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公开(公告)号:US4894333A
公开(公告)日:1990-01-16
申请号:US55108
申请日:1987-05-28
IPC分类号: C12N15/09 , A61K38/00 , A61K39/39 , A61P17/00 , A61P43/00 , C07K14/00 , C07K14/52 , C07K14/54 , C07K14/545 , C12N15/25 , C12P21/02 , C12R1/19 , C12R1/91
CPC分类号: C07K14/545 , A61K38/00
摘要: Cloning and expression of DNA segments encoding bovine IL-.alpha., and processes for producing purified bovine IL-1.alpha. as a product of recombinant cell culture, are disclosed.
摘要翻译: 公开了编码牛IL-α的DNA片段的克隆和表达,以及用于产生纯化的牛IL-1α作为重组细胞培养物的产物的方法。
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公开(公告)号:US5108911A
公开(公告)日:1992-04-28
申请号:US392332
申请日:1989-08-11
IPC分类号: A61K38/00 , C07K14/545 , C12N15/25
CPC分类号: C07K14/545 , A61K38/00
摘要: A process for preparing bovine interleukin I.beta. (bIL-1.beta.) by culturing a microbial host transformed by a vector containing a DNA sequence encoding bIL-1.beta. under conditions suitable for the expression of bIL-1.beta. and recovering bIL-1.beta..
摘要翻译: 通过培养由含有编码bIL-1β的DNA序列的载体在适于表达bIL-1β并恢复bIL-1β的条件下转化的微生物宿主来制备牛白介素Iβ(bIL-1β)的方法。
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公开(公告)号:US5106733A
公开(公告)日:1992-04-21
申请号:US355870
申请日:1989-05-22
申请人: Paul E. Baker , Douglas P. Cerretti , William R. Clevenger , David J. Cosman , Charles R. Maliszewski
发明人: Paul E. Baker , Douglas P. Cerretti , William R. Clevenger , David J. Cosman , Charles R. Maliszewski
IPC分类号: A61K38/00 , C07K14/535 , C12N15/62
CPC分类号: C12N15/625 , C07K14/535 , C12N15/62 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C07K2319/75
摘要: Cloning and expression of DNA segments encoding bovine GM-CSF, and processes for producing recombinant bovine GM-CSF as a product of recombinant cell culture, are disclosed.
摘要翻译: 公开了编码牛GM-CSF的DNA片段的克隆和表达,以及用于产生作为重组细胞培养物的产物的重组牛GM-CSF的方法。
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公开(公告)号:US5962647A
公开(公告)日:1999-10-05
申请号:US827250
申请日:1992-01-29
IPC分类号: A61K38/00 , C07K14/545 , C12N15/25 , C07K1/00
CPC分类号: C07K14/545 , A61K38/00
摘要: Cloning and expression of nucleotide DNA segments encoding bovine IL-1.beta., and processes for producing purified bovine IL-1.beta. as a product of recombinant cell culture, are disclosed.
摘要翻译: 公开了编码牛IL-1β的核苷酸DNA片段的克隆和表达,以及用于产生纯化的牛IL-1β作为重组细胞培养物的产物的方法。
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公开(公告)号:US5266311A
公开(公告)日:1993-11-30
申请号:US813235
申请日:1991-12-23
IPC分类号: A61K38/00 , C07K14/545 , A61K45/05 , A01N37/18 , A61K37/66 , C07K3/00 , C12P19/34 , C12P21/02
CPC分类号: C07K14/545 , A61K38/00
摘要: Cloning and expression of DNA segments encoding bovine IL-1.alpha., and processes for producing purified bovine IL-1.alpha. as a product of recombinant cell culture, are disclosed.
摘要翻译: 公开了编码牛IL-1α的DNA片段的克隆和表达,以及用于产生纯化的牛IL-1α作为重组细胞培养物的产物的方法。
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公开(公告)号:US4879374A
公开(公告)日:1989-11-07
申请号:US25462
申请日:1987-03-13
IPC分类号: C12N15/09 , A61K38/00 , A61K38/21 , A61P17/00 , A61P43/00 , C07K14/52 , C07K14/54 , C07K14/545 , C12P21/02 , C12R1/19
CPC分类号: C07K14/545 , A61K38/00
摘要: Cloning and expression of nucleotide DNA segments encoding bovine IL-1.beta., and processes for producing purified bovine IL-1.beta. as a product of recombinant cell culture, are disclosed.
摘要翻译: 公开了编码牛IL-1β的核苷酸DNA片段的克隆和表达,以及用于产生纯化的牛IL-1β作为重组细胞培养物的产物的方法。
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公开(公告)号:US06949366B2
公开(公告)日:2005-09-27
申请号:US09904954
申请日:2001-07-12
IPC分类号: C12N15/09 , A61K38/00 , A61K38/19 , A61K39/395 , A61K51/00 , A61P35/00 , A61P35/02 , C07H21/02 , C07H21/04 , C07K14/47 , C07K14/52 , C07K16/18 , C07K16/24 , C07K16/46 , C07K19/00 , C12N5/10 , C12N15/19 , C12N15/63 , C12P21/02 , C12P21/08 , C12R1/19
CPC分类号: C07K14/52 , C07K2319/00 , C07K2319/30
摘要: Hek ligand (hek-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing hek-L polypeptides. The hek-L polypeptides bind to a cell surface receptor (hek) that is a member of the receptor tyrosine kinase family. Hek is expressed on cells that include certain tumor cell lines. The hek-L polypeptides also bind a distinct receptor tyrosine kinase known elk.
摘要翻译: Hek配体(hek-L)多肽以及可用于提供hek-L多肽的DNA序列,载体和转化的宿主细胞。 hek-L多肽结合于作为受体酪氨酸激酶家族成员的细胞表面受体(hek)。 Hek在包含某些肿瘤细胞系的细胞上表达。 hek-L多肽还结合不同受体酪氨酸激酶已知的麋鹿。
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公开(公告)号:US06555354B2
公开(公告)日:2003-04-29
申请号:US09726968
申请日:2000-11-29
IPC分类号: C12N948
CPC分类号: C12N9/6489 , C07K16/40
摘要: A metalloprotease that converts TNF-&agr; from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
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公开(公告)号:US06492140B2
公开(公告)日:2002-12-10
申请号:US09754105
申请日:2001-01-03
IPC分类号: C12P2102
CPC分类号: C07K16/24 , A61K38/00 , C07K14/52 , C07K2317/34 , C07K2319/00
摘要: LERK-5 polypeptides are disclosed, along with DNA sequences, vectors and transformed host cells useful in producing LERK-5. The LERK-5 polypeptides bind to elk and to hek, which are members of the eph/elk family of receptor tyrosine kinases.
摘要翻译: 公开了LERK-5多肽以及可用于产生LERK-5的DNA序列载体和转化的宿主细胞。 LERK-5多肽与elk和hek结合,它们是受体酪氨酸激酶的eph / elk家族的成员。
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公开(公告)号:US06479459B1
公开(公告)日:2002-11-12
申请号:US08739333
申请日:1996-10-29
IPC分类号: A61K3819
CPC分类号: C07K16/24 , A61K38/00 , C07K14/52 , C07K2317/34 , C07K2319/00
摘要: LERK-5 polypeptides are disclosed, along with DNA sequences, vectors and transformed host cells useful in producing LERK-5. The LERK-5 polypeptides bind to elk and to hek, which are members of the eph/elk family of receptor tyrosine kinases.
摘要翻译: 公开了LERK-5多肽以及可用于产生LERK-5的DNA序列载体和转化的宿主细胞。 LERK-5多肽与elk和hek结合,它们是受体酪氨酸激酶的eph / elk家族的成员。
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