专利检索 ap:("Dyax Corp." OR "BRACCO SUISSE SA") AND inv:"Bo Song" 第 1 页

1.

发明授权
KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy 有权
标题翻译： KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用

公开(公告)号：US09446155B2

公开(公告)日：2016-09-20

申请号：US14109508

申请日：2013-12-17

申请人： Dyax Corp. , BRACCO SUISSE SA

发明人： Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert Charles Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan

IPC分类号： C07K14/00 , A61K49/22 , A61K47/48 , A61K51/08 , C07K7/08 , C07K14/52 , C07K14/71 , A61K38/00

CPC分类号： A61K49/221 , A61K38/00 , A61K47/62 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58

摘要： The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD

摘要翻译： 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽，肽二聚体和多聚体复合物，其具有各种用途，无论何处治疗，检测，分离或定位血管发生都是有利的。特别公开的是能够以高亲和力（例如具有KD <1μM）结合KDR或VEGF / KDR复合物的合成，分离的多肽，以及包含这些多肽的二聚体和多聚体构建体。

2.

发明授权
Targeting vector-phospholipid conjugates 有权

公开(公告)号：US09381258B2

公开(公告)日：2016-07-05

申请号：US13948505

申请日：2013-07-23

申请人： BRACCO SUISSE SA

发明人： Philippe Bussat , Samir Cherkaoui , Hong (Helen) Fan , Bernard Lamy , Palaniappa Nanjappan , Radhakrishna K. Pillai , Sibylle Pochon , Bo Song , Rolf E. Swenson

IPC分类号： C07K14/00 , A61K49/22 , A61K47/48 , C07K7/08 , C07K14/52 , C07K14/71 , A61K38/00

CPC分类号： A61K49/223 , A61K38/00 , A61K47/544 , A61K47/60 , A61K47/62 , A61K49/227 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/58

摘要： Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.

3.

发明申请
TARGETING VECTOR-PHOSPHOLIPID CONJUGATES 有权

公开(公告)号：US20140206837A1

公开(公告)日：2014-07-24

申请号：US14190860

申请日：2014-02-26

申请人： BRACCO SUISSE SA

发明人： Philippe Bussat , Samir Cherkaoui , Hong (Helen) Fan , Bernard Lamy , Palaniappa Nanjappan , Radhakrishna K. Pillai , Sibylle Pochon , Bo Song , Rolf E. Swenson

IPC分类号： A61K49/22

CPC分类号： A61K49/223 , A61K38/00 , A61K47/544 , A61K47/60 , A61K47/62 , A61K49/227 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/58

摘要： Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.

4.

发明授权
Targeting vector-phospholipid conjugates 有权

公开(公告)号：US09295737B2

公开(公告)日：2016-03-29

申请号：US14190860

申请日：2014-02-26

申请人： BRACCO SUISSE SA

发明人： Philippe Bussat , Samir Cherkaoui , Hong (Helen) Fan , Bernard Lamy , Palaniappa Nanjappan , Radhakrishna K. Pillai , Sibylle Pochon , Bo Song , Rolf E. Swenson

IPC分类号： A61K38/00 , C07K14/00 , A61K49/22 , A61K47/48 , C07K7/08 , C07K14/52 , C07K14/71

CPC分类号： A61K49/223 , A61K38/00 , A61K47/544 , A61K47/60 , A61K47/62 , A61K49/227 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/58

摘要： Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.

5.

发明申请
TARGETING VECTOR-PHOSPHOLIPID CONJUGATES 有权
标题翻译：靶向载体 - 磷脂结合体

公开(公告)号：US20140031520A1

公开(公告)日：2014-01-30

申请号：US13948505

申请日：2013-07-23

申请人： BRACCO SUISSE SA

发明人： Philippe BUSSAT , Samir Cherkaoui , Hong (Helen) Fan , Bernard Lamy , Palaniappa Nanjappan , Radhakrishna K. Pillai , Sibylle Pochon , Bo Song , Rolf E. Swenson

IPC分类号： C07K14/00

CPC分类号： A61K49/223 , A61K38/00 , A61K47/544 , A61K47/60 , A61K47/62 , A61K49/227 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/58

摘要： Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.

摘要翻译： 提供具有高KDR结合亲和力的肽载体和用于制备此类载体的方法。肽载体可以与磷脂结合并包含在超声造影剂组合物中。这样的超声造影剂在治疗和诊断方法中是特别有用的，例如在成像含KDR组织和评估和治疗与肿瘤病症相关的血管生成过程中。本发明还提供大规模生产高纯度二聚体和单体肽磷脂共轭物以及用于形成缀合物的前体材料的方法。本发明还提供了大规模生产含有非常低水平的TFA的高纯度肽磷脂缀合物的方法。