公开(公告)号：US6002062A

公开(公告)日：1999-12-14

申请号：US204503

申请日：1998-12-04

申请人： Dominique Michel ,  Paul Hanselmann

发明人： Dominique Michel ,  Paul Hanselmann

IPC分类号： B01J21/04 ,  C07B61/00 ,  C07C1/20 ,  C07C1/22 ,  C07C13/04 ,  C07C2/00

CPC分类号： C07C13/04 ,  C07C1/20 ,  C07C2101/02 ,  Y02P20/52

摘要： Ethynylcyclopropane is prepared from (1,1-dimethoxyethyl)cyclopropane by a two-stage elimination of methanol. Ethynylcyclopropane is an intermediate in the synthesis of pharmaceutically active ingredients, for example, antiviral agents.

摘要翻译： 乙炔基环丙烷由（1,1-二甲氧基乙基）环丙烷通过两步除甲醇制备。 乙炔基环丙烷是合成药物活性成分的中间体，例如抗病毒剂。

公开(公告)号：US20110207946A1

公开(公告)日：2011-08-25

申请号：US13064147

申请日：2011-03-08

申请人： Dominique Michel ,  Hanspeter Mettler ,  John McGarrity

发明人： Dominique Michel ,  Hanspeter Mettler ,  John McGarrity

IPC分类号： C07D333/20

CPC分类号： C07C213/00 ,  C07B2200/07 ,  C07D333/22

摘要： Provided is a process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols, particularly of (S)-(−)- and (R)-(+)-3-N-methylamino-1-(2-thienyl)-1-propanol, by asymmetrically hydrogenating salts of a carboxylic acids with an aminoketone of formula (II), wherein R1 is selected from the group consisting of 2-thienyl, 2-furanyl and phenyl, each optionally substituted with one or more halogen atoms and/or one or more C1-4-alkoxy groups, and wherein R2 is C1-4-alkyl or phenyl, each optionally substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, and wherein the corresponding aminoalcohols are obtained by subsequent hydrolysis of their salts. Furthermore provided are salts of a carboxylic acid with said aminoketones and the aminoalcohols obtained by asymmetriacally hydrogenating said aminoketones, respectively.

摘要翻译： 提供了制备对映体纯的1-取代-3-氨基醇，特别是（S） - （ - ） - 和（R） - （+） - 3-N-甲基氨基-1-（2-噻吩基） -1-丙醇，通过用式（II）的氨基酮不对称氢化羧酸盐，其中R 1选自2-噻吩基，2-呋喃基和苯基，每个任选被一个或多个卤素原子取代 和/或一个或多个C 1-4 - 烷氧基，并且其中R 2是C 1-4 - 烷基或苯基，各自任选被一个或多个卤素原子和/或一个或多个C 1-4 - 烷基或C 1-4 - 烷氧基，并且其中相应的氨基醇通过其盐的随后水解获得。 此外，还提供了羧酸与所述氨基酮和通过不对称地氢化所述氨基酮而获得的氨基醇的盐。

公开(公告)号：US07921512B2

公开(公告)日：2011-04-12

申请号：US12093142

申请日：2006-11-09

申请人： Dominique Michel

发明人： Dominique Michel

IPC分类号： A47H15/00

CPC分类号： B64D11/0023 ,  Y10T16/35 ,  Y10T16/364 ,  Y10T16/379 ,  Y10T16/381 ,  Y10T16/3825

摘要： An improved arrangement for a transverse dividing element includes an upper cross beam (32), each free end of the cross beam being guided longitudinally by way of an associated guiding structure. The guiding structure includes a slide having a groove in which a free end (34) of the cross beam (32) can slide longitudinally, the free end being equipped with guiding (92, 100) and a locking (102, 104) element. The transverse dividing element can be used to guide an upper cross beam supporting a transverse element that is used to divide the internal space of an aircraft cabin.

摘要翻译： 用于横向分割元件的改进的布置包括上横梁（32），横梁的每个自由端通过相关联的引导结构被纵向地引导。 引导结构包括具有凹槽的滑块，其中横梁（32）的自由端（34）可以纵向滑动，自由端配备有引导件（92,100）和锁定元件（102,104）。 横向分割元件可以用于引导支撑横向元件的上横梁，该横向元件用于分割飞机机舱的内部空间。

公开(公告)号：US6139224A

公开(公告)日：2000-10-31

申请号：US209471

申请日：1998-12-11

申请人： Dominique Michel ,  Francois Gabriel Sedillot ,  Nicolas Francois Andre Parsloe ,  Vincent Frederic Paul Foglia

发明人： Dominique Michel ,  Francois Gabriel Sedillot ,  Nicolas Francois Andre Parsloe ,  Vincent Frederic Paul Foglia

IPC分类号： B63B35/44

CPC分类号： B63B35/4413 ,  B63B1/107 ,  B63B2001/145 ,  B63B2021/505

摘要： The platform comprises a buoyant sub-structure comprising a base and a plurality of columns upstanding from said base, a buoyant deck-hull mounted on the columns and means for ballasting and deballasting at least the base of said sub-structure. It further comprises means for tangentially guiding said deck-hull on said columns during deployment of the platform into a predetermined configuration by ballasting of the sub-structure while the deck-hull is floating and means for locking said deck-hull to the columns in said predetermined configuration.

摘要翻译： 平台包括浮力子结构，其包括基部和从所述基部竖立的多个柱，安装在柱上的浮力甲板船体和至少所述子结构的基部的压载和卸载的装置。 其还包括用于在甲板船体浮起时将平台部署到预定构造中以将该平台部署到预定构造中的装置，用于在所述塔架上切向引导所述甲板船体，并且用于将所述甲板船体锁定在所述塔架中的列 预定配置。

公开(公告)号：US4797034A

公开(公告)日：1989-01-10

申请号：US34944

申请日：1987-04-06

申请人： Loic M. J. Danguy des Deserts ,  Francois G. Sedillot ,  Dominique Michel

发明人： Loic M. J. Danguy des Deserts ,  Francois G. Sedillot ,  Dominique Michel

IPC分类号： B63B35/44 ,  E02B17/02

CPC分类号： B63B35/4406 ,  E02B17/027 ,  E02B2017/0073

摘要： A platform comprising a deck supported by a tower composed of a rigid fixed structure of the jacket type anchored to the sea floor and of an oscillating structure supported by, and connected to, the fixed structure by flexible piles anchored in the lower part of the fixed structure and arranged on the periphery of the oscillating structure, and by a shear device, the oscillating structure being equipped with a floater. The connection between the fixed and oscillating structures is located in a zone between 30 and 60% of the water depth from the water level.

摘要翻译： 一种平台，包括一由甲板支撑的甲板，该塔架由锚固在海底的护套类型的刚性固定结构构成，以及摆动结构，该固定结构由锚固在固定结构的下部的柔性桩支撑并固定在固定结构上 该结构设置在摆动结构的周围，以及一个剪切装置，该摆动结构配有浮子。 固定和振动结构之间的连接位于距离水位的水深的30％至60％之间的区域。

公开(公告)号：US4416473A

公开(公告)日：1983-11-22

申请号：US275394

申请日：1981-06-19

申请人： Jacques E. Lamy ,  Dominique Michel ,  Francisco D. M. Serrano

发明人： Jacques E. Lamy ,  Dominique Michel ,  Francisco D. M. Serrano

IPC分类号： E21B17/08 ,  F16L27/103 ,  F16L27/10

CPC分类号： E21B17/085 ,  F16L27/103

摘要： A flexible joint for connection of two pipes comprises a cup-shaped piece which can be connected to a first pipe, a tubular piece which can be connected to a second pipe, the tubular piece being coaxial with the cuplike piece and being arranged partially inside it, and two flexible spherical rings arranged between the cuplike piece and the tubular piece. The two flexible spherical rings are bolted together and arranged on opposite sides of the center of oscillation, the concave surfaces of the rings being directed towards the center of oscillation and being concentric with respect to this center.

摘要翻译： 用于连接两根管子的柔性接头包括可与第一管连接的杯形件，可连接到第二管的管状件，管件与杯形件同轴并且部分地设置在其内部 以及布置在杯状件和管状件之间的两个柔性球形环。 两个柔性球形环被螺栓连接在一起并且布置在振动中心的相对侧上，环的凹面指向振荡中心并且相对于该中心是同心的。

公开(公告)号：US08558014B2

公开(公告)日：2013-10-15

申请号：US12868419

申请日：2010-08-25

申请人： Dominique Michel ,  Rudolf Fuchs

发明人： Dominique Michel ,  Rudolf Fuchs

IPC分类号： C07D333/06 ,  C07D333/26 ,  C07D307/46

CPC分类号： C07D333/20 ,  C07C213/00 ,  C07C221/00 ,  C07C225/16 ,  C07D307/42 ,  C07D307/46 ,  C07D307/52 ,  C07D307/80 ,  C07D333/16 ,  C07D333/22 ,  C07D333/56

摘要： A process is disclosed for the preparation of a compound of formula and/or an addition salt of a proton acid, wherein R1 and R2 independently represent alkyl, cycloalkyl, aryl or aralkyl, each aryl or aralkyl being optionally further substituted with alkyl, alkoxy and/or halogen. The process involves reacting a mixture comprising a methyl ketone of formula and a compound of formula H2N—R2 (V) and/or an addition salt of proton acid, and formaldehyde in the presence of a solvent selected from the group consisting of water, aliphatic alcohols, cycloaliphatic alcohols and mixtures thereof, and optionally a proton acid to afford a β-amino ketone of formula and/or an addition salt of a proton acid, and reducing the carbonyl group of said β-amino ketone to afford a compound of formula I, and/or an addition salt of a proton acid wherein the first step is carried out at a pressure above 1.5 bar.

摘要翻译： 公开了用于制备式和/或质子酸加成盐的方法，其中R 1和R 2独立地表示烷基，环烷基，芳基或芳烷基，每个芳基或芳烷基任选进一步被烷基，烷氧基和 /或卤素。 该方法包括使含有式的甲基酮和式H2N-R2（V）的化合物和/或质子酸的加成盐和甲醛的混合物在选自水，脂族的溶剂 醇，脂环族醇及其混合物，以及任选的质子酸，得到式的β-氨基酮和/或质子酸的加成盐，并还原所述β-氨基酮的羰基，得到式 I和/或质子酸的加成盐，其中第一步在高于1.5巴的压力下进行。

公开(公告)号：US08501967B2

公开(公告)日：2013-08-06

申请号：US13560621

申请日：2012-07-27

申请人： Walter Brieden ,  Martin Clausen ,  John McGarrity ,  Hanspeter Mettler ,  Dominique Michel

发明人： Walter Brieden ,  Martin Clausen ,  John McGarrity ,  Hanspeter Mettler ,  Dominique Michel

IPC分类号： C07D333/22

CPC分类号： C07C303/22 ,  C07B2200/07 ,  C07C213/02 ,  C07C221/00 ,  C07C309/04 ,  C07C309/07 ,  C07C309/30 ,  C07C215/30 ,  C07C225/16

摘要： A process for the preparation of N-monosubstituted β-aminoalcohol sulfonates of formula (1a), (1b): wherein R1 is C6-20-aryl or C4-12-heteroaryl, each optionally being substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, R2 is C1-4-alkyl or C6-20-aryl, each aryl optionally being substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, and wherein R3 is selected from the group consisting of C1-18-alkyl, C6-20-cycloalkyl, C6-20-aryl and C7-20-aralkyl residues; including a) reacting a methyl ketone, a primary amine, formaldehyde and a sulfonic acid, at a pressure above 1.5 bar, optionally in a organic solvent, said organic solvent which can include water to provide N-monosubstituted β-aminoketone sulfonates of formula (II): wherein R1, R2 and R3 are as defined above, and b) asymmetrically hydrogenating.

摘要翻译： 制备式（1a），（1b）的N-单取代的β-氨基醇磺酸盐的方法：其中R1是C6-20-芳基或C4-12 - 杂芳基，每个任选被一个或多个卤素原子和/ 或一个或多个C 1-4 - 烷基或C 1-4 - 烷氧基，R 2是C 1-4 - 烷基或C 6-20 - 芳基，每个芳基任选地被一个或多个卤素原子和/或一个或多个C 1〜 4-烷基或C 1-4 - 烷氧基，并且其中R 3选自C 1-18 - 烷基，C 6-20 - 环烷基，C 6-20 - 芳基和C 7-20 - 芳烷基残基; 包括a）使甲基酮，伯胺，甲醛和磺酸在高于1.5巴的压力下，任选地在有机溶剂中反应，所述有机溶剂可包括水以提供式（III）的N-单取代的β-氨基酮磺酸盐 II）：其中R1，R2和R3如上定义，和b）不对称氢化。

公开(公告)号：US20100312003A1

公开(公告)日：2010-12-09

申请号：US12682479

申请日：2008-10-10

申请人： Walter Brieden ,  Dominique Michel ,  Wilhelm Quittmann ,  Fabio Rainone ,  Jie-Hui Pan ,  Hang-Bing Fang ,  Ying-Xia Song

发明人： Walter Brieden ,  Dominique Michel ,  Wilhelm Quittmann ,  Fabio Rainone ,  Jie-Hui Pan ,  Hang-Bing Fang ,  Ying-Xia Song

IPC分类号： C07C203/04 ,  C12P13/00

CPC分类号： C07C201/02 ,  C07C201/12 ,  C07C203/04 ,  C07C205/57

摘要： The present invention relates to a process for the preparation of organic nitrates having at least one nitryloxy and at least one hydroxy group, wherein the at least one hydroxy group may be present in form of an esterified hydroxy residue, the latter being esterified with an acid other than nitric acid.

摘要翻译： 本发明涉及一种制备具有至少一个硝基氧基和至少一个羟基的有机硝酸盐的方法，其中至少一个羟基可以酯化羟基残基的形式存在，后者用酸酯化 硝酸除外。

公开(公告)号：US20080313964A1

公开(公告)日：2008-12-25

申请号：US12093378

申请日：2006-11-09

申请人： Dominique Michel

发明人： Dominique Michel

IPC分类号： E05D15/06

CPC分类号： B64D11/0023 ,  E05D15/0652 ,  E05Y2201/684 ,  E05Y2400/658 ,  E05Y2800/28 ,  E05Y2900/502

摘要： The invention relates to an assembly of the type that comprises a guiding slide (36) consisting of a groove (40) having an inner wall which defines longitudinal guiding and/or rolling channels for complementary elements (92) borne by a guiding and/or rolling carriage (34) which is connected to a sub-assembly. The invention is characterised in that the inner wall of the groove (40) comprises at least one longitudinal electrical strip conductor (180) with which electrical contact means (190) can co-operate, said electrical contact means being borne by the guiding carriage (34) and being electrically connected to at least one associated electrical and/or electronic component of the sub-assembly. The invention can be used to guide an upper cross beam supporting a transverse element that is used to divide the internal space of an aircraft cabin.

摘要翻译： 本发明涉及一种类型的组件，其包括导向滑块（36），该引导滑块（36）由具有内壁的凹槽（40）组成，该内壁限定用于互补元件（92）的纵向引导和/或滚动通道，所述互补元件（92）由导向和/ 滚动架（34），其连接到子组件。 本发明的特征在于，凹槽（40）的内壁包括至少一个纵向电条导体（180），电接触装置（190）可以与之配合，所述电接触装置由导向滑架承载 34）并且电连接到子组件的至少一个相关联的电和/或电子部件。 本发明可用于引导支撑用于划分飞机机舱的内部空间的横向元件的上横梁。