公开(公告)号：US06217525B1

公开(公告)日：2001-04-17

申请号：US09229977

申请日：1999-01-13

申请人： Douglas K. Medema ,  Tae H. Joo ,  Paul W. Schmitt ,  David R. Hampton ,  Robert A. Niskanen

发明人： Douglas K. Medema ,  Tae H. Joo ,  Paul W. Schmitt ,  David R. Hampton ,  Robert A. Niskanen

IPC分类号： A61B50402

CPC分类号： A61B5/04028 ,  A61B5/0428 ,  A61B5/04525 ,  A61B5/7207 ,  A61B5/7267

摘要： A reduced lead set device (10) that detects and reports the presence of an acute cardiac ischemic condition in a patient includes a reduced set of sensing electrodes (12, 14, 16, 18, and 20) placed on a patient for acquiring ECG data from the patient. The reduced lead set device evaluates the ECG data on a reduced set of leads by analyzing local features and/or global features of the ECG data. Local features may include local morphological measures such as ST elevation and clinical information on the patient such as age and sex. Global features include projection coefficients calculated from projecting a concatenated vector of heartbeat data onto separate sets of basis vectors that define signal subspaces of ischemic and non-ischemic ECGs. One or more classifiers evaluate the local features and/or global features to determine whether an acute cardiac ischemic condition is detected. The operating point, i.e., sensitivity and specificity, of the reduced lead set device is adjustable. The result of the evaluation is reported to the user of the device.

摘要翻译： 检测和报告患者中急性心肌缺血状况的存在的减少引线装置（10）包括放置在患者身上以获得ECG数据的减少的感测电极组（12,14,16,18和20） 来自病人。 减少引线组装置通过分析ECG数据的局部特征和/或全局特征来评估减少的引线组的ECG数据。 局部特征可能包括局部形态学测量，如ST抬高和患者的临床信息，如年龄和性别。 全局特征包括通过将心跳数据的级联向量投影到限定缺血性和非缺血性心电图的信号子空间的基本向量的单独集合而计算的投影系数。 一个或多个分类器评估局部特征和/或全局特征以确定是否检测到急性心肌缺血状况。 减少引线组装置的工作点，即灵敏度和特异性是可调节的。 评估的结果报告给设备的用户。

公开(公告)号：US06171256B2

公开(公告)日：2001-01-09

申请号：US09209879

申请日：1998-12-11

申请人： Tae H. Joo ,  David R. Hampton ,  Paul W. Schmitt ,  Douglas K. Medema ,  Robert A. Niskanen

发明人： Tae H. Joo ,  David R. Hampton ,  Paul W. Schmitt ,  Douglas K. Medema ,  Robert A. Niskanen

IPC分类号： A61B50402

CPC分类号： A61B5/04028 ,  A61B5/0428 ,  A61B5/04525 ,  A61B5/7267 ,  G06F19/00

摘要： A device (10) that detects and reports the presence of an acute cardiac ischemic condition in a patient includes sensing electrodes (12, 14, 16, 18, 20, 22, 24, 26, 28, and 30) placed on a patient for acquiring multiple (e.g., twelve) lead ECG data from the patient. The device evaluates the acquired ECG data by analyzing global features derived from the ECG data. Global features include projection coefficients calculated from projecting a concatenated vector of representative heartbeat data onto sets of basis vectors that define an acute cardiac ischemic ECG subspace and a non-ischemic ECG subspace. A classifier evaluates the global features to determine whether an acute cardiac ischemic condition is detected. In a further embodiment of the invention, one or more classifiers evaluate local features, such as local morphological features and patient clinical information, in addition to the global features to determine whether an acute cardiac ischemic condition is detected. The device (10) may be configured with an adjustable sensitivity/specificity operating point. The result of the evaluation is reported to the user of the device.

摘要翻译： 检测并报告患者中存在急性心肌缺血状态的装置（10）包括放置在患者身上的感测电极（12,14,16,18,20,22,24,26,28和30），用于 从患者获取多个（例如，十二个）导联ECG数据。 该设备通过分析从ECG数据导出的全局特征来评估所获取的ECG数据。 全局特征包括通过将代表性心跳数据的级联矢量投影到定义急性心肌缺血心电图子空间和非缺血性ECG子空间的基本矢量集合而计算的投影系数。 分类器评估全局特征以确定是否检测到急性心肌缺血状况。 在本发明的另一实施例中，除了确定是否检测到急性心肌缺血状况的全局特征之外，一个或多个分类器还评估局部特征，例如局部形态特征和患者临床信息。 设备（10）可以配置有可调节的灵敏度/特异性操作点。 评估的结果报告给设备的用户。

公开(公告)号：US08532766B2

公开(公告)日：2013-09-10

申请号：US13267783

申请日：2011-10-06

申请人： Tae H. Joo ,  Ronald E. Stickney ,  Cynthia P. Jayne ,  Paula Lank ,  Patricia O'Hearn ,  David R. Hampton ,  James W. Taylor ,  William E. Crone ,  Daniel Yerkovich

发明人： Tae H. Joo ,  Ronald E. Stickney ,  Cynthia P. Jayne ,  Paula Lank ,  Patricia O'Hearn ,  David R. Hampton ,  James W. Taylor ,  William E. Crone ,  Daniel Yerkovich

IPC分类号： A61N1/39

CPC分类号： A61N1/3925 ,  A61B5/0464 ,  A61B5/0535 ,  A61B5/0538 ,  A61B5/7264 ,  A61B7/00 ,  A61B7/04 ,  A61N1/365 ,  A61N1/39 ,  A61N1/3987

摘要： The presence of a cardiac pulse in a patient is determined by evaluating physiological signals in the patient. In one embodiment, a medical device evaluates two or more different physiological signals, such as phonocardiogram (PCG) signals, electrocardiogram (ECG) signals, patient impedance signals, piezoelectric signals, and accelerometer signals for features indicative of the presence of a cardiac pulse. Using these features, the medical device determines whether a cardiac pulse is present in the patient. The medical device may also be configured to report whether the patient is in a VF, VT, asystole, or PEA condition, in addition to being in a pulseless condition, and prompt different therapies, such as chest compressions, rescue breathing, defibrillation, and PEA-specific electrotherapy, depending on the analysis of the physiological signals. Auto-capture of a cardiac pulse using pacing stimuli is further provided.

公开(公告)号：US20120302896A1

公开(公告)日：2012-11-29

申请号：US13569147

申请日：2012-08-07

申请人： Tae H. Joo ,  Ronald E. Stickney ,  Cynthia P. Jayne ,  Paula Lank ,  Patricia O'Hearn ,  David R. Hampton ,  James W. Taylor ,  William E. Crone ,  Daniel Yerkovich

发明人： Tae H. Joo ,  Ronald E. Stickney ,  Cynthia P. Jayne ,  Paula Lank ,  Patricia O'Hearn ,  David R. Hampton ,  James W. Taylor ,  William E. Crone ,  Daniel Yerkovich

IPC分类号： A61N1/39 ,  A61B6/00 ,  A61M16/00 ,  A61B5/024

CPC分类号： A61N1/3925 ,  A61B5/0464 ,  A61B5/0535 ,  A61B5/0538 ,  A61B5/7264 ,  A61B7/00 ,  A61B7/04 ,  A61N1/365 ,  A61N1/39 ,  A61N1/3987

摘要： The presence of a cardiac pulse in a patient is determined by evaluating physiological signals in the patient. In one embodiment, a medical device evaluates two or more different physiological signals, such as phonocardiogram (PCG) signals, electrocardiogram (ECG) signals, patient impedance signals, piezoelectric signals, and accelerometer signals for features indicative of the presence of a cardiac pulse. Using these features, the medical device determines whether a cardiac pulse is present in the patient. The medical device may also be configured to report whether the patient is in a VF, VT, asystole, or PEA condition, in addition to being in a pulseless condition, and prompt different therapies, such as chest compressions, rescue breathing, defibrillation, and PEA-specific electrotherapy, depending on the analysis of the physiological signals. Auto-capture of a cardiac pulse using pacing stimuli is further provided.

公开(公告)号：US20120029584A1

公开(公告)日：2012-02-02

申请号：US13272733

申请日：2011-10-13

申请人： Tae H. Joo ,  Ronald E. Stickney ,  Cynthia P. Jayne ,  Paula Lank ,  Patricia O'Hearn ,  David R. Hampton ,  James W. Taylor ,  William E. Crone ,  Daniel Yerkovich

发明人： Tae H. Joo ,  Ronald E. Stickney ,  Cynthia P. Jayne ,  Paula Lank ,  Patricia O'Hearn ,  David R. Hampton ,  James W. Taylor ,  William E. Crone ,  Daniel Yerkovich

IPC分类号： A61N1/368 ,  A61N1/39 ,  A61N1/365

CPC分类号： A61N1/3925 ,  A61B5/0464 ,  A61B5/0535 ,  A61B5/0538 ,  A61B5/7264 ,  A61B7/00 ,  A61B7/04 ,  A61N1/365 ,  A61N1/39 ,  A61N1/3987

摘要： The presence of a cardiac pulse in a patient is determined by evaluating physiological signals in the patient. In one embodiment, a medical device evaluates two or more different physiological signals, such as phonocardiogram (PCG) signals, electrocardiogram (ECG) signals, patient impedance signals, piezoelectric signals, and accelerometer signals for features indicative of the presence of a cardiac pulse. Using these features, the medical device determines whether a cardiac pulse is present in the patient. The medical device may also be configured to report whether the patient is in a VF, VT, asystole, or PEA condition, in addition to being in a pulseless condition, and prompt different therapies, such as chest compressions, rescue breathing, defibrillation, and PEA-specific electrotherapy, depending on the analysis of the physiological signals. Auto-capture of a cardiac pulse using pacing stimuli is further provided.

公开(公告)号：US08744577B2

公开(公告)日：2014-06-03

申请号：US13569147

申请日：2012-08-07

申请人： Tae H. Joo ,  Ronald E. Stickney ,  Cynthia P. Jayne ,  Paula Lank ,  Patricia O'Hearn ,  David R. Hampton ,  James W. Taylor ,  William E. Crone ,  Daniel Yerkovich

发明人： Tae H. Joo ,  Ronald E. Stickney ,  Cynthia P. Jayne ,  Paula Lank ,  Patricia O'Hearn ,  David R. Hampton ,  James W. Taylor ,  William E. Crone ,  Daniel Yerkovich

IPC分类号： A61N1/365

CPC分类号： A61N1/3925 ,  A61B5/0464 ,  A61B5/0535 ,  A61B5/0538 ,  A61B5/7264 ,  A61B7/00 ,  A61B7/04 ,  A61N1/365 ,  A61N1/39 ,  A61N1/3987

摘要： The presence of a cardiac pulse in a patient is determined by evaluating physiological signals in the patient. In one embodiment, a medical device evaluates two or more different physiological signals, such as phonocardiogram (PCG) signals, electrocardiogram (ECG) signals, patient impedance signals, piezoelectric signals, and accelerometer signals for features indicative of the presence of a cardiac pulse. Using these features, the medical device determines whether a cardiac pulse is present in the patient. The medical device may also be configured to report whether the patient is in a VF, VT, asystole, or PEA condition, in addition to being in a pulseless condition, and prompt different therapies, such as chest compressions, rescue breathing, defibrillation, and PEA-specific electrotherapy, depending on the analysis of the physiological signals. Auto-capture of a cardiac pulse using pacing stimuli is further provided.

摘要翻译： 通过评估患者的生理信号来确定患者心脏脉搏的存在。 在一个实施例中，医疗设备评估两个或更多个不同的生理信号，例如心电图（PCG）信号，心电图（ECG）信号，患者阻抗信号，压电信号和加速度计信号，用于指示存在心脏脉搏的特征。 使用这些特征，医疗装置确定患者心脏脉搏是否存在。 除了处于无脉动状态之外，医疗装置还可以被配置为报告患者是否处于VF，VT，心搏停止或PEA状态，并且提示不同的疗法，例如胸部按压，救援呼吸，除颤和 PEA特异性电疗，取决于生理信号的分析。 进一步提供使用起搏刺激自动捕获心脏脉搏。

公开(公告)号：US20120029583A1

公开(公告)日：2012-02-02

申请号：US13267783

申请日：2011-10-06

申请人： Tae H. Joo ,  Ronald E. Stickney ,  Cynthia P. Jayne ,  Paula Lank ,  Patricia O'Hearn ,  David R. Hampton ,  James W. Taylor ,  William E. Crone ,  Daniel Yerkovich

发明人： Tae H. Joo ,  Ronald E. Stickney ,  Cynthia P. Jayne ,  Paula Lank ,  Patricia O'Hearn ,  David R. Hampton ,  James W. Taylor ,  William E. Crone ,  Daniel Yerkovich

IPC分类号： A61N1/39 ,  A61M16/00

CPC分类号： A61N1/3925 ,  A61B5/0464 ,  A61B5/0535 ,  A61B5/0538 ,  A61B5/7264 ,  A61B7/00 ,  A61B7/04 ,  A61N1/365 ,  A61N1/39 ,  A61N1/3987

摘要： The presence of a cardiac pulse in a patient is determined by evaluating physiological signals in the patient. In one embodiment, a medical device evaluates two or more different physiological signals, such as phonocardiogram (PCG) signals, electrocardiogram (ECG) signals, patient impedance signals, piezoelectric signals, and accelerometer signals for features indicative of the presence of a cardiac pulse. Using these features, the medical device determines whether a cardiac pulse is present in the patient. The medical device may also be configured to report whether the patient is in a VF, VT, asystole, or PEA condition, in addition to being in a pulseless condition, and prompt different therapies, such as chest compressions, rescue breathing, defibrillation, and PEA-specific electrotherapy, depending on the analysis of the physiological signals. Auto-capture of a cardiac pulse using pacing stimuli is further provided.

公开(公告)号：US20120022339A1

公开(公告)日：2012-01-26

申请号：US13249081

申请日：2011-09-29

申请人： Tae H. Joo ,  Ronald E. Stickney ,  Cynthia P. Jayne ,  Paula Lank ,  Patricia O'Hearn ,  David R. Hampton ,  James W. Taylor ,  William E. Crone ,  Daniel Yerkovich

发明人： Tae H. Joo ,  Ronald E. Stickney ,  Cynthia P. Jayne ,  Paula Lank ,  Patricia O'Hearn ,  David R. Hampton ,  James W. Taylor ,  William E. Crone ,  Daniel Yerkovich

IPC分类号： A61N1/39 ,  A61H31/00 ,  A61N1/00 ,  A61N1/37 ,  A61N1/365 ,  A61M16/00 ,  A61B5/0402 ,  A61B5/1455 ,  A61B5/0464 ,  A61B5/046 ,  A61B5/0245 ,  A61B5/053 ,  A61B5/08 ,  A61B8/02 ,  A61B5/0205

CPC分类号： A61N1/3925 ,  A61B5/0464 ,  A61B5/0535 ,  A61B5/0538 ,  A61B5/7264 ,  A61B7/00 ,  A61B7/04 ,  A61N1/365 ,  A61N1/39 ,  A61N1/3987

摘要： The presence of a cardiac pulse in a patient is determined by evaluating physiological signals in the patient. In one embodiment, a medical device evaluates two or more different physiological signals, such as phonocardiogram (PCG) signals, electrocardiogram (ECG) signals, patient impedance signals, piezoelectric signals, and accelerometer signals for features indicative of the presence of a cardiac pulse. Using these features, the medical device determines whether a cardiac pulse is present in the patient. The medical device may also be configured to report whether the patient is in a VF, VT, asystole, or PEA condition, in addition to being in a pulseless condition, and prompt different therapies, such as chest compressions, rescue breathing, defibrillation, and PEA-specific electrotherapy, depending on the analysis of the physiological signals. Auto-capture of a cardiac pulse using pacing stimuli is further provided.

摘要翻译： 通过评估患者的生理信号来确定患者心脏脉搏的存在。 在一个实施例中，医疗设备评估两个或更多个不同的生理信号，例如心电图（PCG）信号，心电图（ECG）信号，患者阻抗信号，压电信号和加速度计信号，用于指示存在心脏脉搏的特征。 使用这些特征，医疗装置确定患者心脏脉搏是否存在。 除了处于无脉动状态之外，医疗装置还可以被配置为报告患者是否处于VF，VT，心搏停止或PEA状态，并且提示不同的疗法，例如胸部按压，救援呼吸，除颤和 PEA特异性电疗，取决于生理信号的分析。 进一步提供使用起搏刺激自动捕获心脏脉搏。

公开(公告)号：US08239024B2

公开(公告)日：2012-08-07

申请号：US13032250

申请日：2011-02-22

申请人： Tae H. Joo ,  Ronald E. Stickney ,  Cynthia P. Jayne ,  Paula Lank ,  Patricia O'Hearn ,  David R. Hampton ,  James W. Taylor ,  William E. Crone ,  Daniel Yerkovich

发明人： Tae H. Joo ,  Ronald E. Stickney ,  Cynthia P. Jayne ,  Paula Lank ,  Patricia O'Hearn ,  David R. Hampton ,  James W. Taylor ,  William E. Crone ,  Daniel Yerkovich

IPC分类号： A61N1/365

CPC分类号： A61N1/3925 ,  A61B5/0464 ,  A61B5/0535 ,  A61B5/0538 ,  A61B5/7264 ,  A61B7/00 ,  A61B7/04 ,  A61N1/365 ,  A61N1/39 ,  A61N1/3987

摘要： The presence of a cardiac pulse in a patient is determined by evaluating physiological signals in the patient. In one embodiment, a medical device evaluates two or more different physiological signals, such as phonocardiogram (PCG) signals, electrocardiogram (ECG) signals, patient impedance signals, piezoelectric signals, and accelerometer signals for features indicative of the presence of a cardiac pulse. Using these features, the medical device determines whether a cardiac pulse is present in the patient. The medical device may also be configured to report whether the patient is in a VF, VT, asystole, or PEA condition, in addition to being in a pulseless condition, and prompt different therapies, such as chest compressions, rescue breathing, defibrillation, and PEA-specific electrotherapy, depending on the analysis of the physiological signals. Auto-capture of a cardiac pulse using pacing stimuli is further provided.

摘要翻译： 通过评估患者的生理信号来确定患者心脏脉搏的存在。 在一个实施例中，医疗设备评估两个或更多个不同的生理信号，例如心电图（PCG）信号，心电图（ECG）信号，患者阻抗信号，压电信号和加速度计信号，用于指示存在心脏脉搏的特征。 使用这些特征，医疗装置确定患者心脏脉搏是否存在。 除了处于无脉动状态之外，医疗装置还可以被配置为报告患者是否处于VF，VT，心搏停止或PEA状态，并且提示不同的疗法，例如胸部按压，救援呼吸，除颤和 PEA特异性电疗，取决于生理信号的分析。 进一步提供使用起搏刺激自动捕获心脏脉搏。

公开(公告)号：US08160703B2

公开(公告)日：2012-04-17

申请号：US11187616

申请日：2005-07-22

申请人： Ronald E. Stickney ,  Cynthia P. Jayne ,  Paula Lank ,  Patricia O'Hearn ,  Tae H. Joo ,  David R. Hampton ,  Richard C. Nova ,  Patrick F. Kelly ,  William E. Saltzstein

发明人： Ronald E. Stickney ,  Cynthia P. Jayne ,  Paula Lank ,  Patricia O'Hearn ,  Tae H. Joo ,  David R. Hampton ,  Richard C. Nova ,  Patrick F. Kelly ,  William E. Saltzstein

IPC分类号： A61N1/362

CPC分类号： A61B5/046 ,  A61B5/1102 ,  A61B5/1107 ,  A61B5/7264 ,  A61B2560/0412 ,  A61B2562/02 ,  A61N1/3712 ,  A61N1/3925

摘要： Signal data obtained from a piezoelectric sensor placed on a patient's body is used to detect the presence of a cardiac pulse. The piezoelectric sensor has a transducing element adapted to sense movement due to a cardiac pulse and produce piezoelectric signal data in response thereto. Processing circuitry analyzes the piezoelectric signal data for a feature indicative of a cardiac pulse and determines whether a cardiac pulse is present in the patient based on the feature. In one aspect, the feature may be a temporal feature such as a relative change in energy. In another aspect, the feature may be a spectral feature such as the energy or frequency of a peak in the energy spectrum of the signal. In yet another aspect, the feature may be obtained by comparing the piezoelectric signal data with a previously-identified pattern known to predict the presence of a cardiac pulse. Multiple features may also be obtained from the piezoelectric signal data and classified to determine the presence of a cardiac pulse.

摘要翻译： 使用从放置在患者身上的压电传感器获得的信号数据来检测心脏脉搏的存在。 压电传感器具有适于感测由心脏脉搏引起的运动的传感元件，并响应于此产生压电信号数据。 处理电路分析用于表示心脏脉搏的特征的压电信号数据，并且基于特征确定患者心脏脉搏是否存在。 在一个方面，该特征可以是时间特征，例如能量的相对变化。 在另一方面，特征可以是光谱特征，例如信号的能谱中的峰的能量或频率。 在另一方面，可以通过将压电信号数据与已知的预测心脏脉搏的存在的先前识别的模式相比较来获得特征。 还可以从压电信号数据获得多个特征，并将其分类以确定心脏脉搏的存在。