公开(公告)号：US06611634B2

公开(公告)日：2003-08-26

申请号：US10095540

申请日：2002-03-11

申请人： James N. Herron ,  Douglas A. Christensen ,  Victor A. Pollak ,  Richard D. McEachern ,  Eric M. Simon

发明人： James N. Herron ,  Douglas A. Christensen ,  Victor A. Pollak ,  Richard D. McEachern ,  Eric M. Simon

IPC分类号： G02B600

CPC分类号： G01N21/0303 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2021/058

摘要： Improvements in a biosensor are disclosed. A biosensor includes a waveguide, at least a portion of which is substantially planar. One or more reservoirs may be formed adjacent to a chemistry-bearing surface of the waveguide. The biosensor may include a gasket to form a seal between the waveguide and side walls of the reservoir. A sample solution may be introduced into the reservoir or otherwise onto the surface of a waveguide through an input port. Waveguides of varying composition (e.g., plastic, quartz, glass, or other suitable waveguide materials) may be used in the biosensor. Also disclosed is a sled-shaped waveguide, which includes a planar portion and a lens at an end thereof and angled relative thereto for coupling light into the waveguide.

公开(公告)号：USD426783S

公开(公告)日：2000-06-20

申请号：US103670

申请日：1999-04-19

申请人： Douglas A. Christensen ,  James N. Herron ,  Eric M. Simon

设计人： Douglas A. Christensen ,  James N. Herron ,  Eric M. Simon

公开(公告)号：US6108463A

公开(公告)日：2000-08-22

申请号：US142948

申请日：1998-09-18

申请人： James N. Herron ,  Douglas A. Christensen ,  Victor A. Pollak ,  Richard D. McEachern ,  Eric M. Simon

发明人： James N. Herron ,  Douglas A. Christensen ,  Victor A. Pollak ,  Richard D. McEachern ,  Eric M. Simon

IPC分类号： G01N21/64 ,  G01N21/03 ,  G01N21/05 ,  G01N33/543 ,  G01N33/552 ,  G02B6/00 ,  G02B6/32 ,  G02B6/26 ,  G01N21/00 ,  G01N33/72 ,  G02B6/10

CPC分类号： G01N21/0303 ,  G01N2021/058

摘要： Improvements in a biosensor of the type having reservoirs or wells for analyzing a biological liquid are disclosed. A biosensor (190) includes a waveguide (164) placed between a plurality of members such as plates (100, 186), at least one of the members (100) being formed to define the walls (132, 134, 136) of the reservoirs where the liquid is biologically analyzed. The walls of the reservoirs are made of an inert, opaque material such as a metal. Although the biosensor may include a gasket (162), the gasket is associated with the members and waveguide in such a way (e.g. by recessing the gasket into a channel formed into a metal plate) so that the gasket does not form any significant portion of the reservoir wall. Waveguides of varying composition (e.g. plastic, quartz or glass) may be associated with the members to form the biosensor. The metal plate of the biosensor has input and output ports for infusing, draining, or oscillating the liquid to be analyzed in the reaction reservoir. Also disclosed is a sled-shaped waveguide associated with a rear lens to couple light out of the waveguide to serve as a quality control measure thus insuring that the biosensor is properly placed and that the light is working.

摘要翻译： PCT No.PCT / US97 / 04398 Sec。 371日期：1998年9月18日 102（e）1998年9月18日PCT PCT 1997年3月19日PCT公布。 公开号WO97 / 35176 日期1997年9月25日公开了具有用于分析生物液体的储库或井的类型的生物传感器的改进。 生物传感器（190）包括布置在诸如板（100,186）之间的多个构件之间的波导（164），所述构件（100）中的至少一个被形成以限定所述壁（132,134,136） 生物分析液体的储层。 储存器的壁由惰性的不透明材料如金属制成。 虽然生物传感器可以包括垫圈（162），但是垫圈以这样的方式（例如通过将垫圈凹入形成金属板的通道）与构件和波导相关联，使得垫圈不形成任何重要的部分 水库墙。 不同成分的波导（例如塑料，石英或玻璃）可与成员相关联以形成生物传感器。 生物传感器的金属板具有输入和输出端口，用于在反应槽中输入，排出或振荡待分析液体。 还公开了一种与后透镜相关联的雪橇形波导，以将光从波导耦合以用作质量控制措施，从而确保生物传感器被正确放置并且光正在工作。

公开(公告)号：USRE39772E1

公开(公告)日：2007-08-14

申请号：US10225687

申请日：1997-03-19

申请人： James N. Herron ,  Douglas A. Christensen ,  Victor A. Pollack ,  Richard D. McEachern ,  Eric M. Simon

发明人： James N. Herron ,  Douglas A. Christensen ,  Victor A. Pollack ,  Richard D. McEachern ,  Eric M. Simon

IPC分类号： G02B6/26 ,  G02B6/10 ,  G01N21/00 ,  G01N33/552 ,  G01N33/72

CPC分类号： G01N21/0303 ,  G01N2021/058

摘要： Improvements in a biosensor of the type having reservoirs or wells for analyzing a biological liquid are disclosed. A biosensor (190) includes a waveguide (164) placed between a plurality of members such as plates (100, 186), at least one of the members (100) being formed to define the walls (132, 134, 136) of the reservoirs where the liquid is biologically analyzed. The walls of the reservoirs are made of an inert, opaque material such as a metal. Although the biosensor may include a gasket (162), the gasket is associated with the members and waveguide in such a way (e.g. by recessing the gasket into a channel formed into a metal plate) so that the gasket does not form any significant portion of the reservoir wall. Waveguides of varying composition (e.g. plastic, quartz or glass) may be associated with the members to form the biosensor. The metal plate of the biosensor has input and output ports for infusing, draining, or oscillating the liquid to be analyzed in the reaction reservoir. Also disclosed is a sled-shaped waveguide associated with a rear lens to couple light out of the waveguide to serve as a quality control measure thus insuring that the biosensor is properly placed and that the light is working.

摘要翻译： 公开了具有用于分析生物液体的储存器或孔的类型的生物传感器的改进。 生物传感器（190）包括布置在诸如板（100,186）之间的多个构件之间的波导（164），所述构件（100）中的至少一个被形成以限定所述壁（132,134,136） 生物分析液体的储层。 储存器的壁由惰性的不透明材料如金属制成。 虽然生物传感器可以包括垫圈（162），但是垫圈以这样的方式（例如通过将垫圈凹入形成金属板的通道）与构件和波导相关联，使得垫圈不形成任何重要的部分 水库墙。 不同组成的波导（例如塑料，石英或玻璃）可以与成员相关联以形成生物传感器。 生物传感器的金属板具有输入和输出端口，用于在反应槽中输入，排出或振荡待分析液体。 还公开了一种与后透镜相关联的雪橇形波导，以将光从波导耦合以用作质量控制措施，从而确保生物传感器被正确放置并且光正在工作。

公开(公告)号：US06356676B1

公开(公告)日：2002-03-12

申请号：US09608714

申请日：2000-06-30

申请人： James N. Herron ,  Douglas A. Christensen ,  Victor A. Pollak ,  Richard D. McEachern ,  Eric M. Simon

发明人： James N. Herron ,  Douglas A. Christensen ,  Victor A. Pollak ,  Richard D. McEachern ,  Eric M. Simon

IPC分类号： G02B626

CPC分类号： G01N21/0303 ,  G01N21/05 ,  G01N2021/0346

摘要： Improvements in a biosensor of the type having reservoirs or wells for analyzing a biological liquid are disclosed. A biosensor includes a waveguide placed between a plurality of members such as plates at least one of the members being formed to define the walls of the reservoirs where the liquid is biologically analyzed. The walls of the reservoirs are made of an inert, opaque material such as a metal. Although the biosensor may include a gasket, the gasket is associated with the members and waveguide in such a way (e.g., by recessing the gasket into a channel formed into a metal plate) so that the gasket does not form any significant portion of the reservoir wall. Waveguides of varying composition (e.g., plastic, quartz or glass) may be associated with the members to form the biosensor. The metal plate of the biosensor has input and output ports for infusing, draining, or oscillating the liquid to be analyzed in the reaction reservoir. Also disclosed is a sled-shaped waveguide associated with a rear lens to couple light out of the waveguide to serve as a quality control measure thus insuring that the biosensor is properly placed and that the light is working.

摘要翻译： 公开了具有用于分析生物液体的储存器或孔的类型的生物传感器的改进。 生物传感器包括放置在诸如板之间的多个构件之间的波导，所述构件中的至少一个形成为限定储存器的壁，其中液体被生物分析。 储存器的壁由惰性的不透明材料如金属制成。 虽然生物传感器可以包括垫圈，但是垫圈以这样的方式（例如通过将垫圈凹入形成金属板的通道）与构件和波导相关联，使得垫圈不形成储存器的任何重要部分 壁。 不同组成的波导（例如，塑料，石英或玻璃）可以与成员相关联以形成生物传感器。 生物传感器的金属板具有输入和输出端口，用于在反应槽中输入，排出或振荡待分析液体。 还公开了一种与后透镜相关联的雪橇形波导，以将光从波导耦合以用作质量控制措施，从而确保生物传感器被正确放置并且光正在工作。

公开(公告)号：US06676113B2

公开(公告)日：2004-01-13

申请号：US09971964

申请日：2001-10-04

申请人： Marc E. Christensen ,  Eric M. Simon

发明人： Marc E. Christensen ,  Eric M. Simon

IPC分类号： E04H1716

CPC分类号： E01F13/022 ,  E01F9/669 ,  E01F9/70

摘要： A control barrier is provided having a barrier wall with one or two support assemblies attached thereto. The barrier wall has a front face with a display recess, wind ports, and tenons and mortises formed thereon. The barrier wall also has a set of projecting arms having either pins or ports to allow a series of control barriers to be connected together. The support assemblies are positionable between a support position and a standing position. Preferably, the support assemblies include a leg and a foot. The leg is extendable and/or rotatable to allow the foot to be positioned between a support position and a standing position.

摘要翻译： 提供了具有阻挡壁的控制屏障，其中连接有一个或两个支撑组件。 阻挡壁具有前表面，其具有形成在其上的显示凹槽，风口和榫眼。 阻挡壁还具有一组具有销或端口的突出臂，以允许一系列控制屏障连接在一起。 支撑组件可定位在支撑位置和竖立位置之间。 优选地，支撑组件包括腿部和脚部。 腿部是可延伸的和/或可旋转的，以允许脚部定位在支撑位置和站立位置之间。

公开(公告)号：US06582442B2

公开(公告)日：2003-06-24

申请号：US09514531

申请日：2000-02-28

申请人： Eric M. Simon ,  Randall D. Block

发明人： Eric M. Simon ,  Randall D. Block

IPC分类号： A61B1750

CPC分类号： A61H9/005 ,  A61H2009/0014

摘要： A method and system for performing abrasion on a surface, such as on the skin of a patient, is disclosed. The dermabrasion apparatus includes apparatus for delivering and retrieving material to and from a selected site to be abraded, a delivery and retrieval hand piece, an abrasive handling device, and a waste retrieval holding device. The hand piece is coupled to the abrasive handling device as well as the waste retrieval holding device, which is further coupled to the delivery and retrieval apparatus. The abrasive handling device further includes an abrasive supply device, a receiving channel, a feeding chamber, and a delivery channel. The abrasive supply device typically is a canister fitted with a funnel-shaped spout that is inverted into the receiving channel. The receiving channel feeds abrasive to the feeding chamber. The delivery and retrieval apparatus, typically a vacuum source that generates a pneumatic air supply within the abrasion apparatus, causes the abrasive within the feeding chamber to loft in an arc such that it reaches the delivery channel. The delivery channel then leads to the hand piece, which is utilized to apply the abrasive to the surface and then retrieve the waste debris during the procedure.

摘要翻译： 公开了一种用于在诸如患者皮肤之类的表面上进行磨损的方法和系统。 磨皮设备包括用于将材料输送和从要磨损的选定部位回收的装置，输送和取回手部件，研磨处理装置和废物回收保持装置。 手持件联接到研磨处理装置以及废物回收保持装置，该装置进一步联接到输送和取出装置。 研磨处理装置还包括磨料供应装置，接收通道，进料室和输送通道。 磨料供应装置通常是装有漏斗状喷嘴的罐，其倒入接收通道。 接收通道将磨料送入给料室。 输送和回收装置，通常是在磨损装置内产生气动空气供应的真空源，使得进料室内的磨料以弧形摆放，使其到达输送通道。 然后，输送通道通向手持件，其用于将磨料施加到表面，然后在该过程期间回收废屑。

公开(公告)号：US5059175A

公开(公告)日：1991-10-22

申请号：US594271

申请日：1990-10-09

申请人： Barry K. Hanover ,  Stephen C. Jacobsen ,  Eric M. Simon ,  Tomasz Petelenz ,  Michael G. Mladejovsky

发明人： Barry K. Hanover ,  Stephen C. Jacobsen ,  Eric M. Simon ,  Tomasz Petelenz ,  Michael G. Mladejovsky

IPC分类号： A61K9/00 ,  A61M31/00

CPC分类号： A61K9/0024 ,  A61M31/002

摘要： An implantable drug delivery system includes a housing having a base end and a discharge end, for holding drug solution at the discharge end, a valve disposed at the discharge end to allow a drug solution to flow from inside the housing, through the valve and out of the housing when solution pressure is applied to the valve, a piston slidably disposed in the housing to slide between the base end and discharge end to force solution toward the discharge end and out the valve, and a spring disposed in the housing between the piston and the base end thereof for urging the piston toward the discharge end. A plurality of different length tethers are connected at one end to the piston and at the other end to a respective release node located at the base end of the housing. Each release node holds the other end of a respective one of the tethers until a release signal is received at which time it releases the tether. A timing circuit is disposed in the housing at the base end to supply release signals sequentially to the nodes in order of the shortest tether node to the longest tether node so that as a tether is released, the piston is allowed to move toward the discharge end of the housing to thereby discharge or bolus of drug solution from the housing, until the next shortest unreleased tether stops further movement of the piston.

摘要翻译： 可植入药物输送系统包括具有基端和排出端的壳体，用于在排出端保持药物溶液，设置在排出端处的阀，以允许药物溶液从壳体内部流过阀门并出口 的壳体，其中所述壳体被施加到所述阀上;活塞，其可滑动地设置在所述壳体中以在所述基端和排出端之间滑动，以迫使溶液朝向排出端并排出所述阀;以及弹簧，设置在所述壳体中的所述活塞 和其基端用于将活塞推向排出端。 多个不同长度的系绳在一端连接到活塞，另一端连接到位于壳体基端的相应的释放节点。 每个释放节点保持系链中相应一个的另一端，直到接收释放信号，此时它释放系绳。 定时电路设置在基座的外壳中，以便按照最短系链节点到最长系绳节点的顺序向节点顺序地提供释放信号，以便当释放系绳时，允许活塞向排放端移动 从而将药物溶液从壳体排出或推出，直到下一个最短的未释放的系链停止活塞的进一步移动。

公开(公告)号：US08475510B2

公开(公告)日：2013-07-02

申请号：US12565616

申请日：2009-09-23

申请人： Eric M. Simon ,  Randall D. Block

发明人： Eric M. Simon ,  Randall D. Block

IPC分类号： A61F7/00 ,  A45D24/22

CPC分类号： A01K13/001 ,  A01K13/002 ,  A01K13/003 ,  A45D20/12 ,  A45D24/30

摘要： Disclosed are embodiments of airflow applicators used for delivering directional, heated air to, for example, the scalp and hair of humans and/or animals to eliminate ectoparasites, such as lice and lice eggs. In preferred embodiments, the applicators are configured to deliver heated airflow (from a separate device, or from another portion of a single device, that generates heated airflow) efficiently right to where ectoparasites and their eggs most frequently reside. Also disclosed are treatment methods, including preferred treatment patterns, for delivering heated airflows for use in eliminating ectoparasites and their eggs on an animal.

摘要翻译： 公开了用于将定向加热的空气递送到人和/或动物的头皮和头发以消除诸如虱子和虱子卵的外寄生物的气流施加器的实施例。 在优选实施例中，施用器被配置成有效地传递加热的气流（来自单独的装置，或者来自单个装置的另一部分，产生加热的气流），直到外寄生虫和它们的卵最常存在的地方。 还公开了用于递送用于在动物上消除体外寄生虫及其卵的热气流的治疗方法，包括优选的处理模式。

公开(公告)号：US20100071713A1

公开(公告)日：2010-03-25

申请号：US12565616

申请日：2009-09-23

申请人： Eric M. Simon ,  Randall D. Block

发明人： Eric M. Simon ,  Randall D. Block

IPC分类号： A45D24/22 ,  A47L7/00

CPC分类号： A01K13/001 ,  A01K13/002 ,  A01K13/003 ,  A45D20/12 ,  A45D24/30

摘要： Disclosed are embodiments of airflow applicators used for delivering directional, heated air to, for example, the scalp and hair of humans and/or animals to eliminate ectoparasites, such as lice and lice eggs. In preferred embodiments, the applicators are configured to deliver heated airflow (from a separate device, or from another portion of a single device, that generates heated airflow) efficiently right to where ectoparasites and their eggs most frequently reside. Also disclosed are treatment methods, including preferred treatment patterns, for delivering heated airflows for use in eliminating ectoparasites and their eggs on an animal.

摘要翻译： 公开了用于将定向加热的空气递送到人和/或动物的头皮和头发以消除诸如虱子和虱子卵的外寄生物的气流施加器的实施例。 在优选实施例中，施用器被配置成有效地传递加热的气流（来自单独的装置，或来自单个装置的另一部分，产生加热的气流），直到其外部寄生虫和它们的卵最常存在的地方。 还公开了用于递送用于在动物上消除体外寄生虫及其卵的热气流的治疗方法，包括优选的处理模式。