公开(公告)号：US20060188499A1

公开(公告)日：2006-08-24

申请号：US11353427

申请日：2006-02-14

申请人： Donald Leung ,  Janine Bilsborough ,  Jane Gross

发明人： Donald Leung ,  Janine Bilsborough ,  Jane Gross

IPC分类号： A61K39/395

CPC分类号： C07K16/244 ,  A61K39/3955 ,  A61K49/0008 ,  A61K49/006 ,  A61K2039/505 ,  A61K2039/545 ,  C07K14/52 ,  C07K16/2803 ,  C07K2317/76 ,  G01N33/505 ,  G01N33/6869 ,  G01N33/6881

摘要： The present invention relates to methods of treating patients suffering from itching and puritis mediated by cutaneous lymphocyte antigen positive T cell. In particular, diseases or disorders including contact dermatitis, drug induced delayed type cutaneous allergic reactions, toxic epidermal necrolysis, cutaneous T cell lymphoma, bullous pemphigoid, alopecia aereata, vitiligo, acne rosacea, prurigo nodularis, and herpes simplex virus, or combination thereof will benefit from the administration of an IL-31 antagonist. The invention also includes methods of predicting a therapeutically responsive patient population.

摘要翻译： 本发明涉及治疗患有由皮肤淋巴细胞抗原阳性T细胞介导的瘙痒和精神炎的患者的方法。 特别是，包括接触性皮炎，药物诱发的延迟型皮肤过敏反应，中毒性表皮坏死松解症，皮肤T细胞淋巴瘤，大疱性类天疱疮，秃头症，白癜风，痤疮性红斑痤疮，结节性痤疮，单纯疱疹病毒或其组合的疾病或病症， 受益于IL-31拮抗剂的给药。 本发明还包括预测治疗响应的患者群体的方法。

公开(公告)号：US20060188500A1

公开(公告)日：2006-08-24

申请号：US11353454

申请日：2006-02-14

申请人： Donald Leung ,  Janine Bilsborough ,  Jane Gross

发明人： Donald Leung ,  Janine Bilsborough ,  Jane Gross

IPC分类号： A61K39/395

CPC分类号： C07K16/244 ,  A61K39/3955 ,  A61K49/0008 ,  A61K49/006 ,  A61K2039/505 ,  A61K2039/545 ,  C07K14/52 ,  C07K16/2803 ,  C07K2317/76 ,  G01N33/505 ,  G01N33/6869 ,  G01N33/6881

摘要： The present invention relates to predicting therapeutic response of treating patients suffering from itching and puritis mediated by cutaneous lymphocyte antigen positive T cells in atopic dermatitis. The invention also includes methods of predicting a therapeutically responsive patient population.

摘要翻译： 本发明涉及预测在特应性皮炎中治疗患有瘙痒和由皮肤淋巴细胞抗原阳性T细胞介导的血清的患者的治疗反应。 本发明还包括预测治疗响应的患者群体的方法。

公开(公告)号：US20070048835A1

公开(公告)日：2007-03-01

申请号：US11552721

申请日：2006-10-25

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

IPC分类号： C12P21/06 ,  C07H21/04 ,  C07K14/715

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20070048833A1

公开(公告)日：2007-03-01

申请号：US11552688

申请日：2006-10-25

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

IPC分类号： C07K14/715 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20070048259A1

公开(公告)日：2007-03-01

申请号：US11551356

申请日：2006-10-20

申请人： Julia Novak ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

发明人： Julia Novak ,  Scott Presnell ,  Cindy Sprecher ,  Donald Foster ,  Richard Holly ,  Jane Gross ,  Janet Johnston ,  Andrew Nelson ,  Stacey Dillon ,  Angela Hammond

IPC分类号： A61K48/00 ,  A61K38/19

CPC分类号： C07K14/001 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  A61K38/18 ,  C07K14/52 ,  C07K14/535 ,  C07K14/54 ,  C07K14/5406 ,  C07K14/715 ,  C07K16/24 ,  C07K16/2866 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/24 ,  C07K2319/30 ,  C07K2319/55 ,  C12N15/62 ,  C12N15/8509 ,  C12N2799/026 ,  G01N2333/52 ,  A61K2300/00

摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.

摘要翻译： 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。

公开(公告)号：US20070048223A1

公开(公告)日：2007-03-01

申请号：US11553835

申请日：2006-10-27

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

IPC分类号： A61K51/00 ,  A61K39/395 ,  C07K16/28 ,  C07K16/46

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20060286093A1

公开(公告)日：2006-12-21

申请号：US11458968

申请日：2006-07-20

申请人： Jane Gross ,  Wenfeng Xu ,  Karen Madden ,  David Yee

发明人： Jane Gross ,  Wenfeng Xu ,  Karen Madden ,  David Yee

IPC分类号： A61K38/17 ,  A61K39/395 ,  C07H21/04 ,  C12P21/04 ,  C07K14/74

CPC分类号： C07K14/70578 ,  A61K38/00 ,  C07K16/2875 ,  C07K16/2878 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/30

摘要： Soluble, secreted tumor necrosis factor receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise one cysteine-rich repeat that is homologous to other tumor necrosis factor receptors, such as transmembrane activator and CAML-interactor (TACI). The polypeptides may be used for detecting ligands, agonists and antagonists. The polypeptides may also be used in methods that modulate B cell activation.

摘要翻译： 公开了可溶性，分泌的肿瘤坏死因子受体多肽，编码多肽的多核苷酸，以及相关的组合物和方法。 多肽包含与其它肿瘤坏死因子受体如跨膜激活因子和CAML相互作用因子（TACI）同源的富含半胱氨酸的重复序列。 多肽可用于检测配体，激动剂和拮抗剂。 多肽也可用于调节B细胞活化的方法。

公开(公告)号：US20060286092A1

公开(公告)日：2006-12-21

申请号：US11433267

申请日：2006-05-12

申请人： Zeren Gao ,  Steven Levin ,  Christopher Clegg ,  Jane Gross ,  Wenfeng Xu ,  Frederick Ramsdell ,  Cameron Brandt

发明人： Zeren Gao ,  Steven Levin ,  Christopher Clegg ,  Jane Gross ,  Wenfeng Xu ,  Frederick Ramsdell ,  Cameron Brandt

IPC分类号： A61K39/395 ,  A61K39/00

CPC分类号： C07K14/70532 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/21

摘要： Novel methods of using isolated polypeptides, isolated polynucleotides encoding the polypeptides, and related compositions are disclosed for pNKp30 protein. The methods involved modulating the proliferation of T-cells in vitro and in vivo and modulation of immune response. The present invention also includes methods for producing pNKp30, including soluble molecules, uses therefor and antibodies thereto.

摘要翻译： 公开了使用分离的多肽，编码多肽的分离的多核苷酸和相关组合物的新方法，用于pNKp30蛋白。 所述方法包括在体外和体内调节T细胞的增殖和调节免疫应答。 本发明还包括生产pNKp30的方法，包括可溶性分子，其用途和抗体。

公开(公告)号：US20060034852A1

公开(公告)日：2006-02-16

申请号：US11242294

申请日：2005-10-03

申请人： Mark Rixon ,  Jane Gross

发明人： Mark Rixon ,  Jane Gross

IPC分类号： A61K39/395 ,  C07K16/30

CPC分类号： C07K16/241 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/70578 ,  C07K2319/00 ,  C07K2319/30

摘要： Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor, have proven usefulness in both basic research and as therapeutics. The present invention provides improved soluble transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptors.

公开(公告)号：US20070111266A1

公开(公告)日：2007-05-17

申请号：US11613091

申请日：2006-12-19

申请人： CINDY SPRECHER ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Angela Hammond ,  Jane Gross

发明人： CINDY SPRECHER ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Angela Hammond ,  Jane Gross

IPC分类号： G01N33/567 ,  C07K16/24 ,  C07K16/28

CPC分类号： C07K16/24 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/52 ,  C07K2317/24

摘要： The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

摘要翻译： 本发明涉及zcytor17lig多核苷酸，多肽和抗zcytor17抗体分子。 zcytor17lig是一种新型细胞因子。 多肽可用于刺激免疫系统的方法，体外和体内造血细胞的增殖和/或发育。 本发明还包括生产蛋白质的方法，用途及其抗体。