摘要:
Compounds of formula (I), wherein R is a hydrogen atom or a carboxy, alkoxycarbonyl, --CO--NR.sub.4 R.sub.5, --PO.sub.3 H.sub.2 or --CH.sub.2 OH radical, and R.sub.1 is an -alk-NH.sub.2, -alk-NH--CO--R.sub.3, -alk-COOR.sub.4, -alk-CO--NR.sub.5 R.sub.6 or --CO--NH--R.sub.7 radical. The compounds of formula (I) have valuable pharmacological properties and are antagonists of the .alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor also known as the quisqualate receptor. Furthermore, the compounds of formula (I) are non-competitive antagonists of the N-methyl-D-aspartame (NMDA) receptor and more specifically are ligands for NMDA receptor glycine modulator sites.
摘要:
A compound of formula (II): ##STR1## in which R is a hydrogen atom or a carboxy, alkoxycarbonyl, --CO--NR.sub.4 R.sub.5, --PO.sub.3 H.sub.2 or --CH.sub.2 OH radical, and R.sub.1 is an -alk-NH.sub.2, -alk-NH--CO--R.sub.3, -alk-COOR.sub.4, -alk-CO--NR.sub.5 R.sub.6 or --CO--NH--R.sub.7 radical. The compounds of formula (II) can be used to prepare compounds of formula (I): ##STR2## in which R and R.sub.1 have the same meanings as above. The compounds of formula (I) have valuable pharmacological properties and are antagonists of the .alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, also known as the quisqualate receptor. The compounds of formula (I) are also non-competitive antagonists of the N-methyl-D-aspartate (NMDA) receptor and more specifically are ligands for NMDA receptor glycine modulator sites.
摘要:
Novel compounds having the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
摘要:
A nitroxide radical of the formula (I) or (II): ##STR1## in which R.sub.1 and R.sub.2 are independently chosen from among the optionally deuterated alkyl, alkoxyl, dialkylaminyl and phenyl radicals, H, D or Cl; R.sub.3, R.sub.8 and R.sub.9 are independently chosen from among the optionally deuterated alkyl, alkoxyl and phenyl radicals; R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are independently chosen from among the optionally deuterated alkyl, alkoxyl, dialkylaminyl and phenyl radicals, COOH, OH, OD, H, D, a halogen, COOR (in which R is an alkyl radical); R.sub.10 and R.sub.11 are independently chosen from among optionally deuterated alkyl, alkoxyl, dialkylaminyl and phenyl radicals, COOH, OH, OD, H, D, a halogen, COOR (in which R is an alkyl radical) or represent an oxygen atom linked with the cycle of the radical by a double bond is described.
摘要翻译:式(I)或(II)的氮氧自由基:其中R 1和R 2独立地选自任选的氘代烷基,烷氧基,二烷基氨基和苯基,H, D或Cl; R3,R8和R9独立地选自任选的氘代烷基,烷氧基和苯基; R 4,R 5,R 6和R 7独立地选自任选的氘代烷基,烷氧基,二烷基氨基和苯基,COOH,OH,OD,H,D,卤素,COOR(其中R是烷基) R 10和R 11独立地选自氘代烷基,烷氧基,二烷基氨基和苯基,COOH,OH,OD,H,D,卤素,COOR(其中R是烷基)或代表与 描述了基团的双键循环。
摘要:
This invention relates to novel 4-hydroxy-5-(substituted phosphinyl)ethyleneureas of the general Formula I ##STR1## to methods of making the same, to flame resistant compositions containing such compounds and to the use of compositions containing such compounds to impart flame resistance to cellulose and cellulose containing materials.In the compounds of the Formula I X or Y may be hydrogen or alkyl, R.sub.1 and R.sub.2 may be the same or different radicals including alkoxy, cycloalkoxy, aryloxy, arylalkoxy, alkyl, aryl as well as such radicals containing substituents such as halogen; in addition, R.sub.1 and/or R.sub.2 may be hydroxy.