-
1.发明申请AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS 审中-公开AZA-BICYCLOALKYL ETHERS及其作为ALPHA7-NACHR AGONISTS的用途公开(公告)号：US20120220599A1
公开(公告)日：2012-08-30
申请号：US13462187
申请日：2012-05-02
IPC分类号： A61K31/501 , A61K31/506 , A61K31/4439 , A61P25/28 , A61P25/18 , C07D487/08 , C07D453/02 , A61K31/439
CPC分类号： A61K31/439 , A61K9/20 , A61K31/444 , C07D453/02 , C07D487/08
摘要： The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及式I的1-氮杂 - 双环烷基衍生物，其中X是CH 2或单键; Y是一组式，其中R具有本说明书中定义的含义，该化合物是α7烟碱型乙酰胆碱受体（nAChR）激动剂; 其制备方法，它们作为药物的用途以及包含它们的药物组合物。
-
公开(公告)号：US20100179160A1
公开(公告)日：2010-07-15
申请号：US12732646
申请日：2010-03-26
申请人： Dominik FEUERBACH , Mathias FREDERIKSEN , Konstanze HURTH , Bernard Lucien ROY , Beatrix WAGNER
发明人： Dominik FEUERBACH , Mathias FREDERIKSEN , Konstanze HURTH , Bernard Lucien ROY , Beatrix WAGNER
IPC分类号： A61K31/501 , C07D487/08 , A61K31/496 , A61K31/444 , A61P1/14
CPC分类号： C07D471/08 , A61K31/439 , A61K31/501 , A61K31/506 , A61K45/06
摘要： The present invention relates to 1-aza-bicycloalkyl derivatives of Formula (I) wherein the substituents are as defined in the specification and to processes for their production to pharmaceutical compositions comprising them and to their use in the manufacture of a medicament for the treatment and/or delay of progression of psychotic and nemodegenerative disorders.
摘要翻译： 本发明涉及式（I）的1-氮杂 - 双环烷基衍生物，其中取代基如本说明书中所定义，并且其制备方法为包含它们的药物组合物及其在制备用于治疗和/ /或延迟精神病和再生障碍的进展。
-
3.发明申请COMBINATIONS OF NICOTINIC ACETYLCHOLINE ALPHA 7 RECEPTOR AGONISTS 审中-公开NICOTINIC ACETYLCHOLINE ALPHA 7受体激素的组合公开(公告)号：US20100125063A1
公开(公告)日：2010-05-20
申请号：US12690905
申请日：2010-01-20
申请人： Hans O. KALKMAN , Joachim NOZULAK , Annick VASSOUT , Konstanze HURTH , Dominik FEUERBACH , Conrad GENTSCH , Graeme BILBE
发明人： Hans O. KALKMAN , Joachim NOZULAK , Annick VASSOUT , Konstanze HURTH , Dominik FEUERBACH , Conrad GENTSCH , Graeme BILBE
IPC分类号： A61K31/554 , A61K31/439 , A61K31/501 , A61K31/497 , A61K31/454 , A61K31/551 , A61P25/18
CPC分类号： A61K31/46 , A61K45/06 , A61K2300/00
摘要： Combinations which comprise at least one nicotinic acetylcholine alpha 7 receptor agonist and at least one compound selected from the group consisting of (a) conventional antipsychotics (b) atypical antipsychotics (c) cognition, attention and/or memory enhancers (d) and to use of these combinations in the treatment of psychiatric disorders.
摘要翻译： 包含至少一种烟碱乙酰胆碱α7受体激动剂和选自（a）常规抗精神病药（b）非典型抗精神病药（c）认知，注意力和/或记忆增强剂（d）的至少一种化合物的组合，并使用 的这些组合在治疗精神疾病。
-
4.发明申请3-(HETEROARYL-OXY)-2-ALKYL-1-AZA-BICYCLOALKYL DERIVATIVES AS ALPHA. 7-NACHR LIGANDS FOR THE TREATMENT OF CNS DISEASES 有权3-（异丁氧基）-2-烷基-1-氮杂双环己基衍生物作为ALPHA。 用于治疗CNS疾病的7-NACHR配偶公开(公告)号：US20100093746A1
公开(公告)日：2010-04-15
申请号：US12638880
申请日：2009-12-15
IPC分类号： A61K31/501 , C07D403/02 , C07D453/02 , A61K31/439 , C07D239/02 , A61K31/505 , A61P43/00
CPC分类号： C07D453/02 , C07D487/08
摘要： The present invention relates to 1-aza-bicycloalkyl derivatives of formula (I) wherein the substituents are as defined in the specification, to processes for their production, their use as pharmaceuticals in the prevention and treatment of psychotic and neurodegenerative disorders. The claimed compounds act as nicotinic acetylcholine receptors (NACHR) ligands.
摘要翻译： 本发明涉及式（I）的1-氮杂 - 双环烷基衍生物，其中取代基如说明书中所定义，其制备方法，它们作为药物用于预防和治疗精神病和神经变性疾病。 所要求的化合物作为烟碱乙酰胆碱受体（NACHR）配体。
-
公开(公告)号：US20160106753A1
公开(公告)日：2016-04-21
申请号：US14976998
申请日：2015-12-21
申请人： Giorgio CARAVATTI , Sylvie CHAMOIN , Pascal FURET , Klemens HOGENAUER , Konstanze HURTH , Christoph KALIS , Karen KAMMERTOENS , Ian LEWIS , Henrik MOEBITZ , Alexander Baxter SMITH , Nicolas SOLDERMANN , Romain WOLF , Frederic ZECRI
发明人： Giorgio CARAVATTI , Sylvie CHAMOIN , Pascal FURET , Klemens HOGENAUER , Konstanze HURTH , Christoph KALIS , Karen KAMMERTOENS , Ian LEWIS , Henrik MOEBITZ , Alexander Baxter SMITH , Nicolas SOLDERMANN , Romain WOLF , Frederic ZECRI
IPC分类号： A61K31/5383 , A61K31/538
CPC分类号： A61K31/5383 , A61K31/538 , C07D413/14 , C07D498/04 , C12N9/12 , C12Q1/25 , C12Q1/686 , Y02A50/409 , Y02A50/411
摘要： The invention relates to dihydro-benzo-oxazine and dihydro-pyrido-oxazine compounds of the formula (I) and/or pharmaceutically acceptable salts and/or solvates thereof, wherein Y, V, W, U, Q, R1, R5, R7 and R30 are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
-
6.发明申请Novel Heterocyclic Derivatives and Their Use in the Treatment of Neurological Disorders 有权新型杂环衍生物及其在神经障碍治疗中的应用公开(公告)号：US20120184539A1
公开(公告)日：2012-07-19
申请号：US13348039
申请日：2012-01-11
申请人： Sangamesh BADIGER , Murali CHEBROLU , Konstanze HURTH , Sébastien JACQUIER , Rainer Martin LUEOEND , Rainer MACHAUER , Heinrich RUEEGER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
发明人： Sangamesh BADIGER , Murali CHEBROLU , Konstanze HURTH , Sébastien JACQUIER , Rainer Martin LUEOEND , Rainer MACHAUER , Heinrich RUEEGER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
IPC分类号： A61K31/5377 , A61P25/28 , A61P9/12 , A61P3/10 , A61P3/04 , C07D413/14 , A61P25/00
CPC分类号： C07D413/14 , A61K31/5377 , C07B59/002 , C07B2200/05 , C07D471/04 , C07D487/04 , A61K2300/00
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，其药物组合物，其组合及其作为药物的用途，特别是用于通过BACE-抑制剂的抑制治疗阿尔茨海默病或糖尿病， 1或BACE-2。
-
7.发明申请OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS 审中-公开氧合物衍生物及其在治疗神经疾病中的应用公开(公告)号：US20150018338A1
公开(公告)日：2015-01-15
申请号：US14324883
申请日：2014-07-07
申请人： Sangamesh BADIGER , Murali CHEBROLU , Mathias FREDERIKSEN , Philipp HOLZER , Konstanze HURTH , Rainer Martin LEUOEND , Rainer MACHAUER , Henrik MOEBITZ , Ulf NEUMANN , Rita RAMOS , Henrich RUEEGER , Michael SCHAEFER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
发明人： Sangamesh BADIGER , Murali CHEBROLU , Mathias FREDERIKSEN , Philipp HOLZER , Konstanze HURTH , Rainer Martin LEUOEND , Rainer MACHAUER , Henrik MOEBITZ , Ulf NEUMANN , Rita RAMOS , Henrich RUEEGER , Michael SCHAEFER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
IPC分类号： C07D487/04 , A61K31/5377 , C07D413/14 , C07D471/04 , C07D417/12 , A61K31/553 , C07D413/12
CPC分类号： C07D487/04 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D265/30 , C07D267/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备，其医疗用途和包含它们的药物。
-
8.发明申请Novel Heterocyclic Derivatives and Their Use in the Treatment of Neurological Disorders 有权新型杂环衍生物及其在神经障碍治疗中的应用公开(公告)号：US20140107118A1
公开(公告)日：2014-04-17
申请号：US14136855
申请日：2013-12-20
申请人： Sangamesh BADIGER , Murali CHEBROLU , Konstanze HURTH , Sebastien JACQUIER , Rainer Martin LUEOEND , Rainer MACHAUER , Heinrich RUEEGER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
发明人： Sangamesh BADIGER , Murali CHEBROLU , Konstanze HURTH , Sebastien JACQUIER , Rainer Martin LUEOEND , Rainer MACHAUER , Heinrich RUEEGER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
IPC分类号： C07D413/14 , C07D487/04 , C07D471/04 , A61K31/5377
CPC分类号： C07D413/14 , A61K31/5377 , C07B59/002 , C07B2200/05 , C07D471/04 , C07D487/04 , A61K2300/00
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，其药物组合物，其组合及其作为药物的用途，特别是用于通过BACE-抑制剂的抑制治疗阿尔茨海默病或糖尿病， 1或BACE-2。
-
9.发明申请Oxazine Derivatives and their Use in the Treatment of Neurological Disorders 审中-公开恶嗪衍生物及其在神经障碍治疗中的应用公开(公告)号：US20120172359A1
公开(公告)日：2012-07-05
申请号：US13414440
申请日：2012-03-07
申请人： Sangamesh BADIGER , Murali CHEBROLU , Mathias FREDERIKSEN , Philipp HOLZER , Konstanze HURTH , Rainer Martin LUEOEND , Lei LI , Hui LIU , Rainer MACHAUER , Henrik MOEBITZ , Ulf NEUMANN , Rita RAMOS , Heinrich RUEEGER , Michael SCHAEFER , Siem Jacob VEENSTRA , Marina TINTELNOT-BLOMLEY , Markus VOEGTLE , Xin XIONG
发明人： Sangamesh BADIGER , Murali CHEBROLU , Mathias FREDERIKSEN , Philipp HOLZER , Konstanze HURTH , Rainer Martin LUEOEND , Lei LI , Hui LIU , Rainer MACHAUER , Henrik MOEBITZ , Ulf NEUMANN , Rita RAMOS , Heinrich RUEEGER , Michael SCHAEFER , Siem Jacob VEENSTRA , Marina TINTELNOT-BLOMLEY , Markus VOEGTLE , Xin XIONG
IPC分类号： A61K31/5377 , A61P25/18 , A61P25/00 , A61P35/00 , A61P25/22 , A61P25/08 , A61P25/06 , A61P25/24 , A61P25/28 , A61P29/00 , A61P17/04 , A61P1/08 , A61P3/04 , A61P21/02 , A61P27/16 , A61P27/06 , A61P25/30 , C07D413/12
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备，其医疗用途和包含它们的药物。
-
10.发明申请Novel Heterocyclic Derivatives and Their Use in the Treatment of Neurological Disorders 审中-公开新型杂环衍生物及其在神经障碍治疗中的应用公开(公告)号：US20150203481A1
公开(公告)日：2015-07-23
申请号：US14482662
申请日：2014-09-10
申请人： Sangamesh BADIGER , Murali CHEBROLU , Konstanze HURTH , Sebastien JACQUIER , Rainer Martin LUEOEND , Rainer MACHAUER , Heinrich RUEEGER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
发明人： Sangamesh BADIGER , Murali CHEBROLU , Konstanze HURTH , Sebastien JACQUIER , Rainer Martin LUEOEND , Rainer MACHAUER , Heinrich RUEEGER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
IPC分类号： C07D413/14 , C07D487/04 , C07D471/04 , A61K31/5377
CPC分类号： C07D413/14 , A61K31/5377 , C07B59/002 , C07B2200/05 , C07D471/04 , C07D487/04 , A61K2300/00
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，其药物组合物，其组合及其作为药物的用途，特别是用于通过BACE-抑制剂的抑制治疗阿尔茨海默病或糖尿病， 1或BACE-2。
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.024 秒)
