container is not within an authorized volume range for the time period, or if a fluid connection is unauthorized.

公开(公告)号：US09511181B2

公开(公告)日：2016-12-06

申请号：US12602906

申请日：2008-05-31

申请人： Goetz Günther ,  Andrea Günther ,  Richard Robert Bernd Günther ,  Gesa Dagmar Günther ,  Michael Herrenbauer ,  Martin Lauer ,  Ralf Müller

发明人： Goetz Günther ,  Michael Herrenbauer ,  Martin Lauer ,  Ralf Müller

IPC分类号： A61M37/00 ,  A61M1/30

CPC分类号： A61M1/306 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/307 ,  A61M1/308 ,  A61M2205/07 ,  A61M2205/3337 ,  A61M2205/3368

摘要： The present invention relates to a device and a method for blood treatment in a single-needle operating mode. The blood treatment device has an extracorporeal blood circuit comprising a blood supply line leading to the inlet of a blood treatment unit and a blood return line leading away from the outlet of the blood treatment unit. Blood collecting means, for example a blood collecting container, is provided in the blood return line, said means being connected to means for storing gas, for example an air reservoir, by a flow line. The flow connection comprises two line branches, one branch being used to transfer gas from the air reservoir into the blood collecting container and the other branch being used to transfer gas from the blood collecting container into the air reservoir. The connection branch for transferring gas from the air store into the blood collecting container contains means for compressing air, for example a compressor. The device according to the present invention may be operated in such a way that the filling level of the means for collecting blood can be determined as precisely as possible.

摘要翻译： 本发明涉及在单针操作模式下进行血液处理的装置和方法。 血液处理装置具有体外血液回路，其包括通向血液处理单元的入口的血液供给管线和远离血液处理单元的出口的血液回流管路。 血液收集装置例如采血容器设置在血液返回管线中，所述装置通过流动管路连接到用于储存气体的装置，例如储气器。 流动连接包括两个分支，一个分支用于将气体从空气储存器传送到采集容器中，另一个分支用于将气体从采集容器转移到储气器中。 用于将气体从空气存储器传送到采集容器中的连接支路含有用于压缩空气的装置，例如压缩机。 根据本发明的装置可以以可以精确地确定用于采集血液的装置的填充水平的方式操作。

公开(公告)号：US08652082B2

公开(公告)日：2014-02-18

申请号：US12937858

申请日：2009-04-14

申请人： Lennart Jönsson ,  Olof Jansson ,  Mattias Holmer ,  Eddie Nilsson

发明人： Lennart Jönsson ,  Olof Jansson ,  Mattias Holmer ,  Eddie Nilsson

IPC分类号： A61M37/00

CPC分类号： A61M1/30 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/106 ,  A61M1/1086 ,  A61M1/302 ,  A61M1/303 ,  A61M1/306 ,  A61M1/3626 ,  A61M2205/331

摘要： A proposed blood treatment apparatus includes: a blood treatment unit, at least one fluid pump and at least one blood pump. The blood treatment unit is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps are configured to pass blood treatment fluid through the blood treatment unit. The blood pumps are configured to extract untreated blood from a blood source, pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel. Additionally, at least one of the fluid pumps is configured to control the operation of at least one blood pump via the blood treatment fluid. Moreover, at least one of the blood pumps is integrated into a joint apparatus element, which includes the blood treatment unit. Thus, this blood pump and the unit may be mounted as well as be discarded jointly.

摘要翻译： 所提出的血液处理装置包括：血液处理单元，至少一个流体泵和至少一个血液泵。 血液处理单元被配置为接收未处理的血液和新鲜血液处理液，并且排出经处理的血液和使用的血液处理液。 流体泵配置成使血液处理液通过血液处理单元。 血泵被构造成从血液源中提取未经处理的血液，将提取的血液通过血液处理单元并将处理的血液输送到目标血管。 另外，流体泵中的至少一个配置成经由血液处理流体控制至少一个血液泵的操作。 此外，至少一个血泵被集成到包括血液处理单元的关节装置元件中。 因此，该血泵和单元可以被安装并被联合丢弃。