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1.发明授权公开(公告)号：US09012451B2
公开(公告)日：2015-04-21
申请号：US13462187
申请日：2012-05-02
IPC分类号： A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D487/08 , C07D453/02 , A61P25/18 , A61P25/08 , A61P25/16 , A61P33/06 , A61P25/02 , A61P25/28
CPC分类号： A61K31/439 , A61K9/20 , A61K31/444 , C07D453/02 , C07D487/08
摘要： The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及式I的1-氮杂 - 双环烷基衍生物，其中X是CH 2或单键; Y是一组式，其中R具有本说明书中定义的含义，该化合物是α7烟碱型乙酰胆碱受体（nAChR）激动剂; 其制备方法，它们作为药物的用途以及包含它们的药物组合物。
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公开(公告)号：US08236803B2
公开(公告)日：2012-08-07
申请号：US12262896
申请日：2008-10-31
IPC分类号： A61K31/501 , C07D401/12 , A61P25/18 , A61P25/16 , A61P25/28 , A61P25/08 , A61P9/10
CPC分类号： A61K31/439 , A61K9/20 , A61K31/444 , C07D453/02 , C07D487/08
摘要： The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及式I的1-氮杂 - 双环烷基衍生物，其中X是CH 2或单键; Y是一组式，其中R具有本说明书中定义的含义，该化合物是α7烟碱型乙酰胆碱受体（nAChR）激动剂; 其制备方法，它们作为药物的用途以及包含它们的药物组合物。
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3.发明申请AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS 有权AZA-BICYCLOALKYL ETHERS及其作为ALPHA7-NACHR AGONISTS的用途公开(公告)号：US20090054446A1
公开(公告)日：2009-02-26
申请号：US12262896
申请日：2008-10-31
IPC分类号： C07D453/02 , A61K31/501 , A61K31/506 , A61K31/439 , A61P25/00 , A61P25/28 , A61P25/18
CPC分类号： A61K31/439 , A61K9/20 , A61K31/444 , C07D453/02 , C07D487/08
摘要： The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及式I的1-氮杂 - 双环烷基衍生物，其中X是CH 2或单键; Y是一组式，其中R具有本说明书中定义的含义，该化合物是α7烟碱型乙酰胆碱受体（nAChR）激动剂; 其制备方法，它们作为药物的用途以及包含它们的药物组合物。
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公开(公告)号：US08211902B2
公开(公告)日：2012-07-03
申请号：US13089943
申请日：2011-04-19
申请人： Timothy John Ritchie , Andrew James Culshaw , Christopher Thomas Brain , Edward Karol Dziadulewicz , Terance William Hart
发明人： Timothy John Ritchie , Andrew James Culshaw , Christopher Thomas Brain , Edward Karol Dziadulewicz , Terance William Hart
IPC分类号： A61K31/517
CPC分类号： C07D401/04 , C07D239/91
摘要： The present invention relates to the use of a quinazolinone compound of the formula (I) wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form, as a vanilloid.
摘要翻译： 本发明涉及式（I）的喹唑啉酮化合物，其中R 1，R 2，R 3，R 4，R 5和m如说明书和权利要求中所定义，为游离形式或盐形式， 在可能的情况下，以酸加成盐形式，作为香草素。
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公开(公告)号：US20090082365A1
公开(公告)日：2009-03-26
申请号：US12095995
申请日：2006-12-06
申请人： Gurdip Bhalay , Andrew James Culshaw , Edward Karol Dziadulewicz , Christopher Thomas Brain , Timothy John Ritchie , David Beattie , Kamlesh Jagdis Bala , Alice Brewer , Glyn Hughes
发明人： Gurdip Bhalay , Andrew James Culshaw , Edward Karol Dziadulewicz , Christopher Thomas Brain , Timothy John Ritchie , David Beattie , Kamlesh Jagdis Bala , Alice Brewer , Glyn Hughes
IPC分类号： A61K31/517 , C07D239/90 , C07D401/04 , C07D403/04
CPC分类号： C07D239/95 , C07D239/91 , C07D401/04 , C07D403/04
摘要： The present invention relates to quinazolinone compounds of the formula wherein R2, R3, R5, R6, R7 and R8 are as defined in the specification and in the claims, in free form or in salt form, processes for their preparation and their use as pharmaceuticals, particularly in the treatment of disorders ameliorated by administration of TRPV1 antagonists.
摘要翻译： 本发明涉及下式的喹唑啉酮化合物，其中R2，R3，R5，R6，R7和R8如说明书和权利要求中所定义，以游离形式或盐形式，其制备方法及其作为药物的用途 特别是在通过施用TRPV1拮抗剂而改善的疾病的治疗中。
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公开(公告)号：US08765743B2
公开(公告)日：2014-07-01
申请号：US12994253
申请日：2009-06-03
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号： A61K31/4439 , A61K31/5377 , A61K31/4545 , A61K31/496 , C07D401/14 , C07D413/14 , C07D405/14 , C07D471/04
CPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D471/04
摘要： The invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译： 本发明涉及式（I）的化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号：US20120238571A1
公开(公告)日：2012-09-20
申请号：US13513079
申请日：2010-12-03
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Christian Alan Paul Smethurst
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Katherine Louise Jones , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Christian Alan Paul Smethurst
IPC分类号： C07D417/14 , A61K31/437 , A61K31/4439 , A61K31/427 , C07D413/14 , C07D471/04 , A61P11/00 , A61P37/08 , A61P37/00 , A61P29/00 , A61P9/00 , A61P25/28 , A61P1/18 , A61P13/12 , A61P35/00 , A61P15/00 , A61P41/00 , A61P25/00 , A61P11/06 , A61P19/02 , A61P1/00 , A61P9/10 , A61K31/5377
CPC分类号： C07D417/14 , C07D417/12 , C07D471/04
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译： 本发明涉及某些新化合物。 具体地，本发明涉及式（I）的化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号：US20120238559A1
公开(公告)日：2012-09-20
申请号：US13513048
申请日：2010-12-03
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号： A61K31/4439 , A61P37/08 , A61P37/06 , A61P29/00 , A61P9/00 , A61P25/28 , A61P13/12 , A61P7/02 , A61P35/00 , A61P15/00 , A61P9/10 , A61P19/02 , A61P11/06 , C07D401/14 , C07D471/04 , A61K31/437 , C07D413/14 , A61K31/422 , C07D403/14 , A61K31/416 , C07D417/14 , A61K31/427 , C07D491/048 , A61K31/4355 , A61K31/5377 , A61K31/541 , A61K31/4545 , A61P11/00
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/048
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译： 本发明涉及某些新化合物。 具体地，本发明涉及式（I）的化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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公开(公告)号：US20120015932A1
公开(公告)日：2012-01-19
申请号：US13202139
申请日：2010-02-24
申请人： Heather Hobbs , Simon Teanby Hodgson , Yannick Maurice LaCroix , Deborah Needham , Nigel James Parr , Panayiotis Alexandrou Procopiou , Timothy John Ritchie , Michael David Woodrow
发明人： Heather Hobbs , Simon Teanby Hodgson , Yannick Maurice LaCroix , Deborah Needham , Nigel James Parr , Panayiotis Alexandrou Procopiou , Timothy John Ritchie , Michael David Woodrow
IPC分类号： A61K31/416 , C07D413/14 , C07D409/14 , A61K31/5377 , A61P29/00 , A61K31/496 , A61K31/422 , A61K31/4178 , A61P37/00 , C07D409/12 , A61K31/454
CPC分类号： C07D409/12 , C07D409/14 , C07D413/14
摘要： Indazole compounds, processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing such compounds and their use in therapy.
摘要翻译： 吲唑化合物，其制备方法，可用于这些方法的中间体，含有这些化合物的药物组合物及其在治疗中的用途。
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公开(公告)号：US20110178063A1
公开(公告)日：2011-07-21
申请号：US12994250
申请日：2009-06-03
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号： A61K31/553 , C07D413/14 , A61K31/5377 , C07D417/14 , A61K31/541 , A61K31/5386 , C07D401/14 , A61K31/454 , A61K31/427 , A61K31/496 , A61K31/4439 , C07D471/04 , A61K31/4985 , C07D487/04 , A61K31/519 , A61P11/00 , A61P37/08 , A61P9/00 , A61P19/02 , A61P25/28 , A61P1/00 , A61P7/02 , A61P29/00
CPC分类号： C07D231/56
摘要： The invention is directed to certain novel compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译： 本发明涉及某些新的式（I）化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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