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公开(公告)号：US10029013B2
公开(公告)日：2018-07-24
申请号：US13499709
申请日：2010-10-01
申请人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K47/44 , A61K31/593 , A61K31/167 , A61K31/65 , A61K31/58 , A61K47/46 , A61K9/12 , A61P17/00 , A61P17/10 , A61P37/08 , A61P17/14 , A61P31/04 , A61P35/00 , A61P17/02 , A61P25/00 , A61P29/00 , A61P31/10 , A61P17/04 , A61P17/06 , A61P17/08 , A61K31/327 , A61K47/06 , A61K9/00 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K8/34 , A61K8/36 , A61K47/10 , A61K47/12 , A61K31/137 , A61K31/192 , A61K45/06 , A61K47/02 , A61K47/24 , A61K8/31 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： A substantially surface active agent-free and foam adjuvant-free composition which includes a hydrophobic solvent, a wax and a propellant. A substantially surface active agent-free and foam adjuvant-free composition, further comprising, a tetracycline antibiotic, or one or More other active agents. A method of treatment, using a substantially surface active agent-free and substantially foam adjuvant-free composition.
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2.发明授权Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses 有权非表面活性剂非聚合剂水醇发泡组合物，易碎泡沫及其用途公开(公告)号：US09072667B2
公开(公告)日：2015-07-07
申请号：US13359787
申请日：2012-01-27
申请人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
发明人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
CPC分类号： A61K9/122 , A61K8/046 , A61K8/34 , A61K8/342 , A61K9/12 , A61K31/573 , A61K47/10 , A61K47/12 , A61K47/44 , A61Q19/00
摘要： A substantially surface active agent-free and substantially polymeric agent-free foamable composition which includes short-chain alcohol, water, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free and substantially polymeric agent-free foamable composition which includes water, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent-free and substantially polymeric agent-free foamable composition.
摘要翻译： 一种基本上无表面活性剂和基本上无聚合物的可发泡组合物，其包括短链醇，水，脂肪醇或脂肪酸，或脂肪醇和脂肪酸与推进剂的组合。 一种基本上无表面活性剂和基本上无聚合物的可发泡组合物，其包括水，脂肪醇或脂肪酸和推进剂。 一种使用基本上无表面活性剂和基本上不含聚合物的可发泡组合物进行处理的方法。
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公开(公告)号：US08636982B2
公开(公告)日：2014-01-28
申请号：US12187840
申请日：2008-08-07
申请人： Dov Tamarkin , Rita Keynan , David Schuz , Tal Berman
发明人： Dov Tamarkin , Rita Keynan , David Schuz , Tal Berman
IPC分类号： A61K9/12
CPC分类号： A61K9/124 , A61K8/046 , A61K8/31 , A61K8/342 , A61K8/361 , A61K8/4993 , A61K8/86 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0046 , A61K9/1075 , A61K9/122 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/44 , A61Q5/006 , A61Q7/00 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： Unique foamable vehicles or carriers comprising at least one wax, waxy substance, counterpart or derivative, a stabilizer, water, and a propellant are provided. In some embodiments, the wax is a liquid wax. In some embodiments, the wax includes a solid wax and a liquid wax. The compositions are substantially free of crystals. The components are selected to provide a composition that is substantially resistant to aging and to phase separation, and/or can substantially solubilize and or stabilize active ingredients. Pharmaceutical and cosmetic compositions with potentially enhanced skin delivery and their uses are also provided.
摘要翻译： 提供了包含至少一种蜡，蜡质物质，对应物或衍生物，稳定剂，水和推进剂的独特的可发泡车辆或载体。 在一些实施方案中，蜡是液体蜡。 在一些实施方案中，蜡包括固体蜡和液体蜡。 组合物基本上不含晶体。 选择组分以提供基本上耐老化和相分离的组合物和/或可以基本上溶解和/或稳定活性成分。 还提供了具有潜在增强的皮肤递送及其用途的药物和化妆品组合物。
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4.发明授权公开(公告)号：US08618081B2
公开(公告)日：2013-12-31
申请号：US13100724
申请日：2011-05-04
申请人： Dov Tamarkin , Elana Gazal , Yohan Hazot , David Schuz , Irakliy Papiashvili
发明人： Dov Tamarkin , Elana Gazal , Yohan Hazot , David Schuz , Irakliy Papiashvili
CPC分类号： A61K47/44 , A61K8/31 , A61K8/342 , A61K8/361 , A61K9/0014 , A61K9/0048 , A61K9/12 , A61K9/122 , A61K9/124 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K2800/31 , A61K2800/33 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.
摘要翻译： 本公开一般涉及用于化妆品或药物应用的组合物。 组合物包括载体和流变学调节剂。
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公开(公告)号：US20110268665A1
公开(公告)日：2011-11-03
申请号：US13123213
申请日：2009-10-06
申请人： Dov Tamarkin , David Schuz , Yohan Hazot , Elana Gazal
发明人： Dov Tamarkin , David Schuz , Yohan Hazot , Elana Gazal
IPC分类号： A61K9/12 , A01P7/02 , A61P17/12 , A61P17/10 , A61P29/00 , A61P37/08 , A61P31/04 , A61K8/02 , A61Q19/08 , A61P25/24 , A61P33/00 , A61P9/00 , A01P7/04 , A01P3/00 , A61Q19/04 , A61Q19/02 , A01N25/16
摘要： A waterless foamable carrier and pharmaceutical composition which is suitable for external and internal administration is disclosed. The composition is single phase and includes at least one liquid oil; and a glyceride. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.
摘要翻译： 公开了一种适用于外部和内部给药的无水可发泡载体和药物组合物。 组合物是单相的，包括至少一种液体油; 和甘油酯。 进一步描述包含活性剂的药物组合物，其制备方法，适用于载体的推进剂及其用途。
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6.发明授权公开(公告)号：US09265725B2
公开(公告)日：2016-02-23
申请号：US11825406
申请日：2007-07-05
申请人： Dov Tamarkin , Doron Friedman , Tal Berman , Enbal Ziv , David Schuz
发明人： Dov Tamarkin , Doron Friedman , Tal Berman , Enbal Ziv , David Schuz
IPC分类号： A61K9/12 , A61K8/362 , A61K8/37 , A61K8/49 , A61K8/86 , A61K9/00 , A61Q19/00 , A01N25/16 , A61K8/04
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K8/362 , A61K8/37 , A61K8/4993 , A61K8/86 , A61K9/0014 , A61Q19/00
摘要： The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.
摘要翻译： 本发明教导了一种可发泡药物载体，其包含选自二羧酸和二羧酸酯的有益剂; 选自由至少一种表面活性剂组成的组的稳定剂; 至少一种聚合物及其混合物; 选自水，亲水溶剂，疏水溶剂，有效溶剂，极性溶剂，硅氧烷，软化剂及其混合物的溶剂，其中选择有益剂，稳定剂和溶剂以提供组合物 其基本上耐老化和相分离，或基本上稳定其它活性成分。 本发明还涉及另外含有液化烃气体推进剂的可发泡组合物。
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7.发明授权Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses 有权非表面活性剂水醇发泡组合物，易碎泡沫及其用途公开(公告)号：US09167813B2
公开(公告)日：2015-10-27
申请号：US13359709
申请日：2012-01-27
申请人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
发明人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
CPC分类号： A61K31/7056 , A01N25/16 , A61K9/0014 , A61K9/122 , A61K31/196 , A61K31/327 , A61K31/573 , A61K31/58 , A61K47/10 , A61K47/38
摘要： A substantially surface active agent-free foamable composition which includes short-chain alcohol, water, polymer, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free foamable composition which includes, water, polymer, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent-free foamable compositions.
摘要翻译： 一种基本上无表面活性剂的可发泡组合物，其包括短链醇，水，聚合物，脂肪醇或脂肪酸，或脂肪醇和脂肪酸与推进剂的组合。 一种基本上无表面活性剂的可发泡组合物，其包括水，聚合物，脂肪醇或脂肪酸和推进剂。 一种使用基本上无表面活性剂的可发泡组合物的处理方法。
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公开(公告)号：US08617100B2
公开(公告)日：2013-12-31
申请号：US12204771
申请日：2008-09-04
申请人： Meir Eini , David Schuz , Helen Shifrin , Yohan Hazot , Dov Tamarkin
发明人： Meir Eini , David Schuz , Helen Shifrin , Yohan Hazot , Dov Tamarkin
CPC分类号： A61M31/00
摘要： A device for delivery of a foamable composition to a body cavity includes a pressurized composition reservoir; a hollow body having a longitudinally extending wall and having at least one aperture provided through a wall of said body, the proximal end in fluid communication with the reservoir for receiving a foamable composition from said composition reservoir; and an actuator operatively connected to the composition reservoir for effecting release of a foamable composition from said composition reservoir into a body cavity through said hollow body; wherein said body has a length less than about 125 mm and internal diameter in the range of about 1.5 mm to about 3.5 mm, wherein said length and internal diameter are selected to provide a delivery of at least about 70% of the foamable composition during operation. The foam delivery device can have multiple apertures.
摘要翻译： 用于将可发泡组合物递送到体腔的装置包括加压组合物储存器; 具有纵向延伸的壁并具有通过所述主体的壁设置的至少一个孔的空心体，所述近端与所述储存器流体连通以从所述组合物储存器接收可发泡组合物; 以及致动器，其可操作地连接到所述组合物储存器，用于通过所述中空体从所述组合物储存器中释放可发泡组合物到体腔中; 其中所述主体具有小于约125mm的长度，并且内径在约1.5mm至约3.5mm的范围内，其中所述长度和内径被选择为在操作期间提供至少约70％的可发泡组合物的输送 。 泡沫输送装置可以具有多个孔。
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9.发明申请公开(公告)号：US20130161351A1
公开(公告)日：2013-06-27
申请号：US13809669
申请日：2011-07-12
申请人： Meir Eini , Tami Winitz , David Schuz
发明人： Meir Eini , Tami Winitz , David Schuz
IPC分类号： B65D83/52
CPC分类号： B01F15/0087 , B01F3/04446 , B01F5/0606 , B01F5/0607 , B01F13/0022 , B05B7/08 , B65D83/14 , B65D83/16 , B65D83/201 , B65D83/202 , B65D83/205 , B65D83/206 , B65D83/207 , B65D83/40 , B65D83/48 , B65D83/525 , B65D83/54 , B65D83/546 , B65D83/68 , B65D83/682
摘要： A apparatus for delivering a predetermined quantity of content from a pressurized container includes a dispensing assembly which sits on the container and connects with an upper portion of a valve stem of the valve assembly, wherein the dispensing assembly includes a) an actuator cap having a discharge passage, which is open or obstructed and wherein the actuator cap acts as a metering chamber in combination with b) an adaptor which fits inside the cap and also snuggly engages the valve stem. The cap fits snuggly over the adjuster to define a metering chamber which depending on its position can close off the metered chamber or open it to the dispensing conduit\nozzle. When the cap is depressed it pushes down on the adjuster which depresses the valve. The chamber fills, but nothing is released until the upstroke.
摘要翻译： 用于从加压容器输送预定量的内容物的装置包括分配组件，其位于容器上并与阀组件的阀杆的上部连接，其中分配组件包括：a）具有放电的致动器盖 通道，其是敞开的或阻塞的，并且其中致动器盖用作计量室，其结合b）适配器，其适配在盖内并且紧密地接合阀杆。 盖子紧紧地配合在调节器上以限定计量室，其根据其位置可以关闭计量室或将其打开到分配管道\喷嘴。 当盖子被压下时，按下压下阀门的调节器。 房间填满，但是直到上冲才释放。
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10.发明申请Non Surface Active Agent Non Polymeric Agent Hydro-Alcoholic Foamable Compositions, Breakable Foams and Their Uses 有权非表面活性剂非聚合物水可发泡组合物，可破坏泡沫及其用途公开(公告)号：US20120213710A1
公开(公告)日：2012-08-23
申请号：US13359787
申请日：2012-01-27
申请人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
发明人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
CPC分类号： A61K9/122 , A61K8/046 , A61K8/34 , A61K8/342 , A61K9/12 , A61K31/573 , A61K47/10 , A61K47/12 , A61K47/44 , A61Q19/00
摘要： A substantially surface active agent-free and substantially polymeric agent-free foamable composition which includes short-chain alcohol, water, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free and substantially polymeric agent-free foamable composition which includes water, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent-free and substantially polymeric agent-free foamable composition.
摘要翻译： 一种基本上无表面活性剂和基本上无聚合物的可发泡组合物，其包括短链醇，水，脂肪醇或脂肪酸，或脂肪醇和脂肪酸与推进剂的组合。 一种基本上无表面活性剂和基本上无聚合物的可发泡组合物，其包括水，脂肪醇或脂肪酸和推进剂。 一种使用基本上无表面活性剂和基本上不含聚合物的可发泡组合物进行处理的方法。
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