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公开(公告)号：US08741866B2
公开(公告)日：2014-06-03
申请号：US13410262
申请日：2012-03-01
CPC分类号： C12N15/113 , A61K9/0019 , A61K31/713 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/335 , C12N2310/3515 , C12N2320/30 , C12N2320/32 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
摘要翻译： 本发明涉及靶向转甲状腺素蛋白（TTR）基因的双链核糖核酸（dsRNA）以及使用dsRNA抑制TTR表达的方法。
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公开(公告)号：US08168775B2
公开(公告)日：2012-05-01
申请号：US12582669
申请日：2009-10-20
CPC分类号： C12N15/113 , A61K9/0019 , A61K31/713 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/335 , C12N2310/3515 , C12N2320/30 , C12N2320/32 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
摘要翻译： 本发明涉及靶向转甲状腺素蛋白（TTR）基因的双链核糖核酸（dsRNA）以及使用dsRNA抑制TTR表达的方法。
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3.发明申请公开(公告)号：US20120225927A1
公开(公告)日：2012-09-06
申请号：US13410262
申请日：2012-03-01
IPC分类号： A61K31/713 , A61P25/28 , C12N5/071 , C12N15/113
CPC分类号： C12N15/113 , A61K9/0019 , A61K31/713 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/335 , C12N2310/3515 , C12N2320/30 , C12N2320/32 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
摘要翻译： 本发明涉及靶向转甲状腺素蛋白（TTR）基因的双链核糖核酸（dsRNA）以及使用dsRNA抑制TTR表达的方法。
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4.发明申请公开(公告)号：US20100120893A1
公开(公告)日：2010-05-13
申请号：US12582669
申请日：2009-10-20
IPC分类号： A61K31/7088 , C07H21/04 , C12N15/63 , C12N5/10 , A61P43/00
CPC分类号： C12N15/113 , A61K9/0019 , A61K31/713 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/335 , C12N2310/3515 , C12N2320/30 , C12N2320/32 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
摘要翻译： 本发明涉及靶向转甲状腺素蛋白（TTR）基因的双链核糖核酸（dsRNA）以及使用dsRNA抑制TTR表达的方法。
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公开(公告)号：US09029525B2
公开(公告)日：2015-05-12
申请号：US13615164
申请日：2012-09-13
申请人： Dinah Wen-Yee Sah , Gregory Hinkle
发明人： Dinah Wen-Yee Sah , Gregory Hinkle
IPC分类号： C07H21/04 , C12N15/11 , C12N15/113
CPC分类号： C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2320/30 , C12Y207/11026 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting Glycogen Synthase Kinase-3 (GSK-3), and methods of using the dsRNA to inhibit expression of GSK-3.
摘要翻译： 本发明涉及靶向糖原合酶激酶-3（GSK-3）的双链核糖核酸（dsRNA）和使用dsRNA抑制GSK-3表达的方法。
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公开(公告)号：US20130012572A1
公开(公告)日：2013-01-10
申请号：US13615164
申请日：2012-09-13
申请人： Dinah Wen-Yee Sah , Gregory Hinkle
发明人： Dinah Wen-Yee Sah , Gregory Hinkle
IPC分类号： A61K31/713 , C12N5/071 , C12N15/63 , C12N15/113 , C12N5/10
CPC分类号： C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2320/30 , C12Y207/11026 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting Glycogen Synthase Kinase-3 (GSK-3), and methods of using the dsRNA to inhibit expression of GSK-3.
摘要翻译： 本发明涉及靶向糖原合酶激酶-3（GSK-3）的双链核糖核酸（dsRNA）和使用dsRNA抑制GSK-3表达的方法。
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公开(公告)号：US20110184046A1
公开(公告)日：2011-07-28
申请号：US13003740
申请日：2009-07-13
申请人： Dinah Wen-Yee Sah , Dinah Sah , Gregory Hinkle
发明人： Dinah Wen-Yee Sah , Dinah Sah , Gregory Hinkle
IPC分类号： A61K31/713 , C07H21/02 , C12N15/63 , C12N5/071 , A61P3/00 , A61P3/10 , A61P25/00 , A61P25/28 , A61P25/16 , A61P25/18 , A61P25/24 , A61P35/00 , A61P33/02 , A61P29/00 , A61P21/00 , A61P7/00 , C12N5/10
CPC分类号： C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2320/30 , C12Y207/11026 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting Glycogen Synthase Kinase-3 (GSK-3), and methods of using the dsRNA to inhibit expression of GSK-3.
摘要翻译： 本发明涉及靶向糖原合酶激酶-3（GSK-3）的双链核糖核酸（dsRNA）和使用dsRNA抑制GSK-3表达的方法。
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公开(公告)号：US08623838B2
公开(公告)日：2014-01-07
申请号：US13363504
申请日：2012-02-01
申请人： Jinyun Chen , Gregory Hinkle , Satyanarayana Kuchimanchi , Stuart Milstein , Markus Warmuth , Wenlai Zhou , Ping Zhu , Tracy S. Zimmermann
发明人： Jinyun Chen , Gregory Hinkle , Satyanarayana Kuchimanchi , Stuart Milstein , Markus Warmuth , Wenlai Zhou , Ping Zhu , Tracy S. Zimmermann
CPC分类号： C12N15/113 , A61K31/713 , A61K45/06 , C07H21/02 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2320/31 , C12N2320/51 , C12N2320/53 , Y02A50/467 , C12N2310/3521
摘要： The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.
摘要翻译： 本公开涉及使用治疗有效量的RNAi剂对HSF治疗热休克因子1（HSF1）相关疾病如癌症和病毒性疾病的方法。
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公开(公告)号：US08344127B2
公开(公告)日：2013-01-01
申请号：US13090580
申请日：2011-04-20
申请人： Antonin De Fougerolles , John L. Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Sprague
发明人： Antonin De Fougerolles , John L. Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Sprague
CPC分类号： C12N15/1138 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3513 , C12N2310/3515 , C12N2310/3517 , C12N2310/3521
摘要： The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.
摘要翻译： 本公开涉及可用于使用治疗有效量治疗β-ENAC相关疾病如囊性纤维化，1型假性醛固酮增多症（1例（PHA1），跛行综合征，高血压，碱中毒，低钾血症和肥胖相关性高血压）的方法中的RNAi剂 的RNAi试剂到β-ENaC。
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公开(公告)号：US08598335B2
公开(公告)日：2013-12-03
申请号：US13614836
申请日：2012-09-13
申请人： Antonin De Fougerolles , John Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Griffin Sprague
发明人： Antonin De Fougerolles , John Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Griffin Sprague
CPC分类号： C12N15/1138 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3513 , C12N2310/3515 , C12N2310/3517 , C12N2310/3521
摘要： The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.
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