公开(公告)号：US20180298110A1

公开(公告)日：2018-10-18

申请号：US15562671

申请日：2016-03-30

Applicant: Dyax Corp. ,  SYNVINA C.V.

Inventor： Yung Chyung ,  Burt Adelman ,  Daniel J. Sexton

IPC: C07K16/40 ,  A61P7/10

Abstract: Provided herein are plasma kallikrein antibodies binding to active plasma kallikrein and methods of using such antibodies in preventing hereditary angioedema attack or reducing the rate of hereditary angioedema attack.

公开(公告)号：US20210322972A1

公开(公告)日：2021-10-21

申请号：US17102509

申请日：2020-11-24

Applicant: Dyax Corp.

Inventor： Daniel J. Sexton ,  Ryan Faucette

IPC: B01L3/00 ,  A61B5/15 ,  A61B5/154 ,  C07K16/40 ,  G01N33/564 ,  G01N33/573 ,  G01N33/96

Abstract: Disclosed herein are evacuated blood collection tubes comprising protease inhibitor cocktails in liquid form and uses thereof for assessing features associated with the contact system in a subject, including the endogenous level of contact system activation, the endogenous level of a drug that targets a component of contact system during treatment, and/or the immunogenicity of such a drug.

公开(公告)号：US20210309741A1

公开(公告)日：2021-10-07

申请号：US17203816

申请日：2021-03-17

Applicant: Dyax Corp.

Inventor： Daniel J. Sexton ,  Christopher TenHoor ,  Malini Viswanathan

IPC: C07K16/28 ,  A61K49/00 ,  G01N33/68 ,  A61K39/395 ,  A61K48/00

Abstract: The disclosure relates to antibodies that bind FcRn and methods of using these antibodies.

公开(公告)号：US20210087293A1

公开(公告)日：2021-03-25

申请号：US17010354

申请日：2020-09-02

Applicant: Dyax Corp.

Inventor： Daniel J. Sexton ,  Burt Adelman ,  Yung Chyung ,  Christopher TenHoor ,  Jon A. Kenniston ,  Ryan Faucette ,  Ryan Iarrobino ,  Joseph Biedenkapp

IPC: C07K16/40

Abstract: Provided herein are plasma kallikrein binding proteins such as antibodies binding to active plasma kallikrein and methods of using such proteins in treating hereditary angioedema.

公开(公告)号：US10370453B2

公开(公告)日：2019-08-06

申请号：US14969498

申请日：2015-12-15

Applicant: Dyax Corp.

Inventor： Daniel J. Sexton ,  Malini Viswanathan

IPC: C07K16/40 ,  G01N33/573 ,  A61K39/00

Abstract: Plasma kallikrein binding proteins and methods of using such proteins are described.

公开(公告)号：US20180002448A1

公开(公告)日：2018-01-04

申请号：US15706621

申请日：2017-09-15

Applicant: Dyax Corp.

Inventor： Daniel J. Sexton ,  Malini Viswanathan

IPC: C07K16/40 ,  A61K49/00 ,  A61K39/00

CPC classification number: C07K16/40 ,  A61K49/0004 ,  A61K2039/505 ,  C07K2317/76 ,  C07K2317/92

Abstract: Plasma kallikrein binding proteins and methods of using such proteins are described.

公开(公告)号：US20160102150A1

公开(公告)日：2016-04-14

申请号：US14969498

申请日：2015-12-15

Applicant: Dyax Corp.

Inventor： Daniel J. Sexton ,  Malini Viswanathan

IPC: C07K16/40 ,  G01N33/573

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/573 ,  G01N2333/96455 ,  G01N2500/04

Abstract: Plasma kallikrein binding proteins and methods of using such proteins are described.

Abstract translation: 描述了血浆激肽释放酶结合蛋白和使用这些蛋白质的方法。

公开(公告)号：US20150274841A1

公开(公告)日：2015-10-01

申请号：US14669607

申请日：2015-03-26

Applicant: Dyax Corp.

Inventor： Gregory P. Conley ,  Andrew Nixon ,  Daniel J. Sexton

IPC: C07K16/40 ,  A61K9/00

CPC classification number: C07K16/40 ,  A61K9/0051 ,  A61K2039/505 ,  C07K2317/30 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92

Abstract: Disclosed herein are compositions comprising one or more antibodies that specifically bind active plasma kallikrein (e.g., human plasma kallikrein) and methods of using such compositions for the treatment of retinal diseases, such as diabetic macular edema.

Abstract translation: 本文公开了包含一种或多种特异性结合活性血浆激肽释放酶（例如人血浆激肽释放酶）的抗体的组合物以及使用该组合物治疗视网膜疾病如糖尿病性黄斑水肿的方法。

公开(公告)号：US20210270842A1

公开(公告)日：2021-09-02

申请号：US17141690

申请日：2021-01-05

Applicant: Dyax Corp.

Inventor： Daniel J. Sexton ,  Ryan Faucette ,  Janja Cosic

IPC: G01N33/68 ,  G01N33/86 ,  C07K16/36 ,  G01N33/543

Abstract: The present disclosure provides immunoassay methods of detecting a cleaved high molecular weight kininogen (HMWK) with high sensitivity and specificity and isolated antibodies that specifically bind cleaved HMWK.

公开(公告)号：US20210025898A1

公开(公告)日：2021-01-28

申请号：US16062734

申请日：2016-12-15

Applicant: Dyax Corp.

Inventor： Jiang Wu ,  Guodong Zhang ,  Daniel J. Sexton ,  Ryan Faucette ,  Gul M. Mustafa ,  Mark Szewc

IPC: G01N33/68 ,  G01N30/88 ,  G01N30/72

Abstract: Methods for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK in a sample are provided herein. Such methods may comprise treating a biological sample with a protease to generate a plurality of digested peptides, and measuring one or more signature peptides, which are indicative of cleaved HMWK and/or full-length HMWK.