公开(公告)号：US09446155B2

公开(公告)日：2016-09-20

申请号：US14109508

申请日：2013-12-17

申请人： Dyax Corp. ,  BRACCO SUISSE SA

发明人： Aaron K. Sato ,  Daniel J. Sexton ,  Daniel T. Dransfield ,  Robert Charles Ladner ,  Christophe Arbogast ,  Philippe Bussat ,  Hong Fan ,  Sudha Khurana ,  Karen E. Linder ,  Edmund R. Marinelli ,  Palaniappa Nanjappan ,  Adrian D. Nunn ,  Radhakrishna K. Pillai ,  Sibylle Pochon ,  Kondareddiar Ramalingam ,  Ajay Shrivastava ,  Bo Song ,  Rolf E. Swenson ,  Mathew A. Von Wronski ,  Feng Yan

IPC分类号： C07K14/00 ,  A61K49/22 ,  A61K47/48 ,  A61K51/08 ,  C07K7/08 ,  C07K14/52 ,  C07K14/71 ,  A61K38/00

CPC分类号： A61K49/221 ,  A61K38/00 ,  A61K47/62 ,  A61K49/223 ,  A61K51/088 ,  C07K7/08 ,  C07K14/001 ,  C07K14/52 ,  C07K14/71 ,  C07K2319/00 ,  Y02A50/411 ,  Y02A50/58

摘要： The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD

摘要翻译： 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽，肽二聚体和多聚体复合物，其具有各种用途，无论何处治疗，检测，分离或定位血管发生都是有利的。 特别公开的是能够以高亲和力（例如具有KD <1μM）结合KDR或VEGF / KDR复合物的合成，分离的多肽，以及包含这些多肽的二聚体和多聚体构建体。

公开(公告)号：US20200325469A1

公开(公告)日：2020-10-15

申请号：US16789468

申请日：2020-02-13

申请人： Dyax Corp.

发明人： Robert Charles Ladner

IPC分类号： C12N15/10 ,  C07K16/00 ,  C40B40/02

摘要： Focused libraries of vectors or genetic packages that display, display and express, or comprise a member of a diverse family of antibody peptides, polypeptides or proteins and collectively display, display and express, or comprise at least a portion of the focused diversity of the family. The libraries have length and sequence diversities that mimic that found in native human antibodies.

公开(公告)号：US09683028B2

公开(公告)日：2017-06-20

申请号：US14557171

申请日：2014-12-01

申请人： Dyax Corp.

发明人： Robert Charles Ladner ,  Edward Hirsch Cohen ,  Horacio Gabriel Nastri ,  Kristin L. Rookey ,  Rene Hoet ,  Hendricus Renerus Jacobus Mattheus Hoogenboom

IPC分类号： C40B40/08 ,  C07K16/00 ,  C12N15/10 ,  C12N15/66 ,  C40B40/02

CPC分类号： C07K16/005 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/622 ,  C12N15/10 ,  C12N15/1037 ,  C12N15/1093 ,  C12N15/66 ,  C40B40/02 ,  C40B40/08

摘要： Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.

公开(公告)号：US20160222110A1

公开(公告)日：2016-08-04

申请号：US14982649

申请日：2015-12-29

申请人： DYAX CORP. ,  BIOGEN HEMOPHILIA INC.

发明人： Christopher TenHoor ,  Arumugam Muruganandam ,  Robert Charles Ladner ,  Clive Wood ,  Alan J. Bitonti ,  James M. McGivney ,  Kevin A. McDonnell ,  Liming Liu ,  Jennifer Dumont ,  Aaron K. Sato ,  Malini Viswanathan

IPC分类号： C07K16/28 ,  G01N33/68 ,  A61K49/00 ,  A61K51/10 ,  A61K49/16

摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

公开(公告)号：US09260520B2

公开(公告)日：2016-02-16

申请号：US14168839

申请日：2014-01-30

申请人： DYAX CORP. ,  BIOGEN HEMOPHILIA INC.

发明人： Christopher TenHoor ,  Arumugam Muruganandam ,  Robert Charles Ladner ,  Clive Wood ,  Alan J. Bitonti ,  James McGivney ,  Kevin McDonnell ,  Liming Liu ,  Jennifer Dumont ,  Aaron K. Sato ,  Malini Viswanathan

IPC分类号： C07K16/28 ,  G01N33/579 ,  G01N33/68 ,  A61K39/00

CPC分类号： C07K16/283 ,  A61K49/0058 ,  A61K49/16 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/68 ,  G01N33/6854 ,  G01N2333/70535

摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

摘要翻译： 本公开尤其提供结合FcRn的蛋白质，例如以高亲和力和选择性抑制FcRn的免疫球蛋白。 FcRn结合蛋白可用于治疗多种疾病，包括自身免疫性疾病。

公开(公告)号：US20180291368A1

公开(公告)日：2018-10-11

申请号：US15797927

申请日：2017-10-30

申请人： Dyax Corp.

发明人： Robert Charles Ladner

IPC分类号： C12N15/10 ,  C07K16/00 ,  C40B40/02

摘要： Focused libraries of vectors or genetic packages that display, display and express, or comprise a member of a diverse family of antibody peptides, polypeptides or proteins and collectively display, display and express, or comprise at least a portion of the focused diversity of the family. The libraries have length and sequence diversities that mimic that found in native human antibodies.

公开(公告)号：US20180251912A1

公开(公告)日：2018-09-06

申请号：US15836230

申请日：2017-12-08

申请人： Dyax Corp.

发明人： Robert Charles Ladner

IPC分类号： C40B40/08 ,  C07K16/00 ,  C07K16/28 ,  C40B50/06 ,  C07K16/12

CPC分类号： C40B40/08 ,  C07K16/005 ,  C07K16/1275 ,  C07K16/28 ,  C07K2317/565 ,  C40B50/06

摘要： Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in sequence and in length from very short to very long which in certain embodiments may bind to a carbohydrate moiety or the active site of an enzyme. Libraries coding for antibodies with the CDR3s are also provided. The libraries can be provided by modifying a pre-existing nucleic acid library.

公开(公告)号：US20160361395A1

公开(公告)日：2016-12-15

申请号：US15175644

申请日：2016-06-07

申请人： Dyax Corp.

发明人： Robert Charles Ladner ,  Arthur Charles Ley ,  Shirish Hirani ,  Anthony Williams

IPC分类号： A61K38/57 ,  A61K9/00

CPC分类号： A61K38/57 ,  A61K9/0019 ,  A61K38/55 ,  C12N9/6445

摘要： Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.

摘要翻译： 描述了用于预防或减少患者中缺血和/或全身炎症反应的方法，例如进行心胸外科手术的患者中的围手术期失血和/或全身炎症反应。 冠状动脉旁路移植术等外科手术，特别是当此类手术涉及体外循环，如体外循环时。

公开(公告)号：US20160222112A1

公开(公告)日：2016-08-04

申请号：US14984162

申请日：2015-12-30

申请人： DYAX CORP. ,  BIOGEN HEMOPHILIA INC.

发明人： Christopher TenHoor ,  Arumugam Muruganandam ,  Robert Charles Ladner ,  Clive Wood ,  Alan J. Bitonti ,  James M. McGivney ,  Kevin A. McDonnell ,  Liming Liu ,  Jennifer Dumont ,  Aaron K. Sato ,  Malini Viswanathan

IPC分类号： C07K16/28

摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

公开(公告)号：US20160194397A1

公开(公告)日：2016-07-07

申请号：US14985614

申请日：2015-12-31

申请人： DYAX CORP. ,  BIOGEN HEMOPHILIA INC.

发明人： Christopher TenHoor ,  Arumugam Muruganandam ,  Robert Charles Ladner ,  Clive Wood ,  Alan J. Bitonti ,  James M. McGivney ,  Kevin A. McDonnell ,  Liming Liu ,  Jennifer Dumont ,  Aaron K. Sato ,  Malini Viswanathan

IPC分类号： C07K16/28

摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.