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公开(公告)号：US08444668B2
公开(公告)日：2013-05-21
申请号：US11662847
申请日：2005-09-16
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12172 , A61B2017/00867
摘要： A vascular occlusion device that includes an inner embolic member at least partially covered by an expandable generally tubular mesh. The expandable tubular mesh typically comprises a unitary wall with apertures through the wall to assist in the expansion of the generally tubular mesh.
摘要翻译： 一种血管闭塞装置，其包括至少部分被可扩张的大体管状网状物覆盖的内部栓塞构件。 可膨胀的管状网通常包括具有穿过壁的孔的整体壁，以有助于大体上管状的网状物的膨胀。
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公开(公告)号：US07811300B2
公开(公告)日：2010-10-12
申请号：US11662816
申请日：2005-09-16
IPC分类号： A61B17/08
CPC分类号： A61B17/12022 , A61B17/12036 , A61B17/12109 , A61B17/12172 , A61B2017/00867 , A61B2017/1205 , A61B2017/12054
摘要： Thin film devices implantable within a human subject for occlusion of an aneurysm or body vessel are provided. The devices are movable from an elongated, collapsed configuration for delivery to a deployed configuration within the body. Open slots in selected portions of the device telescope as the device moves to its deployed configuration, which causes the associated portions to longitudinally foreshorten and radially expand, while also decreasing in porosity for preventing blood flow. Closed slits in other portions of the device open as the device moves to its deployed configuration, which causes the associated portions to longitudinally foreshorten and radially expand, while remaining open for fluid flow or endothelialization. The occlusion devices may be either self-supporting or supported by a strut structure. Additionally, the occlusion devices may comprise a plurality of mesh layers having unaligned pore systems which further reduce porosity in desired portions of the deployed configuration.
摘要翻译： 提供了植入人体受试者内用于闭塞动脉瘤或体内血管的薄膜装置。 这些装置可以从细长的，折叠的构型移动，以便输送到主体内的展开构型。 当设备移动到其展开的构型时，在设备望远镜的选定部分中开放狭槽，这导致相关部分纵向缩短并且径向膨胀，同时孔隙度也降低以防止血液流动。 当装置移动到其展开构型时，装置的其它部分中的封闭狭缝打开，这导致相关部分纵向缩短并径向膨胀，同时保持打开以用于流体流动或内皮化。 闭塞装置可以是自支撑的或由支柱结构支撑。 另外，闭塞装置可以包括具有未对准孔系统的多个网眼层，其进一步降低展开构型的期望部分中的孔隙率。
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公开(公告)号：US07875044B2
公开(公告)日：2011-01-25
申请号：US11663489
申请日：2005-10-14
IPC分类号： A61B17/08
CPC分类号： A61B17/12022 , A61B17/12118 , A61B17/12172 , A61B2017/12054 , A61F2002/823
摘要： A method of occluding a defect in the wall of a body vessel is provided. An outlet portion of a microcatheter is delivered to the defect, then at least a body portion of a thin film occlusion device is radially expanded from a collapsed orientation to a deployed orientation for engaging the microcatheter and covering at least a portion of the defect. Thereafter, an embolic media is released into the defect from the microcatheter for facilitating thrombosis. The body portion of the occlusion device is substantially porous in the collapsed orientation, but substantially non-porous in the deployed orientation for preventing prolapse of the embolic media into the body vessel.
摘要翻译： 提供了一种在身体容器的壁中闭塞缺陷的方法。 微导管的出口部分被输送到缺陷，然后薄膜闭塞装置的至少主体部分从收缩方向径向扩张到展开方向，以便与微导管接合并覆盖缺陷的至少一部分。 此后，栓塞介质从微导管释放到缺陷中以便于血栓形成。 闭塞装置的主体部分在塌缩方向上基本上是多孔的，但是在展开方向上基本上是无孔的，以防止栓塞介质向身体容器脱垂。
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公开(公告)号：US08361104B2
公开(公告)日：2013-01-29
申请号：US11663133
申请日：2005-09-16
IPC分类号： A61F2/06
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12172 , A61B2017/00867
摘要： A vascular occlusion device that includes a central support member that has at least one mesh embolic ribbon extending outwardly from the central support member in the generally radial direction is provided. The mesh embolic ribbon has a collapsed and an expanded configuration.
摘要翻译： 提供一种血管阻塞装置，其包括中心支撑构件，所述中央支撑构件具有沿大致径向方向从中心支撑构件向外延伸的至少一个网状栓状带。 网状带状带具有折叠和扩张的构造。
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公开(公告)号：US11083364B2
公开(公告)日：2021-08-10
申请号：US13539661
申请日：2012-07-02
IPC分类号： A61B1/018 , A61B17/04 , A61B1/04 , A61B17/06 , A61B17/062 , A61B17/068 , A61B17/00 , A61B17/064 , A61B17/29
摘要： An endoscopic tissue grasper device includes a flexible tubular member, a flexible shaft extending through the tubular member, a proximal handle for moving the shaft and tubular member relative to each other, and a distal helical coil having a sharpened end for engaging tissue. The tissue grasper is advanced through a working channel of an endoscope, engaged relative to tissue, and retracted to pull tissue into a path of a movable needle coupled at a distal end of the endoscope so that the needle can be passed through the tissue. The needle is preferably provided with a suture so that as the needle is passed through the tissue a stitch is formed.
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公开(公告)号：US09943313B2
公开(公告)日：2018-04-17
申请号：US14759053
申请日：2014-01-02
CPC分类号： A61B17/12109 , A61B17/1214 , A61B17/12145 , A61B17/12154 , A61B2017/00367 , A61B2017/1205 , A61B2017/12054
摘要： A medical implant deployment system for placing an implant at a preselected site comprising a deployment system that includes a mechanical coupling assembly at the distal end of a delivery member that engages the proximal end of the implant and a release member having an extended configuration in which the release member cooperatively maintains the coupling assembly engagement with the implant proximal end and a retracted configuration where the release member allows the coupling assembly to disengage from the implant proximal end. An attachable handle assembly is provided to place the release member in the retracted configuration allowing the coupling assembly to disengage from the implant proximal end, thereby releasing the implant.
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公开(公告)号：US08911467B2
公开(公告)日：2014-12-16
申请号：US13413275
申请日：2012-03-06
申请人： Vladimir Mitelberg , Donald K. Jones , David Y. Yuan , Brett E. Naglreiter , J. Landon Gilkey , Christopher J. Gostout , Pankaj J. Pasricha
发明人： Vladimir Mitelberg , Donald K. Jones , David Y. Yuan , Brett E. Naglreiter , J. Landon Gilkey , Christopher J. Gostout , Pankaj J. Pasricha
IPC分类号： A61M29/00 , A61B17/34 , A61B17/3207 , A61B18/14 , A61B17/22 , A61B10/02 , A61B17/3205 , A61B18/00 , A61B17/00 , A61B17/32 , A61B17/29 , A61B18/22
CPC分类号： A61B17/320783 , A61B10/0283 , A61B17/22031 , A61B17/32056 , A61B17/3478 , A61B18/1477 , A61B18/1492 , A61B18/22 , A61B2017/00269 , A61B2017/00539 , A61B2017/2937 , A61B2017/320048 , A61B2018/00291 , A61B2018/1407 , A61B2018/1425
摘要： Instruments, systems and methods are provided for performing submucosal medical procedures in a desired area of the digestive tract using endoscopy. Instruments include a safe access needle injection instrument, a submucosal tunneling instrument, a submucosal dissection instrument, a mucosal resection device. Systems include a combination of one or more of such instruments with or without injectable agents. Embodiments of various methods for performing the procedures are also provided.
摘要翻译： 提供了仪器，系统和方法，用于使用内窥镜检查在消化道的期望区域中进行粘膜下的医学过程。 仪器包括安全进针针注射器械，粘膜下隧道仪，粘膜下剥离仪，粘膜切除装置。 系统包括具有或不具有可注射剂的一种或多种这样的仪器的组合。 还提供了用于执行该过程的各种方法的实施例。
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公开(公告)号：US08540763B2
公开(公告)日：2013-09-24
申请号：US11903463
申请日：2007-09-21
IPC分类号： A61F2/06
CPC分类号： A61B17/12022 , A61B17/12118 , A61B2017/1205 , A61F2/91 , A61F2/95 , A61F2002/823 , A61F2230/0008
摘要： A self-expanding aneurysm cover device which takes the form of an outwardly biased cylindrical skeletal frame in which the proximal end of the cylindrical skeletal frame forms a loop which extends at an oblique angle to the axis of the cylindrical skeletal frame. A positioning tab extends from the proximal end of the skeletal frame which when pulled causes the cylindrical skeletal frame to collapse to a reduced diameter for removal of the device from a vessel.
摘要翻译： 一种自膨胀动脉瘤覆盖装置，其采取向外偏压的圆柱形骨架框架的形式，其中圆柱形骨架框架的近端形成以与圆柱形骨架框架的轴线成倾斜角度延伸的环。 定位突片从骨架框架的近端延伸，当被拉动时，该突出部分使得圆柱形骨架框架塌缩到减小的直径，以将装置从容器中取出。
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9.发明授权Methods and systems for submucosal implantation of a device for diagnosis and treatment with a therapeutic agent 有权用于用治疗剂诊断和治疗的装置的粘膜下植入的方法和系统公开(公告)号：US08491472B2
公开(公告)日：2013-07-23
申请号：US13304055
申请日：2011-11-23
申请人： Vladimir Mitelberg , Donald K. Jones , David Y. Yuan , Brett E. Naglreiter , Dennis L. McWilliams , Pankaj J. Pasricha
发明人： Vladimir Mitelberg , Donald K. Jones , David Y. Yuan , Brett E. Naglreiter , Dennis L. McWilliams , Pankaj J. Pasricha
IPC分类号： A61B1/32
CPC分类号： A61B17/3468 , A61B1/00165 , A61B1/2736 , A61B5/4839 , A61B17/22031 , A61B17/29 , A61B17/320016 , A61B17/3478 , A61B90/02 , A61B2017/00269 , A61B2017/00893 , A61B2017/2933 , A61B2017/2937 , A61B2017/306 , A61B2017/320044 , A61B2017/320048 , A61B2017/320056
摘要： Instruments, systems, implants, and methods are provided for performing submucosal medical procedures in a desired area of the digestive tract using endoscopy. Instruments include a safe access needle injection instrument, a submucosal tunneling instrument, a submucosal dissection instrument, and a mucosal resection device. A submucosal implant device for diagnosing and treating disorders of the body may be implanted. A passive submucosal implant device may take the form of a drug delivery depot in which a therapeutic agent within the depot elutes from the depot according to a predetermined elution profile. An active submucosal implant device may take the form of a drug delivery device that incorporates a self-contained diagnostic system to determine the appropriate delivery time and dosage of a therapeutic agent to be administered.
摘要翻译： 提供了仪器，系统，植入物和方法，用于使用内窥镜检查在消化道的期望区域中进行粘膜下的医学程序。 仪器包括安全进针针注射器械，粘膜下隧道仪器，粘膜下剥离仪器和粘膜切除装置。 可以植入用于诊断和治疗身体疾病的粘膜下植入装置。 被动粘膜下植入装置可以采取药物递送贮库的形式，其中贮库内的治疗剂根据预定的洗脱曲线从贮库中洗脱出来。 活性粘膜下移植物装置可以采用药物递送装置的形式，其结合独立的诊断系统以确定要施用的治疗剂的适当递送时间和剂量。
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公开(公告)号：US08128592B2
公开(公告)日：2012-03-06
申请号：US11775996
申请日：2007-07-11
申请人： Vladimir Mitelberg , Donald K. Jones , David Y. Yuan , Brett E. Naglreiter , J. Landon Gilkey , Christopher J. Gostout , Pankaj J. Pasricha
发明人： Vladimir Mitelberg , Donald K. Jones , David Y. Yuan , Brett E. Naglreiter , J. Landon Gilkey , Christopher J. Gostout , Pankaj J. Pasricha
IPC分类号： A61M31/00
CPC分类号： A61B17/320783 , A61B10/0283 , A61B17/22031 , A61B17/32056 , A61B17/3478 , A61B18/1477 , A61B18/1492 , A61B18/22 , A61B2017/00269 , A61B2017/00539 , A61B2017/2937 , A61B2017/320048 , A61B2018/00291 , A61B2018/1407 , A61B2018/1425
摘要： Instruments, systems and methods are provided for performing submucosal medical procedures in a desired area of the digestive tract using endoscopy. Instruments include a safe access needle injection instrument, a submucosal tunneling instrument, a submucosal dissection instrument, a mucosal resection device. Systems include a combination of one or more of such instruments with or without injectable agents. Embodiments of various methods for performing the procedures are also provided.
摘要翻译： 提供了仪器，系统和方法，用于使用内窥镜检查在消化道的期望区域中进行粘膜下的医学过程。 仪器包括安全进针针注射器械，粘膜下隧道仪，粘膜下剥离仪，粘膜切除装置。 系统包括具有或不具有可注射剂的一种或多种这样的仪器的组合。 还提供了用于执行该过程的各种方法的实施例。
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