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    Substituted N-benzylindol-3-ylglyoxylic acid derivatives having antitumor action
    6.
    发明授权
    Substituted N-benzylindol-3-ylglyoxylic acid derivatives having antitumor action 有权

    公开(公告)号：US06432987B1

    公开(公告)日：2002-08-13

    申请号：US09736431

    申请日：2000-12-15

    申请人： Eckhard Gunther ,  Peter Emig ,  Dietmar Reichert ,  Guillaume Le Baut ,  Bernd Nickel ,  Gerald Bacher

    发明人： Eckhard Gunther ,  Peter Emig ,  Dietmar Reichert ,  Guillaume Le Baut ,  Bernd Nickel ,  Gerald Bacher

    IPC分类号： A01N4340

    摘要： The invention relates to novel, substituted N-benzyl-indol-3-ylglyoxylic acid derivatives of the following formula and their use for the treatment of oncoses The invention further relates to their physiologically tolerable acid addition salts and if possible their N-oxides. In addition, the invention relates to pharmaceutical preparations containing at least one of the compounds of the abovementioned formula or their salts or N-oxides with physiologically tolerable inorganic or organic acids and, if appropriate, pharmaceutically utilizable vehicles and/or diluents or excipients and also administration forms of the compounds of the abovementioned formula containing at least one of the compounds of this formula or their salts in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments

    USE OF INSULIN C-PEPTIDE, ALONE OR IN COMBINATION WITH GLP-1, AS A THERAPEUTIC AGENT
    10.
    发明申请
    USE OF INSULIN C-PEPTIDE, ALONE OR IN COMBINATION WITH GLP-1, AS A THERAPEUTIC AGENT 审中-公开
    使用胰岛素C-肽，单独使用或与GLP-1组合使用，作为治疗剂

    公开(公告)号：US20100292132A1

    公开(公告)日：2010-11-18

    申请号：US12676899

    申请日：2008-09-09

    申请人： Dorian Bevec ,  Fabio Cavalli ,  Vera Cavalli ,  Gerald Bacher

    发明人： Dorian Bevec ,  Fabio Cavalli ,  Vera Cavalli ,  Gerald Bacher

    IPC分类号： A61K38/16 ,  A61P35/00 ,  A61P25/00 ,  A61P9/00 ,  A61P31/18 ,  A61P31/12 ,  A61P25/24

    CPC分类号： A61K38/22 ,  A23L33/18 ,  A23L33/40 ,  A23V2002/00 ,  Y02A50/385 ,  Y02A50/402 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/423 ,  A23V2200/308 ,  A23V2200/318 ,  A23V2200/322 ,  A23V2200/324 ,  A23V2200/326 ,  A23V2250/55

    摘要： The present invention is directed to the use of the peptide compound Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquide buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-GIn-OH optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

    摘要翻译： 本发明涉及肽化合物Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly- Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-OH作为预防和/或治疗癌症，自身免疫疾病，纤维化疾病，炎性疾病，神经变性疾病 ，传染病，肺部疾病，心血管疾病和代谢疾病。 此外，本发明涉及优选形式为冻干物或液体缓冲溶液或人造母乳制剂或含有肽Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val- Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-OH任选与至少一种药学 可接受的载体，冷冻保护剂，冻干保护剂，赋形剂和/或稀释剂。