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公开(公告)号：US20120029626A1
公开(公告)日：2012-02-02
申请号：US13206697
申请日：2011-08-10
CPC分类号： A61L31/022 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61L31/16 , A61L2300/416 , A61L2300/60
摘要： A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments where at least one surface of the filaments has a roughened or abraded surface. The stent may include a therapeutic agent on the abraded surface.
摘要翻译： 设计用于放置在血管损伤部位，用于抑制现场再狭窄的径向可扩张的血管内支架，使用方法和制造支架的方法。 支架包括由一个或多个金属细丝形成的径向可扩张体，其中长丝的至少一个表面具有粗糙或磨损的表面。 支架可以在研磨表面上包括治疗剂。
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公开(公告)号：US20120330406A1
公开(公告)日：2012-12-27
申请号：US13554296
申请日：2012-07-20
CPC分类号： A61L31/16 , A61F2/82 , A61F2/848 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91541 , A61F2002/91566 , A61F2210/0004 , A61F2210/0014 , A61F2220/0025 , A61F2230/0013 , A61F2240/001 , A61F2250/0023 , A61F2250/0025 , A61F2250/0026 , A61F2250/0036 , A61F2250/0037 , A61F2250/0051 , A61F2250/0067 , A61F2250/0068 , A61F2250/0096 , A61L31/022 , A61L31/10 , A61L2300/416 , A61L2300/606 , A61L2420/02
摘要： An improvement in drug-eluting stents, and method of their making, are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 μin (0.5 μm) and a surface roughness range of between about 300-700 μin (7.5-17.5 μm). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.
摘要翻译： 披露了药物洗脱支架的改进及其制作方法。 金属支架的表面被粗糙化以具有至少约20μin（0.5μm）的表面粗糙度和在约300-700μin（7.5-17.5μm）之间的表面粗糙度范围。 粗糙化的支架表面覆盖有无聚合物的斜肌药物涂层，涂层厚度大于粗糙化支架表面的表面粗糙度范围。
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公开(公告)号：US09579424B2
公开(公告)日：2017-02-28
申请号：US13554296
申请日：2012-07-20
CPC分类号： A61L31/16 , A61F2/82 , A61F2/848 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91541 , A61F2002/91566 , A61F2210/0004 , A61F2210/0014 , A61F2220/0025 , A61F2230/0013 , A61F2240/001 , A61F2250/0023 , A61F2250/0025 , A61F2250/0026 , A61F2250/0036 , A61F2250/0037 , A61F2250/0051 , A61F2250/0067 , A61F2250/0068 , A61F2250/0096 , A61L31/022 , A61L31/10 , A61L2300/416 , A61L2300/606 , A61L2420/02
摘要： An improvement in drug-eluting stents, and method of their making, are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 μin (0.5 μm) and a surface roughness range of between about 300-700 μin (7.5-17.5 μm). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.
摘要翻译： 披露了药物洗脱支架的改进及其制作方法。 金属支架的表面被粗糙化以具有至少约20μin（0.5μm）的表面粗糙度和在约300-700μin（7.5-17.5μm）之间的表面粗糙度范围。 粗糙化的支架表面覆盖有无聚合物的斜肌药物涂层，涂层厚度大于粗糙化支架表面的表面粗糙度范围。
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公开(公告)号：US20080097591A1
公开(公告)日：2008-04-24
申请号：US11751268
申请日：2007-05-21
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61F2/82 , A61F2/848 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91541 , A61F2002/91566 , A61F2210/0004 , A61F2210/0014 , A61F2220/0025 , A61F2230/0013 , A61F2240/001 , A61F2250/0023 , A61F2250/0025 , A61F2250/0026 , A61F2250/0036 , A61F2250/0037 , A61F2250/0051 , A61F2250/0067 , A61F2250/0068 , A61F2250/0096 , A61L31/022 , A61L31/10 , A61L2300/416 , A61L2300/606 , A61L2420/02
摘要： An improvement in drug-eluting stents, and method of their making are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 μin (0.5 μm) and a surface roughness range of between about 300-700 μin (7.5-17.5 μm). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.
摘要翻译： 披露了药物洗脱支架的改进及其制作方法。 金属支架的表面被粗糙化以具有至少约20微米（0.5μm）的表面粗糙度和约300-700μ（7.5-17.5μm）之间的表面粗糙度范围。 粗糙化的支架表面覆盖有无聚合物的斜肌药物涂层，涂层厚度大于粗糙化支架表面的表面粗糙度范围。
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公开(公告)号：US08067055B2
公开(公告)日：2011-11-29
申请号：US11690768
申请日：2007-03-23
IPC分类号： A61L33/00
CPC分类号： A61L31/022 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61L31/16 , A61L2300/416 , A61L2300/60
摘要： A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments where at least one surface of the filaments has a roughened or abraded surface. The stent may include a therapeutic agent on the abraded surface.
摘要翻译： 设计用于放置在血管损伤部位，用于抑制现场再狭窄的径向可扩张的血管内支架，使用方法和制造支架的方法。 支架包括由一个或多个金属细丝形成的径向可扩张体，其中长丝的至少一个表面具有粗糙或磨损的表面。 支架可以在研磨表面上包括治疗剂。
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公开(公告)号：US20080097568A1
公开(公告)日：2008-04-24
申请号：US11690768
申请日：2007-03-23
IPC分类号： A61F2/06
CPC分类号： A61L31/022 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61L31/16 , A61L2300/416 , A61L2300/60
摘要： A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments where at least one surface of the filaments has a roughened or abraded surface. The stent may include a therapeutic agent on the abraded surface.
摘要翻译： 设计用于放置在血管损伤部位，用于抑制现场再狭窄的径向可扩张的血管内支架，使用方法和制造支架的方法。 支架包括由一个或多个金属细丝形成的径向可扩张体，其中长丝的至少一个表面具有粗糙或磨损的表面。 支架可以在研磨表面上包括治疗剂。
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公开(公告)号：US20090287294A1
公开(公告)日：2009-11-19
申请号：US12427620
申请日：2009-04-21
申请人： Arturo S. Rosqueta , Frank P. Becking , Maria G. Aboytes , Siddharth Loganathan , Chi Vu , Sepehr Fariabi
发明人： Arturo S. Rosqueta , Frank P. Becking , Maria G. Aboytes , Siddharth Loganathan , Chi Vu , Sepehr Fariabi
CPC分类号： A61B17/12159 , A61B17/12022 , A61B17/12031 , A61B17/12109 , A61B17/12113 , A61B17/12118 , A61B17/1215 , A61B17/12172 , A61B2017/00526 , A61B2017/00862 , A61B2017/00867 , A61B2017/1205 , A61B2017/12054 , A61B2017/12068 , A61B2018/00416 , A61B2090/3966 , A61M29/02 , Y10T156/1051
摘要： Embolic implants, delivery systems and methods of manufacture and delivery are disclosed. The devices can be used for aneurysm treatment and/or parent vessel occlusion. Implant designs offer low profile compressibility for delivery to neurovasculature, while maintaining other necessary features such as density for occlusion purposes and desirable radial strength characteristics.
摘要翻译： 公开了栓塞植入物，递送系统以及制造和递送方法。 该装置可用于动脉瘤治疗和/或母体血管闭塞。 植入物设计提供低调压缩性以递送至神经血管系统，同时保持其他必要特征，例如闭塞目的的密度和期望的径向强度特征。
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公开(公告)号：US07244319B2
公开(公告)日：2007-07-17
申请号：US10291930
申请日：2002-11-11
申请人： Robert M. Abrams , Sepehr Fariabi
发明人： Robert M. Abrams , Sepehr Fariabi
IPC分类号： A61F2/86
CPC分类号： A61L31/14 , A61L31/022 , A61L2400/16 , A61M25/09 , A61M2025/09008 , A61M2025/09083 , A61M2025/09141 , A61M2025/09175 , A61M2205/0266 , C22C14/00 , C22C30/00 , C22F1/006
摘要： An improved guiding member for use within a body lumen having a unique combination of superelastic characteristics. The superelastic alloy material has a composition consisting of about 30% to about 52% (atomic) titanium, and about 38% to 52% nickel and may have one or more elements selected from the group consisting of iron, cobalt, platinum, palladium, vanadium, copper, zirconium, hafnium and niobium. The alloy material is subjected to thermomechanical processing which includes a final cold working of about 10 to about 75% and then a heat treatment at a temperature between about 450° and about 600° C. and preferably about 475° to about 550° C. Before the heat treatment the cold worked alloy material is preferably subjected to mechanical straightening. The alloy material is preferably subjected to stresses equal to about 5 to about 50% of the room temperature ultimate yield stress of the material during the thermal treatment. The guiding member using such improved material exhibits a stress-induced austenite-to-martensite phase transformation at an exceptionally high constant yield strength of over 90 ksi for solid members and over 70 ksi for tubular members with a broad recoverable strain of at least about 4% during the phase transformation. An essentially whip free product is obtained.
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公开(公告)号：US06652472B2
公开(公告)日：2003-11-25
申请号：US10186858
申请日：2002-07-01
申请人： Mo Jafari , Sepehr Fariabi , Lawrence E. Brennan , Wayne E. Cornish , Marc M. Jalisi , David M. Anderson
发明人： Mo Jafari , Sepehr Fariabi , Lawrence E. Brennan , Wayne E. Cornish , Marc M. Jalisi , David M. Anderson
IPC分类号： A61B500
CPC分类号： A61M25/09 , A61M2025/09175
摘要： A guidewire for intraluminal advancement of a medical device within a patient which has an elongate core member with a flexible body member disposed on a distal section thereof. In one embodiment, the distal section of the elongate core member has at least one flexible segment with at least one pair of opposed tapered or parallel faces. Preferably the flexible segment with the tapered or parallel faces is disposed at the distal end of the elongate core and forms a shapable segment.
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公开(公告)号：US06592570B2
公开(公告)日：2003-07-15
申请号：US09884432
申请日：2001-06-18
申请人： Robert M. Abrams , Sepehr Fariabi
发明人： Robert M. Abrams , Sepehr Fariabi
IPC分类号： A61M2501
CPC分类号： A61M25/09 , A61L31/022 , A61L31/14 , A61L2400/16 , A61M2025/09008 , A61M2025/09083 , A61M2025/09141 , A61M2025/09175 , A61M2205/0266 , C22C14/00 , C22C30/00 , C22F1/006
摘要： An improved guiding member for use within a body lumen having a unique combination of superelastic characteristics. The superelastic alloy material has a composition consisting of about 30% to about 52% (atomic) titanium, and about 38% to 52% nickel and may have one or more elements selected from the group consisting of iron, cobalt, platinum, palladium, vanadium, copper, zirconium, hafnium and niobium. The alloy material is subjected to thermomechanical processing which includes a final cold working of about 10 to about 75% and then a heat treatment at a temperature between about 450° and about 600° C. and preferably about 475° to about 550° C. Before the heat treatment the cold worked alloy material is preferably subjected to mechanical straightening. The alloy material is preferably subjected to stresses equal to about 5 to about 50% of the room temperature ultimate yield stress of the material during the thermal treatment. The guiding member using such improved material exhibits a stress-induced austenite-to-martensite phase transformation at an exceptionally high constant yield strength of over 90 ksi for solid members and over 70 ksi for tubular members with a broad recoverable strain of at least about 4% during the phase transformation. An essentially whip free product is obtained.
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