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1.发明申请Compositions and Methods for Stimulation MAGP-1 to Improve the Appearance of Skin 有权用于刺激MAGP-1改善皮肤外观的组合物和方法公开(公告)号：US20120003332A1
公开(公告)日：2012-01-05
申请号：US13158947
申请日：2011-06-13
申请人： Qian Zheng , Siming W. Chen , Uma Santhanam , John W. Lyga
发明人： Qian Zheng , Siming W. Chen , Uma Santhanam , John W. Lyga
CPC分类号： A61K8/97 , A61K8/466 , A61K8/49 , A61K31/5377 , A61K36/185 , A61K36/39 , A61K36/53 , A61K36/74 , A61K45/06 , A61K2800/20 , A61Q19/00 , A61Q19/08
摘要： The present disclosure relates to methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, by application of one or a combination of natural compounds or extracts that stimulate MAGP-1 expression and which improves the appearance of aged and/or photodamaged skin. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof in an amount effective to improve the condition and aesthetic appearance of skin.
摘要翻译： 本公开内容涉及用于治疗，预防和改善皮肤的状况和美学外观的方法，特别是通过施用一种或其组合来治疗，预防，改善，减少和/或消除皮肤细纹和/或皱纹 刺激MAGP-1表达的天然化合物或提取物，并改善老化和/或光损伤皮肤的外观。 本发明的组合物局部施用于皮肤，或通过定向方式递送至有效改善皮肤状况和美观外观的量的有需要的部位。
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公开(公告)号：US10195136B2
公开(公告)日：2019-02-05
申请号：US13216626
申请日：2011-08-24
摘要： Methods and compositions for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ a botanical extract of Justicia ventricosa, Archidendron clypearia, Abrus fruticulosus, or combinations thereof and a cosmetically acceptable vehicle.
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公开(公告)号：US20130052288A1
公开(公告)日：2013-02-28
申请号：US13216626
申请日：2011-08-24
CPC分类号： A61K8/97 , A61K36/19 , A61K36/48 , A61Q19/08 , A61K2300/00
摘要： Methods and compositions for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ a botanical extract of Justicia ventricosa, Archidendron clypearia, Abrus fruticulosus, or combinations thereof and a cosmetically acceptable vehicle.
摘要翻译： 提供了用于预防，改善或减少老化皮肤病学症状的方法和组合物，其采用了法蒂西娅（Petricia ventricosa）的植物提取物，西葫芦（Archidendron clypearia）或其组合以及美容上可接受的载体。
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4.发明授权Compositions and methods for stimulation MAGP-1 to improve the appearance of skin 有权用于刺激MAGP-1以改善皮肤外观的组合物和方法公开(公告)号：US09132294B2
公开(公告)日：2015-09-15
申请号：US13158947
申请日：2011-06-13
申请人： Qian Zheng , Siming W. Chen , Uma Santhanam , John W. Lyga
发明人： Qian Zheng , Siming W. Chen , Uma Santhanam , John W. Lyga
CPC分类号： A61K8/97 , A61K8/466 , A61K8/49 , A61K31/5377 , A61K36/185 , A61K36/39 , A61K36/53 , A61K36/74 , A61K45/06 , A61K2800/20 , A61Q19/00 , A61Q19/08
摘要： The present disclosure relates to methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, by application of one or a combination of natural compounds or extracts that stimulate MAGP-1 expression and which improves the appearance of aged and/or photodamaged skin. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof in an amount effective to improve the condition and aesthetic appearance of skin.
摘要翻译： 本公开内容涉及用于治疗，预防和改善皮肤的状况和美学外观的方法，特别是通过施用一种或其组合来治疗，预防，改善，减少和/或消除皮肤细纹和/或皱纹 刺激MAGP-1表达的天然化合物或提取物，并改善老化和/或光损伤皮肤的外观。 本发明的组合物局部施用于皮肤，或通过定向方式递送至有效改善皮肤状况和美观外观的量的有需要的部位。
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公开(公告)号：US20130224269A1
公开(公告)日：2013-08-29
申请号：US13817570
申请日：2011-11-03
CPC分类号： A61K8/0245 , A61K8/0241 , A61K8/19 , A61K8/64 , A61K2800/412 , A61K2800/624 , A61Q1/02 , A61Q3/02 , A61Q5/00 , A61Q5/065 , A61Q19/00
摘要： An extended wear cosmetic composition for application to a keratinous surface comprising a cosmetic particle coated with a biofunctional polymer wherein said coated particle adheres to the keratinous surface for an extended time period. A delivery system for conjugating a biofunctional polymer and cosmetic particle to specific cells on a keratinous surface such that the particle adheres to the keratinous surface for an extended time period.
摘要翻译： 一种用于角质表面的延长耐磨化妆品组合物，其包含涂覆有生物功能性聚合物的化妆品颗粒，其中所述涂覆的颗粒在角质表面附着较长时间。 用于将生物官能聚合物和化妆品颗粒与角质表面上的特定细胞缀合的递送系统，使得颗粒粘附至角质表面延长时间。
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6.发明申请Topical Compositions Containing Desthiobiotin and its Derivatives and a Method of Treating Skin 有权含有脱氧生物素及其衍生物的外用组合物和治疗皮肤的方法公开(公告)号：US20100267792A1
公开(公告)日：2010-10-21
申请号：US12747364
申请日：2008-11-19
IPC分类号： A61K31/4166 , A61Q19/00 , A61Q19/08
CPC分类号： A61Q19/08 , A61K8/4946 , A61Q19/00
摘要： Topical compositions and methods of use to treat symptoms of reduced skin elasticity are provided comprising desthiobiotin and certain desthiobiotin analogues. These compounds are effective in stimulating LOXL-1 activity and can thus increase elastin remodeling and improve appearance of fine lines, wrinkles, skin sagging and other symptoms of reduced elastin function.
摘要翻译： 提供用于治疗皮肤弹性降低症状的局部组合物和方法，其包括脱硫生物素和某些脱硫生物素类似物。 这些化合物在刺激LOXL-1活性方面是有效的，因此可以增加弹性蛋白重塑，改善细纹，皱纹，皮肤下垂等症状，减少弹性蛋白功能的其他症状。
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公开(公告)号：US09066896B2
公开(公告)日：2015-06-30
申请号：US13602557
申请日：2012-09-04
申请人： Qian Zheng , Russell Wyborski , Uma Santhanam , John W. Lyga , Dimitri S. Ptchelintsev , Siming W. Chen
发明人： Qian Zheng , Russell Wyborski , Uma Santhanam , John W. Lyga , Dimitri S. Ptchelintsev , Siming W. Chen
CPC分类号： A61K8/97 , A61K8/342 , A61K8/4906 , A61K8/4926 , A61K36/00 , A61Q19/08 , C12Q1/6881 , C12Q2600/158 , C12Q2600/16
摘要： Cosmetic compositions comprising one or more paxillin stimulators and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The paxillin stimulators and combinations thereof are believed to have modulatory activity against at least one biochemical pathway implicated in skin aging.
摘要翻译： 公开了包含一种或多种桩蛋白刺激剂的化妆品组合物和使用这些组合物以赋予皮肤抗衰老益处的方法。 据信桩蛋白刺激剂及其组合对至少一种与皮肤老化有关的生物化学途径具有调节活性。
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公开(公告)号：US08394427B2
公开(公告)日：2013-03-12
申请号：US12966098
申请日：2010-12-13
申请人： Qian Zheng , Russell Wyborski , Uma Santhanam , John W. Lyga , Dmitri S. Ptchelintsev , Siming W. Chen
发明人： Qian Zheng , Russell Wyborski , Uma Santhanam , John W. Lyga , Dmitri S. Ptchelintsev , Siming W. Chen
IPC分类号： A01N65/00
CPC分类号： A61K8/97 , A61K8/342 , A61K8/4906 , A61K8/4926 , A61K36/00 , A61Q19/08 , C12Q1/6881 , C12Q2600/158 , C12Q2600/16
摘要： Cosmetic compositions comprising one or more paxillin stimulators and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The paxillin stimulators and combinations thereof are believed to have modulatory activity against at least one biochemical pathway implicated in skin aging.
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公开(公告)号：US20110151029A1
公开(公告)日：2011-06-23
申请号：US12966098
申请日：2010-12-13
申请人： Qian ZHENG , Russell WYBORSKI , Uma SANTHANAM , John W. LYGA , Dmitri S. PTCHELINTSEV , Siming W. CHEN
发明人： Qian ZHENG , Russell WYBORSKI , Uma SANTHANAM , John W. LYGA , Dmitri S. PTCHELINTSEV , Siming W. CHEN
CPC分类号： A61K8/97 , A61K8/342 , A61K8/4906 , A61K8/4926 , A61K36/00 , A61Q19/08 , C12Q1/6881 , C12Q2600/158 , C12Q2600/16
摘要： Cosmetic compositions comprising one or more paxillin stimulators and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The paxillin stimulators and combinations thereof are believed to have modulatory activity against at least one biochemical pathway implicated in skin aging.
摘要翻译： 公开了包含一种或多种桩蛋白刺激剂的化妆品组合物和使用这些组合物以赋予皮肤抗衰老益处的方法。 据信桩蛋白刺激剂及其组合对至少一种与皮肤老化有关的生物化学途径具有调节活性。
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10.发明授权Topical compositions containing desthiobiotin and its derivatives and a method of treating skin 有权含有脱硫生物素及其衍生物的局部组合物和治疗皮肤的方法公开(公告)号：US08450353B2
公开(公告)日：2013-05-28
申请号：US12747364
申请日：2008-11-19
IPC分类号： A61K31/12 , A01N43/50 , C07C59/86 , C07D413/00
CPC分类号： A61Q19/08 , A61K8/4946 , A61Q19/00
摘要： Topical compositions and methods of use to treat symptoms of reduced skin elasticity are provided comprising desthiobiotin and certain desthiobiotin analogues. These compounds are effective in stimulating LOXL-1 activity and can thus increase elastin remodeling and improve appearance of fine lines, wrinkles, skin sagging and other symptoms of reduced elastin function.
摘要翻译： 提供用于治疗皮肤弹性降低症状的局部组合物和方法，其包括脱硫生物素和某些脱硫生物素类似物。 这些化合物在刺激LOXL-1活性方面是有效的，因此可以增加弹性蛋白重塑，改善细纹，皱纹，皮肤下垂等症状，减少弹性蛋白功能的其他症状。
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