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公开(公告)号：US10214567B2
公开(公告)日：2019-02-26
申请号：US15981316
申请日：2018-05-16
发明人： Haitao Guo , Dawei Cai , Andrea Cuconati , Changhua Ji
摘要： The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit covalently closed circular (ccc) DNA of a hepadnavirus, like hepatitis B virus. The methods and uses take advantage of cells comprising a nucleic sequence encoding a tagged hepadnavirus e antigen, like Hepatitis B virus e antigen (HBeAg). Furthermore, the present invention provides nucleic acid sequences encoding a tagged hepadnavirus e antigen and proteins encoded thereby. Also kits for use in the screening methods are provided.
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公开(公告)号：US20180312546A1
公开(公告)日：2018-11-01
申请号：US15981316
申请日：2018-05-16
发明人： Haitao Guo , Dawei Cai , Andrea Cuconati , Changhua Ji
IPC分类号： C07K14/005 , G01N33/50
CPC分类号： C07K14/005 , C07K2319/40 , C07K2319/42 , C12N2730/10122 , C12N2730/10151 , C12N2830/006 , G01N33/502 , G01N2333/02
摘要： The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit covalently closed circular (ccc) DNA of a hepadnavirus, like hepatitis B virus. The methods and uses take advantage of cells comprising a nucleic sequence encoding a tagged hepadnavirus e antigen, like Hepatitis B virus e antigen (HBeAg). Furthermore, the present invention provides nucleic acid sequences encoding a tagged hepadnavirus e antigen and proteins encoded thereby. Also kits for use in the screening methods are provided.
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公开(公告)号：US10072047B2
公开(公告)日：2018-09-11
申请号：US15309680
申请日：2015-06-19
发明人： Haitao Guo , Dawei Cai , Andrea Cuconati , Changhua Ji
IPC分类号： A01N43/04 , A61K31/70 , A61K31/715 , A01N37/18 , A61K31/16 , C07K14/005 , G01N33/50
CPC分类号： C07K14/005 , C07K2319/40 , C07K2319/42 , C12N2730/10122 , C12N2730/10151 , C12N2830/006 , G01N33/502 , G01N2333/02
摘要： The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit covalently closed circular (ccc) DNA of a hepadnavirus, like hepatitis B virus. The methods and uses take advantage of cells comprising a nucleic sequence encoding a tagged hepadnavirus e antigen, like Hepatitis B virus e antigen (HBeAg). Furthermore, the present invention provides nucleic acid sequences encoding a tagged hepadnavirus e antigen and proteins encoded thereby. Also kits for use in the screening methods are provided.
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4.发明授权公开(公告)号：US09657013B2
公开(公告)日：2017-05-23
申请号：US14382074
申请日：2013-02-28
发明人： Andrea Cuconati , Haitao Guo , Timothy M. Block , Ju-Tao Guo , Xiaodong Xu , Huagang Lu , Dawei Cai
IPC分类号： A61K31/4409 , A61K31/505 , A61K31/4465 , A61K31/445 , A61K31/428 , A61K31/165 , A61K31/495 , C07D471/04 , C07D263/56 , C07D213/76 , C07D235/08 , C07D401/12 , C07D239/26 , C07D209/08 , C07D277/64 , C07D211/26 , C07D213/40 , C07C311/21 , C07D295/135 , C07C317/32 , C07D211/34 , C07D211/60 , C07D213/56 , C07D295/155
CPC分类号： C07D471/04 , A61K31/4409 , A61K31/445 , A61K31/4465 , A61K31/505 , C07C311/21 , C07C317/32 , C07D209/08 , C07D211/26 , C07D211/34 , C07D211/60 , C07D213/40 , C07D213/56 , C07D213/76 , C07D235/08 , C07D239/26 , C07D263/56 , C07D277/64 , C07D295/135 , C07D295/155 , C07D401/12
摘要： Pharmaceutical compositions of the invention comprise covalently closed circular DNA formation inhibitors having a disease-modifying action in the treatment of diseases associated with the formation of covalently closed circular DNA that include hepatitis B infection, and any disease involving formation of covalently closed circular DNA.
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5.发明申请INHIBITORS OF HEPATITIS B VIRUS CONVALENTLY CLOSED CIRCULAR DNA FORMATION AND THEIR METHOD OF USE 有权乙型肝炎病毒乙型肝炎病毒绝对封闭圆形DNA形成的抑制剂及其使用方法公开(公告)号：US20150038515A1
公开(公告)日：2015-02-05
申请号：US14382074
申请日：2013-02-28
发明人： Andrea Cuconati , Haitao Guo , Timothy M. Block , Ju-Tao Guo , Xiaodong Xu , Huagang Lu , Dawei Cai
IPC分类号： C07D471/04 , C07D239/26 , C07D295/155 , C07C317/32 , C07D211/34 , C07D277/64 , C07D213/56 , C07D211/60
CPC分类号： C07D471/04 , A61K31/4409 , A61K31/445 , A61K31/4465 , A61K31/505 , C07C311/21 , C07C317/32 , C07D209/08 , C07D211/26 , C07D211/34 , C07D211/60 , C07D213/40 , C07D213/56 , C07D213/76 , C07D235/08 , C07D239/26 , C07D263/56 , C07D277/64 , C07D295/135 , C07D295/155 , C07D401/12
摘要： Pharmaceutical compositions of the invention comprise covalently closed circular DNA formation inhibitors having a disease-modifying action in the treatment of diseases associated with the formation of covalently closed circular DNA that include hepatitis B infection, and any disease involving formation of covalently closed circular DNA.
摘要翻译： 本发明的药物组合物包括共价闭合的环状DNA形成抑制剂，其在治疗与形成共价闭合的环状DNA（包括乙型肝炎感染）有关的疾病以及涉及形成共价闭合的环状DNA的任何疾病中具有疾病修饰作用。
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公开(公告)号：US11243200B2
公开(公告)日：2022-02-08
申请号：US16216848
申请日：2018-12-11
申请人： Drexel University
发明人： Wan Y. Shih , Wei Wu , Wei-Heng Shih , Mehmet Cagri Soylu , Haitao Guo , Suresh G. Joshi , Ceyhun Ekrim Kirimli , Ying-Hsiu Su
IPC分类号： G01N33/543 , G01N29/02 , G01N29/036 , C12Q1/6825
摘要： A piezoelectric plate sensor comprising a piezoelectric layer; two electrodes; and an insulation layer. The insulation layer is produced by soaking the piezoelectric layer and two electrodes in a mercaptopropyltrimethoxysilane solution with an amount of water from 0.1 v/v. % to about 1 v/v % and at pH from about 8 to about 150 for a period from about 8 to about 15 hours, and the mercaptopropyltrimethoxysilane solution has a concentration of mercaptopropyltrimethoxysilane from about 0.01 v/v % to about 0.5 v/v %. A method of detecting a biomolecule in a sample using the piezoelectric plate sensor in particular, that of detecting a genetic marker with PCR sensitivity and specificity without the need of DNA isolation or amplification is also provided. The piezoelectric plate sensor may be used to diagnose various diseases including breast cancer, myocardial infarction, diarrhea, Clostridium difficile infection, and hepatitis B infection.
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