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    Continuous metal fiber brushes
    1.
    发明授权
    Continuous metal fiber brushes 有权
    连续金属纤维刷

    公开(公告)号：US06245440B1

    公开(公告)日：2001-06-12

    申请号：US09147100

    申请日：1999-02-05

    申请人： Doris Kuhlmann-Wilsdorf ,  David D. Makel ,  George T. Gillies

    发明人： Doris Kuhlmann-Wilsdorf ,  David D. Makel ,  George T. Gillies

    IPC分类号： H01R3924

    CPC分类号： H01R43/12 ,  H01R39/22 ,  H01R39/24 ,  Y10T29/49119 ,  Y10T428/12465

    摘要： A conductive fiber brush including a brush stock composed of plural conductive fibers or strands of fibers at least some of which may have plural bends along the leg of the fibers or strands. The fibers may have a diameter less than 0.2 mm and are arranged in contacting engagement with each other with the touching points among the fibers or strands maintaining elastic tension between the fibers or strands and thereby maintaining voids between the fibers or strands to produce a packing fraction between 1 and 50% and in extreme cases up to 70% but generally between 10-20% depending on the various factors, including the materials used, the current densities to be conducted, and the sliding speeds under operation. The plural bends are implemented by producing fibers or strands having a regular or irregular spiral, wavy, saw-tooth, triangular, and/or rectangular pattern, or other undulating pattern. Optionally, the voids in brush stock may be partially filled with a strengthening, lubricating, abrasive, and/or polishing material, and may be wrapped in an outer sheath, slid into a casing, or provided with an other covering of all or part of the area of the brush stock, be infiltrated or sprayed at the surface with some material, have an increased packing fraction at the surface and/or have some or all of the touching points between the fibers or strands soldered, welded or otherwise thermally joined. Optionally also, the friction among the fibers may be reduced through light lubrication applied by rinsing the brush or brush stock in a lubricant. In one embodiment, the fiber brush is employed in a brush loading device having a hydrostatically controlled brush holder wherein the force exerted on the brush is controlled by a metallic or other conductive hydrostatic fluid which at the same time conducts the current to the brush.

    摘要翻译： 一种导电纤维刷，其包括由多根导电纤维或纤维束构成的刷子，其中至少一些可沿着纤维或股线的腿部具有多个弯曲部。 纤维可以具有小于0.2mm的直径并且布置成彼此接触接合，纤维或股线之间的接触点保持纤维或股线之间的弹性张力，从而保持纤维或股线之间的空隙以产生填充分数 根据各种因素，包括使用的材料，要进行的电流密度，以及正在运行的滑动速度，在1％至50％之间，极端情况下最多可达70％，但通常在10-20％之间。 多个弯曲通过产生具有规则或不规则的螺旋，波浪，锯齿，三角形和/或矩形图案或其它起伏图案的纤维或股线来实现。 可选地，电刷原料中的空隙可以部分地填充有强化，润滑，磨蚀和/或抛光材料，并且可以包裹在外护套中，滑入外壳中，或者设置有全部或部分 刷子坯料的面积在某些材料的表面被渗透或喷射，在表面具有增加的填充分数和/或在焊接，焊接或以其他方式热连接的纤维或线之间具有一些或全部接触点。 还可选地，纤维之间的摩擦可以通过通过在润滑剂中冲洗刷子或刷子料而施加的轻微润滑来减少。 在一个实施例中，纤维刷被用于具有流体静力控制的电刷架的电刷加载装置中，其中施加在电刷上的力由金属或其它导电静电流体控制，同时将电流传导到电刷。

    Method and System for Enhanced Imaging Visualization of Deep Brain Anatomy Using Infusion
    3.
    发明申请
    Method and System for Enhanced Imaging Visualization of Deep Brain Anatomy Using Infusion 审中-公开
    使用输液增强成像可视化深层解剖学的方法与系统

    公开(公告)号：US20150238685A1

    公开(公告)日：2015-08-27

    申请号：US14429592

    申请日：2013-09-18

    申请人： William J. ELIAS ,  Aaron E. BOND ,  George T. GILLIES

    发明人： William J. Elias ,  Aaron E. Bond ,  George T. Gillies

    IPC分类号： A61M5/00 ,  A61M25/10 ,  A61M25/00 ,  A61B5/055 ,  A61N1/36

    CPC分类号： A61M5/007 ,  A61B5/0042 ,  A61B5/055 ,  A61B6/032 ,  A61B6/12 ,  A61B6/481 ,  A61B6/501 ,  A61M25/0026 ,  A61M25/007 ,  A61M25/0127 ,  A61M25/10 ,  A61M25/1002 ,  A61M31/005 ,  A61M2025/0037 ,  A61M2025/0042 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1093 ,  A61N1/36139 ,  G01R33/285

    摘要： Provided is a method and system for delivering a diagnostic agent to a site in the brain of a subject for imaging at least a portion of the brain site on a medical imaging system. The method and system includes a catheter device with associated lumens having diagnostic agent ports for delivering the diagnostic agent (e.g., infusate) through the lumens and advancing the diagnostic agent so as to exit out from the lumens to at least a portion of the brain site and while sealing a portion of the brain site thereby preventing the exited diagnostic agent from travelling proximally beyond the sealing location, and at the same time imaging at least a portion of the brain site during at least a portion of the sealing duration so that the brain site can be visualized on a medical imaging system. The diagnostic agent (infusate) is able to highlight borders and internal patterns of the deep structures of the brain thereby enabling direct targeting. Ultimately this leads to reduced complications, enhanced therapy, and the elimination of the need for awake surgery. The method and system provides the capability heretofore not possible to visualize the small, often indistinct regions, which will greatly improve clinical outcomes with therapeutic interventions.

    摘要翻译： 提供了一种用于将诊断剂递送到受试者脑中的位置以在医学成像系统上成像脑部位的至少一部分的方法和系统。 所述方法和系统包括具有相关联腔的导管装置，所述导管装置具有诊断剂端口，用于将诊断剂（例如，输注液体）输送通过管腔并推进诊断剂以便从腔内离开至脑部位的至少一部分 并且同时密封脑部位的一部分，从而防止被退出的诊断剂向近侧移动超过密封位置，并且同时在至少一部分密封持续时间期间对脑部位的至少一部分进行成像，使得大脑 现场可以在医学成像系统上显现。 诊断剂（输注物）能够突出大脑深层结构的边界和内部模式，从而实现直接靶向。 最终导致并发症减少，治疗加强，消除了清醒手术的需要。 该方法和系统提供了迄今为止不可能将小的，通常不清楚的区域可视化的能力，这将大大改善临床结果与治疗干预。

    ACCESS TROCAR AND RELATED METHOD THEREOF
    5.
    发明申请
    ACCESS TROCAR AND RELATED METHOD THEREOF 有权
    访问权限及其相关方法

    公开(公告)号：US20120123461A1

    公开(公告)日：2012-05-17

    申请号：US13318450

    申请日：2010-04-30

    申请人： George T. Gillies ,  Peter Pollak ,  Srijoy Mahapatra

    发明人： George T. Gillies ,  Peter Pollak ,  Srijoy Mahapatra

    IPC分类号： A61B17/34

    CPC分类号： A61B17/3423 ,  A61B17/3403 ,  A61B2017/00247 ,  A61B2017/3413 ,  A61B2017/3425 ,  A61B2018/00392

    摘要： System and method that is directed to medical treatments of organs having anatomical spaces, such as (but not limited to) the heart and the pericardial space. Specifically, an apparatus and method is provided for safely accessing anatomical spaces with surfaces to deliver medical devices or media into such spaces, or to remove fluids from such spaces. The methods and apparatus may include a first elongated member with a sharp tip used to penetrate the surface surrounding the anatomical space with a second elongated member with a helical tine used to engage the surface and lift the surface away from the underlying anatomical space. Once the first elongated member has incised the surface, it is removed, and the incision may be used as a point of entry for delivering media or medical devices into the anatomical space, or for carrying out further medical procedures.

    摘要翻译： 针对具有解剖空间的器官的医学治疗的系统和方法，例如（但不限于）心脏和心包空间。 具体地说，提供了一种装置和方法，用于安全地接触具有表面的解剖空间，以将医疗装置或介质输送到这样的空间中，或者从这些空间移除流体。 所述方法和装置可以包括具有尖端的第一细长构件，所述第一细长构件用于用具有螺旋齿的第二细长构件穿过围绕所述解剖空间的表面，所述第二细长构件用于接合所述表面并将所述表面提升离开所述下面的解剖空间。 一旦第一细长构件已经切开表面，就将其移除，并且切口可以用作将介质或医疗装置输送到解剖空间中的进入点，或者用于执行进一步的医疗程序。

    Coaxial Catheter Systems for Transference of Medium
    6.
    发明申请
    Coaxial Catheter Systems for Transference of Medium 有权
    用于传播介质的同轴导管系统

    公开(公告)号：US20100198137A1

    公开(公告)日：2010-08-05

    申请号：US12760837

    申请日：2010-04-15

    申请人： William C. Broaddus ,  Zhi-Jian Chen ,  George T. Gillies

    发明人： William C. Broaddus ,  Zhi-Jian Chen ,  George T. Gillies

    IPC分类号： A61M25/00

    CPC分类号： A61M25/0026 ,  A61M5/007 ,  A61M25/00 ,  A61M25/0045 ,  A61M25/007 ,  A61M27/006 ,  A61M2025/1013

    摘要： A method, technique and system is disclosed for the delivery of therapeutic agents and/or into the bulk brain tissues and other parts, tissues and organs of the body, including vasculature. A novel form of coaxial catheter provides a means for implanting an outer tube into the brain, then inserting an inner tube into the outer tube and aligning them such that port holes on both of the tubes will overlap and permit a flux of the therapeutic agent to flow into the brain in such a way as to minimize the effects of trapped air, virtually eliminate backflow of the agent, and avoid the potential for additional damage to the brain since only one surgical placement of the outer tube is needed. Similarly, the method, technique system may be utilized to remove fluids or other medium from the brain, tissues, and organs to minimize the effects of escaped air or negative pressure.

    摘要翻译： 公开了用于递送治疗剂和/或进入体内的大脑组织和身体其他部位，组织和器官的方法，技术和系统，包括脉管系统。 同轴导管的新颖形式提供了一种用于将外管植入大脑中的装置，然后将内管插入外管并对准它们，使得两个管上的孔口将重叠并允许治疗剂的通量 流入大脑，以尽可能减少被捕获的空气的影响，实际上消除了药剂的回流，并避免了额外的损害大脑的潜力，因为只需要一个手术放置外管。 类似地，该方法技术系统可用于从脑，组织和器官中除去流体或其它介质，以最小化逃逸空气或负压的影响。

    Epicardial Ablation Catheter and Method of Use
    7.
    发明申请
    Epicardial Ablation Catheter and Method of Use 审中-公开
    心外膜消融导管及其使用方法

    公开(公告)号：US20100114093A1

    公开(公告)日：2010-05-06

    申请号：US12530938

    申请日：2008-03-13

    申请人： Srijoy Mahapatra ,  George T. Gillies

    发明人： Srijoy Mahapatra ,  George T. Gillies

    IPC分类号： A61B18/14

    CPC分类号： A61B18/1492 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00363 ,  A61B2018/00577 ,  A61B2218/002 ,  A61B2218/007

    摘要： An aspect of various embodiments of the present invention system and method provide, but not limited thereto, a novel means for epicardial ablation using a double-curve steerable sheath and a double-curve deflectable open irrigated-tip/suction catheter that can be guided around the apex of the heart and adjusted so as to position the distal tip optimally. The catheter can also both deliver fluid to and withdraw fluid from the pericardial space. Access to the epicardial surface of the heart is via a subxiphoid entry. The method and means presented include, but are not limited to, steering, energy delivery, bipolar mapping, placement and use of electrodes, irrigation, suction of irrigation fluid, and other details of the subject invention.

    摘要翻译： 本发明系统和方法的各种实施例的一个方面提供但不限于此，使用双曲线可操纵护套的心外膜消融和可以围绕引导的双曲线可偏转打开的灌注式/吸引导管的新颖手段 心脏的顶点进行调整，以便最佳位置的远端。 导管还可以将流体从心包空间输送并从中取出流体。 进入心脏的心外膜表面是通过亚剑齿条目。 所提出的方法和手段包括但不限于转向，能量递送，双极性映射，电极的放置和使用，灌溉，冲洗流体的抽吸以及本发明的其它细节。

    Multi-Port Catheter System with Medium Control and Measurement Systems for Therapy and Diagnosis Delivery
    9.
    发明申请
    Multi-Port Catheter System with Medium Control and Measurement Systems for Therapy and Diagnosis Delivery 审中-公开
    多端口导管系统，带有用于治疗和诊断输送的中等控制和测量系统

    公开(公告)号：US20090048577A1

    公开(公告)日：2009-02-19

    申请号：US12160378

    申请日：2007-01-09

    申请人： George T. Gillies ,  Richard E. Latchaw

    发明人： George T. Gillies ,  Richard E. Latchaw

    IPC分类号： A61M25/09 ,  A61B6/00 ,  A61M25/00 ,  A61B5/05

    CPC分类号： A61M25/007 ,  A61B5/0084 ,  A61B5/064 ,  A61B5/6852 ,  A61B6/00

    摘要： A series of embodiments of multi-lumen, multisegmented (or variable diameter) catheters and associated multi-channel flow control and measurement systems and methods for simultaneous delivery of a medium to a plurality of locations is described. The need for precise, stable reliable, and repeatable flow control in therapy delivery catheters is crucial to the efficacious treatment of the clinical manifestations of peripheral vascular disease (PVD) and other such maladies. Such treatments may involve the placement of multi-lumen catheters into peripheral arterial trees, with the subsequent need to govern the flow dynamics within each individual lumen of the multi-lumen device in such a way that an optimum distribution of the agent is achieved intra-arterially. Combinations of pumps, flow monitors, pressure monitors, feedback loops and related hardware and software collectively capable of achieving this goal are described. In other embodiments, this device and method could be used for infusions into tissues and solid organs, and microcoil systems can be added to the various components of the catheter systems to improve the imaging quality during MR-guided procedures.

    摘要翻译： 描述了用于将介质同时传送到多个位置的多腔，多分段（或可变直径）导管和相关联的多通道流量控制和测量系统和方法的一系列实施例。 在治疗输送导管中需要精确，稳定可靠和可重复的流量控制对于有效治疗外周血管疾病（PVD）和其他这种疾病的临床表现是至关重要的。 这样的治疗可以涉及将多腔导管放置到外周动脉树中，随后需要对多管腔装置的每个单个管腔内的流动动力学进行调节，使得该药剂的最佳分布达到 动脉。 描述了泵，流量监视器，压力监视器，反馈回路以及共同能够实现该目标的相关硬件和软件的组合。 在其他实施方案中，该装置和方法可以用于输注到组织和实体器官中，并且可以将微线圈系统添加到导管系统的各种组件中，以改善MR引导过程中的成像质量。