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公开(公告)号：US11583819B2
公开(公告)日：2023-02-21
申请号：US16817299
申请日：2020-03-12
IPC分类号： A61K9/14 , B01J2/00 , C07K14/78 , A61L31/16 , A61L27/34 , A61L29/08 , A61L31/10 , C12M1/00 , B01J13/06 , C07K19/00 , A61K38/00 , B01J2/06 , A61L27/54
摘要： Nano- to microscale liquid coacervate particles are provided. The liquid coacervate particles are produced by a process including stimulating a population of liquid droplets containing one or a mixture of components to induce a phase separation point of a first component, and maintaining stimulation at the phase separation point to form a coacervate domain of the first component within each of the droplets to form the liquid coacervate particles. The self-assembled nano, meso, micro and macro liquid coacervate particles and related coated substrates can have utility in drug delivery, bioanalytical systems, controlled cell culture, tissue engineering, biomanufacturing and drug discovery.
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公开(公告)号：US20160271262A1
公开(公告)日：2016-09-22
申请号：US15074132
申请日：2016-03-18
申请人： Duke University
CPC分类号： A61K47/64 , A61K9/06 , A61K47/6907 , A61L27/227 , A61L27/52 , A61L2300/252 , A61L2300/626 , C07K14/78 , C08J3/075 , C08J2389/00
摘要： The presently disclosed subject matter is directed to compositions, methods, and systems (e.g., platforms) comprising the same, the systems comprising, consisting of, or consisting essentially of micro- and macro-hydrogels that are formed from polypeptide micelles. The systems have enhanced mechanical properties that can be useful in a wide variety of applications, can be used for controlled release of drug-loaded micelles, and can be designed to reversibly assemble and disassemble on demand.
摘要翻译： 目前公开的主题涉及包含其的组合物，方法和系统（例如，平台），所述系统包含由多肽胶束形成的微水凝胶和大水凝胶，或由其组成。 这些系统具有增强的机械性能，其可用于各种应用中，可用于控制释放载药胶束，并且可以设计成可按要求可逆地组装和拆卸。
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公开(公告)号：US09956300B2
公开(公告)日：2018-05-01
申请号：US15074132
申请日：2016-03-18
申请人： Duke University
IPC分类号： A61K47/00 , C07K14/00 , A61K47/48 , A61K9/06 , C08J3/075 , A61L27/22 , A61L27/52 , C07K14/78 , A61K47/64 , A61K47/69
CPC分类号： A61K47/64 , A61K9/06 , A61K47/6907 , A61L27/227 , A61L27/52 , A61L2300/252 , A61L2300/626 , C07K14/78 , C08J3/075 , C08J2389/00
摘要： The presently disclosed subject matter is directed to compositions, methods, and systems (e.g., platforms) comprising the same, the systems comprising, consisting of, or consisting essentially of micro- and macro-hydrogels that are formed from polypeptide micelles. The systems have enhanced mechanical properties that can be useful in a wide variety of applications, can be used for controlled release of drug-loaded micelles, and can be designed to reversibly assemble and disassemble on demand.
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公开(公告)号：US20170216808A1
公开(公告)日：2017-08-03
申请号：US15487543
申请日：2017-04-14
申请人： Duke University
CPC分类号： B01J13/06 , A61K9/146 , A61K38/39 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/62 , B01J2/00 , B01J2/06 , C07K14/78 , C07K19/00 , C12M23/20
摘要： Nano- to microscale liquid coacervate particles are provided. The liquid coacervate particles are produced by a process including stimulating a population of liquid droplets containing one or a mixture of components to induce a phase separation point of a first component, and maintaining stimulation at the phase separation point to form a coacervate domain of the first component within each of the droplets to form the liquid coacervate particles. The self-assembled nano, meso, micro and macro liquid coacervate particles and related coated substrates can have utility in drug delivery, bioanalytical systems, controlled cell culture, tissue engineering, biomanufacturing and drug discovery.
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