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1.发明申请Foamable vehicle and vitamin and flavonoid pharmaceutical compositions thereof 审中-公开可发泡载体及其维生素和类黄酮药物组合物公开(公告)号：US20080069779A1
公开(公告)日：2008-03-20
申请号：US11900072
申请日：2007-09-10
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Tal Berman , David Schuz
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Tal Berman , David Schuz
CPC分类号： A61K9/124 , A61K8/046 , A61K8/498 , A61K8/67 , A61K8/671 , A61K8/675 , A61K8/676 , A61K9/0014 , A61K2800/522 , A61Q5/006 , A61Q19/00 , A61Q19/08
摘要： Vitamin and flavonoid containing compositions are provided that are stable to degradation. Stabilized compositions include one or more features including a hygroscopic solvent at a sufficient concentration to provide an Aw value of the hygroscopic vitamin and or flavonoid containing composition of less than 0.9, antioxidant flavonoids that are preferentially oxidized before the vitamin, preservatives, and hydrocarbon propellants selected to reduce the oxidation potential of the composition.
摘要翻译： 提供含有维生素和类黄酮的组合物，其对降解是稳定的。 稳定的组合物包括一个或多个特征，包括足够浓度的吸湿溶剂，以提供在选择维生素，防腐剂和烃推进剂之前优先氧化的吸湿性维生素和/或类黄酮组合物的Aw值小于0.9的抗氧化黄酮 以降低组合物的氧化电位。
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公开(公告)号：US09320705B2
公开(公告)日：2016-04-26
申请号：US12350650
申请日：2009-01-08
申请人： Dov Tamarkin , Meir Eini , Doron Friedman , Ella Zlatkis , David Schuz , Tal Berman
发明人： Dov Tamarkin , Meir Eini , Doron Friedman , Ella Zlatkis , David Schuz , Tal Berman
IPC分类号： A61K9/00 , A61K8/04 , A61K8/34 , A61K8/42 , A61K8/92 , A61K8/97 , A61K9/12 , A61Q19/00 , A01N25/16
CPC分类号： A61K9/0014 , A01N25/16 , A61K8/046 , A61K8/34 , A61K8/345 , A61K8/42 , A61K8/731 , A61K8/736 , A61K8/8152 , A61K8/8158 , A61K8/87 , A61K8/922 , A61K8/97 , A61K9/122 , A61K2800/24 , A61K2800/242 , A61K2800/244 , A61K2800/30 , A61Q17/02 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/08
摘要： This invention relates to foamable compositions that are capable of producing a sensation or sensation modifying effect upon application on a body surface. More particularly the invention relates to foamable pharmaceutical, therapeutic and cosmetic compositions, comprising an active agent, having a sensation or sensation modifying affect on a body surface, upon application. More particularly, the invention relates to foamable compositions comprising: (a) a foamable carrier; (b) at least one sensation or sensation modifying agent, selected from the group of a cooling agent; a warming agent; a relaxing or soothing agent; stimulating or refreshing agent; or mixtures thereof and (c) a propellant at a concentration of about 3% to about 45% by weight of the total composition. The foamable carrier can be an emollient emulsion foamable vehicle, a foamable gel vehicle and can also be a substantially non aqueous foamable vehicle.
摘要翻译： 本发明涉及能够在施用于身体表面时产生感觉或感觉改变作用的可发泡组合物。 更具体地说，本发明涉及包含活性剂的可发泡药物，治疗和美容组合物，其在施用时具有对身体表面的感觉或感觉修饰作用。 更具体地，本发明涉及可发泡组合物，其包含：（a）可发泡载体; （b）至少一种感觉或感觉改性剂，其选自冷却剂组; 加热剂; 一个放松或舒缓的代理; 刺激或清爽剂; 或其混合物和（c）浓度为总组合物重量的约3％至约45％的推进剂。 可发泡载体可以是润肤乳液可发泡载体，可发泡凝胶载体，也可以是基本上非水性的可发泡载体。
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3.发明授权Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses 有权基本上无水可发泡的凡士林的药物和美容组合物及其用途公开(公告)号：US08795635B2
公开(公告)日：2014-08-05
申请号：US12778591
申请日：2010-05-12
申请人： Dov Tamarkin , Doron Friedman , Enbal Ziv , Meir Eini , Tal Berman , Jorge Danziger , Rita Keynan , David Schuz
发明人： Dov Tamarkin , Doron Friedman , Enbal Ziv , Meir Eini , Tal Berman , Jorge Danziger , Rita Keynan , David Schuz
CPC分类号： A61K8/046 , A61K8/31 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K47/06 , A61K2800/31 , A61Q19/00 , Y10S514/859
摘要： The present invention relates to stable substantially non-aqueous, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum or mixtures thereof, at least one foam agent, at least one propellant, and with and without the addition of an active agent. The formulations may contain a solvent substantially miscible therein. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject in need thereof, comprising administering the above-mentioned compositions to an afflicted target site of said mammalian subject.
摘要翻译： 本发明涉及包含凡士林或其混合物，至少一种泡沫剂，至少一种推进剂，以及加入和不添加活性剂的稳定的基本上非水性，非醇，非硅氧烷，可发泡的载体组合物。 制剂可以含有其中基本上可混溶的溶剂。 本发明还提供了治疗，减轻或预防有此需要的哺乳动物受试者病症的方法，包括将上述组合物施用于所述哺乳动物受试者的受影响的靶位点。
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4.发明授权公开(公告)号：US08486374B2
公开(公告)日：2013-07-16
申请号：US12014088
申请日：2008-01-14
申请人： Dov Tamarkin , Meir Eini , Doron Friedman , Alex Besonov , David Schuz , Tal Berman , Jorge Danziger , Rita Keynan , Ella Zlatkis
发明人： Dov Tamarkin , Meir Eini , Doron Friedman , Alex Besonov , David Schuz , Tal Berman , Jorge Danziger , Rita Keynan , Ella Zlatkis
IPC分类号： A61K33/00 , A61K47/34 , A61K31/375 , A61K31/355 , A61K31/351 , A61K31/4412 , A61K31/47 , A61K31/57 , A61K9/12 , A61K31/522 , A61K31/135 , A61K31/00
CPC分类号： A61K9/12 , A01N25/02 , A01N25/16 , A61K9/0014 , A61K9/122 , A61K31/047 , A61K31/135 , A61K31/351 , A61K31/355 , A61K31/375 , A61K31/4412 , A61K31/522 , A61K47/10 , A61K47/14 , A61K47/38
摘要： A waterless composition suitable for delivery of an active agent to a body surface or cavity includes a vehicle having about 70% to about 99% by weight of a hydrophilic polar solvent, said hydrophilic solvent selected from the group consisting of (i) a mixture of two or more different polyethylene glycols (PEGs), wherein at least one PEG is a high molecular weight PEG having a melting point greater than 25° C.; and (ii) propylene glycol (PG); about 0% to about 10% of at least one surface active agent; about 0% to about 5% of a polymeric agent; about 0% to about 30% of a secondary hydrophilic solvent; and about 0% to about 5% of a silicone oil; and about 3% to about 25% hydrophobic propellant. The composition is otherwise substantially free of a hydrophobic solvent and includes at least one of a surface active agent and a polymeric agent. The vehicle and the propellant are sufficiently miscible that the components may be homogeneously distributed with mild shaking.
摘要翻译： 适用于将活性剂递送到体表或空腔的无水组合物包括具有约70％至约99％重量的亲水极性溶剂的载体，所述亲水性溶剂选自（i） 两种或更多种不同的聚乙二醇（PEG），其中至少一种PEG是熔点大于25℃的高分子量PEG; 和（ii）丙二醇（PG）; 约0％至约10％的至少一种表面活性剂; 约0％至约5％的聚合物; 约0％至约30％的第二亲水溶剂; 和约0％至约5％的硅油; 和约3％至约25％的疏水性推进剂。 组合物基本上不含疏水性溶剂，并且包括表面活性剂和聚合物剂中的至少一种。 车辆和推进剂是充分混溶的，这些组分可以均匀分布，温和摇动。
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公开(公告)号：US20080063607A1
公开(公告)日：2008-03-13
申请号：US11894798
申请日：2007-08-20
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov , Jorge Danziger , David Schuz , Tal Berman
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov , Jorge Danziger , David Schuz , Tal Berman
CPC分类号： A61K8/86 , A61K9/0031 , A61K9/0034 , A61K9/0046 , A61K9/122 , A61K2800/5422 , A61Q17/04 , A61Q19/007 , A61Q19/04 , A61Q19/08 , A61Q19/10
摘要： The invention relates to stable pharmaceutical or cosmetic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent comprising polyethylene glycol (PEG) or PEG derivative and mixtures thereof, or comprising propylene glycol, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition.
摘要翻译： 本发明涉及含有某些活性剂的稳定的药物或化妆品泡沫组合物，具有独特的治疗性质和使用这种组合物的治疗方法。 可发泡组合物包括至少一种包含聚乙二醇（PEG）或PEG衍生物及其混合物或包含丙二醇的溶剂，其中溶剂的浓度为总组合物重量的约70％至约96.5％，在 至少一种非离子表面活性剂，其浓度为总组合物重量的约0.1％至小于约10％。
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公开(公告)号：US08795693B2
公开(公告)日：2014-08-05
申请号：US11947751
申请日：2007-11-29
申请人： Dov Tamarkin , Meir Eini , Doron Friedman , Tal Berman , David Schuz
发明人： Dov Tamarkin , Meir Eini , Doron Friedman , Tal Berman , David Schuz
CPC分类号： A61K47/12 , A61K9/0014 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0046 , A61K9/0048 , A61K9/0056 , A61K9/122 , A61K31/167 , A61K31/341 , A61K31/375 , A61K31/56 , A61K31/573 , A61K31/593 , A61K47/18 , A61K47/183 , A61K47/26 , A61K47/32
摘要： The present invention relates to a waterless composition and foam as a vehicle in which an active pharmaceutical or cosmetic agent, when added is stable or stabilized by or its destabilization is impeded by the presence of a modulating agent. The pharmaceutical or cosmetic composition and foam, includes: a waterless solvent, a modulating agent and one or more active pharmaceutical or cosmetic agents. The present invention also relates to a method of treatment administering the waterless composition and foam.
摘要翻译： 本发明涉及作为载体的无水组合物和泡沫，其中活性药物或化妆品在添加时稳定或稳定化或其不稳定性受到调节剂的存在的阻碍。 药物或化妆品组合物和泡沫体包括：无水溶剂，调节剂和一种或多种活性药物或化妆品。 本发明还涉及给予无水组合物和泡沫的治疗方法。
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7.发明申请SUBSTANTIALLY NON-AQUEOUS FOAMABLE PETROLATUM BASED PHARMACEUTICAL AND COSMETIC COMPOSITIONS AND THEIR USES 有权基于非水性可泡沫PETROLATUM的药物和化妆品组合物及其用途公开(公告)号：US20100221195A1
公开(公告)日：2010-09-02
申请号：US12778591
申请日：2010-05-12
申请人： Dov TAMARKIN , Doron Friedman , Enbal Ziv , Meir Eini , Tal Berman , Jorge Danziger , Rita Keynan , David Schuz
发明人： Dov TAMARKIN , Doron Friedman , Enbal Ziv , Meir Eini , Tal Berman , Jorge Danziger , Rita Keynan , David Schuz
IPC分类号： A61K9/12 , A61P31/00 , A61P33/00 , A61P29/00 , A61P37/00 , A61P17/00 , A61P35/00 , A01P1/00 , A01P3/00 , A01P7/00
CPC分类号： A61K8/046 , A61K8/31 , A61K9/0014 , A61K9/107 , A61K9/122 , A61K47/06 , A61K2800/31 , A61Q19/00 , Y10S514/859
摘要： The present invention relates to stable substantially non-aqueous, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum or mixtures thereof, at least one foam agent, at least one propellant, and with and without the addition of an active agent. The formulations may contain a solvent substantially miscible therein. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject in need thereof, comprising administering the above-mentioned compositions to an afflicted target site of said mammalian subject.
摘要翻译： 本发明涉及包含凡士林或其混合物，至少一种泡沫剂，至少一种推进剂，以及加入和不添加活性剂的稳定的基本上非水性，非醇，非硅氧烷，可发泡的载体组合物。 制剂可以含有其中基本上可混溶的溶剂。 本发明还提供了治疗，减轻或预防有此需要的哺乳动物受试者病症的方法，包括将上述组合物施用于所述哺乳动物受试者的受影响的靶位点。
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8.发明申请公开(公告)号：US20080299220A1
公开(公告)日：2008-12-04
申请号：US12014088
申请日：2008-01-14
申请人： Dov Tamarkin , Meir Eini , Doron Friedman , Alex Besonov , David Schuz , Tal Berman , Jorge Danziger , Rita Keynan , Ella Zlatkis
发明人： Dov Tamarkin , Meir Eini , Doron Friedman , Alex Besonov , David Schuz , Tal Berman , Jorge Danziger , Rita Keynan , Ella Zlatkis
IPC分类号： A61K33/00 , A61K47/34 , A61K31/375 , A61K31/355 , A61K31/351 , A61K31/4412 , A61K31/047 , A61K31/57 , A61K9/12 , A61K31/522 , A61K31/135
CPC分类号： A61K9/12 , A01N25/02 , A01N25/16 , A61K9/0014 , A61K9/122 , A61K31/047 , A61K31/135 , A61K31/351 , A61K31/355 , A61K31/375 , A61K31/4412 , A61K31/522 , A61K47/10 , A61K47/14 , A61K47/38
摘要： A waterless composition suitable for delivery of an active agent to a body surface or cavity includes a vehicle having about 70% to about 99% by weight of a hydrophilic polar solvent, said hydrophilic solvent selected from the group consisting of (i) a mixture of two or more different polyethylene glycols (PEGs), wherein at least one PEG is a high molecular weight PEG having a melting point greater than 25° C.; and (ii) propylene glycol (PG); about 0% to about 10% of at least one surface active agent; about 0% to about 5% of a polymeric agent; about 0% to about 30% of a secondary hydrophilic solvent; and about 0% to about 5% of a silicone oil; and about 3% to about 25% hydrophobic propellant. The composition is otherwise substantially free of a hydrophobic solvent and includes at least one of a surface active agent and a polymeric agent. The vehicle and the propellant are sufficiently miscible that the components may be homogeneously distributed with mild shaking.
摘要翻译： 适用于将活性剂递送到体表或空腔的无水组合物包括具有约70％至约99％重量的亲水极性溶剂的载体，所述亲水性溶剂选自（i） 两种或更多种不同的聚乙二醇（PEG），其中至少一种PEG是熔点大于25℃的高分子量PEG; 和（ii）丙二醇（PG）; 约0％至约10％的至少一种表面活性剂; 约0％至约5％的聚合物; 约0％至约30％的第二亲水溶剂; 和约0％至约5％的硅油; 和约3％至约25％的疏水性推进剂。 组合物基本上不含疏水性溶剂，并且包括表面活性剂和聚合物剂中的至少一种。 车辆和推进剂是充分混溶的，这些组分可以均匀分布，温和摇动。
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公开(公告)号：US20080206159A1
公开(公告)日：2008-08-28
申请号：US11947751
申请日：2007-11-29
申请人： Dov Tamarkin , Meir Eini , Doron Friedman , Tal Berman , David Schuz
发明人： Dov Tamarkin , Meir Eini , Doron Friedman , Tal Berman , David Schuz
IPC分类号： A61K9/12 , A61K47/30 , A61K47/36 , A61K47/38 , A61K31/56 , A61P17/00 , A61P35/00 , A61P31/12
CPC分类号： A61K47/12 , A61K9/0014 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0046 , A61K9/0048 , A61K9/0056 , A61K9/122 , A61K31/167 , A61K31/341 , A61K31/375 , A61K31/56 , A61K31/573 , A61K31/593 , A61K47/18 , A61K47/183 , A61K47/26 , A61K47/32
摘要： The present invention relates to a waterless composition and foam as a vehicle in which an active pharmaceutical or cosmetic agent, when added is stable or stabilized by or its destabilization is impeded by the presence of a modulating agent. The pharmaceutical or cosmetic composition and foam, includes: a waterless solvent, a modulating agent and one or more active pharmaceutical or cosmetic agents. The present invention also relates to a method of treatment administering the waterless composition and foam.
摘要翻译： 本发明涉及作为载体的无水组合物和泡沫，其中活性药物或化妆品在添加时稳定或稳定化或其不稳定性受到调节剂的存在的阻碍。 药物或化妆品组合物和泡沫体包括：无水溶剂，调节剂和一种或多种活性药物或化妆品。 本发明还涉及给予无水组合物和泡沫的治疗方法。
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公开(公告)号：US20070292461A1
公开(公告)日：2007-12-20
申请号：US11653205
申请日：2007-01-12
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov , Jorge Danziger , David Schuz , Tal Berman
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov , Jorge Danziger , David Schuz , Tal Berman
IPC分类号： A61K8/02 , A61P17/12 , A61P23/02 , A61P3/02 , A61P31/00 , A61P31/12 , A61P35/00 , A61Q19/02 , A61Q19/04 , A61Q19/08
CPC分类号： A61K8/86 , A61K9/0031 , A61K9/0034 , A61K9/0046 , A61K9/122 , A61K2800/5422 , A61Q17/04 , A61Q19/007 , A61Q19/04 , A61Q19/08 , A61Q19/10
摘要： The invention relates to stable pharmaceutical or cosmetic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent comprising polyethylene glycol (PEG) or PEG derivative and mixtures thereof, or comprising propylene glycol, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition.
摘要翻译： 本发明涉及含有某些活性剂的稳定的药物或化妆品泡沫组合物，具有独特的治疗性质和使用这种组合物的治疗方法。 可发泡组合物包括至少一种包含聚乙二醇（PEG）或PEG衍生物及其混合物或包含丙二醇的溶剂，其中溶剂的浓度为总组合物重量的约70％至约96.5％，在 至少一种非离子表面活性剂，其浓度为总组合物重量的约0.1％至小于约10％。
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