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1.发明申请Topical Compositions Containing Desthiobiotin and its Derivatives and a Method of Treating Skin 有权含有脱氧生物素及其衍生物的外用组合物和治疗皮肤的方法公开(公告)号：US20100267792A1
公开(公告)日：2010-10-21
申请号：US12747364
申请日：2008-11-19
IPC分类号： A61K31/4166 , A61Q19/00 , A61Q19/08
CPC分类号： A61Q19/08 , A61K8/4946 , A61Q19/00
摘要： Topical compositions and methods of use to treat symptoms of reduced skin elasticity are provided comprising desthiobiotin and certain desthiobiotin analogues. These compounds are effective in stimulating LOXL-1 activity and can thus increase elastin remodeling and improve appearance of fine lines, wrinkles, skin sagging and other symptoms of reduced elastin function.
摘要翻译： 提供用于治疗皮肤弹性降低症状的局部组合物和方法，其包括脱硫生物素和某些脱硫生物素类似物。 这些化合物在刺激LOXL-1活性方面是有效的，因此可以增加弹性蛋白重塑，改善细纹，皱纹，皮肤下垂等症状，减少弹性蛋白功能的其他症状。
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2.发明授权Topical compositions containing desthiobiotin and its derivatives and a method of treating skin 有权含有脱硫生物素及其衍生物的局部组合物和治疗皮肤的方法公开(公告)号：US08450353B2
公开(公告)日：2013-05-28
申请号：US12747364
申请日：2008-11-19
IPC分类号： A61K31/12 , A01N43/50 , C07C59/86 , C07D413/00
CPC分类号： A61Q19/08 , A61K8/4946 , A61Q19/00
摘要： Topical compositions and methods of use to treat symptoms of reduced skin elasticity are provided comprising desthiobiotin and certain desthiobiotin analogues. These compounds are effective in stimulating LOXL-1 activity and can thus increase elastin remodeling and improve appearance of fine lines, wrinkles, skin sagging and other symptoms of reduced elastin function.
摘要翻译： 提供用于治疗皮肤弹性降低症状的局部组合物和方法，其包括脱硫生物素和某些脱硫生物素类似物。 这些化合物在刺激LOXL-1活性方面是有效的，因此可以增加弹性蛋白重塑，改善细纹，皱纹，皮肤下垂等症状，减少弹性蛋白功能的其他症状。
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3.发明申请Topical Compositions Containing Derris Scandens Benth and a Method of Treating Skin 审中-公开含有Derris Scandens Benth和治疗皮肤的方法的专题组成公开(公告)号：US20120237623A1
公开(公告)日：2012-09-20
申请号：US13395682
申请日：2010-10-14
摘要： Topical compositions and methods of use to treat symptoms of reduced skin elasticity are provided comprising extracts of a. Derris scandens Benth. plant. These compositions are effective in stimulating LOXL-1, activity, inhibiting calcineurin activity, and stimulating glycosaminoglycan synthesis in skin cells and can thus reduce age-related skin damage and improve appearance of fine lines, wrinkles, skin sagging and other symptoms of skin aging and/or skin damage.
摘要翻译： 提供用于治疗皮肤弹性降低症状的局部组合物和方法，其包括a。 Derris scandens Benth。 厂。 这些组合物在刺激LOXL-1，活性，抑制钙调神经磷酸酶活性和刺激皮肤细胞中的糖胺聚糖合成方面是有效的，因此可以减少年龄相关的皮肤损伤，改善细纹，皱纹，皮肤下垂等皮肤老化症状的出现， /或皮肤损伤。
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4.发明申请Topical Compositions Comprising Non-Proteogenic Amino Acids and Methods of Treating Skin 有权包含非蛋白质氨基酸的局部组合物和治疗皮肤的方法公开(公告)号：US20100261769A1
公开(公告)日：2010-10-14
申请号：US12747272
申请日：2008-11-14
IPC分类号： A61K8/49 , A61K31/426 , A61Q19/00 , A61P17/00 , A61Q19/08
CPC分类号： A61K8/042 , A61K8/25 , A61K8/26 , A61K8/447 , A61K8/49 , A61K8/4913 , A61K8/492 , A61K8/4926 , A61K8/494 , A61K8/4946 , A61K8/4953 , A61K8/4973 , A61K8/4986 , A61K8/891 , A61K31/325 , A61K2800/262 , A61K2800/412 , A61K2800/413 , A61Q19/08
摘要： Cosmetic compositions comprising non-natural, non-proteogenic amino acids and methods of using such compositions to impart antiaging benefits to the skin are disclosed. The non-natural, non-proteogenic amino acids are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging, and in particular, are enhancers of LOXL-1.
摘要翻译： 公开了包含非天然的，非蛋白质的氨基酸的化妆品组合物和使用这些组合物赋予皮肤抗衰老益处的方法。 认为非天然的，非蛋白质的氨基酸具有针对涉及皮肤老化的一种或多种生物化学途径的调节活性，特别是LOXL-1的增强子。
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5.发明授权Topical compositions comprising non-proteogenic amino acids and methods of treating skin 有权包含非蛋白质氨基酸的局部组合物和治疗皮肤的方法公开(公告)号：US08168212B2
公开(公告)日：2012-05-01
申请号：US12747272
申请日：2008-11-14
IPC分类号： A61K8/02 , A61K31/385 , A01N43/26
CPC分类号： A61K8/042 , A61K8/25 , A61K8/26 , A61K8/447 , A61K8/49 , A61K8/4913 , A61K8/492 , A61K8/4926 , A61K8/494 , A61K8/4946 , A61K8/4953 , A61K8/4973 , A61K8/4986 , A61K8/891 , A61K31/325 , A61K2800/262 , A61K2800/412 , A61K2800/413 , A61Q19/08
摘要： Cosmetic compositions comprising non-natural, non-proteogenic amino acids and methods of using such compositions to impart antiaging benefits to the skin are disclosed.The non-natural, non-proteogenic amino acids are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging, and in particular, are enhancers of LOXL-1.
摘要翻译： 公开了包含非天然的，非蛋白质的氨基酸的化妆品组合物和使用这些组合物赋予皮肤抗衰老益处的方法。 认为非天然的，非蛋白质的氨基酸具有针对涉及皮肤老化的一种或多种生物化学途径的调节活性，特别是LOXL-1的增强子。
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6.发明授权Methods and compositions for preventing or reducing frizzy appearance of hair 有权用于预防或减少头发卷曲外观的方法和组合物公开(公告)号：US08932569B2
公开(公告)日：2015-01-13
申请号：US12912859
申请日：2010-10-27
申请人： Mark S. Garrison , Freda E. Robinson , Giovana A. Sandstrom , Kenneth A. Buckridge , Sen Yang , Xiaochun Luo
发明人： Mark S. Garrison , Freda E. Robinson , Giovana A. Sandstrom , Kenneth A. Buckridge , Sen Yang , Xiaochun Luo
CPC分类号： A61K8/898 , A61K8/0241 , A61K8/25 , A61K8/26 , A61K8/34 , A61K8/37 , A61K8/416 , A61K8/585 , A61K8/8152 , A61K8/86 , A61K8/891 , A61K8/895 , A61K8/897 , A61K8/91 , A61K2800/412 , A61K2800/413 , A61K2800/594 , A61K2800/623 , A61Q5/06
摘要： Compositions and methods are disclosed for preventing or reducing frizzy appearance of keratin fibers, including hair, and reducing the amount of fly-away strands of hair, particularly in humid conditions, by forming a coating on hair that is resistant to water vapors from the air or surrounding environment. The compositions comprise a combination of a hydrophobic particulate material comprising a hydrophobically surface-modified aluminum oxide and one or more hydrophobic film formers in a cosmetically acceptable vehicle.
摘要翻译： 公开了用于防止或减少包括毛发在内的角蛋白纤维的卷曲外观的组合物和方法，并且通过在头发上形成对来自空气的水蒸气具有抗性的毛发上的涂层来减少特别是在潮湿条件下的飞散的毛发的量 或周围环境。 组合物包含在化妆品可接受的载体中包含疏水表面改性的氧化铝和一种或多种疏水性成膜剂的疏水性颗粒材料的组合。
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7.发明授权Hair and scalp composition with a crosslinked silicone elastomer and method of using same 有权具有交联硅氧烷弹性体的头发和头皮组合物及其使用方法公开(公告)号：US07491382B2
公开(公告)日：2009-02-17
申请号：US11862689
申请日：2007-09-27
IPC分类号： A61Q5/02
CPC分类号： A61K8/895 , A61K8/8152 , A61Q5/008 , A61Q5/12
摘要： The present invention provides a water-based composition comprising a non-emulsifying crosslinked silicone elastomer in an amount effective to decrease the amount of sebum on the hair or scalp. The water-based compositions of the present invention are in non-emulsion form. More preferably, the water-based compositions of the present invention have a suspending agent in an amount effective to suspend the crosslinked silicone elastomer within the water-based composition. The present invention also provides to a method of method for absorbing and/or removing sebum and/or styling product residue from the hair or scalp. The method comprises the step of applying the water-based composition to the hair and/or scalp. Preferably, the water-based hair composition is distributed through the hair and/or scalp, e.g., by using a comb or brush.
摘要翻译： 本发明提供一种包含非乳化交联的硅氧烷弹性体的水性组合物，其量可以有效地减少毛发或头皮上的皮脂的量。 本发明的水基组合物是非乳液形式。 更优选地，本发明的水基组合物具有使交联的硅氧烷弹性体悬浮在水基组合物中的量的悬浮剂。 本发明还提供一种用于从头发或头皮吸收和/或去除皮脂和/或造型产品残留物的方法的方法。 该方法包括将水基组合物施用于毛发和/或头皮的步骤。 优选地，水性毛发组合物例如通过使用梳子或刷子分布在头发和/或头皮上。
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8.发明申请公开(公告)号：US20110110992A1
公开(公告)日：2011-05-12
申请号：US12912859
申请日：2010-10-27
申请人： Mark S. Garrison , Freda E. Robinson , Giovana A. Sandstrom , Kenneth A. Buckridge , Sen Yang , Xiaochun Luo
发明人： Mark S. Garrison , Freda E. Robinson , Giovana A. Sandstrom , Kenneth A. Buckridge , Sen Yang , Xiaochun Luo
CPC分类号： A61K8/898 , A61K8/0241 , A61K8/25 , A61K8/26 , A61K8/34 , A61K8/37 , A61K8/416 , A61K8/585 , A61K8/8152 , A61K8/86 , A61K8/891 , A61K8/895 , A61K8/897 , A61K8/91 , A61K2800/412 , A61K2800/413 , A61K2800/594 , A61K2800/623 , A61Q5/06
摘要： Compositions and methods are disclosed for preventing or reducing frizzy appearance of keratin fibers, including hair, and reducing the amount of fly-away strands of hair, particularly in humid conditions, by forming a coating on hair that is resistant to water vapors from the air or surrounding environment. The compositions comprise a combination of a hydrophobic particulate material comprising a hydrophobically surface-modified aluminum oxide and one or more hydrophobic film formers in a cosmetically acceptable vehicle.
摘要翻译： 公开了用于防止或减少包括毛发在内的角蛋白纤维的卷曲外观的组合物和方法，并且通过在头发上形成对来自空气的水蒸气具有抗性的毛发上的涂层来减少特别是在潮湿条件下的飞散的毛发的量 或周围环境。 组合物包含在化妆品可接受的载体中包含疏水表面改性的氧化铝和一种或多种疏水性成膜剂的疏水性颗粒材料的组合。
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9.发明申请Hair And Scalp Composition With A Crosslinked Silicone Elastomer And Method Of Using Same 有权头发和头皮组合物与交联的硅酮弹性体和使用方法公开(公告)号：US20080014165A1
公开(公告)日：2008-01-17
申请号：US11862689
申请日：2007-09-27
申请人： Glen Anderson , Clifford Milow , Xiaochun Luo
发明人： Glen Anderson , Clifford Milow , Xiaochun Luo
CPC分类号： A61K8/895 , A61K8/8152 , A61Q5/008 , A61Q5/12
摘要： The present invention provides a water-based composition comprising a non-emulsifying crosslinked silicone elastomer in an amount effective to decrease the amount of sebum on the hair or scalp. The water-based compositions of the present invention are in non-emulsion form. More preferably, the water-based compositions of the present invention have a suspending agent in an amount effective to suspend the crosslinked silicone elastomer within the water-based composition. The present invention also provides to a method of method for absorbing and/or removing sebum and/or styling product residue from the hair or scalp. The method comprises the step of applying the water-based composition to the hair and/or scalp. Preferably, the water-based hair composition is distributed through the hair and/or scalp, e.g., by using a comb or brush.
摘要翻译： 本发明提供一种包含非乳化交联的硅氧烷弹性体的水性组合物，其量可以有效地减少毛发或头皮上的皮脂的量。 本发明的水基组合物是非乳液形式。 更优选地，本发明的水基组合物具有使交联的硅氧烷弹性体悬浮在水基组合物中的量的悬浮剂。 本发明还提供一种用于从头发或头皮吸收和/或去除皮脂和/或造型产品残留物的方法的方法。 该方法包括将水基组合物施用于毛发和/或头皮的步骤。 优选地，水性毛发组合物例如通过使用梳子或刷子分布在头发和/或头皮上。
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公开(公告)号：US09622945B2
公开(公告)日：2017-04-18
申请号：US12912816
申请日：2010-10-27
申请人： Mark S. Garrison , Freda E. Robinson , Giovana A. Sandstrom , Kenneth A. Buckridge , Sen Yang , Xiaochun Luo
发明人： Mark S. Garrison , Freda E. Robinson , Giovana A. Sandstrom , Kenneth A. Buckridge , Sen Yang , Xiaochun Luo
IPC分类号： A61K8/02 , A61Q5/12 , A61K8/89 , A61K8/26 , A61K8/58 , A61K8/891 , A61K8/895 , A61K8/897 , A61K8/898 , A61Q5/06 , A61K8/81
CPC分类号： A61K8/0241 , A61K8/26 , A61K8/585 , A61K8/8152 , A61K8/891 , A61K8/895 , A61K8/897 , A61K8/898 , A61K2800/413 , A61K2800/623 , A61Q5/06
摘要： Compositions and methods are disclosed for preventing or reducing frizzy appearance of keratin fibers, including hair, and reducing the amount of fly-away strands of hair, particularly in humid conditions, by forming a coating on hair that is resistant to water vapors from the air or surrounding environment. The compositions comprise a combination of a hydrophobic particulate material comprising a hydrophobically surface-modified oxide and one or more hydrophobic film formers in a cosmetically acceptable vehicle.
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