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公开(公告)号：US20120029626A1
公开(公告)日：2012-02-02
申请号：US13206697
申请日：2011-08-10
CPC分类号： A61L31/022 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61L31/16 , A61L2300/416 , A61L2300/60
摘要： A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments where at least one surface of the filaments has a roughened or abraded surface. The stent may include a therapeutic agent on the abraded surface.
摘要翻译： 设计用于放置在血管损伤部位，用于抑制现场再狭窄的径向可扩张的血管内支架，使用方法和制造支架的方法。 支架包括由一个或多个金属细丝形成的径向可扩张体，其中长丝的至少一个表面具有粗糙或磨损的表面。 支架可以在研磨表面上包括治疗剂。
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公开(公告)号：US20120330406A1
公开(公告)日：2012-12-27
申请号：US13554296
申请日：2012-07-20
CPC分类号： A61L31/16 , A61F2/82 , A61F2/848 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91541 , A61F2002/91566 , A61F2210/0004 , A61F2210/0014 , A61F2220/0025 , A61F2230/0013 , A61F2240/001 , A61F2250/0023 , A61F2250/0025 , A61F2250/0026 , A61F2250/0036 , A61F2250/0037 , A61F2250/0051 , A61F2250/0067 , A61F2250/0068 , A61F2250/0096 , A61L31/022 , A61L31/10 , A61L2300/416 , A61L2300/606 , A61L2420/02
摘要： An improvement in drug-eluting stents, and method of their making, are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 μin (0.5 μm) and a surface roughness range of between about 300-700 μin (7.5-17.5 μm). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.
摘要翻译： 披露了药物洗脱支架的改进及其制作方法。 金属支架的表面被粗糙化以具有至少约20μin（0.5μm）的表面粗糙度和在约300-700μin（7.5-17.5μm）之间的表面粗糙度范围。 粗糙化的支架表面覆盖有无聚合物的斜肌药物涂层，涂层厚度大于粗糙化支架表面的表面粗糙度范围。
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公开(公告)号：US08067055B2
公开(公告)日：2011-11-29
申请号：US11690768
申请日：2007-03-23
IPC分类号： A61L33/00
CPC分类号： A61L31/022 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61L31/16 , A61L2300/416 , A61L2300/60
摘要： A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments where at least one surface of the filaments has a roughened or abraded surface. The stent may include a therapeutic agent on the abraded surface.
摘要翻译： 设计用于放置在血管损伤部位，用于抑制现场再狭窄的径向可扩张的血管内支架，使用方法和制造支架的方法。 支架包括由一个或多个金属细丝形成的径向可扩张体，其中长丝的至少一个表面具有粗糙或磨损的表面。 支架可以在研磨表面上包括治疗剂。
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公开(公告)号：US20080097591A1
公开(公告)日：2008-04-24
申请号：US11751268
申请日：2007-05-21
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61F2/82 , A61F2/848 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91541 , A61F2002/91566 , A61F2210/0004 , A61F2210/0014 , A61F2220/0025 , A61F2230/0013 , A61F2240/001 , A61F2250/0023 , A61F2250/0025 , A61F2250/0026 , A61F2250/0036 , A61F2250/0037 , A61F2250/0051 , A61F2250/0067 , A61F2250/0068 , A61F2250/0096 , A61L31/022 , A61L31/10 , A61L2300/416 , A61L2300/606 , A61L2420/02
摘要： An improvement in drug-eluting stents, and method of their making are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 μin (0.5 μm) and a surface roughness range of between about 300-700 μin (7.5-17.5 μm). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.
摘要翻译： 披露了药物洗脱支架的改进及其制作方法。 金属支架的表面被粗糙化以具有至少约20微米（0.5μm）的表面粗糙度和约300-700μ（7.5-17.5μm）之间的表面粗糙度范围。 粗糙化的支架表面覆盖有无聚合物的斜肌药物涂层，涂层厚度大于粗糙化支架表面的表面粗糙度范围。
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公开(公告)号：US09579424B2
公开(公告)日：2017-02-28
申请号：US13554296
申请日：2012-07-20
CPC分类号： A61L31/16 , A61F2/82 , A61F2/848 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91541 , A61F2002/91566 , A61F2210/0004 , A61F2210/0014 , A61F2220/0025 , A61F2230/0013 , A61F2240/001 , A61F2250/0023 , A61F2250/0025 , A61F2250/0026 , A61F2250/0036 , A61F2250/0037 , A61F2250/0051 , A61F2250/0067 , A61F2250/0068 , A61F2250/0096 , A61L31/022 , A61L31/10 , A61L2300/416 , A61L2300/606 , A61L2420/02
摘要： An improvement in drug-eluting stents, and method of their making, are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 μin (0.5 μm) and a surface roughness range of between about 300-700 μin (7.5-17.5 μm). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.
摘要翻译： 披露了药物洗脱支架的改进及其制作方法。 金属支架的表面被粗糙化以具有至少约20μin（0.5μm）的表面粗糙度和在约300-700μin（7.5-17.5μm）之间的表面粗糙度范围。 粗糙化的支架表面覆盖有无聚合物的斜肌药物涂层，涂层厚度大于粗糙化支架表面的表面粗糙度范围。
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公开(公告)号：US20080097568A1
公开(公告)日：2008-04-24
申请号：US11690768
申请日：2007-03-23
IPC分类号： A61F2/06
CPC分类号： A61L31/022 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61L31/16 , A61L2300/416 , A61L2300/60
摘要： A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments where at least one surface of the filaments has a roughened or abraded surface. The stent may include a therapeutic agent on the abraded surface.
摘要翻译： 设计用于放置在血管损伤部位，用于抑制现场再狭窄的径向可扩张的血管内支架，使用方法和制造支架的方法。 支架包括由一个或多个金属细丝形成的径向可扩张体，其中长丝的至少一个表面具有粗糙或磨损的表面。 支架可以在研磨表面上包括治疗剂。
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公开(公告)号：US09168159B2
公开(公告)日：2015-10-27
申请号：US13128078
申请日：2009-11-04
申请人： Shih-Horng Su , Fuh-Sheng Chen , Debashis Dutta
发明人： Shih-Horng Su , Fuh-Sheng Chen , Debashis Dutta
CPC分类号： A61F2/82 , A61F2/0077 , A61F2/04 , A61F2/06 , A61F2/848 , A61F2002/0081 , A61F2230/0002 , A61F2250/0067 , A61F2250/0068 , A61F2250/0071 , A61K33/00 , A61L2400/12
摘要： Devices and methods for controlling the flaking of coating fragments from medical implants and improving the delivery of therapeutic agents from such coatings are described.
摘要翻译： 描述了用于控制来自医疗植入物的涂层碎片的剥落和改善来自这些涂层的治疗剂的递送的装置和方法。
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公开(公告)号：US20130261733A1
公开(公告)日：2013-10-03
申请号：US13587219
申请日：2012-08-16
申请人： Shih-Horng Su
发明人： Shih-Horng Su
IPC分类号： A61F2/82
CPC分类号： A61F2/88 , A61F2/885 , A61F2/954 , A61F2002/061 , A61F2002/825 , A61F2210/0004 , A61F2230/0067 , A61F2230/0091 , A61F2250/0029 , A61F2250/0039 , A61F2250/0067 , A61F2250/0098
摘要： An expandable, bioabsorbable stent having a coiled-coil configuration is described. The stent further comprises regions of variable pitch that allow for variation in either rigidity, or variability diameter within sub-regions along the length of the deployed stent. By varying the diameter allows the stent to extend into regions such as branched vessels, or into the neck of aneurysms. In some embodiments, the stent comprises longitudinal support fibers that run substantially the length of the deployed stent to provide additional strength. In addition, the stent may also comprise regional support fibers that run less than the length of the stent, and which provide increased regional strength while permitting flexibility of the stent. The stent further comprises micro-tubes that are configured to be visible using medical imaging techniques. The stent can be manufactured from materials that are bioabsorbable and/or include the ability to release pharmacologically active substances over time.
摘要翻译： 描述了具有盘绕线圈结构的可扩张的生物可吸收支架。 支架还包括可变节距的区域，其允许沿着展开的支架的长度的子区域内的刚度或变异性直径的变化。 通过改变直径允许支架延伸到诸如分支血管的区域中，或者延伸到动脉瘤的颈部。 在一些实施例中，支架包括纵向支撑纤维，其基本上延伸展开的支架的长度以提供额外的强度。 此外，支架还可以包括运行小于支架长度的区域支撑纤维，并且在允许支架的柔性的同时提供增加的区域强度。 支架还包括使用医学成像技术构造成可见的微管。 支架可以由生物可吸收的材料和/或包括随时间释放药理活性物质的能力制造。
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公开(公告)号：US20110301259A1
公开(公告)日：2011-12-08
申请号：US13206430
申请日：2011-08-09
申请人： Shih-Horng Su , John E. Shulze , Debashis Dutta , John Nguyen
发明人： Shih-Horng Su , John E. Shulze , Debashis Dutta , John Nguyen
IPC分类号： A61F2/82
CPC分类号： A61F2/86 , A61F2/88 , A61F2/91 , A61F2/915 , A61F2002/828 , A61F2002/91525 , A61F2002/91541 , A61F2002/91558 , A61F2002/91566 , A61F2002/91591 , A61F2210/0076 , B29C41/14 , B29C41/34 , B29K2067/046
摘要： A biodegradable polymer stent with radiopacity and a method of making and using a stent with enhanced mechanical strength and/or controlled degradation for use in a bodily lumen is described.
摘要翻译： 描述了具有放射不透性的可生物降解的聚合物支架以及用于制造和使用具有增强的机械强度和/或受控降解的用于体腔的支架的方法。
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公开(公告)号：US06806364B2
公开(公告)日：2004-10-19
申请号：US10207376
申请日：2002-07-29
IPC分类号： C08L128
CPC分类号： A61K9/0048 , A61K31/198 , A61K31/717 , A61K33/14 , A61K33/22 , A61K33/30 , A61K33/42 , A61K2300/00
摘要： An aqueous ophthalmic solution containing 0.2 to 2.5 percent by weight a polymeric demulcent, 0.045 to 0.065 percent by weight a calcium salt, and 0.14 to 1.4 percent by weight a phosphate salt. The solution has a viscosity of 20 to 150 centipoise and is buffered to a pH 5.5 to 8.5.
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